Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0Z9_LEIMA

TriTrypDb:

LmjF.36.4150 , LMJLV39_360052600 , LMJSD75_360052500

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	6
GO:0031514	motile cilium	5	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

Q4Q0Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Z9

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0030030	cell projection organization	4	2
GO:0044782	cilium organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	575	579	PF00656	0.502
CLV_C14_Caspase3-7	77	81	PF00656	0.614
CLV_NRD_NRD_1	172	174	PF00675	0.406
CLV_NRD_NRD_1	249	251	PF00675	0.433
CLV_NRD_NRD_1	292	294	PF00675	0.622
CLV_NRD_NRD_1	438	440	PF00675	0.500
CLV_NRD_NRD_1	474	476	PF00675	0.566
CLV_NRD_NRD_1	571	573	PF00675	0.573
CLV_PCSK_KEX2_1	172	174	PF00082	0.406
CLV_PCSK_KEX2_1	249	251	PF00082	0.441
CLV_PCSK_KEX2_1	292	294	PF00082	0.693
CLV_PCSK_KEX2_1	570	572	PF00082	0.592
CLV_PCSK_PC7_1	168	174	PF00082	0.505
CLV_PCSK_SKI1_1	207	211	PF00082	0.495
CLV_PCSK_SKI1_1	250	254	PF00082	0.492
CLV_PCSK_SKI1_1	261	265	PF00082	0.388
CLV_PCSK_SKI1_1	268	272	PF00082	0.368
CLV_PCSK_SKI1_1	3	7	PF00082	0.768
CLV_PCSK_SKI1_1	417	421	PF00082	0.454
CLV_PCSK_SKI1_1	439	443	PF00082	0.429
DEG_APCC_DBOX_1	248	256	PF00400	0.408
DEG_APCC_DBOX_1	71	79	PF00400	0.443
DEG_SCF_FBW7_2	84	89	PF00400	0.620
DEG_SPOP_SBC_1	370	374	PF00917	0.627
DOC_CYCLIN_RxL_1	207	218	PF00134	0.582
DOC_MAPK_gen_1	427	436	PF00069	0.400
DOC_MAPK_MEF2A_6	430	438	PF00069	0.399
DOC_MAPK_RevD_3	158	173	PF00069	0.510
DOC_USP7_MATH_1	108	112	PF00917	0.666
DOC_USP7_MATH_1	215	219	PF00917	0.534
DOC_USP7_MATH_1	319	323	PF00917	0.710
DOC_USP7_MATH_1	357	361	PF00917	0.620
DOC_USP7_MATH_1	370	374	PF00917	0.446
DOC_USP7_MATH_1	505	509	PF00917	0.513
DOC_USP7_MATH_1	531	535	PF00917	0.487
DOC_USP7_MATH_1	582	586	PF00917	0.582
DOC_USP7_MATH_1	62	66	PF00917	0.559
DOC_USP7_UBL2_3	524	528	PF12436	0.552
DOC_USP7_UBL2_3	605	609	PF12436	0.571
DOC_WW_Pin1_4	10	15	PF00397	0.577
DOC_WW_Pin1_4	117	122	PF00397	0.515
DOC_WW_Pin1_4	82	87	PF00397	0.667
LIG_14-3-3_CanoR_1	226	236	PF00244	0.541
LIG_14-3-3_CanoR_1	292	300	PF00244	0.658
LIG_14-3-3_CanoR_1	342	346	PF00244	0.658
LIG_14-3-3_CanoR_1	368	378	PF00244	0.602
LIG_14-3-3_CanoR_1	430	435	PF00244	0.415
LIG_14-3-3_CanoR_1	61	67	PF00244	0.439
LIG_14-3-3_CanoR_1	7	14	PF00244	0.507
LIG_14-3-3_CanoR_1	99	107	PF00244	0.665
LIG_Actin_WH2_2	207	224	PF00022	0.474
LIG_BIR_III_4	530	534	PF00653	0.486
LIG_BIR_III_4	80	84	PF00653	0.638
LIG_FHA_1	182	188	PF00498	0.650
LIG_FHA_1	222	228	PF00498	0.525
LIG_FHA_1	251	257	PF00498	0.483
LIG_FHA_1	271	277	PF00498	0.390
LIG_FHA_1	34	40	PF00498	0.651
LIG_FHA_1	431	437	PF00498	0.583
LIG_FHA_1	458	464	PF00498	0.555
LIG_FHA_1	489	495	PF00498	0.495
LIG_FHA_2	26	32	PF00498	0.651
LIG_FHA_2	335	341	PF00498	0.473
LIG_FHA_2	488	494	PF00498	0.469
LIG_FHA_2	50	56	PF00498	0.577
LIG_FHA_2	515	521	PF00498	0.522
LIG_FHA_2	541	547	PF00498	0.460
LIG_Integrin_isoDGR_2	247	249	PF01839	0.434
LIG_LIR_Gen_1	303	311	PF02991	0.506
LIG_LIR_Gen_1	372	383	PF02991	0.436
LIG_LIR_Gen_1	55	64	PF02991	0.632
LIG_LIR_Nem_3	171	177	PF02991	0.375
LIG_LIR_Nem_3	240	245	PF02991	0.453
LIG_LIR_Nem_3	372	378	PF02991	0.459
LIG_LIR_Nem_3	493	498	PF02991	0.522
LIG_LIR_Nem_3	55	59	PF02991	0.649
LIG_MYND_1	192	196	PF01753	0.515
LIG_NRBOX	251	257	PF00104	0.412
LIG_NRBOX	74	80	PF00104	0.455
LIG_Pex14_2	346	350	PF04695	0.594
LIG_SH2_NCK_1	581	585	PF00017	0.453
LIG_SH2_STAT5	498	501	PF00017	0.480
LIG_SH3_3	118	124	PF00018	0.553
LIG_SH3_3	186	192	PF00018	0.528
LIG_SH3_3	199	205	PF00018	0.489
LIG_SH3_3	364	370	PF00018	0.577
LIG_SUMO_SIM_anti_2	159	166	PF11976	0.498
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.537
LIG_SUMO_SIM_anti_2	71	77	PF11976	0.453
LIG_SUMO_SIM_par_1	144	149	PF11976	0.577
LIG_SUMO_SIM_par_1	74	80	PF11976	0.532
LIG_TRAF2_1	551	554	PF00917	0.609
MOD_CDK_SPK_2	117	122	PF00069	0.529
MOD_CDK_SPxK_1	82	88	PF00069	0.484
MOD_CK1_1	10	16	PF00069	0.651
MOD_CK1_1	111	117	PF00069	0.674
MOD_CK1_1	135	141	PF00069	0.486
MOD_CK1_1	324	330	PF00069	0.631
MOD_CK1_1	336	342	PF00069	0.624
MOD_CK1_1	429	435	PF00069	0.319
MOD_CK1_1	49	55	PF00069	0.616
MOD_CK2_1	156	162	PF00069	0.478
MOD_CK2_1	18	24	PF00069	0.763
MOD_CK2_1	334	340	PF00069	0.625
MOD_CK2_1	487	493	PF00069	0.420
MOD_CK2_1	514	520	PF00069	0.511
MOD_CK2_1	540	546	PF00069	0.459
MOD_CK2_1	582	588	PF00069	0.520
MOD_Cter_Amidation	247	250	PF01082	0.419
MOD_GlcNHglycan	102	105	PF01048	0.694
MOD_GlcNHglycan	20	23	PF01048	0.702
MOD_GlcNHglycan	3	6	PF01048	0.767
MOD_GlcNHglycan	316	319	PF01048	0.606
MOD_GlcNHglycan	495	498	PF01048	0.520
MOD_GSK3_1	291	298	PF00069	0.714
MOD_GSK3_1	3	10	PF00069	0.620
MOD_GSK3_1	321	328	PF00069	0.649
MOD_GSK3_1	334	341	PF00069	0.541
MOD_GSK3_1	426	433	PF00069	0.324
MOD_GSK3_1	483	490	PF00069	0.464
MOD_GSK3_1	95	102	PF00069	0.647
MOD_N-GLC_1	311	316	PF02516	0.630
MOD_N-GLC_1	95	100	PF02516	0.730
MOD_NEK2_1	1	6	PF00069	0.704
MOD_NEK2_1	146	151	PF00069	0.551
MOD_NEK2_1	221	226	PF00069	0.455
MOD_NEK2_1	227	232	PF00069	0.530
MOD_NEK2_1	291	296	PF00069	0.693
MOD_NEK2_1	311	316	PF00069	0.518
MOD_NEK2_1	32	37	PF00069	0.533
MOD_NEK2_1	350	355	PF00069	0.498
MOD_NEK2_1	371	376	PF00069	0.580
MOD_NEK2_1	603	608	PF00069	0.586
MOD_PIKK_1	146	152	PF00454	0.527
MOD_PIKK_1	176	182	PF00454	0.540
MOD_PIKK_1	227	233	PF00454	0.570
MOD_PIKK_1	270	276	PF00454	0.545
MOD_PIKK_1	385	391	PF00454	0.474
MOD_PIKK_1	49	55	PF00454	0.596
MOD_PKA_1	292	298	PF00069	0.690
MOD_PKA_2	221	227	PF00069	0.472
MOD_PKA_2	291	297	PF00069	0.662
MOD_PKA_2	324	330	PF00069	0.641
MOD_PKA_2	341	347	PF00069	0.548
MOD_PKA_2	357	363	PF00069	0.636
MOD_PKA_2	426	432	PF00069	0.407
MOD_PKA_2	540	546	PF00069	0.531
MOD_PKA_2	558	564	PF00069	0.386
MOD_PKA_2	596	602	PF00069	0.615
MOD_PKA_2	6	12	PF00069	0.634
MOD_Plk_1	132	138	PF00069	0.600
MOD_Plk_1	250	256	PF00069	0.460
MOD_Plk_1	261	267	PF00069	0.461
MOD_Plk_2-3	514	520	PF00069	0.485
MOD_Plk_2-3	74	80	PF00069	0.499
MOD_Plk_4	111	117	PF00069	0.719
MOD_Plk_4	156	162	PF00069	0.554
MOD_Plk_4	181	187	PF00069	0.671
MOD_Plk_4	341	347	PF00069	0.599
MOD_Plk_4	582	588	PF00069	0.500
MOD_Plk_4	74	80	PF00069	0.508
MOD_ProDKin_1	10	16	PF00069	0.578
MOD_ProDKin_1	117	123	PF00069	0.511
MOD_ProDKin_1	82	88	PF00069	0.675
MOD_SUMO_for_1	434	437	PF00179	0.460
MOD_SUMO_rev_2	508	518	PF00179	0.427
MOD_SUMO_rev_2	548	557	PF00179	0.427
TRG_DiLeu_BaEn_1	251	256	PF01217	0.411
TRG_DiLeu_BaEn_1	71	76	PF01217	0.432
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.506
TRG_ENDOCYTIC_2	174	177	PF00928	0.367
TRG_ENDOCYTIC_2	375	378	PF00928	0.520
TRG_ER_diArg_1	172	174	PF00400	0.435
TRG_ER_diArg_1	291	293	PF00400	0.670
TRG_ER_diArg_1	570	572	PF00400	0.572
TRG_ER_diLys_1	610	615	PF00400	0.657
TRG_NES_CRM1_1	426	437	PF08389	0.482
TRG_NLS_MonoCore_2	607	612	PF00514	0.589
TRG_NLS_MonoExtC_3	607	612	PF00514	0.603
TRG_NLS_MonoExtN_4	605	612	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	226	231	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM9	Leptomonas seymouri	58%	92%
A0A1X0P338	Trypanosomatidae	36%	100%
A0A3R7NMF4	Trypanosoma rangeli	37%	100%
A0A3S7XBE2	Leishmania donovani	94%	100%
A4HPT4	Leishmania braziliensis	78%	93%
A4IE58	Leishmania infantum	94%	100%
D0A8P9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ATJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BS07	Trypanosoma cruzi	38%	100%