IQ calmodulin-binding motif family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q107_LEIMA

TriTrypDb:

LmjF.36.4080 , LMJLV39_360051800 , LMJSD75_360051700

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q107

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q107

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005516	calmodulin binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.697
CLV_C14_Caspase3-7	485	489	PF00656	0.547
CLV_NRD_NRD_1	103	105	PF00675	0.307
CLV_NRD_NRD_1	140	142	PF00675	0.302
CLV_NRD_NRD_1	193	195	PF00675	0.413
CLV_NRD_NRD_1	285	287	PF00675	0.578
CLV_NRD_NRD_1	32	34	PF00675	0.454
CLV_NRD_NRD_1	413	415	PF00675	0.786
CLV_NRD_NRD_1	416	418	PF00675	0.749
CLV_NRD_NRD_1	462	464	PF00675	0.627
CLV_NRD_NRD_1	528	530	PF00675	0.675
CLV_PCSK_KEX2_1	105	107	PF00082	0.295
CLV_PCSK_KEX2_1	184	186	PF00082	0.530
CLV_PCSK_KEX2_1	193	195	PF00082	0.425
CLV_PCSK_KEX2_1	285	287	PF00082	0.547
CLV_PCSK_KEX2_1	462	464	PF00082	0.783
CLV_PCSK_KEX2_1	467	469	PF00082	0.698
CLV_PCSK_KEX2_1	528	530	PF00082	0.592
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.330
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.596
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.721
CLV_PCSK_PC7_1	463	469	PF00082	0.719
CLV_PCSK_SKI1_1	384	388	PF00082	0.669
CLV_PCSK_SKI1_1	493	497	PF00082	0.542
CLV_PCSK_SKI1_1	82	86	PF00082	0.380
DEG_COP1_1	203	210	PF00400	0.640
DEG_Nend_UBRbox_3	1	3	PF02207	0.614
DEG_SCF_FBW7_1	223	228	PF00400	0.540
DOC_CKS1_1	222	227	PF01111	0.638
DOC_CKS1_1	37	42	PF01111	0.570
DOC_CKS1_1	385	390	PF01111	0.669
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.687
DOC_MAPK_gen_1	299	308	PF00069	0.527
DOC_PP2B_LxvP_1	309	312	PF13499	0.745
DOC_SPAK_OSR1_1	463	467	PF12202	0.717
DOC_USP7_MATH_1	159	163	PF00917	0.548
DOC_USP7_MATH_1	215	219	PF00917	0.657
DOC_USP7_MATH_1	225	229	PF00917	0.566
DOC_USP7_MATH_1	250	254	PF00917	0.658
DOC_USP7_MATH_1	273	277	PF00917	0.605
DOC_USP7_MATH_1	300	304	PF00917	0.585
DOC_USP7_MATH_1	313	317	PF00917	0.623
DOC_USP7_MATH_1	339	343	PF00917	0.694
DOC_USP7_MATH_1	355	359	PF00917	0.711
DOC_USP7_MATH_1	360	364	PF00917	0.752
DOC_USP7_MATH_1	441	445	PF00917	0.768
DOC_USP7_MATH_1	450	454	PF00917	0.534
DOC_USP7_MATH_1	455	459	PF00917	0.471
DOC_USP7_MATH_1	491	495	PF00917	0.734
DOC_USP7_MATH_1	59	63	PF00917	0.362
DOC_USP7_MATH_2	373	379	PF00917	0.750
DOC_WW_Pin1_4	221	226	PF00397	0.654
DOC_WW_Pin1_4	242	247	PF00397	0.728
DOC_WW_Pin1_4	314	319	PF00397	0.690
DOC_WW_Pin1_4	347	352	PF00397	0.704
DOC_WW_Pin1_4	36	41	PF00397	0.691
DOC_WW_Pin1_4	384	389	PF00397	0.677
LIG_14-3-3_CanoR_1	111	115	PF00244	0.511
LIG_14-3-3_CanoR_1	160	166	PF00244	0.399
LIG_14-3-3_CanoR_1	193	201	PF00244	0.502
LIG_14-3-3_CanoR_1	295	299	PF00244	0.649
LIG_14-3-3_CanoR_1	33	38	PF00244	0.492
LIG_14-3-3_CanoR_1	359	369	PF00244	0.569
LIG_14-3-3_CanoR_1	408	416	PF00244	0.675
LIG_14-3-3_CanoR_1	454	464	PF00244	0.669
LIG_Actin_WH2_2	166	181	PF00022	0.544
LIG_CaM_IQ_9	128	144	PF13499	0.492
LIG_CaM_IQ_9	68	84	PF13499	0.492
LIG_CaM_IQ_9	91	107	PF13499	0.492
LIG_EVH1_2	403	407	PF00568	0.568
LIG_FHA_1	202	208	PF00498	0.521
LIG_FHA_1	477	483	PF00498	0.615
LIG_FHA_2	120	126	PF00498	0.459
LIG_FHA_2	169	175	PF00498	0.458
LIG_FHA_2	228	234	PF00498	0.678
LIG_FHA_2	321	327	PF00498	0.592
LIG_LIR_Gen_1	122	131	PF02991	0.461
LIG_LIR_Gen_1	32	42	PF02991	0.520
LIG_LIR_LC3C_4	303	308	PF02991	0.516
LIG_LIR_Nem_3	122	127	PF02991	0.458
LIG_LIR_Nem_3	32	38	PF02991	0.525
LIG_LIR_Nem_3	74	78	PF02991	0.550
LIG_MYND_1	347	351	PF01753	0.699
LIG_Pex14_2	460	464	PF04695	0.610
LIG_SH2_CRK	35	39	PF00017	0.496
LIG_SH2_GRB2like	153	156	PF00017	0.417
LIG_SH2_NCK_1	35	39	PF00017	0.518
LIG_SH2_SRC	153	156	PF00017	0.494
LIG_SH2_STAP1	148	152	PF00017	0.453
LIG_SH2_STAT3	147	150	PF00017	0.482
LIG_SH2_STAT3	78	81	PF00017	0.440
LIG_SH2_STAT5	119	122	PF00017	0.416
LIG_SH2_STAT5	153	156	PF00017	0.453
LIG_SH3_3	207	213	PF00018	0.606
LIG_SH3_3	243	249	PF00018	0.716
LIG_SH3_3	332	338	PF00018	0.686
LIG_SH3_3	348	354	PF00018	0.622
LIG_SH3_3	379	385	PF00018	0.627
LIG_SUMO_SIM_par_1	305	310	PF11976	0.586
LIG_WRC_WIRS_1	457	462	PF05994	0.615
MOD_CDC14_SPxK_1	319	322	PF00782	0.702
MOD_CDK_SPK_2	384	389	PF00069	0.640
MOD_CDK_SPxK_1	316	322	PF00069	0.696
MOD_CK1_1	140	146	PF00069	0.586
MOD_CK1_1	203	209	PF00069	0.518
MOD_CK1_1	316	322	PF00069	0.667
MOD_CK1_1	36	42	PF00069	0.633
MOD_CK1_1	444	450	PF00069	0.800
MOD_CK2_1	15	21	PF00069	0.584
MOD_CK2_1	168	174	PF00069	0.455
MOD_CK2_1	227	233	PF00069	0.642
MOD_CK2_1	250	256	PF00069	0.723
MOD_CK2_1	320	326	PF00069	0.585
MOD_CK2_1	49	55	PF00069	0.542
MOD_CK2_1	495	501	PF00069	0.606
MOD_Cter_Amidation	412	415	PF01082	0.694
MOD_GlcNHglycan	252	255	PF01048	0.696
MOD_GlcNHglycan	275	278	PF01048	0.583
MOD_GlcNHglycan	335	338	PF01048	0.822
MOD_GlcNHglycan	341	344	PF01048	0.632
MOD_GlcNHglycan	377	380	PF01048	0.632
MOD_GlcNHglycan	443	446	PF01048	0.779
MOD_GlcNHglycan	493	496	PF01048	0.713
MOD_GlcNHglycan	497	500	PF01048	0.604
MOD_GlcNHglycan	51	54	PF01048	0.564
MOD_GlcNHglycan	525	528	PF01048	0.709
MOD_GSK3_1	155	162	PF00069	0.502
MOD_GSK3_1	221	228	PF00069	0.638
MOD_GSK3_1	29	36	PF00069	0.562
MOD_GSK3_1	307	314	PF00069	0.626
MOD_GSK3_1	316	323	PF00069	0.647
MOD_GSK3_1	360	367	PF00069	0.589
MOD_GSK3_1	394	401	PF00069	0.665
MOD_GSK3_1	403	410	PF00069	0.675
MOD_GSK3_1	444	451	PF00069	0.709
MOD_GSK3_1	491	498	PF00069	0.653
MOD_N-GLC_1	225	230	PF02516	0.646
MOD_N-GLC_1	361	366	PF02516	0.698
MOD_N-GLC_1	486	491	PF02516	0.673
MOD_NEK2_1	126	131	PF00069	0.353
MOD_NEK2_1	15	20	PF00069	0.615
MOD_NEK2_1	201	206	PF00069	0.530
MOD_NEK2_1	398	403	PF00069	0.746
MOD_NEK2_1	407	412	PF00069	0.634
MOD_NEK2_1	476	481	PF00069	0.644
MOD_NEK2_1	523	528	PF00069	0.749
MOD_NEK2_2	119	124	PF00069	0.465
MOD_NEK2_2	456	461	PF00069	0.734
MOD_PIKK_1	168	174	PF00454	0.529
MOD_PIKK_1	349	355	PF00454	0.676
MOD_PIKK_1	396	402	PF00454	0.732
MOD_PIKK_1	407	413	PF00454	0.663
MOD_PKA_1	33	39	PF00069	0.449
MOD_PKA_2	110	116	PF00069	0.408
MOD_PKA_2	140	146	PF00069	0.586
MOD_PKA_2	159	165	PF00069	0.553
MOD_PKA_2	192	198	PF00069	0.436
MOD_PKA_2	294	300	PF00069	0.550
MOD_PKA_2	407	413	PF00069	0.787
MOD_Plk_1	187	193	PF00069	0.587
MOD_Plk_1	320	326	PF00069	0.617
MOD_Plk_4	119	125	PF00069	0.496
MOD_Plk_4	206	212	PF00069	0.531
MOD_Plk_4	33	39	PF00069	0.557
MOD_Plk_4	42	48	PF00069	0.477
MOD_ProDKin_1	221	227	PF00069	0.655
MOD_ProDKin_1	242	248	PF00069	0.724
MOD_ProDKin_1	314	320	PF00069	0.686
MOD_ProDKin_1	347	353	PF00069	0.706
MOD_ProDKin_1	36	42	PF00069	0.691
MOD_ProDKin_1	384	390	PF00069	0.678
MOD_SUMO_rev_2	176	186	PF00179	0.522
MOD_SUMO_rev_2	508	514	PF00179	0.600
TRG_ENDOCYTIC_2	153	156	PF00928	0.557
TRG_ENDOCYTIC_2	35	38	PF00928	0.473
TRG_ER_diArg_1	104	107	PF00400	0.574
TRG_ER_diArg_1	284	286	PF00400	0.530
TRG_ER_diArg_1	357	360	PF00400	0.621
TRG_ER_diArg_1	462	464	PF00400	0.780
TRG_NLS_MonoCore_2	413	418	PF00514	0.756
TRG_NLS_MonoExtC_3	413	418	PF00514	0.692

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I2	Leptomonas seymouri	42%	100%
A0A3S7XBK4	Leishmania donovani	88%	100%
A4HPS6	Leishmania braziliensis	68%	100%
A4IE66	Leishmania infantum	88%	100%
E9ATJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%