Tetratricopeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q111_LEIMA

TriTrypDb:

LmjF.36.4040 , LMJLV39_360051400 , LMJSD75_360051300

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q111

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q111

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	2
GO:0006335	DNA replication-dependent chromatin assembly	5	2
GO:0006338	chromatin remodeling	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0031055	chromatin remodeling at centromere	6	2
GO:0034080	CENP-A containing chromatin assembly	7	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0042393	histone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.544
CLV_NRD_NRD_1	401	403	PF00675	0.632
CLV_PCSK_KEX2_1	406	408	PF00082	0.667
CLV_PCSK_KEX2_1	421	423	PF00082	0.704
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.730
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.704
CLV_PCSK_PC7_1	402	408	PF00082	0.719
CLV_PCSK_SKI1_1	127	131	PF00082	0.475
DEG_APCC_DBOX_1	266	274	PF00400	0.454
DEG_SPOP_SBC_1	50	54	PF00917	0.819
DOC_CKS1_1	322	327	PF01111	0.660
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.678
DOC_PP1_RVXF_1	167	173	PF00149	0.338
DOC_PP2B_LxvP_1	357	360	PF13499	0.583
DOC_PP2B_LxvP_1	381	384	PF13499	0.632
DOC_USP7_MATH_1	352	356	PF00917	0.683
DOC_USP7_MATH_1	384	388	PF00917	0.775
DOC_USP7_MATH_2	325	331	PF00917	0.621
DOC_WW_Pin1_4	321	326	PF00397	0.661
DOC_WW_Pin1_4	388	393	PF00397	0.716
LIG_14-3-3_CanoR_1	265	271	PF00244	0.485
LIG_Actin_WH2_2	239	257	PF00022	0.374
LIG_BIR_II_1	1	5	PF00653	0.738
LIG_BIR_III_2	226	230	PF00653	0.493
LIG_FHA_1	158	164	PF00498	0.429
LIG_FHA_1	391	397	PF00498	0.777
LIG_FHA_2	1	7	PF00498	0.611
LIG_FHA_2	142	148	PF00498	0.656
LIG_FHA_2	267	273	PF00498	0.491
LIG_FHA_2	322	328	PF00498	0.528
LIG_FHA_2	406	412	PF00498	0.725
LIG_FHA_2	51	57	PF00498	0.841
LIG_FHA_2	78	84	PF00498	0.511
LIG_GBD_Chelix_1	281	289	PF00786	0.537
LIG_LIR_Gen_1	160	170	PF02991	0.351
LIG_LIR_Gen_1	353	363	PF02991	0.632
LIG_LIR_Nem_3	105	111	PF02991	0.412
LIG_LIR_Nem_3	160	165	PF02991	0.380
LIG_LIR_Nem_3	327	331	PF02991	0.642
LIG_NRBOX	288	294	PF00104	0.455
LIG_PCNA_PIPBox_1	107	116	PF02747	0.381
LIG_PCNA_yPIPBox_3	138	150	PF02747	0.605
LIG_SH2_CRK	108	112	PF00017	0.389
LIG_SH2_CRK	221	225	PF00017	0.406
LIG_SH2_GRB2like	162	165	PF00017	0.499
LIG_SH2_PTP2	162	165	PF00017	0.499
LIG_SH2_SRC	100	103	PF00017	0.440
LIG_SH2_STAP1	100	104	PF00017	0.416
LIG_SH2_STAP1	207	211	PF00017	0.387
LIG_SH2_STAP1	214	218	PF00017	0.328
LIG_SH2_STAT5	128	131	PF00017	0.337
LIG_SH2_STAT5	162	165	PF00017	0.521
LIG_SH2_STAT5	356	359	PF00017	0.697
LIG_SH3_3	146	152	PF00018	0.650
LIG_SH3_3	389	395	PF00018	0.770
LIG_TRAF2_1	228	231	PF00917	0.506
LIG_TRAF2_1	324	327	PF00917	0.539
LIG_TRAF2_1	45	48	PF00917	0.665
LIG_TRAF2_1	80	83	PF00917	0.517
LIG_TYR_ITIM	106	111	PF00017	0.378
LIG_TYR_ITIM	219	224	PF00017	0.411
MOD_CK1_1	355	361	PF00069	0.582
MOD_CK1_1	4	10	PF00069	0.670
MOD_CK1_1	42	48	PF00069	0.746
MOD_CK1_1	51	57	PF00069	0.658
MOD_CK2_1	254	260	PF00069	0.578
MOD_CK2_1	266	272	PF00069	0.452
MOD_CK2_1	321	327	PF00069	0.531
MOD_CK2_1	42	48	PF00069	0.699
MOD_CK2_1	51	57	PF00069	0.641
MOD_CK2_1	77	83	PF00069	0.517
MOD_DYRK1A_RPxSP_1	388	392	PF00069	0.760
MOD_GlcNHglycan	121	124	PF01048	0.534
MOD_GlcNHglycan	340	343	PF01048	0.598
MOD_GlcNHglycan	361	364	PF01048	0.669
MOD_GlcNHglycan	388	391	PF01048	0.760
MOD_GlcNHglycan	426	429	PF01048	0.826
MOD_GSK3_1	1	8	PF00069	0.724
MOD_GSK3_1	277	284	PF00069	0.488
MOD_GSK3_1	355	362	PF00069	0.577
MOD_GSK3_1	367	374	PF00069	0.556
MOD_GSK3_1	384	391	PF00069	0.674
MOD_GSK3_1	39	46	PF00069	0.782
MOD_GSK3_1	405	412	PF00069	0.772
MOD_GSK3_1	48	55	PF00069	0.701
MOD_NEK2_1	377	382	PF00069	0.640
MOD_NEK2_1	5	10	PF00069	0.513
MOD_NEK2_2	157	162	PF00069	0.411
MOD_PIKK_1	132	138	PF00454	0.346
MOD_PIKK_1	43	49	PF00454	0.702
MOD_PKA_2	266	272	PF00069	0.489
MOD_PKB_1	422	430	PF00069	0.759
MOD_Plk_1	352	358	PF00069	0.605
MOD_Plk_1	409	415	PF00069	0.775
MOD_Plk_1	5	11	PF00069	0.514
MOD_Plk_1	72	78	PF00069	0.577
MOD_Plk_2-3	327	333	PF00069	0.610
MOD_Plk_4	232	238	PF00069	0.472
MOD_Plk_4	281	287	PF00069	0.575
MOD_Plk_4	352	358	PF00069	0.716
MOD_Plk_4	377	383	PF00069	0.654
MOD_ProDKin_1	321	327	PF00069	0.661
MOD_ProDKin_1	388	394	PF00069	0.717
MOD_SUMO_rev_2	226	235	PF00179	0.498
MOD_SUMO_rev_2	271	275	PF00179	0.540
MOD_SUMO_rev_2	330	338	PF00179	0.668
MOD_SUMO_rev_2	414	423	PF00179	0.660
TRG_DiLeu_BaEn_1	21	26	PF01217	0.607
TRG_DiLeu_BaEn_1	288	293	PF01217	0.452
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.456
TRG_ENDOCYTIC_2	108	111	PF00928	0.410
TRG_ENDOCYTIC_2	162	165	PF00928	0.499
TRG_ENDOCYTIC_2	221	224	PF00928	0.375
TRG_ENDOCYTIC_2	356	359	PF00928	0.605
TRG_NLS_Bipartite_1	403	425	PF00514	0.720
TRG_NLS_MonoExtC_3	401	406	PF00514	0.643
TRG_NLS_MonoExtC_3	420	426	PF00514	0.664
TRG_NLS_MonoExtN_4	402	407	PF00514	0.626
TRG_NLS_MonoExtN_4	418	425	PF00514	0.723
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXN4	Leptomonas seymouri	83%	100%
A0A0S4IPT5	Bodo saltans	46%	100%
A0A1X0P488	Trypanosomatidae	49%	89%
A0A3R7NPK3	Trypanosoma rangeli	50%	95%
A0A3S7XBE8	Leishmania donovani	97%	100%
A4HPS2	Leishmania braziliensis	84%	99%
A4ICZ1	Leishmania infantum	97%	100%
D0A8N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ATI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BS19	Trypanosoma cruzi	52%	94%