Putative phosphoglycerate mutase family member 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglycerate mutase family member 5, putative

Species:

Leishmania major

UniProt:

Q4Q108_LEIMA

TriTrypDb:

LmjF.36.4070 , LMJLV39_360051700 , LMJSD75_360051600

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 7
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q108

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q108

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0010638	positive regulation of organelle organization	6	2
GO:0010821	regulation of mitochondrion organization	6	2
GO:0010822	positive regulation of mitochondrion organization	7	2
GO:0016311	dephosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0022603	regulation of anatomical structure morphogenesis	4	2
GO:0033043	regulation of organelle organization	5	2
GO:0035970	peptidyl-threonine dephosphorylation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050793	regulation of developmental process	3	2
GO:0050794	regulation of cellular process	3	2
GO:0051094	positive regulation of developmental process	4	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051130	positive regulation of cellular component organization	5	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0090140	regulation of mitochondrial fission	5	2
GO:0090141	positive regulation of mitochondrial fission	5	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0004722	protein serine/threonine phosphatase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.458
CLV_NRD_NRD_1	147	149	PF00675	0.421
CLV_NRD_NRD_1	179	181	PF00675	0.549
CLV_NRD_NRD_1	229	231	PF00675	0.492
CLV_NRD_NRD_1	6	8	PF00675	0.602
CLV_PCSK_KEX2_1	139	141	PF00082	0.442
CLV_PCSK_KEX2_1	147	149	PF00082	0.398
CLV_PCSK_KEX2_1	6	8	PF00082	0.602
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.486
CLV_PCSK_SKI1_1	139	143	PF00082	0.479
CLV_PCSK_SKI1_1	149	153	PF00082	0.441
CLV_PCSK_SKI1_1	163	167	PF00082	0.501
CLV_PCSK_SKI1_1	186	190	PF00082	0.534
CLV_PCSK_SKI1_1	249	253	PF00082	0.602
CLV_PCSK_SKI1_1	290	294	PF00082	0.376
CLV_PCSK_SKI1_1	6	10	PF00082	0.570
DEG_APCC_DBOX_1	147	155	PF00400	0.558
DEG_SCF_FBW7_2	123	128	PF00400	0.462
DEG_SCF_FBW7_2	250	256	PF00400	0.465
DOC_CKS1_1	250	255	PF01111	0.465
DOC_CYCLIN_RxL_1	136	145	PF00134	0.499
DOC_CYCLIN_RxL_1	290	302	PF00134	0.305
DOC_MAPK_gen_1	129	138	PF00069	0.494
DOC_MAPK_gen_1	211	220	PF00069	0.436
DOC_MAPK_gen_1	6	14	PF00069	0.602
DOC_MAPK_MEF2A_6	7	16	PF00069	0.683
DOC_MAPK_RevD_3	216	231	PF00069	0.457
DOC_PP2B_LxvP_1	297	300	PF13499	0.305
DOC_PP4_FxxP_1	269	272	PF00568	0.359
DOC_USP7_MATH_1	272	276	PF00917	0.527
DOC_USP7_MATH_1	310	314	PF00917	0.324
DOC_USP7_MATH_1	39	43	PF00917	0.620
DOC_USP7_MATH_1	92	96	PF00917	0.580
DOC_WW_Pin1_4	121	126	PF00397	0.441
DOC_WW_Pin1_4	16	21	PF00397	0.646
DOC_WW_Pin1_4	249	254	PF00397	0.506
LIG_14-3-3_CanoR_1	211	220	PF00244	0.358
LIG_14-3-3_CanoR_1	290	295	PF00244	0.438
LIG_14-3-3_CanoR_1	306	310	PF00244	0.206
LIG_14-3-3_CanoR_1	7	13	PF00244	0.650
LIG_14-3-3_CanoR_1	94	103	PF00244	0.414
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BRCT_BRCA1_1	1	5	PF00533	0.598
LIG_CtBP_PxDLS_1	337	341	PF00389	0.449
LIG_FHA_1	213	219	PF00498	0.368
LIG_FHA_1	277	283	PF00498	0.290
LIG_FHA_1	314	320	PF00498	0.317
LIG_FHA_1	71	77	PF00498	0.510
LIG_FHA_2	174	180	PF00498	0.585
LIG_FHA_2	275	281	PF00498	0.357
LIG_FHA_2	62	68	PF00498	0.515
LIG_LIR_Apic_2	266	272	PF02991	0.392
LIG_LIR_Apic_2	73	77	PF02991	0.471
LIG_LIR_Apic_2	80	85	PF02991	0.388
LIG_LIR_Nem_3	2	8	PF02991	0.611
LIG_LIR_Nem_3	262	268	PF02991	0.373
LIG_LIR_Nem_3	332	336	PF02991	0.465
LIG_Pex14_2	265	269	PF04695	0.372
LIG_Pex14_2	5	9	PF04695	0.579
LIG_PTB_Apo_2	51	58	PF02174	0.627
LIG_Rb_pABgroove_1	51	59	PF01858	0.513
LIG_SH2_STAT5	137	140	PF00017	0.398
LIG_SH2_STAT5	268	271	PF00017	0.355
LIG_SH2_STAT5	291	294	PF00017	0.305
LIG_SH2_STAT5	70	73	PF00017	0.519
LIG_SH3_3	244	250	PF00018	0.445
LIG_SH3_3	32	38	PF00018	0.678
LIG_Sin3_3	185	192	PF02671	0.426
LIG_SUMO_SIM_par_1	339	344	PF11976	0.514
LIG_TRAF2_1	170	173	PF00917	0.597
MOD_CDK_SPxxK_3	16	23	PF00069	0.691
MOD_CK1_1	207	213	PF00069	0.378
MOD_CK1_1	275	281	PF00069	0.335
MOD_CK1_1	313	319	PF00069	0.271
MOD_CK2_1	173	179	PF00069	0.544
MOD_CK2_1	274	280	PF00069	0.417
MOD_CK2_1	61	67	PF00069	0.516
MOD_DYRK1A_RPxSP_1	249	253	PF00069	0.511
MOD_GlcNHglycan	253	256	PF01048	0.481
MOD_GlcNHglycan	274	277	PF01048	0.590
MOD_GlcNHglycan	42	45	PF01048	0.638
MOD_GlcNHglycan	47	50	PF01048	0.592
MOD_GlcNHglycan	93	97	PF01048	0.534
MOD_GSK3_1	164	171	PF00069	0.479
MOD_GSK3_1	272	279	PF00069	0.369
MOD_GSK3_1	315	322	PF00069	0.376
MOD_NEK2_1	1	6	PF00069	0.614
MOD_NEK2_1	142	147	PF00069	0.298
MOD_NEK2_1	196	201	PF00069	0.419
MOD_NEK2_1	29	34	PF00069	0.642
MOD_NEK2_1	305	310	PF00069	0.305
MOD_NEK2_1	8	13	PF00069	0.555
MOD_PIKK_1	173	179	PF00454	0.526
MOD_PKA_2	131	137	PF00069	0.394
MOD_PKA_2	305	311	PF00069	0.305
MOD_PKA_2	319	325	PF00069	0.305
MOD_Plk_2-3	168	174	PF00069	0.601
MOD_Plk_4	323	329	PF00069	0.437
MOD_ProDKin_1	121	127	PF00069	0.434
MOD_ProDKin_1	16	22	PF00069	0.647
MOD_ProDKin_1	249	255	PF00069	0.506
MOD_SUMO_rev_2	173	182	PF00179	0.575
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.688
TRG_ENDOCYTIC_2	291	294	PF00928	0.378
TRG_ENDOCYTIC_2	333	336	PF00928	0.463
TRG_ER_diArg_1	138	140	PF00400	0.491
TRG_ER_diArg_1	227	230	PF00400	0.448
TRG_ER_diArg_1	5	7	PF00400	0.596
TRG_NLS_Bipartite_1	139	153	PF00514	0.496
TRG_NLS_MonoCore_2	146	151	PF00514	0.319
TRG_NLS_MonoExtC_3	147	152	PF00514	0.559
TRG_NLS_MonoExtN_4	147	153	PF00514	0.559
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P665	Leptomonas seymouri	66%	100%
A0A0N0P6K6	Leptomonas seymouri	62%	100%
A0A0S4J0R9	Bodo saltans	35%	98%
A0A1X0P349	Trypanosomatidae	51%	100%
A0A3S7XBE7	Leishmania donovani	96%	100%
A4HPS5	Leishmania braziliensis	84%	100%
A4ICY8	Leishmania infantum	95%	100%
B3MR30	Drosophila ananassae	33%	100%
B3P9N0	Drosophila erecta	33%	100%
B4GXS1	Drosophila persimilis	33%	100%
B4I9J6	Drosophila sechellia	33%	100%
B4JMM7	Drosophila grimshawi	35%	100%
B4L6S9	Drosophila mojavensis	31%	100%
B4M7S0	Drosophila virilis	34%	100%
B4NE96	Drosophila willistoni	34%	100%
B4PY69	Drosophila yakuba	33%	100%
B4R313	Drosophila simulans	33%	100%
D0A8P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ATJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O46084	Drosophila melanogaster	33%	100%
Q29HG0	Drosophila pseudoobscura pseudoobscura	33%	100%
Q562B5	Rattus norvegicus	35%	100%
Q96HS1	Homo sapiens	36%	100%
V5B6V2	Trypanosoma cruzi	55%	100%