Adenosylhomocysteinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

S-adenosylhomocysteine hydrolase

Species:

Leishmania major

UniProt:

Q4Q124_LEIMA

TriTrypDb:

LmjF.36.3910 , LMJLV39_360049800 , LMJSD75_360049600

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q124

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q124

PDB structure(s): 3g1u_A , 3g1u_B , 3g1u_C , 3g1u_D

Function

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Biological processes
Term	Name	Level	Count
GO:0006730	one-carbon metabolic process	3	12
GO:0006790	sulfur compound metabolic process	3	2
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0033353	S-adenosylmethionine cycle	4	2
GO:0044237	cellular metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046500	S-adenosylmethionine metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	12
GO:0004013	adenosylhomocysteinase activity	5	12
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	1
GO:0016787	hydrolase activity	2	12
GO:0016801	hydrolase activity, acting on ether bonds	3	12
GO:0016802	trialkylsulfonium hydrolase activity	4	12
GO:0036094	small molecule binding	2	2
GO:0097159	organic cyclic compound binding	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.516
CLV_C14_Caspase3-7	373	377	PF00656	0.525
CLV_C14_Caspase3-7	80	84	PF00656	0.530
CLV_NRD_NRD_1	15	17	PF00675	0.317
CLV_NRD_NRD_1	33	35	PF00675	0.310
CLV_PCSK_KEX2_1	165	167	PF00082	0.316
CLV_PCSK_KEX2_1	203	205	PF00082	0.314
CLV_PCSK_KEX2_1	33	35	PF00082	0.328
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.316
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.316

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A087WNH6	Bradyrhizobium elkanii	59%	92%
A0A0N0P671	Leptomonas seymouri	94%	100%
A0A1X0P3F7	Trypanosomatidae	88%	100%
A0A3R7RKL4	Trypanosoma rangeli	85%	100%
A0A3S7XBG7	Leishmania donovani	99%	100%
A0M5W6	Gramella forsetii (strain KT0803)	67%	100%
A0PRF5	Mycobacterium ulcerans (strain Agy99)	55%	89%
A1BEZ2	Chlorobium phaeobacteroides (strain DSM 266)	59%	93%
A1KNQ0	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	55%	88%
A1TUG3	Acidovorax citrulli (strain AAC00-1)	58%	92%

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