Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania major

UniProt:

Q4Q102_LEIMA

TriTrypDb:

LmjF.36.4130 , LMJLV39_360052300 , LMJSD75_360052200

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q102

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q102

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	7	9	PF00675	0.469
CLV_PCSK_KEX2_1	11	13	PF00082	0.564
CLV_PCSK_KEX2_1	7	9	PF00082	0.469
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.564
CLV_PCSK_PC7_1	3	9	PF00082	0.554
CLV_PCSK_SKI1_1	133	137	PF00082	0.516
CLV_PCSK_SKI1_1	164	168	PF00082	0.312
CLV_PCSK_SKI1_1	29	33	PF00082	0.423
DEG_APCC_DBOX_1	163	171	PF00400	0.512
DEG_APCC_DBOX_1	28	36	PF00400	0.423
DOC_CKS1_1	210	215	PF01111	0.362
DOC_CKS1_1	52	57	PF01111	0.537
DOC_MAPK_DCC_7	164	172	PF00069	0.550
DOC_MAPK_MEF2A_6	102	109	PF00069	0.460
DOC_MAPK_MEF2A_6	164	172	PF00069	0.512
DOC_MAPK_MEF2A_6	93	100	PF00069	0.544
DOC_PP2B_PxIxI_1	54	60	PF00149	0.538
DOC_PP4_FxxP_1	52	55	PF00568	0.453
DOC_WW_Pin1_4	209	214	PF00397	0.362
DOC_WW_Pin1_4	51	56	PF00397	0.450
LIG_Actin_WH2_2	15	31	PF00022	0.550
LIG_APCC_ABBA_1	103	108	PF00400	0.372
LIG_APCC_ABBAyCdc20_2	102	108	PF00400	0.375
LIG_BRCT_BRCA1_1	158	162	PF00533	0.384
LIG_EH1_1	226	234	PF00400	0.423
LIG_eIF4E_1	227	233	PF01652	0.376
LIG_FHA_1	147	153	PF00498	0.405
LIG_FHA_1	224	230	PF00498	0.423
LIG_FHA_1	52	58	PF00498	0.541
LIG_FHA_1	89	95	PF00498	0.456
LIG_LIR_Apic_2	50	55	PF02991	0.437
LIG_LIR_Gen_1	159	170	PF02991	0.442
LIG_LIR_Nem_3	108	114	PF02991	0.519
LIG_LIR_Nem_3	131	135	PF02991	0.315
LIG_LIR_Nem_3	146	151	PF02991	0.266
LIG_LIR_Nem_3	163	169	PF02991	0.464
LIG_LIR_Nem_3	33	39	PF02991	0.380
LIG_LIR_Nem_3	77	81	PF02991	0.513
LIG_MLH1_MIPbox_1	158	162	PF16413	0.423
LIG_NRBOX	38	44	PF00104	0.491
LIG_PDZ_Class_2	232	237	PF00595	0.423
LIG_Pex14_2	132	136	PF04695	0.341
LIG_Pex14_2	162	166	PF04695	0.536
LIG_Pex14_2	217	221	PF04695	0.438
LIG_Rb_LxCxE_1	126	143	PF01857	0.299
LIG_REV1ctd_RIR_1	133	141	PF16727	0.398
LIG_REV1ctd_RIR_1	159	167	PF16727	0.423
LIG_SH2_CRK	111	115	PF00017	0.542
LIG_SH2_STAT3	122	125	PF00017	0.338
LIG_SH2_STAT5	227	230	PF00017	0.423
LIG_SH2_STAT5	36	39	PF00017	0.423
LIG_SH3_3	104	110	PF00018	0.472
LIG_SUMO_SIM_par_1	143	149	PF11976	0.423
LIG_TYR_ITIM	109	114	PF00017	0.684
LIG_TYR_ITIM	34	39	PF00017	0.491
MOD_CDK_SPxxK_3	51	58	PF00069	0.687
MOD_CK1_1	143	149	PF00069	0.370
MOD_CK1_1	223	229	PF00069	0.451
MOD_CK1_1	231	237	PF00069	0.393
MOD_CK1_1	50	56	PF00069	0.676
MOD_GSK3_1	156	163	PF00069	0.402
MOD_GSK3_1	174	181	PF00069	0.166
MOD_GSK3_1	205	212	PF00069	0.502
MOD_GSK3_1	223	230	PF00069	0.306
MOD_GSK3_1	47	54	PF00069	0.535
MOD_N-GLC_1	116	121	PF02516	0.491
MOD_N-GLC_1	88	93	PF02516	0.537
MOD_NEK2_1	156	161	PF00069	0.358
MOD_NEK2_1	174	179	PF00069	0.166
MOD_NEK2_1	180	185	PF00069	0.324
MOD_NEK2_1	228	233	PF00069	0.379
MOD_NEK2_1	98	103	PF00069	0.672
MOD_NEK2_2	24	29	PF00069	0.461
MOD_PIKK_1	116	122	PF00454	0.491
MOD_Plk_1	116	122	PF00069	0.477
MOD_Plk_1	47	53	PF00069	0.635
MOD_Plk_1	62	68	PF00069	0.496
MOD_Plk_1	81	87	PF00069	0.373
MOD_Plk_4	143	149	PF00069	0.386
MOD_Plk_4	223	229	PF00069	0.423
MOD_Plk_4	231	237	PF00069	0.423
MOD_Plk_4	30	36	PF00069	0.339
MOD_Plk_4	47	53	PF00069	0.502
MOD_Plk_4	69	75	PF00069	0.599
MOD_Plk_4	81	87	PF00069	0.550
MOD_ProDKin_1	209	215	PF00069	0.441
MOD_ProDKin_1	51	57	PF00069	0.561
MOD_SUMO_rev_2	5	13	PF00179	0.757
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.423
TRG_ENDOCYTIC_2	111	114	PF00928	0.663
TRG_ENDOCYTIC_2	36	39	PF00928	0.423
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA59	Leptomonas seymouri	63%	100%
A0A1X0P3I9	Trypanosomatidae	35%	100%
A0A3S7XBG4	Leishmania donovani	93%	100%
A4IE61	Leishmania infantum	93%	100%
E9ATJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%