Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q104_LEIMA

TriTrypDb:

LmjF.36.4110 , LMJLV39_360052100 , LMJSD75_360052000

Length:

1021

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q104

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q104

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.658
CLV_C14_Caspase3-7	593	597	PF00656	0.614
CLV_MEL_PAP_1	858	864	PF00089	0.523
CLV_NRD_NRD_1	1015	1017	PF00675	0.550
CLV_NRD_NRD_1	251	253	PF00675	0.660
CLV_NRD_NRD_1	384	386	PF00675	0.798
CLV_NRD_NRD_1	695	697	PF00675	0.538
CLV_NRD_NRD_1	760	762	PF00675	0.546
CLV_NRD_NRD_1	8	10	PF00675	0.714
CLV_NRD_NRD_1	805	807	PF00675	0.619
CLV_NRD_NRD_1	85	87	PF00675	0.697
CLV_NRD_NRD_1	873	875	PF00675	0.475
CLV_NRD_NRD_1	950	952	PF00675	0.492
CLV_PCSK_FUR_1	1013	1017	PF00082	0.548
CLV_PCSK_KEX2_1	1015	1017	PF00082	0.550
CLV_PCSK_KEX2_1	185	187	PF00082	0.657
CLV_PCSK_KEX2_1	251	253	PF00082	0.660
CLV_PCSK_KEX2_1	384	386	PF00082	0.740
CLV_PCSK_KEX2_1	565	567	PF00082	0.718
CLV_PCSK_KEX2_1	695	697	PF00082	0.538
CLV_PCSK_KEX2_1	760	762	PF00082	0.546
CLV_PCSK_KEX2_1	8	10	PF00082	0.780
CLV_PCSK_KEX2_1	805	807	PF00082	0.619
CLV_PCSK_KEX2_1	85	87	PF00082	0.697
CLV_PCSK_KEX2_1	873	875	PF00082	0.475
CLV_PCSK_KEX2_1	950	952	PF00082	0.492
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.657
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.734
CLV_PCSK_PC7_1	4	10	PF00082	0.764
CLV_PCSK_SKI1_1	356	360	PF00082	0.523
CLV_PCSK_SKI1_1	421	425	PF00082	0.481
CLV_PCSK_SKI1_1	444	448	PF00082	0.595
CLV_PCSK_SKI1_1	600	604	PF00082	0.557
CLV_PCSK_SKI1_1	696	700	PF00082	0.599
CLV_PCSK_SKI1_1	903	907	PF00082	0.366
DEG_APCC_DBOX_1	355	363	PF00400	0.513
DEG_SCF_FBW7_1	360	367	PF00400	0.564
DEG_SCF_FBW7_2	491	496	PF00400	0.524
DEG_SIAH_1	111	119	PF03145	0.603
DEG_SPOP_SBC_1	23	27	PF00917	0.737
DEG_SPOP_SBC_1	458	462	PF00917	0.527
DEG_SPOP_SBC_1	877	881	PF00917	0.685
DEG_SPOP_SBC_1	930	934	PF00917	0.640
DEG_SPOP_SBC_1	976	980	PF00917	0.678
DOC_CKS1_1	124	129	PF01111	0.591
DOC_CKS1_1	490	495	PF01111	0.504
DOC_CYCLIN_RxL_1	418	426	PF00134	0.481
DOC_CYCLIN_RxL_1	438	449	PF00134	0.277
DOC_CYCLIN_yCln2_LP_2	10	16	PF00134	0.771
DOC_CYCLIN_yCln2_LP_2	586	592	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	638	644	PF00134	0.523
DOC_MAPK_DCC_7	185	194	PF00069	0.524
DOC_MAPK_gen_1	1013	1021	PF00069	0.565
DOC_MAPK_gen_1	577	586	PF00069	0.681
DOC_MAPK_gen_1	803	811	PF00069	0.660
DOC_MAPK_gen_1	907	916	PF00069	0.579
DOC_PP2B_LxvP_1	601	604	PF13499	0.557
DOC_PP2B_LxvP_1	683	686	PF13499	0.426
DOC_PP4_FxxP_1	1011	1014	PF00568	0.507
DOC_PP4_FxxP_1	368	371	PF00568	0.805
DOC_PP4_FxxP_1	455	458	PF00568	0.408
DOC_PP4_FxxP_1	884	887	PF00568	0.577
DOC_USP7_MATH_1	218	222	PF00917	0.617
DOC_USP7_MATH_1	23	27	PF00917	0.742
DOC_USP7_MATH_1	358	362	PF00917	0.497
DOC_USP7_MATH_1	606	610	PF00917	0.454
DOC_USP7_MATH_1	837	841	PF00917	0.654
DOC_USP7_MATH_1	843	847	PF00917	0.591
DOC_USP7_MATH_1	875	879	PF00917	0.646
DOC_USP7_MATH_1	930	934	PF00917	0.641
DOC_USP7_MATH_1	976	980	PF00917	0.678
DOC_WW_Pin1_4	108	113	PF00397	0.709
DOC_WW_Pin1_4	114	119	PF00397	0.683
DOC_WW_Pin1_4	123	128	PF00397	0.492
DOC_WW_Pin1_4	24	29	PF00397	0.736
DOC_WW_Pin1_4	360	365	PF00397	0.504
DOC_WW_Pin1_4	44	49	PF00397	0.677
DOC_WW_Pin1_4	489	494	PF00397	0.502
DOC_WW_Pin1_4	846	851	PF00397	0.514
DOC_WW_Pin1_4	920	925	PF00397	0.611
LIG_14-3-3_CanoR_1	18	28	PF00244	0.616
LIG_14-3-3_CanoR_1	203	207	PF00244	0.642
LIG_14-3-3_CanoR_1	566	572	PF00244	0.751
LIG_14-3-3_CanoR_1	580	586	PF00244	0.584
LIG_14-3-3_CanoR_1	726	730	PF00244	0.517
LIG_14-3-3_CanoR_1	874	884	PF00244	0.525
LIG_14-3-3_CanoR_1	917	924	PF00244	0.627
LIG_14-3-3_CanoR_1	950	960	PF00244	0.518
LIG_Actin_WH2_2	187	205	PF00022	0.608
LIG_Actin_WH2_2	901	919	PF00022	0.597
LIG_APCC_ABBA_1	862	867	PF00400	0.496
LIG_APCC_ABBAyCdc20_2	861	867	PF00400	0.496
LIG_BIR_II_1	1	5	PF00653	0.811
LIG_BRCT_BRCA1_1	235	239	PF00533	0.756
LIG_BRCT_BRCA1_1	880	884	PF00533	0.648
LIG_BRCT_BRCA1_2	880	886	PF00533	0.566
LIG_Clathr_ClatBox_1	192	196	PF01394	0.498
LIG_CSL_BTD_1	343	346	PF09270	0.576
LIG_CtBP_PxDLS_1	850	854	PF00389	0.536
LIG_deltaCOP1_diTrp_1	283	289	PF00928	0.562
LIG_deltaCOP1_diTrp_1	714	721	PF00928	0.737
LIG_FHA_1	135	141	PF00498	0.616
LIG_FHA_1	150	156	PF00498	0.332
LIG_FHA_1	265	271	PF00498	0.721
LIG_FHA_1	275	281	PF00498	0.537
LIG_FHA_1	350	356	PF00498	0.520
LIG_FHA_1	411	417	PF00498	0.581
LIG_FHA_1	424	430	PF00498	0.406
LIG_FHA_1	435	441	PF00498	0.541
LIG_FHA_1	447	453	PF00498	0.465
LIG_FHA_1	543	549	PF00498	0.502
LIG_FHA_1	680	686	PF00498	0.524
LIG_FHA_1	697	703	PF00498	0.543
LIG_FHA_1	720	726	PF00498	0.698
LIG_FHA_1	753	759	PF00498	0.540
LIG_FHA_1	853	859	PF00498	0.544
LIG_FHA_1	904	910	PF00498	0.426
LIG_FHA_1	95	101	PF00498	0.737
LIG_FHA_1	952	958	PF00498	0.459
LIG_FHA_2	296	302	PF00498	0.576
LIG_FHA_2	314	320	PF00498	0.507
LIG_FHA_2	459	465	PF00498	0.752
LIG_FHA_2	658	664	PF00498	0.674
LIG_FHA_2	701	707	PF00498	0.598
LIG_FHA_2	786	792	PF00498	0.691
LIG_FHA_2	827	833	PF00498	0.387
LIG_FHA_2	877	883	PF00498	0.763
LIG_FHA_2	984	990	PF00498	0.604
LIG_GBD_Chelix_1	198	206	PF00786	0.506
LIG_Integrin_RGD_1	69	71	PF01839	0.534
LIG_IRF3_LxIS_1	893	900	PF10401	0.603
LIG_LIR_Apic_2	367	371	PF02991	0.800
LIG_LIR_Apic_2	881	887	PF02991	0.571
LIG_LIR_Gen_1	298	307	PF02991	0.663
LIG_LIR_Gen_1	425	435	PF02991	0.492
LIG_LIR_Gen_1	52	62	PF02991	0.628
LIG_LIR_Gen_1	544	554	PF02991	0.548
LIG_LIR_Gen_1	63	73	PF02991	0.551
LIG_LIR_Gen_1	810	821	PF02991	0.589
LIG_LIR_Gen_1	991	1001	PF02991	0.619
LIG_LIR_Nem_3	154	160	PF02991	0.453
LIG_LIR_Nem_3	298	302	PF02991	0.623
LIG_LIR_Nem_3	425	430	PF02991	0.481
LIG_LIR_Nem_3	484	490	PF02991	0.514
LIG_LIR_Nem_3	52	57	PF02991	0.653
LIG_LIR_Nem_3	544	549	PF02991	0.543
LIG_LIR_Nem_3	63	68	PF02991	0.528
LIG_LIR_Nem_3	810	816	PF02991	0.598
LIG_LIR_Nem_3	991	996	PF02991	0.617
LIG_LYPXL_SIV_4	693	701	PF13949	0.576
LIG_NRBOX	442	448	PF00104	0.594
LIG_PCNA_yPIPBox_3	170	179	PF02747	0.521
LIG_PCNA_yPIPBox_3	941	951	PF02747	0.481
LIG_PDZ_Class_2	1016	1021	PF00595	0.583
LIG_Pex14_1	813	817	PF04695	0.602
LIG_RPA_C_Fungi	575	587	PF08784	0.775
LIG_RPA_C_Fungi	755	767	PF08784	0.590
LIG_SH2_CRK	528	532	PF00017	0.524
LIG_SH2_CRK	65	69	PF00017	0.555
LIG_SH2_NCK_1	649	653	PF00017	0.680
LIG_SH2_NCK_1	796	800	PF00017	0.581
LIG_SH2_PTP2	490	493	PF00017	0.492
LIG_SH2_PTP2	655	658	PF00017	0.535
LIG_SH2_SRC	649	652	PF00017	0.689
LIG_SH2_STAP1	276	280	PF00017	0.533
LIG_SH2_STAP1	366	370	PF00017	0.779
LIG_SH2_STAP1	997	1001	PF00017	0.621
LIG_SH2_STAT5	276	279	PF00017	0.585
LIG_SH2_STAT5	490	493	PF00017	0.615
LIG_SH2_STAT5	65	68	PF00017	0.556
LIG_SH2_STAT5	655	658	PF00017	0.535
LIG_SH2_STAT5	769	772	PF00017	0.499
LIG_SH3_1	185	191	PF00018	0.632
LIG_SH3_3	115	121	PF00018	0.723
LIG_SH3_3	185	191	PF00018	0.497
LIG_SH3_3	205	211	PF00018	0.325
LIG_SH3_3	404	410	PF00018	0.667
LIG_SH3_3	472	478	PF00018	0.650
LIG_SH3_3	890	896	PF00018	0.652
LIG_Sin3_3	681	688	PF02671	0.617
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.531
LIG_SUMO_SIM_anti_2	439	444	PF11976	0.392
LIG_SUMO_SIM_anti_2	522	527	PF11976	0.500
LIG_SUMO_SIM_anti_2	748	755	PF11976	0.597
LIG_SUMO_SIM_anti_2	854	860	PF11976	0.475
LIG_SUMO_SIM_anti_2	954	961	PF11976	0.581
LIG_SUMO_SIM_par_1	131	137	PF11976	0.531
LIG_SUMO_SIM_par_1	849	855	PF11976	0.581
LIG_SUMO_SIM_par_1	895	900	PF11976	0.579
LIG_TRAF2_1	533	536	PF00917	0.496
LIG_TRAF2_1	591	594	PF00917	0.697
LIG_TRAF2_1	781	784	PF00917	0.659
LIG_TRAF2_1	866	869	PF00917	0.584
LIG_TYR_ITIM	526	531	PF00017	0.519
LIG_UBA3_1	133	139	PF00899	0.527
LIG_WRC_WIRS_1	365	370	PF05994	0.663
LIG_WRC_WIRS_1	608	613	PF05994	0.467
LIG_WRC_WIRS_1	630	635	PF05994	0.498
LIG_WW_2	893	896	PF00397	0.608
MOD_CDC14_SPxK_1	27	30	PF00782	0.710
MOD_CDK_SPK_2	24	29	PF00069	0.655
MOD_CDK_SPxK_1	24	30	PF00069	0.709
MOD_CK1_1	213	219	PF00069	0.583
MOD_CK1_1	227	233	PF00069	0.682
MOD_CK1_1	331	337	PF00069	0.640
MOD_CK1_1	387	393	PF00069	0.807
MOD_CK1_1	495	501	PF00069	0.547
MOD_CK1_1	56	62	PF00069	0.706
MOD_CK1_1	570	576	PF00069	0.694
MOD_CK1_1	679	685	PF00069	0.557
MOD_CK1_1	730	736	PF00069	0.739
MOD_CK1_1	792	798	PF00069	0.616
MOD_CK1_1	846	852	PF00069	0.535
MOD_CK1_1	876	882	PF00069	0.713
MOD_CK1_1	90	96	PF00069	0.595
MOD_CK1_1	920	926	PF00069	0.686
MOD_CK1_1	968	974	PF00069	0.665
MOD_CK2_1	313	319	PF00069	0.640
MOD_CK2_1	331	337	PF00069	0.777
MOD_CK2_1	376	382	PF00069	0.839
MOD_CK2_1	459	465	PF00069	0.736
MOD_CK2_1	588	594	PF00069	0.613
MOD_CK2_1	657	663	PF00069	0.638
MOD_CK2_1	700	706	PF00069	0.680
MOD_CK2_1	777	783	PF00069	0.642
MOD_CK2_1	826	832	PF00069	0.440
MOD_CK2_1	876	882	PF00069	0.686
MOD_CMANNOS	286	289	PF00535	0.482
MOD_CMANNOS	718	721	PF00535	0.706
MOD_CMANNOS	939	942	PF00535	0.483
MOD_Cter_Amidation	382	385	PF01082	0.745
MOD_GlcNHglycan	212	215	PF01048	0.581
MOD_GlcNHglycan	220	223	PF01048	0.620
MOD_GlcNHglycan	226	229	PF01048	0.655
MOD_GlcNHglycan	256	259	PF01048	0.728
MOD_GlcNHglycan	321	324	PF01048	0.612
MOD_GlcNHglycan	373	376	PF01048	0.681
MOD_GlcNHglycan	389	392	PF01048	0.704
MOD_GlcNHglycan	549	552	PF01048	0.604
MOD_GlcNHglycan	581	584	PF01048	0.732
MOD_GlcNHglycan	590	593	PF01048	0.558
MOD_GlcNHglycan	624	627	PF01048	0.659
MOD_GlcNHglycan	678	681	PF01048	0.581
MOD_GlcNHglycan	733	736	PF01048	0.753
MOD_GlcNHglycan	779	782	PF01048	0.689
MOD_GlcNHglycan	839	842	PF01048	0.656
MOD_GlcNHglycan	875	878	PF01048	0.689
MOD_GlcNHglycan	89	92	PF01048	0.565
MOD_GlcNHglycan	919	922	PF01048	0.631
MOD_GlcNHglycan	933	936	PF01048	0.371
MOD_GlcNHglycan	966	970	PF01048	0.748
MOD_GSK3_1	19	26	PF00069	0.641
MOD_GSK3_1	198	205	PF00069	0.584
MOD_GSK3_1	213	220	PF00069	0.476
MOD_GSK3_1	223	230	PF00069	0.637
MOD_GSK3_1	259	266	PF00069	0.710
MOD_GSK3_1	327	334	PF00069	0.653
MOD_GSK3_1	360	367	PF00069	0.635
MOD_GSK3_1	434	441	PF00069	0.440
MOD_GSK3_1	453	460	PF00069	0.394
MOD_GSK3_1	696	703	PF00069	0.650
MOD_GSK3_1	721	728	PF00069	0.629
MOD_GSK3_1	785	792	PF00069	0.601
MOD_GSK3_1	837	844	PF00069	0.677
MOD_GSK3_1	873	880	PF00069	0.621
MOD_GSK3_1	90	97	PF00069	0.738
MOD_GSK3_1	978	985	PF00069	0.629
MOD_LATS_1	338	344	PF00433	0.545
MOD_N-GLC_1	233	238	PF02516	0.707
MOD_N-GLC_1	295	300	PF02516	0.619
MOD_N-GLC_1	519	524	PF02516	0.619
MOD_N-GLC_1	676	681	PF02516	0.650
MOD_NEK2_1	134	139	PF00069	0.631
MOD_NEK2_1	198	203	PF00069	0.601
MOD_NEK2_1	217	222	PF00069	0.413
MOD_NEK2_1	295	300	PF00069	0.619
MOD_NEK2_1	423	428	PF00069	0.488
MOD_NEK2_1	446	451	PF00069	0.519
MOD_NEK2_1	542	547	PF00069	0.501
MOD_NEK2_1	607	612	PF00069	0.569
MOD_NEK2_1	676	681	PF00069	0.629
MOD_NEK2_1	725	730	PF00069	0.472
MOD_NEK2_1	746	751	PF00069	0.602
MOD_NEK2_1	835	840	PF00069	0.597
MOD_NEK2_1	851	856	PF00069	0.307
MOD_NEK2_1	982	987	PF00069	0.546
MOD_NEK2_2	364	369	PF00069	0.643
MOD_NEK2_2	721	726	PF00069	0.693
MOD_PIKK_1	727	733	PF00454	0.714
MOD_PIKK_1	739	745	PF00454	0.501
MOD_PIKK_1	785	791	PF00454	0.726
MOD_PK_1	53	59	PF00069	0.638
MOD_PKA_1	384	390	PF00069	0.791
MOD_PKA_1	565	571	PF00069	0.802
MOD_PKA_1	873	879	PF00069	0.490
MOD_PKA_2	202	208	PF00069	0.639
MOD_PKA_2	327	333	PF00069	0.762
MOD_PKA_2	384	390	PF00069	0.770
MOD_PKA_2	565	571	PF00069	0.692
MOD_PKA_2	579	585	PF00069	0.702
MOD_PKA_2	725	731	PF00069	0.476
MOD_PKA_2	873	879	PF00069	0.490
MOD_PKA_2	909	915	PF00069	0.479
MOD_PKA_2	94	100	PF00069	0.795
MOD_PKB_1	915	923	PF00069	0.551
MOD_Plk_1	233	239	PF00069	0.698
MOD_Plk_1	295	301	PF00069	0.630
MOD_Plk_1	438	444	PF00069	0.394
MOD_Plk_4	202	208	PF00069	0.560
MOD_Plk_4	340	346	PF00069	0.559
MOD_Plk_4	423	429	PF00069	0.577
MOD_Plk_4	438	444	PF00069	0.373
MOD_Plk_4	521	527	PF00069	0.498
MOD_Plk_4	629	635	PF00069	0.497
MOD_Plk_4	679	685	PF00069	0.564
MOD_Plk_4	749	755	PF00069	0.593
MOD_Plk_4	943	949	PF00069	0.471
MOD_Plk_4	978	984	PF00069	0.579
MOD_Plk_4	988	994	PF00069	0.524
MOD_ProDKin_1	108	114	PF00069	0.710
MOD_ProDKin_1	123	129	PF00069	0.480
MOD_ProDKin_1	24	30	PF00069	0.735
MOD_ProDKin_1	360	366	PF00069	0.514
MOD_ProDKin_1	44	50	PF00069	0.676
MOD_ProDKin_1	489	495	PF00069	0.507
MOD_ProDKin_1	846	852	PF00069	0.508
MOD_ProDKin_1	920	926	PF00069	0.617
TRG_DiLeu_BaEn_1	131	136	PF01217	0.538
TRG_DiLeu_BaEn_1	594	599	PF01217	0.630
TRG_DiLeu_BaEn_4	131	137	PF01217	0.531
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.688
TRG_ENDOCYTIC_2	146	149	PF00928	0.564
TRG_ENDOCYTIC_2	528	531	PF00928	0.527
TRG_ENDOCYTIC_2	65	68	PF00928	0.556
TRG_ENDOCYTIC_2	655	658	PF00928	0.546
TRG_ER_diArg_1	1012	1015	PF00400	0.514
TRG_ER_diArg_1	250	252	PF00400	0.641
TRG_ER_diArg_1	694	696	PF00400	0.536
TRG_ER_diArg_1	7	9	PF00400	0.753
TRG_ER_diArg_1	914	917	PF00400	0.514
TRG_NES_CRM1_1	153	165	PF08389	0.491
TRG_NLS_MonoExtN_4	562	568	PF00514	0.724
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	961	966	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHV3	Leptomonas seymouri	43%	99%
A0A3S7XBE1	Leishmania donovani	91%	100%
A4HPS9	Leishmania braziliensis	76%	100%
A4IE63	Leishmania infantum	91%	100%
E9ATJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%