ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q114_LEIMA

TriTrypDb:

LmjF.36.4010 , LMJLV39_360051100 , LMJSD75_360051000

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q114

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q114

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.679
CLV_NRD_NRD_1	146	148	PF00675	0.534
CLV_NRD_NRD_1	171	173	PF00675	0.741
CLV_NRD_NRD_1	310	312	PF00675	0.605
CLV_NRD_NRD_1	396	398	PF00675	0.734
CLV_NRD_NRD_1	413	415	PF00675	0.722
CLV_NRD_NRD_1	428	430	PF00675	0.589
CLV_PCSK_KEX2_1	146	148	PF00082	0.532
CLV_PCSK_KEX2_1	171	173	PF00082	0.737
CLV_PCSK_KEX2_1	310	312	PF00082	0.628
CLV_PCSK_KEX2_1	395	397	PF00082	0.691
CLV_PCSK_KEX2_1	413	415	PF00082	0.519
CLV_PCSK_KEX2_1	428	430	PF00082	0.589
CLV_PCSK_KEX2_1	434	436	PF00082	0.556
CLV_PCSK_KEX2_1	473	475	PF00082	0.646
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.558
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.614
CLV_PCSK_PC7_1	392	398	PF00082	0.677
CLV_PCSK_SKI1_1	225	229	PF00082	0.715
CLV_PCSK_SKI1_1	256	260	PF00082	0.569
CLV_PCSK_SKI1_1	413	417	PF00082	0.688
CLV_PCSK_SKI1_1	473	477	PF00082	0.614
CLV_PCSK_SKI1_1	77	81	PF00082	0.409
CLV_PCSK_SKI1_1	99	103	PF00082	0.368
DEG_APCC_DBOX_1	110	118	PF00400	0.530
DEG_APCC_DBOX_1	171	179	PF00400	0.486
DEG_APCC_DBOX_1	76	84	PF00400	0.559
DEG_Nend_UBRbox_2	1	3	PF02207	0.713
DOC_CYCLIN_RxL_1	134	145	PF00134	0.369
DOC_MAPK_gen_1	108	117	PF00069	0.541
DOC_MAPK_HePTP_8	131	143	PF00069	0.443
DOC_MAPK_MEF2A_6	134	143	PF00069	0.281
DOC_MAPK_MEF2A_6	256	263	PF00069	0.363
DOC_MAPK_RevD_3	131	147	PF00069	0.417
DOC_PP1_RVXF_1	136	143	PF00149	0.367
DOC_PP2B_LxvP_1	215	218	PF13499	0.505
DOC_USP7_MATH_1	273	277	PF00917	0.339
DOC_USP7_MATH_1	312	316	PF00917	0.431
DOC_USP7_MATH_1	339	343	PF00917	0.513
DOC_USP7_MATH_1	366	370	PF00917	0.490
DOC_USP7_MATH_1	380	384	PF00917	0.413
DOC_USP7_MATH_1	493	497	PF00917	0.351
DOC_WW_Pin1_4	193	198	PF00397	0.391
DOC_WW_Pin1_4	335	340	PF00397	0.532
DOC_WW_Pin1_4	43	48	PF00397	0.578
LIG_14-3-3_CanoR_1	11	17	PF00244	0.577
LIG_14-3-3_CanoR_1	111	115	PF00244	0.530
LIG_14-3-3_CanoR_1	413	422	PF00244	0.426
LIG_14-3-3_CanoR_1	474	479	PF00244	0.438
LIG_Actin_WH2_2	288	304	PF00022	0.262
LIG_APCC_ABBA_1	512	517	PF00400	0.319
LIG_BRCT_BRCA1_1	446	450	PF00533	0.349
LIG_EH1_1	285	293	PF00400	0.344
LIG_EVH1_1	215	219	PF00568	0.533
LIG_FHA_1	121	127	PF00498	0.326
LIG_FHA_1	207	213	PF00498	0.586
LIG_FHA_1	382	388	PF00498	0.417
LIG_FHA_1	66	72	PF00498	0.619
LIG_FHA_1	74	80	PF00498	0.558
LIG_FHA_2	369	375	PF00498	0.515
LIG_FHA_2	414	420	PF00498	0.457
LIG_FHA_2	44	50	PF00498	0.615
LIG_FHA_2	67	73	PF00498	0.610
LIG_FHA_2	95	101	PF00498	0.580
LIG_LIR_Gen_1	510	515	PF02991	0.380
LIG_LIR_Nem_3	447	453	PF02991	0.360
LIG_LIR_Nem_3	510	514	PF02991	0.403
LIG_MYND_1	323	327	PF01753	0.518
LIG_NRBOX	139	145	PF00104	0.337
LIG_NRBOX	296	302	PF00104	0.326
LIG_NRBOX	406	412	PF00104	0.376
LIG_Pex14_1	106	110	PF04695	0.569
LIG_Rb_LxCxE_1	510	526	PF01857	0.383
LIG_SH2_CRK	511	515	PF00017	0.398
LIG_SH2_NCK_1	478	482	PF00017	0.413
LIG_SH2_STAP1	122	126	PF00017	0.360
LIG_SH2_STAP1	457	461	PF00017	0.321
LIG_SH2_STAT5	122	125	PF00017	0.366
LIG_SH2_STAT5	37	40	PF00017	0.597
LIG_SH3_1	213	219	PF00018	0.507
LIG_SH3_3	213	219	PF00018	0.536
LIG_SH3_3	258	264	PF00018	0.334
LIG_SH3_3	323	329	PF00018	0.527
LIG_SUMO_SIM_anti_2	127	132	PF11976	0.353
LIG_SUMO_SIM_par_1	125	132	PF11976	0.471
LIG_TRAF2_1	416	419	PF00917	0.410
LIG_TRAF2_1	421	424	PF00917	0.404
LIG_TRAF2_1	501	504	PF00917	0.377
LIG_UBA3_1	130	134	PF00899	0.416
LIG_UBA3_1	179	186	PF00899	0.583
MOD_CK1_1	10	16	PF00069	0.455
MOD_CK1_1	129	135	PF00069	0.477
MOD_CK1_1	321	327	PF00069	0.614
MOD_CK1_1	333	339	PF00069	0.620
MOD_CK1_1	369	375	PF00069	0.602
MOD_CK1_1	65	71	PF00069	0.532
MOD_CK2_1	142	148	PF00069	0.526
MOD_CK2_1	244	250	PF00069	0.519
MOD_CK2_1	368	374	PF00069	0.699
MOD_CK2_1	413	419	PF00069	0.496
MOD_CK2_1	446	452	PF00069	0.406
MOD_CK2_1	66	72	PF00069	0.523
MOD_CK2_1	94	100	PF00069	0.481
MOD_Cter_Amidation	169	172	PF01082	0.678
MOD_GlcNHglycan	148	151	PF01048	0.506
MOD_GlcNHglycan	156	159	PF01048	0.510
MOD_GlcNHglycan	275	278	PF01048	0.449
MOD_GlcNHglycan	288	291	PF01048	0.389
MOD_GlcNHglycan	332	335	PF01048	0.630
MOD_GlcNHglycan	367	371	PF01048	0.636
MOD_GlcNHglycan	446	449	PF01048	0.526
MOD_GlcNHglycan	479	482	PF01048	0.403
MOD_GSK3_1	113	120	PF00069	0.359
MOD_GSK3_1	122	129	PF00069	0.307
MOD_GSK3_1	142	149	PF00069	0.258
MOD_GSK3_1	150	157	PF00069	0.494
MOD_GSK3_1	189	196	PF00069	0.597
MOD_GSK3_1	335	342	PF00069	0.670
MOD_GSK3_1	366	373	PF00069	0.701
MOD_GSK3_1	442	449	PF00069	0.554
MOD_GSK3_1	477	484	PF00069	0.536
MOD_GSK3_1	516	523	PF00069	0.364
MOD_GSK3_1	62	69	PF00069	0.515
MOD_NEK2_1	110	115	PF00069	0.284
MOD_NEK2_1	126	131	PF00069	0.284
MOD_NEK2_1	142	147	PF00069	0.375
MOD_NEK2_1	152	157	PF00069	0.633
MOD_NEK2_1	179	184	PF00069	0.655
MOD_NEK2_1	286	291	PF00069	0.403
MOD_NEK2_1	347	352	PF00069	0.687
MOD_NEK2_1	444	449	PF00069	0.408
MOD_NEK2_1	453	458	PF00069	0.359
MOD_NEK2_2	159	164	PF00069	0.600
MOD_NEK2_2	493	498	PF00069	0.452
MOD_NEK2_2	516	521	PF00069	0.354
MOD_PIKK_1	189	195	PF00454	0.688
MOD_PIKK_1	242	248	PF00454	0.655
MOD_PKA_1	146	152	PF00069	0.504
MOD_PKA_1	413	419	PF00069	0.519
MOD_PKA_2	10	16	PF00069	0.482
MOD_PKA_2	110	116	PF00069	0.374
MOD_PKA_2	146	152	PF00069	0.504
MOD_PKA_2	413	419	PF00069	0.477
MOD_PKA_2	520	526	PF00069	0.395
MOD_PKA_2	63	69	PF00069	0.551
MOD_PKA_2	73	79	PF00069	0.460
MOD_Plk_1	13	19	PF00069	0.578
MOD_Plk_1	423	429	PF00069	0.396
MOD_Plk_1	516	522	PF00069	0.376
MOD_Plk_1	62	68	PF00069	0.511
MOD_Plk_2-3	206	212	PF00069	0.579
MOD_Plk_4	110	116	PF00069	0.302
MOD_Plk_4	179	185	PF00069	0.546
MOD_Plk_4	296	302	PF00069	0.363
MOD_Plk_4	321	327	PF00069	0.629
MOD_Plk_4	382	388	PF00069	0.675
MOD_Plk_4	507	513	PF00069	0.463
MOD_ProDKin_1	193	199	PF00069	0.488
MOD_ProDKin_1	335	341	PF00069	0.683
MOD_ProDKin_1	43	49	PF00069	0.458
MOD_SUMO_rev_2	400	407	PF00179	0.570
MOD_SUMO_rev_2	468	475	PF00179	0.483
MOD_SUMO_rev_2	503	510	PF00179	0.490
MOD_SUMO_rev_2	95	103	PF00179	0.442
TRG_DiLeu_BaEn_1	358	363	PF01217	0.727
TRG_DiLeu_BaEn_4	210	216	PF01217	0.702
TRG_ENDOCYTIC_2	36	39	PF00928	0.570
TRG_ENDOCYTIC_2	511	514	PF00928	0.400
TRG_ER_diArg_1	329	332	PF00400	0.712
TRG_ER_diArg_1	394	397	PF00400	0.611
TRG_ER_diArg_1	413	415	PF00400	0.542
TRG_ER_diArg_1	427	429	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	413	418	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL78	Leptomonas seymouri	69%	100%
A0A1X0P397	Trypanosomatidae	34%	100%
A0A3Q8IW98	Leishmania donovani	95%	100%
A0A3R7KTQ7	Trypanosoma rangeli	31%	100%
A4HPR9	Leishmania braziliensis	82%	100%
A4ICZ4	Leishmania infantum	95%	100%
E9ATI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5B6V7	Trypanosoma cruzi	33%	100%