Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q106_LEIMA

TriTrypDb:

LmjF.36.4090 , LMJLV39_360051900 , LMJSD75_360051800

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q106

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q106

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	420	424	PF00656	0.618
CLV_C14_Caspase3-7	56	60	PF00656	0.651
CLV_NRD_NRD_1	133	135	PF00675	0.514
CLV_NRD_NRD_1	237	239	PF00675	0.663
CLV_NRD_NRD_1	396	398	PF00675	0.522
CLV_NRD_NRD_1	85	87	PF00675	0.449
CLV_PCSK_FUR_1	278	282	PF00082	0.639
CLV_PCSK_KEX2_1	133	135	PF00082	0.490
CLV_PCSK_KEX2_1	280	282	PF00082	0.686
CLV_PCSK_KEX2_1	352	354	PF00082	0.515
CLV_PCSK_KEX2_1	396	398	PF00082	0.513
CLV_PCSK_KEX2_1	85	87	PF00082	0.449
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.683
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.515
CLV_PCSK_SKI1_1	113	117	PF00082	0.403
CLV_PCSK_SKI1_1	255	259	PF00082	0.637
CLV_PCSK_SKI1_1	29	33	PF00082	0.556
CLV_PCSK_SKI1_1	316	320	PF00082	0.520
CLV_PCSK_SKI1_1	352	356	PF00082	0.512
CLV_PCSK_SKI1_1	419	423	PF00082	0.502
DEG_APCC_DBOX_1	315	323	PF00400	0.518
DEG_MDM2_SWIB_1	158	165	PF02201	0.382
DEG_Nend_UBRbox_1	1	4	PF02207	0.654
DEG_SPOP_SBC_1	191	195	PF00917	0.642
DEG_SPOP_SBC_1	51	55	PF00917	0.715
DOC_CYCLIN_RxL_1	252	261	PF00134	0.614
DOC_CYCLIN_RxL_1	349	359	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	135	141	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	31	34	PF00134	0.608
DOC_MAPK_DCC_7	293	303	PF00069	0.605
DOC_MAPK_DCC_7	316	324	PF00069	0.510
DOC_MAPK_MEF2A_6	316	324	PF00069	0.510
DOC_PP2B_LxvP_1	135	138	PF13499	0.432
DOC_PP2B_LxvP_1	265	268	PF13499	0.678
DOC_PP2B_LxvP_1	31	34	PF13499	0.681
DOC_PP4_FxxP_1	65	68	PF00568	0.469
DOC_USP7_MATH_1	120	124	PF00917	0.534
DOC_USP7_MATH_1	126	130	PF00917	0.459
DOC_USP7_MATH_1	139	143	PF00917	0.306
DOC_USP7_MATH_1	288	292	PF00917	0.642
DOC_USP7_MATH_1	341	345	PF00917	0.676
DOC_USP7_MATH_1	356	360	PF00917	0.575
DOC_USP7_MATH_1	364	368	PF00917	0.515
DOC_USP7_MATH_1	51	55	PF00917	0.701
DOC_WW_Pin1_4	2	7	PF00397	0.504
DOC_WW_Pin1_4	205	210	PF00397	0.697
DOC_WW_Pin1_4	258	263	PF00397	0.601
DOC_WW_Pin1_4	32	37	PF00397	0.575
LIG_14-3-3_CanoR_1	113	122	PF00244	0.472
LIG_14-3-3_CanoR_1	188	198	PF00244	0.556
LIG_14-3-3_CanoR_1	202	209	PF00244	0.605
LIG_14-3-3_CanoR_1	255	261	PF00244	0.612
LIG_14-3-3_CanoR_1	373	378	PF00244	0.545
LIG_14-3-3_CanoR_1	86	92	PF00244	0.422
LIG_BRCT_BRCA1_1	154	158	PF00533	0.382
LIG_BRCT_BRCA1_1	290	294	PF00533	0.548
LIG_DLG_GKlike_1	373	381	PF00625	0.436
LIG_eIF4E_1	9	15	PF01652	0.580
LIG_EVH1_2	68	72	PF00568	0.580
LIG_FHA_1	10	16	PF00498	0.573
LIG_FHA_1	114	120	PF00498	0.418
LIG_FHA_1	17	23	PF00498	0.513
LIG_FHA_1	298	304	PF00498	0.592
LIG_FHA_1	372	378	PF00498	0.514
LIG_FHA_2	35	41	PF00498	0.499
LIG_FHA_2	54	60	PF00498	0.505
LIG_LIR_Gen_1	155	166	PF02991	0.376
LIG_LIR_Nem_3	155	161	PF02991	0.383
LIG_NRBOX	40	46	PF00104	0.557
LIG_PCNA_yPIPBox_3	408	422	PF02747	0.506
LIG_Pex14_2	127	131	PF04695	0.402
LIG_Pex14_2	154	158	PF04695	0.411
LIG_SH2_STAP1	350	354	PF00017	0.516
LIG_SH2_STAT3	149	152	PF00017	0.392
LIG_SH2_STAT5	160	163	PF00017	0.368
LIG_SH2_STAT5	276	279	PF00017	0.629
LIG_SH2_STAT5	410	413	PF00017	0.468
LIG_SH3_3	116	122	PF00018	0.507
LIG_SH3_3	30	36	PF00018	0.522
LIG_SH3_3	314	320	PF00018	0.661
LIG_SH3_3	333	339	PF00018	0.507
LIG_SUMO_SIM_anti_2	300	305	PF11976	0.597
LIG_SUMO_SIM_par_1	256	261	PF11976	0.612
LIG_SUMO_SIM_par_1	373	378	PF11976	0.590
MOD_CDK_SPK_2	2	7	PF00069	0.504
MOD_CK1_1	192	198	PF00069	0.638
MOD_CK1_1	205	211	PF00069	0.625
MOD_CK1_1	223	229	PF00069	0.573
MOD_CK1_1	357	363	PF00069	0.591
MOD_CK1_1	371	377	PF00069	0.433
MOD_CK1_1	5	11	PF00069	0.569
MOD_CK2_1	34	40	PF00069	0.509
MOD_Cter_Amidation	278	281	PF01082	0.688
MOD_GlcNHglycan	204	207	PF01048	0.769
MOD_GlcNHglycan	220	223	PF01048	0.650
MOD_GlcNHglycan	241	244	PF01048	0.628
MOD_GlcNHglycan	246	249	PF01048	0.636
MOD_GlcNHglycan	250	253	PF01048	0.631
MOD_GlcNHglycan	330	333	PF01048	0.653
MOD_GlcNHglycan	342	346	PF01048	0.571
MOD_GlcNHglycan	356	359	PF01048	0.620
MOD_GlcNHglycan	370	373	PF01048	0.497
MOD_GlcNHglycan	47	50	PF01048	0.614
MOD_GlcNHglycan	72	75	PF01048	0.592
MOD_GSK3_1	109	116	PF00069	0.374
MOD_GSK3_1	152	159	PF00069	0.392
MOD_GSK3_1	198	205	PF00069	0.663
MOD_GSK3_1	23	30	PF00069	0.429
MOD_GSK3_1	244	251	PF00069	0.630
MOD_GSK3_1	364	371	PF00069	0.641
MOD_GSK3_1	425	432	PF00069	0.508
MOD_GSK3_1	5	12	PF00069	0.618
MOD_GSK3_1	53	60	PF00069	0.745
MOD_N-GLC_1	248	253	PF02516	0.577
MOD_N-GLC_1	362	367	PF02516	0.581
MOD_NEK2_1	107	112	PF00069	0.352
MOD_NEK2_1	114	119	PF00069	0.425
MOD_NEK2_1	190	195	PF00069	0.536
MOD_NEK2_1	220	225	PF00069	0.666
MOD_NEK2_1	233	238	PF00069	0.538
MOD_NEK2_1	25	30	PF00069	0.558
MOD_NEK2_1	354	359	PF00069	0.500
MOD_NEK2_1	45	50	PF00069	0.590
MOD_NEK2_2	139	144	PF00069	0.500
MOD_NEK2_2	153	158	PF00069	0.366
MOD_PKA_2	182	188	PF00069	0.512
MOD_PKA_2	198	204	PF00069	0.796
MOD_Plk_2-3	425	431	PF00069	0.500
MOD_Plk_4	153	159	PF00069	0.369
MOD_Plk_4	95	101	PF00069	0.402
MOD_ProDKin_1	2	8	PF00069	0.503
MOD_ProDKin_1	205	211	PF00069	0.696
MOD_ProDKin_1	258	264	PF00069	0.600
MOD_ProDKin_1	32	38	PF00069	0.568
MOD_SUMO_rev_2	174	182	PF00179	0.593
TRG_DiLeu_BaEn_1	10	15	PF01217	0.580
TRG_DiLeu_BaEn_1	40	45	PF01217	0.487
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.557
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.639
TRG_DiLeu_BaLyEn_6	350	355	PF01217	0.516
TRG_ER_diArg_1	133	135	PF00400	0.490
TRG_ER_diArg_1	395	397	PF00400	0.556
TRG_ER_diArg_1	85	87	PF00400	0.455
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	373	378	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIJ2	Leptomonas seymouri	36%	87%
A0A3Q8ILA1	Leishmania donovani	89%	100%
A4HPS7	Leishmania braziliensis	68%	100%
A4IE65	Leishmania infantum	89%	100%
E9ATJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%