Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q126_LEIMA

TriTrypDb:

LmjF.36.3890 , LMJLV39_360049600 , LMJSD75_360049400

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	8
GO:0031974	membrane-enclosed lumen	2	8
GO:0043233	organelle lumen	3	8
GO:0070013	intracellular organelle lumen	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q126

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q126

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.708
CLV_NRD_NRD_1	25	27	PF00675	0.651
CLV_NRD_NRD_1	298	300	PF00675	0.323
CLV_NRD_NRD_1	46	48	PF00675	0.717
CLV_NRD_NRD_1	89	91	PF00675	0.524
CLV_PCSK_KEX2_1	214	216	PF00082	0.513
CLV_PCSK_KEX2_1	25	27	PF00082	0.520
CLV_PCSK_KEX2_1	46	48	PF00082	0.717
CLV_PCSK_KEX2_1	5	7	PF00082	0.724
CLV_PCSK_KEX2_1	89	91	PF00082	0.543
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.488
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.724
CLV_PCSK_PC7_1	210	216	PF00082	0.451
CLV_PCSK_SKI1_1	285	289	PF00082	0.346
CLV_PCSK_SKI1_1	378	382	PF00082	0.526
DEG_APCC_DBOX_1	214	222	PF00400	0.439
DEG_APCC_DBOX_1	350	358	PF00400	0.583
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DEG_SPOP_SBC_1	148	152	PF00917	0.601
DOC_CYCLIN_RxL_1	375	383	PF00134	0.524
DOC_MAPK_MEF2A_6	253	260	PF00069	0.523
DOC_PP4_FxxP_1	372	375	PF00568	0.548
DOC_USP7_MATH_1	108	112	PF00917	0.728
DOC_USP7_MATH_1	14	18	PF00917	0.720
DOC_USP7_MATH_1	148	152	PF00917	0.714
DOC_USP7_MATH_1	35	39	PF00917	0.652
DOC_USP7_MATH_1	64	68	PF00917	0.545
DOC_WW_Pin1_4	106	111	PF00397	0.699
DOC_WW_Pin1_4	178	183	PF00397	0.708
LIG_14-3-3_CanoR_1	335	341	PF00244	0.564
LIG_14-3-3_CanoR_1	46	55	PF00244	0.607
LIG_14-3-3_CterR_2	390	394	PF00244	0.580
LIG_BRCT_BRCA1_1	338	342	PF00533	0.523
LIG_Clathr_ClatBox_1	373	377	PF01394	0.534
LIG_deltaCOP1_diTrp_1	332	340	PF00928	0.564
LIG_FHA_1	49	55	PF00498	0.685
LIG_FHA_2	187	193	PF00498	0.627
LIG_FHA_2	238	244	PF00498	0.566
LIG_LIR_Apic_2	369	375	PF02991	0.556
LIG_LIR_Apic_2	91	96	PF02991	0.615
LIG_LIR_Gen_1	319	329	PF02991	0.485
LIG_LIR_Gen_1	71	81	PF02991	0.454
LIG_LIR_Nem_3	243	247	PF02991	0.323
LIG_LIR_Nem_3	339	343	PF02991	0.489
LIG_LIR_Nem_3	71	77	PF02991	0.459
LIG_PTB_Apo_2	315	322	PF02174	0.480
LIG_PTB_Phospho_1	315	321	PF10480	0.480
LIG_Rb_pABgroove_1	315	323	PF01858	0.564
LIG_SH2_CRK	304	308	PF00017	0.480
LIG_SH2_CRK	93	97	PF00017	0.605
LIG_SH2_NCK_1	93	97	PF00017	0.605
LIG_SH2_SRC	343	346	PF00017	0.454
LIG_SH2_STAT5	343	346	PF00017	0.529
LIG_SH2_STAT5	349	352	PF00017	0.526
LIG_SH2_STAT5	93	96	PF00017	0.637
LIG_SH3_1	5	11	PF00018	0.605
LIG_SH3_1	93	99	PF00018	0.606
LIG_SH3_3	180	186	PF00018	0.668
LIG_SH3_3	273	279	PF00018	0.523
LIG_SH3_3	5	11	PF00018	0.652
LIG_SH3_3	93	99	PF00018	0.545
LIG_SUMO_SIM_anti_2	38	43	PF11976	0.686
LIG_TRAF2_1	281	284	PF00917	0.528
LIG_TRAF2_1	29	32	PF00917	0.626
LIG_TRAF2_1	50	53	PF00917	0.610
LIG_UBA3_1	76	82	PF00899	0.488
LIG_WRC_WIRS_1	238	243	PF05994	0.578
LIG_WW_3	231	235	PF00397	0.667
MOD_CK1_1	124	130	PF00069	0.628
MOD_CK1_1	150	156	PF00069	0.637
MOD_CK1_1	48	54	PF00069	0.559
MOD_CK2_1	159	165	PF00069	0.741
MOD_CK2_1	181	187	PF00069	0.661
MOD_CK2_1	278	284	PF00069	0.523
MOD_CK2_1	47	53	PF00069	0.588
MOD_CMANNOS	333	336	PF00535	0.323
MOD_Cter_Amidation	44	47	PF01082	0.699
MOD_GlcNHglycan	123	126	PF01048	0.690
MOD_GlcNHglycan	133	136	PF01048	0.814
MOD_GlcNHglycan	16	19	PF01048	0.671
MOD_GlcNHglycan	280	283	PF01048	0.364
MOD_GlcNHglycan	32	36	PF01048	0.555
MOD_GlcNHglycan	70	73	PF01048	0.453
MOD_GSK3_1	102	109	PF00069	0.720
MOD_GSK3_1	146	153	PF00069	0.661
MOD_GSK3_1	31	38	PF00069	0.599
MOD_GSK3_1	64	71	PF00069	0.406
MOD_N-GLC_1	129	134	PF02516	0.762
MOD_PIKK_1	150	156	PF00454	0.723
MOD_PIKK_1	181	187	PF00454	0.672
MOD_PIKK_1	56	62	PF00454	0.527
MOD_PKA_2	103	109	PF00069	0.663
MOD_PKA_2	14	20	PF00069	0.671
MOD_PKA_2	175	181	PF00069	0.700
MOD_PKA_2	45	51	PF00069	0.637
MOD_Plk_1	186	192	PF00069	0.675
MOD_Plk_1	31	37	PF00069	0.654
MOD_Plk_1	56	62	PF00069	0.527
MOD_Plk_2-3	165	171	PF00069	0.566
MOD_Plk_4	108	114	PF00069	0.535
MOD_Plk_4	336	342	PF00069	0.525
MOD_ProDKin_1	106	112	PF00069	0.694
MOD_ProDKin_1	178	184	PF00069	0.707
TRG_DiLeu_BaEn_1	284	289	PF01217	0.506
TRG_DiLeu_BaEn_1	369	374	PF01217	0.493
TRG_DiLeu_BaEn_4	369	375	PF01217	0.498
TRG_ENDOCYTIC_2	321	324	PF00928	0.485
TRG_ENDOCYTIC_2	74	77	PF00928	0.462
TRG_ENDOCYTIC_2	81	84	PF00928	0.408
TRG_ER_diArg_1	215	218	PF00400	0.462
TRG_ER_diArg_1	24	26	PF00400	0.656
TRG_ER_diArg_1	88	90	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	47	52	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBQ8	Leptomonas seymouri	60%	100%
A0A0S4JKT7	Bodo saltans	32%	100%
A0A3Q8IGD8	Leishmania donovani	91%	100%
A4HPQ6	Leishmania braziliensis	80%	100%
A4ID07	Leishmania infantum	91%	100%
E9ATH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%