Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TatD related DNase, putative

Species:

Leishmania major

UniProt:

Q4Q110_LEIMA

TriTrypDb:

LmjF.36.4050 , LMJLV39_360051500 , LMJSD75_360051400

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q110

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q110

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	106	112	PF00089	0.269
CLV_NRD_NRD_1	203	205	PF00675	0.356
CLV_NRD_NRD_1	252	254	PF00675	0.526
CLV_NRD_NRD_1	256	258	PF00675	0.611
CLV_NRD_NRD_1	36	38	PF00675	0.363
CLV_NRD_NRD_1	58	60	PF00675	0.233
CLV_PCSK_FUR_1	253	257	PF00082	0.482
CLV_PCSK_KEX2_1	203	205	PF00082	0.356
CLV_PCSK_KEX2_1	252	254	PF00082	0.478
CLV_PCSK_KEX2_1	255	257	PF00082	0.524
CLV_PCSK_KEX2_1	285	287	PF00082	0.750
CLV_PCSK_KEX2_1	36	38	PF00082	0.330
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.478
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.524
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.750
CLV_PCSK_SKI1_1	246	250	PF00082	0.306
CLV_PCSK_SKI1_1	257	261	PF00082	0.554
CLV_PCSK_SKI1_1	299	303	PF00082	0.280
CLV_PCSK_SKI1_1	328	332	PF00082	0.409
CLV_PCSK_SKI1_1	92	96	PF00082	0.340
DEG_SCF_FBW7_1	47	53	PF00400	0.433
DOC_CKS1_1	47	52	PF01111	0.433
DOC_CYCLIN_RxL_1	243	250	PF00134	0.576
DOC_CYCLIN_RxL_1	325	335	PF00134	0.474
DOC_MAPK_gen_1	295	302	PF00069	0.440
DOC_MAPK_MEF2A_6	212	220	PF00069	0.550
DOC_PP1_RVXF_1	297	303	PF00149	0.373
DOC_PP1_SILK_1	154	159	PF00149	0.433
DOC_USP7_MATH_1	115	119	PF00917	0.531
DOC_USP7_MATH_1	139	143	PF00917	0.546
DOC_USP7_MATH_1	144	148	PF00917	0.551
DOC_USP7_MATH_1	149	153	PF00917	0.564
DOC_USP7_MATH_1	357	361	PF00917	0.664
DOC_USP7_MATH_1	367	371	PF00917	0.637
DOC_USP7_MATH_1	40	44	PF00917	0.565
DOC_USP7_MATH_1	401	405	PF00917	0.595
DOC_USP7_MATH_1	407	411	PF00917	0.580
DOC_USP7_MATH_1	423	427	PF00917	0.521
DOC_USP7_MATH_1	50	54	PF00917	0.543
DOC_USP7_MATH_1	6	10	PF00917	0.747
DOC_USP7_MATH_1	64	68	PF00917	0.478
DOC_USP7_MATH_1	86	90	PF00917	0.533
DOC_WW_Pin1_4	117	122	PF00397	0.573
DOC_WW_Pin1_4	226	231	PF00397	0.483
DOC_WW_Pin1_4	262	267	PF00397	0.691
DOC_WW_Pin1_4	36	41	PF00397	0.495
DOC_WW_Pin1_4	46	51	PF00397	0.477
LIG_14-3-3_CanoR_1	203	209	PF00244	0.483
LIG_14-3-3_CanoR_1	286	296	PF00244	0.671
LIG_14-3-3_CanoR_1	358	362	PF00244	0.565
LIG_14-3-3_CanoR_1	366	372	PF00244	0.499
LIG_14-3-3_CanoR_1	386	392	PF00244	0.425
LIG_14-3-3_CanoR_1	65	69	PF00244	0.531
LIG_14-3-3_CanoR_1	92	97	PF00244	0.540
LIG_Actin_WH2_2	21	38	PF00022	0.531
LIG_BIR_II_1	1	5	PF00653	0.787
LIG_BRCT_BRCA1_1	306	310	PF00533	0.510
LIG_BRCT_BRCA1_1	347	351	PF00533	0.564
LIG_FHA_1	237	243	PF00498	0.495
LIG_FHA_1	291	297	PF00498	0.552
LIG_FHA_1	315	321	PF00498	0.480
LIG_FHA_1	67	73	PF00498	0.531
LIG_FHA_2	287	293	PF00498	0.707
LIG_LIR_Gen_1	79	90	PF02991	0.494
LIG_LIR_Nem_3	298	304	PF02991	0.439
LIG_LIR_Nem_3	334	340	PF02991	0.629
LIG_LIR_Nem_3	79	85	PF02991	0.479
LIG_PTB_Apo_2	391	398	PF02174	0.575
LIG_SH2_CRK	202	206	PF00017	0.506
LIG_SH2_CRK	214	218	PF00017	0.531
LIG_SH2_CRK	25	29	PF00017	0.484
LIG_SH2_NCK_1	420	424	PF00017	0.508
LIG_SH2_STAP1	420	424	PF00017	0.508
LIG_SH3_3	44	50	PF00018	0.574
LIG_TRAF2_1	8	11	PF00917	0.566
LIG_TYR_ITIM	23	28	PF00017	0.424
LIG_UBA3_1	248	255	PF00899	0.602
MOD_CK1_1	117	123	PF00069	0.537
MOD_CK1_1	133	139	PF00069	0.552
MOD_CK1_1	2	8	PF00069	0.675
MOD_CK1_1	247	253	PF00069	0.564
MOD_CK1_1	316	322	PF00069	0.507
MOD_CK1_1	428	434	PF00069	0.647
MOD_CK1_1	43	49	PF00069	0.508
MOD_CK2_1	121	127	PF00069	0.569
MOD_CK2_1	335	341	PF00069	0.676
MOD_CK2_1	344	350	PF00069	0.610
MOD_CK2_1	423	429	PF00069	0.579
MOD_CK2_1	6	12	PF00069	0.617
MOD_Cter_Amidation	57	60	PF01082	0.233
MOD_GlcNHglycan	124	127	PF01048	0.299
MOD_GlcNHglycan	135	138	PF01048	0.281
MOD_GlcNHglycan	146	149	PF01048	0.371
MOD_GlcNHglycan	153	156	PF01048	0.316
MOD_GlcNHglycan	261	265	PF01048	0.692
MOD_GlcNHglycan	275	278	PF01048	0.794
MOD_GlcNHglycan	337	340	PF01048	0.679
MOD_GlcNHglycan	347	350	PF01048	0.731
MOD_GlcNHglycan	42	45	PF01048	0.329
MOD_GlcNHglycan	88	91	PF01048	0.278
MOD_GSK3_1	117	124	PF00069	0.497
MOD_GSK3_1	2	9	PF00069	0.690
MOD_GSK3_1	286	293	PF00069	0.739
MOD_GSK3_1	304	311	PF00069	0.285
MOD_GSK3_1	36	43	PF00069	0.459
MOD_GSK3_1	46	53	PF00069	0.448
MOD_N-GLC_1	139	144	PF02516	0.340
MOD_N-GLC_1	313	318	PF02516	0.531
MOD_NEK2_1	15	20	PF00069	0.650
MOD_NEK2_1	260	265	PF00069	0.635
MOD_NEK2_1	28	33	PF00069	0.252
MOD_NEK2_1	412	417	PF00069	0.495
MOD_NEK2_1	73	78	PF00069	0.479
MOD_NEK2_2	357	362	PF00069	0.715
MOD_PIKK_1	314	320	PF00454	0.469
MOD_PK_1	204	210	PF00069	0.476
MOD_PKA_2	133	139	PF00069	0.587
MOD_PKA_2	16	22	PF00069	0.696
MOD_PKA_2	281	287	PF00069	0.778
MOD_PKA_2	357	363	PF00069	0.564
MOD_PKA_2	64	70	PF00069	0.546
MOD_Plk_1	139	145	PF00069	0.433
MOD_Plk_1	401	407	PF00069	0.548
MOD_Plk_4	244	250	PF00069	0.502
MOD_Plk_4	387	393	PF00069	0.551
MOD_Plk_4	407	413	PF00069	0.240
MOD_Plk_4	92	98	PF00069	0.576
MOD_ProDKin_1	117	123	PF00069	0.573
MOD_ProDKin_1	226	232	PF00069	0.483
MOD_ProDKin_1	262	268	PF00069	0.692
MOD_ProDKin_1	36	42	PF00069	0.495
MOD_ProDKin_1	46	52	PF00069	0.477
TRG_DiLeu_BaEn_3	10	16	PF01217	0.549
TRG_DiLeu_BaEn_4	11	17	PF01217	0.541
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.576
TRG_ENDOCYTIC_2	214	217	PF00928	0.531
TRG_ENDOCYTIC_2	25	28	PF00928	0.491
TRG_ENDOCYTIC_2	337	340	PF00928	0.675
TRG_ER_diArg_1	202	204	PF00400	0.556
TRG_ER_diArg_1	256	258	PF00400	0.642
TRG_ER_diArg_1	35	37	PF00400	0.551
TRG_NLS_MonoCore_2	251	256	PF00514	0.516
TRG_NLS_MonoExtC_3	251	256	PF00514	0.579
TRG_NLS_MonoExtN_4	252	259	PF00514	0.545
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEL6	Leptomonas seymouri	50%	100%
A0A0S4JGI4	Bodo saltans	36%	100%
A0A1X0P3J3	Trypanosomatidae	35%	100%
A0A3S5IS07	Trypanosoma rangeli	41%	100%
A0A3S7XBG3	Leishmania donovani	88%	100%
A4ICZ0	Leishmania infantum	88%	100%
D0A8N8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ATI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%