CDC73_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase-associated protein CDC73, putative

Species:

Leishmania major

UniProt:

Q4Q117_LEIMA

TriTrypDb:

LmjF.36.3980 , LMJLV39_360050700 , LMJSD75_360050600

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0008023	transcription elongation factor complex	3	10
GO:0016593	Cdc73/Paf1 complex	4	10
GO:0032991	protein-containing complex	1	10
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	10

Expansion

Sequence features

Q4Q117

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q117

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006354	DNA-templated transcription elongation	6	10
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0006368	transcription elongation by RNA polymerase II	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009987	cellular process	1	10
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0016043	cellular component organization	3	2
GO:0016070	RNA metabolic process	5	10
GO:0016570	histone modification	5	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0019538	protein metabolic process	3	10
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0032774	RNA biosynthetic process	5	10
GO:0032784	regulation of DNA-templated transcription elongation	7	2
GO:0032786	positive regulation of DNA-templated transcription, elongation	8	2
GO:0032968	positive regulation of transcription elongation by RNA polymerase II	9	2
GO:0034243	regulation of transcription elongation by RNA polymerase II	8	2
GO:0034402	recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0045893	positive regulation of DNA-templated transcription	7	2
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	2
GO:0045944	positive regulation of transcription by RNA polymerase II	8	2
GO:0046483	heterocycle metabolic process	3	10
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051254	positive regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	10
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901576	organic substance biosynthetic process	3	10
GO:1902680	positive regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0000993	RNA polymerase II complex binding	5	2
GO:0001098	basal transcription machinery binding	3	2
GO:0001099	basal RNA polymerase II transcription machinery binding	4	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0043175	RNA polymerase core enzyme binding	5	2
GO:0070063	RNA polymerase binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.550
CLV_NRD_NRD_1	137	139	PF00675	0.754
CLV_NRD_NRD_1	168	170	PF00675	0.596
CLV_PCSK_FUR_1	135	139	PF00082	0.758
CLV_PCSK_KEX2_1	135	137	PF00082	0.740
CLV_PCSK_PC7_1	131	137	PF00082	0.764
CLV_PCSK_SKI1_1	101	105	PF00082	0.685
CLV_PCSK_SKI1_1	193	197	PF00082	0.344
CLV_PCSK_SKI1_1	295	299	PF00082	0.454
CLV_PCSK_SKI1_1	322	326	PF00082	0.348
DEG_SPOP_SBC_1	2	6	PF00917	0.684
DOC_CDC14_PxL_1	70	78	PF14671	0.393
DOC_CYCLIN_RxL_1	319	327	PF00134	0.387
DOC_MAPK_gen_1	169	176	PF00069	0.499
DOC_MAPK_gen_1	219	228	PF00069	0.444
DOC_MAPK_HePTP_8	167	179	PF00069	0.564
DOC_MAPK_MEF2A_6	169	178	PF00069	0.478
DOC_MAPK_MEF2A_6	326	333	PF00069	0.444
DOC_PP1_RVXF_1	13	20	PF00149	0.369
DOC_PP2B_LxvP_1	76	79	PF13499	0.675
DOC_PP4_FxxP_1	233	236	PF00568	0.444
DOC_USP7_MATH_1	123	127	PF00917	0.830
DOC_USP7_MATH_1	2	6	PF00917	0.715
DOC_USP7_MATH_1	332	336	PF00917	0.444
DOC_USP7_MATH_1	7	11	PF00917	0.607
DOC_USP7_MATH_1	72	76	PF00917	0.563
DOC_USP7_MATH_1	89	93	PF00917	0.481
DOC_WW_Pin1_4	159	164	PF00397	0.714
DOC_WW_Pin1_4	3	8	PF00397	0.703
LIG_BIR_II_1	1	5	PF00653	0.742
LIG_BRCT_BRCA1_1	287	291	PF00533	0.344
LIG_CaM_NSCaTE_8	18	25	PF13499	0.560
LIG_CtBP_PxDLS_1	48	52	PF00389	0.592
LIG_FHA_1	146	152	PF00498	0.709
LIG_FHA_1	182	188	PF00498	0.384
LIG_FHA_1	204	210	PF00498	0.394
LIG_FHA_1	211	217	PF00498	0.409
LIG_FHA_1	29	35	PF00498	0.566
LIG_FHA_1	319	325	PF00498	0.344
LIG_FHA_1	353	359	PF00498	0.495
LIG_FHA_2	341	347	PF00498	0.416
LIG_FHA_2	80	86	PF00498	0.555
LIG_Integrin_isoDGR_2	129	131	PF01839	0.816
LIG_LIR_Apic_2	232	236	PF02991	0.444
LIG_LIR_Apic_2	352	357	PF02991	0.595
LIG_LIR_Apic_2	43	48	PF02991	0.614
LIG_LIR_Gen_1	16	27	PF02991	0.524
LIG_LIR_Gen_1	256	266	PF02991	0.444
LIG_LIR_Gen_1	288	299	PF02991	0.344
LIG_LIR_Gen_1	335	345	PF02991	0.344
LIG_LIR_Gen_1	57	65	PF02991	0.552
LIG_LIR_Gen_1	92	98	PF02991	0.703
LIG_LIR_Nem_3	105	111	PF02991	0.724
LIG_LIR_Nem_3	16	22	PF02991	0.478
LIG_LIR_Nem_3	172	176	PF02991	0.401
LIG_LIR_Nem_3	256	261	PF02991	0.418
LIG_LIR_Nem_3	288	294	PF02991	0.344
LIG_LIR_Nem_3	335	341	PF02991	0.344
LIG_LIR_Nem_3	57	62	PF02991	0.539
LIG_LIR_Nem_3	92	97	PF02991	0.702
LIG_PDZ_Class_3	358	363	PF00595	0.659
LIG_Pex14_1	338	342	PF04695	0.344
LIG_Pex14_2	297	301	PF04695	0.401
LIG_Pex14_2	93	97	PF04695	0.706
LIG_SH2_CRK	354	358	PF00017	0.576
LIG_SH2_PTP2	201	204	PF00017	0.344
LIG_SH2_SRC	201	204	PF00017	0.344
LIG_SH2_SRC	45	48	PF00017	0.553
LIG_SH2_STAT5	201	204	PF00017	0.344
LIG_SH2_STAT5	208	211	PF00017	0.344
LIG_SH2_STAT5	300	303	PF00017	0.344
LIG_SH2_STAT5	342	345	PF00017	0.378
LIG_SH2_STAT5	354	357	PF00017	0.459
LIG_SH2_STAT5	40	43	PF00017	0.578
LIG_SH2_STAT5	45	48	PF00017	0.535
LIG_SH3_3	139	145	PF00018	0.713
LIG_SH3_3	30	36	PF00018	0.702
LIG_SUMO_SIM_par_1	175	181	PF11976	0.384
LIG_TRAF2_1	119	122	PF00917	0.763
LIG_TRAF2_1	82	85	PF00917	0.535
LIG_UBA3_1	189	193	PF00899	0.444
LIG_WRC_WIRS_1	341	346	PF05994	0.437
LIG_WRC_WIRS_1	94	99	PF05994	0.707
MOD_CK1_1	162	168	PF00069	0.686
MOD_CK1_1	181	187	PF00069	0.181
MOD_CK1_1	352	358	PF00069	0.608
MOD_CK2_1	79	85	PF00069	0.559
MOD_GlcNHglycan	124	128	PF01048	0.798
MOD_GlcNHglycan	180	183	PF01048	0.403
MOD_GSK3_1	218	225	PF00069	0.380
MOD_GSK3_1	281	288	PF00069	0.410
MOD_GSK3_1	3	10	PF00069	0.624
MOD_GSK3_1	314	321	PF00069	0.444
MOD_GSK3_1	352	359	PF00069	0.543
MOD_GSK3_1	89	96	PF00069	0.620
MOD_NEK2_1	1	6	PF00069	0.736
MOD_NEK2_1	318	323	PF00069	0.416
MOD_NEK2_1	93	98	PF00069	0.650
MOD_PK_1	222	228	PF00069	0.444
MOD_PKA_2	145	151	PF00069	0.707
MOD_PKA_2	210	216	PF00069	0.460
MOD_PKA_2	218	224	PF00069	0.427
MOD_PKA_2	352	358	PF00069	0.567
MOD_Plk_1	104	110	PF00069	0.715
MOD_Plk_1	256	262	PF00069	0.429
MOD_Plk_4	203	209	PF00069	0.378
MOD_Plk_4	340	346	PF00069	0.394
MOD_Plk_4	41	47	PF00069	0.614
MOD_Plk_4	72	78	PF00069	0.607
MOD_Plk_4	89	95	PF00069	0.526
MOD_ProDKin_1	159	165	PF00069	0.712
MOD_ProDKin_1	3	9	PF00069	0.697
MOD_SUMO_rev_2	302	307	PF00179	0.344
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.619
TRG_ENDOCYTIC_2	152	155	PF00928	0.724
TRG_ENDOCYTIC_2	342	345	PF00928	0.378
TRG_ENDOCYTIC_2	94	97	PF00928	0.708
TRG_ER_diArg_1	135	138	PF00400	0.761
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	322	327	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5W1	Leptomonas seymouri	78%	100%
A0A3R7KKW5	Trypanosoma rangeli	37%	96%
A0A3S7XBD7	Leishmania donovani	95%	100%
A4HPR6	Leishmania braziliensis	90%	100%
A4ICZ8	Leishmania infantum	94%	100%
D0A8M8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	93%
E9ATI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BS24	Trypanosoma cruzi	37%	95%