Regulator_of_chromosome_condensation_(RCC1)_repea t

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulator of chromosome condensation 1-like protein

Species:

Leishmania major

UniProt:

Q4Q109_LEIMA

TriTrypDb:

LmjF.36.4060 , LMJLV39_360051600 , LMJSD75_360051500

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0031010	ISWI-type complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0070603	SWI/SNF superfamily-type complex	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1904949	ATPase complex	3	2

Expansion

Sequence features

Q4Q109

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q109

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.393
CLV_C14_Caspase3-7	625	629	PF00656	0.538
CLV_NRD_NRD_1	217	219	PF00675	0.375
CLV_NRD_NRD_1	316	318	PF00675	0.360
CLV_NRD_NRD_1	578	580	PF00675	0.630
CLV_PCSK_FUR_1	607	611	PF00082	0.521
CLV_PCSK_KEX2_1	217	219	PF00082	0.557
CLV_PCSK_KEX2_1	578	580	PF00082	0.501
CLV_PCSK_KEX2_1	609	611	PF00082	0.745
CLV_PCSK_KEX2_1	638	640	PF00082	0.596
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.745
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.563
CLV_PCSK_SKI1_1	510	514	PF00082	0.356
CLV_PCSK_SKI1_1	638	642	PF00082	0.564
DEG_APCC_KENBOX_2	336	340	PF00400	0.472
DEG_Nend_Nbox_1	1	3	PF02207	0.293
DEG_SPOP_SBC_1	155	159	PF00917	0.362
DEG_SPOP_SBC_1	46	50	PF00917	0.679
DEG_SPOP_SBC_1	589	593	PF00917	0.605
DOC_CKS1_1	253	258	PF01111	0.411
DOC_CYCLIN_yCln2_LP_2	420	426	PF00134	0.398
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.444
DOC_MAPK_gen_1	264	272	PF00069	0.301
DOC_MAPK_gen_1	549	559	PF00069	0.333
DOC_MAPK_MEF2A_6	266	274	PF00069	0.283
DOC_MAPK_MEF2A_6	552	561	PF00069	0.469
DOC_PP1_RVXF_1	309	315	PF00149	0.267
DOC_PP1_RVXF_1	639	645	PF00149	0.451
DOC_PP2B_LxvP_1	173	176	PF13499	0.479
DOC_PP4_FxxP_1	9	12	PF00568	0.432
DOC_USP7_MATH_1	370	374	PF00917	0.451
DOC_USP7_MATH_1	408	412	PF00917	0.473
DOC_USP7_MATH_1	46	50	PF00917	0.699
DOC_USP7_MATH_1	479	483	PF00917	0.679
DOC_USP7_MATH_1	581	585	PF00917	0.781
DOC_USP7_MATH_1	589	593	PF00917	0.726
DOC_USP7_MATH_1	616	620	PF00917	0.747
DOC_USP7_MATH_1	63	67	PF00917	0.402
DOC_USP7_MATH_1	86	90	PF00917	0.401
DOC_USP7_MATH_1	99	103	PF00917	0.535
DOC_USP7_UBL2_3	459	463	PF12436	0.742
DOC_WW_Pin1_4	252	257	PF00397	0.360
DOC_WW_Pin1_4	29	34	PF00397	0.433
DOC_WW_Pin1_4	628	633	PF00397	0.700
LIG_14-3-3_CanoR_1	311	315	PF00244	0.258
LIG_14-3-3_CanoR_1	37	41	PF00244	0.590
LIG_14-3-3_CanoR_1	447	452	PF00244	0.693
LIG_14-3-3_CanoR_1	578	586	PF00244	0.511
LIG_Actin_WH2_2	22	39	PF00022	0.304
LIG_Actin_WH2_2	539	554	PF00022	0.383
LIG_APCC_ABBA_1	654	659	PF00400	0.465
LIG_BIR_III_4	626	630	PF00653	0.696
LIG_BRCT_BRCA1_1	5	9	PF00533	0.374
LIG_BRCT_BRCA1_1	601	605	PF00533	0.590
LIG_CaM_IQ_9	57	73	PF13499	0.436
LIG_deltaCOP1_diTrp_1	643	649	PF00928	0.443
LIG_EVH1_2	21	25	PF00568	0.333
LIG_FHA_1	157	163	PF00498	0.424
LIG_FHA_1	241	247	PF00498	0.393
LIG_FHA_1	253	259	PF00498	0.354
LIG_FHA_1	331	337	PF00498	0.266
LIG_FHA_1	366	372	PF00498	0.420
LIG_FHA_1	432	438	PF00498	0.332
LIG_FHA_1	440	446	PF00498	0.476
LIG_FHA_2	266	272	PF00498	0.381
LIG_FHA_2	287	293	PF00498	0.266
LIG_FHA_2	466	472	PF00498	0.610
LIG_FHA_2	567	573	PF00498	0.470
LIG_FHA_2	660	666	PF00498	0.545
LIG_LIR_Apic_2	6	12	PF02991	0.418
LIG_LIR_Apic_2	681	687	PF02991	0.587
LIG_LIR_Gen_1	167	176	PF02991	0.325
LIG_LIR_Gen_1	192	200	PF02991	0.435
LIG_LIR_Gen_1	482	491	PF02991	0.469
LIG_LIR_Nem_3	115	119	PF02991	0.478
LIG_LIR_Nem_3	167	173	PF02991	0.300
LIG_LIR_Nem_3	192	196	PF02991	0.344
LIG_LIR_Nem_3	226	232	PF02991	0.281
LIG_LIR_Nem_3	292	298	PF02991	0.266
LIG_LIR_Nem_3	482	486	PF02991	0.467
LIG_MYND_1	305	309	PF01753	0.411
LIG_NRBOX	508	514	PF00104	0.422
LIG_PCNA_yPIPBox_3	337	346	PF02747	0.395
LIG_PTB_Apo_2	110	117	PF02174	0.471
LIG_PTB_Phospho_1	110	116	PF10480	0.392
LIG_REV1ctd_RIR_1	292	301	PF16727	0.393
LIG_REV1ctd_RIR_1	346	355	PF16727	0.476
LIG_SH2_CRK	116	120	PF00017	0.386
LIG_SH2_CRK	399	403	PF00017	0.435
LIG_SH2_NCK_1	399	403	PF00017	0.490
LIG_SH2_PTP2	684	687	PF00017	0.560
LIG_SH2_SRC	189	192	PF00017	0.485
LIG_SH2_SRC	28	31	PF00017	0.347
LIG_SH2_SRC	505	508	PF00017	0.529
LIG_SH2_STAP1	126	130	PF00017	0.346
LIG_SH2_STAP1	399	403	PF00017	0.375
LIG_SH2_STAT3	525	528	PF00017	0.531
LIG_SH2_STAT3	7	10	PF00017	0.412
LIG_SH2_STAT5	163	166	PF00017	0.346
LIG_SH2_STAT5	28	31	PF00017	0.347
LIG_SH2_STAT5	288	291	PF00017	0.266
LIG_SH2_STAT5	347	350	PF00017	0.389
LIG_SH2_STAT5	392	395	PF00017	0.358
LIG_SH2_STAT5	399	402	PF00017	0.422
LIG_SH2_STAT5	516	519	PF00017	0.358
LIG_SH2_STAT5	525	528	PF00017	0.379
LIG_SH2_STAT5	684	687	PF00017	0.529
LIG_SH3_2	530	535	PF14604	0.553
LIG_SH3_3	15	21	PF00018	0.592
LIG_SH3_3	250	256	PF00018	0.263
LIG_SH3_3	27	33	PF00018	0.352
LIG_SH3_3	309	315	PF00018	0.319
LIG_SH3_3	361	367	PF00018	0.473
LIG_SH3_3	442	448	PF00018	0.551
LIG_SH3_3	482	488	PF00018	0.487
LIG_SH3_3	527	533	PF00018	0.445
LIG_SH3_3	598	604	PF00018	0.570
LIG_SH3_3	629	635	PF00018	0.691
LIG_SH3_CIN85_PxpxPR_1	530	535	PF14604	0.524
LIG_SUMO_SIM_par_1	330	338	PF11976	0.300
LIG_SUMO_SIM_par_1	650	662	PF11976	0.512
LIG_TRAF2_1	469	472	PF00917	0.718
LIG_TRAF2_1	501	504	PF00917	0.644
LIG_TRAF2_1	622	625	PF00917	0.694
LIG_WW_3	314	318	PF00397	0.360
LIG_WW_3	532	536	PF00397	0.613
MOD_CDK_SPK_2	631	636	PF00069	0.607
MOD_CDK_SPxxK_3	631	638	PF00069	0.670
MOD_CK1_1	431	437	PF00069	0.396
MOD_CK1_1	470	476	PF00069	0.557
MOD_CK1_1	48	54	PF00069	0.676
MOD_CK1_1	590	596	PF00069	0.702
MOD_CK1_1	631	637	PF00069	0.674
MOD_CK2_1	220	226	PF00069	0.317
MOD_CK2_1	265	271	PF00069	0.412
MOD_CK2_1	286	292	PF00069	0.298
MOD_CK2_1	465	471	PF00069	0.756
MOD_CK2_1	655	661	PF00069	0.462
MOD_Cter_Amidation	636	639	PF01082	0.612
MOD_GlcNHglycan	207	210	PF01048	0.469
MOD_GlcNHglycan	38	41	PF01048	0.567
MOD_GlcNHglycan	430	433	PF01048	0.418
MOD_GlcNHglycan	592	595	PF01048	0.782
MOD_GlcNHglycan	618	621	PF01048	0.755
MOD_GSK3_1	150	157	PF00069	0.290
MOD_GSK3_1	162	169	PF00069	0.324
MOD_GSK3_1	185	192	PF00069	0.498
MOD_GSK3_1	205	212	PF00069	0.240
MOD_GSK3_1	248	255	PF00069	0.387
MOD_GSK3_1	36	43	PF00069	0.567
MOD_GSK3_1	366	373	PF00069	0.415
MOD_GSK3_1	44	51	PF00069	0.691
MOD_GSK3_1	470	477	PF00069	0.537
MOD_GSK3_1	52	59	PF00069	0.677
MOD_GSK3_1	595	602	PF00069	0.696
MOD_GSK3_1	655	662	PF00069	0.463
MOD_N-GLC_1	209	214	PF02516	0.319
MOD_N-GLC_1	403	408	PF02516	0.421
MOD_N-GLC_1	44	49	PF02516	0.612
MOD_NEK2_1	139	144	PF00069	0.506
MOD_NEK2_1	3	8	PF00069	0.340
MOD_NEK2_1	341	346	PF00069	0.495
MOD_NEK2_1	36	41	PF00069	0.524
MOD_NEK2_1	559	564	PF00069	0.648
MOD_NEK2_2	63	68	PF00069	0.297
MOD_PIKK_1	191	197	PF00454	0.484
MOD_PIKK_1	240	246	PF00454	0.287
MOD_PIKK_1	383	389	PF00454	0.383
MOD_PIKK_1	40	46	PF00454	0.461
MOD_PIKK_1	608	614	PF00454	0.730
MOD_PKA_2	150	156	PF00069	0.360
MOD_PKA_2	265	271	PF00069	0.468
MOD_PKA_2	310	316	PF00069	0.314
MOD_PKA_2	36	42	PF00069	0.610
MOD_PKA_2	377	383	PF00069	0.325
MOD_Plk_1	166	172	PF00069	0.281
MOD_Plk_1	209	215	PF00069	0.319
MOD_Plk_1	330	336	PF00069	0.300
MOD_Plk_1	470	476	PF00069	0.475
MOD_Plk_1	659	665	PF00069	0.533
MOD_Plk_2-3	467	473	PF00069	0.495
MOD_Plk_2-3	56	62	PF00069	0.471
MOD_Plk_2-3	659	665	PF00069	0.502
MOD_Plk_4	139	145	PF00069	0.416
MOD_Plk_4	150	156	PF00069	0.205
MOD_Plk_4	195	201	PF00069	0.369
MOD_Plk_4	265	271	PF00069	0.381
MOD_Plk_4	330	336	PF00069	0.266
MOD_Plk_4	341	347	PF00069	0.456
MOD_Plk_4	359	365	PF00069	0.444
MOD_Plk_4	431	437	PF00069	0.358
MOD_Plk_4	441	447	PF00069	0.481
MOD_Plk_4	566	572	PF00069	0.413
MOD_Plk_4	652	658	PF00069	0.527
MOD_Plk_4	86	92	PF00069	0.482
MOD_ProDKin_1	252	258	PF00069	0.360
MOD_ProDKin_1	29	35	PF00069	0.432
MOD_ProDKin_1	628	634	PF00069	0.694
MOD_SUMO_for_1	462	465	PF00179	0.715
MOD_SUMO_for_1	501	504	PF00179	0.432
MOD_SUMO_for_1	640	643	PF00179	0.556
MOD_SUMO_rev_2	457	464	PF00179	0.713
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.331
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.493
TRG_ENDOCYTIC_2	116	119	PF00928	0.386
TRG_ENDOCYTIC_2	229	232	PF00928	0.281
TRG_ENDOCYTIC_2	399	402	PF00928	0.419
TRG_ER_diArg_1	264	267	PF00400	0.411
TRG_NES_CRM1_1	62	73	PF08389	0.424
TRG_NLS_MonoExtC_3	637	643	PF00514	0.569
TRG_NLS_MonoExtN_4	635	642	PF00514	0.595
TRG_Pf-PMV_PEXEL_1	510	515	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	68	73	PF00026	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4I0	Leptomonas seymouri	67%	100%
A0A0S4JSE7	Bodo saltans	32%	100%
A0A1X0P381	Trypanosomatidae	42%	100%
A0A3Q8IGE7	Leishmania donovani	93%	100%
A0A3S5IS08	Trypanosoma rangeli	44%	100%
A4HPS4	Leishmania braziliensis	83%	100%
A4ICY9	Leishmania infantum	93%	100%
D0A8N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ATI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DNG6	Trypanosoma cruzi	43%	100%