Putative oxidoreductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase, putative

Species:

Leishmania major

UniProt:

Q4Q0Z7_LEIMA

TriTrypDb:

LmjF.36.4170 , LMJLV39_360052800 , LMJSD75_360052700

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Z7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0003960	NADPH:quinone reductase activity	5	6
GO:0005488	binding	1	8
GO:0008270	zinc ion binding	6	8
GO:0016491	oxidoreductase activity	2	8
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	6
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	6
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.466
CLV_C14_Caspase3-7	201	205	PF00656	0.511
CLV_C14_Caspase3-7	226	230	PF00656	0.434
CLV_C14_Caspase3-7	318	322	PF00656	0.414
CLV_PCSK_SKI1_1	297	301	PF00082	0.352
CLV_PCSK_SKI1_1	310	314	PF00082	0.465
DOC_CYCLIN_yClb5_NLxxxL_5	199	207	PF00134	0.278
DOC_CYCLIN_yCln2_LP_2	106	112	PF00134	0.443
DOC_MAPK_gen_1	144	150	PF00069	0.442
DOC_MAPK_gen_1	297	306	PF00069	0.339
DOC_MAPK_gen_1	8	15	PF00069	0.504
DOC_MAPK_MEF2A_6	120	128	PF00069	0.465
DOC_MAPK_MEF2A_6	300	308	PF00069	0.569
DOC_MIT_MIM_1	201	210	PF04212	0.439
DOC_PP2B_LxvP_1	106	109	PF13499	0.471
DOC_PP4_FxxP_1	257	260	PF00568	0.420
DOC_PP4_FxxP_1	279	282	PF00568	0.386
LIG_14-3-3_CanoR_1	20	26	PF00244	0.527
LIG_14-3-3_CanoR_1	40	44	PF00244	0.181
LIG_Actin_WH2_2	285	302	PF00022	0.498
LIG_APCC_ABBA_1	304	309	PF00400	0.474
LIG_BIR_II_1	1	5	PF00653	0.532
LIG_BRCT_BRCA1_1	15	19	PF00533	0.464
LIG_FHA_1	130	136	PF00498	0.366
LIG_FHA_1	156	162	PF00498	0.439
LIG_FHA_1	198	204	PF00498	0.407
LIG_FHA_1	21	27	PF00498	0.514
LIG_FHA_1	264	270	PF00498	0.443
LIG_FHA_2	224	230	PF00498	0.420
LIG_HCF-1_HBM_1	324	327	PF13415	0.486
LIG_HP1_1	93	97	PF01393	0.395
LIG_LIR_Gen_1	122	131	PF02991	0.458
LIG_LIR_Gen_1	216	227	PF02991	0.439
LIG_LIR_Nem_3	122	126	PF02991	0.464
LIG_LIR_Nem_3	216	222	PF02991	0.439
LIG_LIR_Nem_3	330	335	PF02991	0.427
LIG_LIR_Nem_3	42	48	PF02991	0.502
LIG_LIR_Nem_3	5	10	PF02991	0.514
LIG_MYND_1	117	121	PF01753	0.515
LIG_NRBOX	264	270	PF00104	0.356
LIG_PCNA_PIPBox_1	292	301	PF02747	0.494
LIG_Pex14_2	280	284	PF04695	0.386
LIG_Pex14_2	68	72	PF04695	0.439
LIG_PTB_Apo_2	54	61	PF02174	0.439
LIG_PTB_Phospho_1	54	60	PF10480	0.439
LIG_SH2_CRK	332	336	PF00017	0.428
LIG_SH2_CRK	45	49	PF00017	0.439
LIG_SH2_NCK_1	219	223	PF00017	0.386
LIG_SH2_PTP2	123	126	PF00017	0.443
LIG_SH2_STAT5	123	126	PF00017	0.443
LIG_SH2_STAT5	298	301	PF00017	0.535
LIG_SH2_STAT5	60	63	PF00017	0.439
LIG_SH3_3	206	212	PF00018	0.477
LIG_SUMO_SIM_anti_2	147	152	PF11976	0.416
LIG_SUMO_SIM_anti_2	92	98	PF11976	0.430
LIG_SUMO_SIM_par_1	11	16	PF11976	0.509
LIG_SUMO_SIM_par_1	239	245	PF11976	0.420
LIG_TRAF2_1	179	182	PF00917	0.511
LIG_TYR_ITIM	217	222	PF00017	0.439
LIG_TYR_ITIM	43	48	PF00017	0.439
LIG_TYR_ITSM	328	335	PF00017	0.437
LIG_UBA3_1	267	272	PF00899	0.424
LIG_UBA3_1	295	300	PF00899	0.497
MOD_CK1_1	129	135	PF00069	0.400
MOD_CK1_1	2	8	PF00069	0.507
MOD_CK1_1	245	251	PF00069	0.470
MOD_CK1_1	258	264	PF00069	0.375
MOD_CK1_1	328	334	PF00069	0.481
MOD_CK2_1	176	182	PF00069	0.511
MOD_CK2_1	21	27	PF00069	0.536
MOD_GlcNHglycan	128	131	PF01048	0.456
MOD_GlcNHglycan	250	253	PF01048	0.388
MOD_GlcNHglycan	260	263	PF01048	0.345
MOD_GlcNHglycan	272	275	PF01048	0.315
MOD_GlcNHglycan	327	330	PF01048	0.458
MOD_GSK3_1	170	177	PF00069	0.386
MOD_GSK3_1	244	251	PF00069	0.433
MOD_N-GLC_1	20	25	PF02516	0.427
MOD_N-GLC_1	48	53	PF02516	0.386
MOD_N-GLC_1	56	61	PF02516	0.386
MOD_NEK2_1	186	191	PF00069	0.434
MOD_NEK2_1	19	24	PF00069	0.483
MOD_NEK2_1	270	275	PF00069	0.383
MOD_NEK2_1	53	58	PF00069	0.422
MOD_OFUCOSY	172	178	PF10250	0.386
MOD_PKA_2	19	25	PF00069	0.479
MOD_PKA_2	39	45	PF00069	0.181
MOD_Plk_1	20	26	PF00069	0.427
MOD_Plk_4	170	176	PF00069	0.386
MOD_Plk_4	21	27	PF00069	0.605
MOD_Plk_4	263	269	PF00069	0.442
MOD_Plk_4	291	297	PF00069	0.512
MOD_Plk_4	56	62	PF00069	0.439
MOD_Plk_4	74	80	PF00069	0.261
MOD_SUMO_for_1	119	122	PF00179	0.502
MOD_SUMO_rev_2	179	184	PF00179	0.439
TRG_DiLeu_BaEn_3	181	187	PF01217	0.511
TRG_ENDOCYTIC_2	123	126	PF00928	0.445
TRG_ENDOCYTIC_2	219	222	PF00928	0.386
TRG_ENDOCYTIC_2	332	335	PF00928	0.429
TRG_ENDOCYTIC_2	45	48	PF00928	0.439
TRG_ENDOCYTIC_2	99	102	PF00928	0.389
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I0	Leptomonas seymouri	75%	100%
A0A0N0P6Q4	Leptomonas seymouri	25%	100%
A0A0N0P7C5	Leptomonas seymouri	43%	100%
A0A0N1I4X2	Leptomonas seymouri	25%	73%
A0A0N1I913	Leptomonas seymouri	43%	98%
A0A0S4ILA6	Bodo saltans	28%	100%
A0A0S4ILS9	Bodo saltans	23%	100%
A0A0S4IT20	Bodo saltans	28%	99%
A0A0S4IUY2	Bodo saltans	30%	100%
A0A0S4JMB1	Bodo saltans	46%	97%
A0A0S4KHW9	Bodo saltans	29%	100%
A0A1X0NZZ5	Trypanosomatidae	28%	100%
A0A1X0P0B2	Trypanosomatidae	43%	100%
A0A1X0P8R2	Trypanosomatidae	29%	100%
A0A3Q8IRG0	Leishmania donovani	94%	100%
A0A3R7L374	Trypanosoma rangeli	29%	100%
A0A3S7WR50	Leishmania donovani	26%	92%
A0A3S7WSH2	Leishmania donovani	43%	99%
A0A422NF38	Trypanosoma rangeli	30%	100%
A0A422NKE0	Trypanosoma rangeli	41%	100%
A0A451EJQ8	Leishmania donovani	31%	100%
A4H3L9	Leishmania braziliensis	30%	100%
A4H761	Leishmania braziliensis	44%	99%
A4HPT6	Leishmania braziliensis	85%	100%
A4HUG8	Leishmania infantum	26%	92%
A4HVK0	Leishmania infantum	43%	99%
A4I8R5	Leishmania infantum	24%	97%
A4IE56	Leishmania infantum	93%	100%
A4YGN2	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	25%	100%
A6QQF5	Bos taurus	31%	97%
A7RK30	Nematostella vectensis	31%	93%
B0BNC9	Rattus norvegicus	30%	97%
D0A480	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACK2	Leishmania major	31%	100%
E9AG46	Leishmania infantum	31%	100%
E9AJU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AN67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	71%
E9AP96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	99%
E9ATK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
K4BW79	Solanum lycopersicum	29%	88%
O07615	Bacillus subtilis (strain 168)	27%	100%
O13309	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	24%	98%
O23939	Fragaria vesca	29%	100%
O35017	Bacillus subtilis (strain 168)	26%	100%
O35045	Bacillus subtilis (strain 168)	28%	100%
O45903	Caenorhabditis elegans	26%	99%
O74489	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O94038	Candida albicans (strain SC5314 / ATCC MYA-2876)	25%	98%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	98%
P07246	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	91%
P19333	Tetronarce californica	25%	90%
P20369	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	97%
P28304	Escherichia coli (strain K12)	28%	100%
P38230	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P40783	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	28%	100%
P42865	Leishmania amazonensis	91%	100%
P43903	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	30%	100%
P49384	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	91%
P63475	Staphylococcus aureus (strain Mu50 / ATCC 700699)	27%	100%
P99173	Staphylococcus aureus (strain N315)	27%	100%
Q07288	Kluyveromyces marxianus	24%	98%
Q24K16	Bos taurus	44%	90%
Q28452	Lama guanicoe	29%	100%
Q28GQ2	Xenopus tropicalis	29%	97%
Q32L99	Bos taurus	25%	97%
Q3MIE4	Rattus norvegicus	30%	84%
Q3UNZ8	Mus musculus	30%	97%
Q4J781	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	26%	99%
Q4QG82	Leishmania major	44%	87%
Q4QHF8	Leishmania major	27%	71%
Q4QHF9	Leishmania major	26%	92%
Q54YT4	Dictyostelium discoideum	24%	97%
Q5BK81	Rattus norvegicus	25%	97%
Q5HE19	Staphylococcus aureus (strain COL)	27%	100%
Q5R806	Pongo abelii	24%	97%
Q62465	Mus musculus	30%	84%
Q6G7C8	Staphylococcus aureus (strain MSSA476)	27%	100%
Q6GEP3	Staphylococcus aureus (strain MRSA252)	27%	100%
Q6GQN8	Danio rerio	27%	90%
Q7YS70	Bos taurus	28%	91%
Q80TB8	Mus musculus	24%	82%
Q84V25	Fragaria ananassa	29%	100%
Q8BGC4	Mus musculus	43%	90%
Q8H0M1	Spinacia oleracea	26%	100%
Q8JFV8	Danio rerio	28%	70%
Q8LCU7	Arabidopsis thaliana	27%	91%
Q8N4Q0	Homo sapiens	42%	90%
Q8N8N7	Homo sapiens	23%	97%
Q8NVD1	Staphylococcus aureus (strain MW2)	27%	100%
Q941I0	Fragaria ananassa	28%	100%
Q96XE0	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	26%	98%
Q975C8	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	28%	100%
Q99536	Homo sapiens	30%	87%
Q9AYU1	Triphysaria versicolor	29%	100%
Q9BV79	Homo sapiens	27%	91%
Q9DCS3	Mus musculus	25%	91%
Q9EQZ5	Cavia porcellus	31%	100%
Q9HCJ6	Homo sapiens	24%	81%
Q9P4C2	Kluyveromyces marxianus	24%	98%
Q9P6C8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	96%
Q9SV68	Arabidopsis thaliana	30%	100%
Q9Z311	Rattus norvegicus	26%	91%
Q9ZUC1	Arabidopsis thaliana	29%	88%
S0EJ18	Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)	24%	98%
V5BXF0	Trypanosoma cruzi	29%	100%