Coiled-coil domain-containing protein 22 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q120_LEIMA

TriTrypDb:

LmjF.36.3950 , LMJLV39_360050200 , LMJSD75_360050000

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q120

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q120

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.476
CLV_NRD_NRD_1	208	210	PF00675	0.512
CLV_NRD_NRD_1	99	101	PF00675	0.403
CLV_PCSK_FUR_1	129	133	PF00082	0.457
CLV_PCSK_KEX2_1	13	15	PF00082	0.476
CLV_PCSK_KEX2_1	131	133	PF00082	0.452
CLV_PCSK_KEX2_1	49	51	PF00082	0.521
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.452
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.483
CLV_Separin_Metazoa	2	6	PF03568	0.497
CLV_Separin_Metazoa	92	96	PF03568	0.450
DEG_APCC_DBOX_1	204	212	PF00400	0.477
DEG_Nend_UBRbox_2	1	3	PF02207	0.482
DOC_CKS1_1	145	150	PF01111	0.523
DOC_CYCLIN_yClb5_NLxxxL_5	68	77	PF00134	0.320
DOC_MAPK_gen_1	209	219	PF00069	0.515
DOC_MAPK_gen_1	86	93	PF00069	0.568
DOC_USP7_MATH_1	141	145	PF00917	0.448
DOC_WW_Pin1_4	144	149	PF00397	0.514
LIG_14-3-3_CanoR_1	149	155	PF00244	0.576
LIG_14-3-3_CanoR_1	54	63	PF00244	0.463
LIG_Actin_WH2_2	59	76	PF00022	0.456
LIG_APCC_ABBA_1	36	41	PF00400	0.496
LIG_APCC_ABBAyCdc20_2	52	58	PF00400	0.464
LIG_FHA_1	174	180	PF00498	0.506
LIG_FHA_1	63	69	PF00498	0.335
LIG_FHA_2	103	109	PF00498	0.433
LIG_GBD_Chelix_1	47	55	PF00786	0.467
LIG_LIR_LC3C_4	176	180	PF02991	0.477
LIG_NRBOX	215	221	PF00104	0.496
LIG_PCNA_yPIPBox_3	13	22	PF02747	0.477
LIG_SH2_STAP1	98	102	PF00017	0.452
LIG_SH2_STAT5	238	241	PF00017	0.499
LIG_SUMO_SIM_par_1	123	128	PF11976	0.458
LIG_SUMO_SIM_par_1	218	224	PF11976	0.444
LIG_TRAF2_1	164	167	PF00917	0.443
LIG_TRAF2_1	224	227	PF00917	0.510
LIG_WRC_WIRS_1	222	227	PF05994	0.457
MOD_CDK_SPK_2	144	149	PF00069	0.514
MOD_CK1_1	144	150	PF00069	0.471
MOD_CK2_1	102	108	PF00069	0.569
MOD_CK2_1	221	227	PF00069	0.546
MOD_CK2_1	58	64	PF00069	0.605
MOD_CK2_1	73	79	PF00069	0.302
MOD_CK2_1	86	92	PF00069	0.349
MOD_GlcNHglycan	201	204	PF01048	0.666
MOD_GSK3_1	195	202	PF00069	0.630
MOD_GSK3_1	54	61	PF00069	0.617
MOD_N-GLC_1	150	155	PF02516	0.509
MOD_N-GLC_1	68	73	PF02516	0.441
MOD_NEK2_1	120	125	PF00069	0.437
MOD_NEK2_1	178	183	PF00069	0.493
MOD_NEK2_2	141	146	PF00069	0.456
MOD_PKA_1	86	92	PF00069	0.440
MOD_PKB_1	52	60	PF00069	0.464
MOD_Plk_1	150	156	PF00069	0.546
MOD_Plk_1	173	179	PF00069	0.501
MOD_Plk_1	78	84	PF00069	0.361
MOD_Plk_2-3	221	227	PF00069	0.456
MOD_Plk_2-3	58	64	PF00069	0.464
MOD_Plk_4	120	126	PF00069	0.357
MOD_Plk_4	184	190	PF00069	0.537
MOD_ProDKin_1	144	150	PF00069	0.518
MOD_SUMO_for_1	114	117	PF00179	0.467
MOD_SUMO_for_1	130	133	PF00179	0.511
MOD_SUMO_for_1	189	192	PF00179	0.529
MOD_SUMO_for_1	25	28	PF00179	0.488
MOD_SUMO_rev_2	79	89	PF00179	0.455
TRG_DiLeu_BaEn_1	174	179	PF01217	0.478
TRG_DiLeu_BaEn_1	212	217	PF01217	0.514
TRG_ER_diArg_1	13	16	PF00400	0.553
TRG_ER_diArg_1	51	54	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JLH7	Bodo saltans	37%	71%
A0A3S7XBE4	Leishmania donovani	97%	100%
A4ID01	Leishmania infantum	97%	88%
E9ATH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B6W3	Trypanosoma cruzi	44%	88%