UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative

Species:

Leishmania major

UniProt:

Q4Q0Z6_LEIMA

TriTrypDb:

LmjF.36.4180 , LMJLV39_360052900 , LMJSD75_360052800

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q0Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Z6

Function

Biological processes
Term	Name	Level	Count
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	12
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	12
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003975	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.425
CLV_C14_Caspase3-7	301	305	PF00656	0.314
CLV_MEL_PAP_1	181	187	PF00089	0.523
CLV_NRD_NRD_1	73	75	PF00675	0.379
CLV_PCSK_KEX2_1	72	74	PF00082	0.395
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.379
CLV_PCSK_SKI1_1	155	159	PF00082	0.238
CLV_PCSK_SKI1_1	294	298	PF00082	0.459
CLV_PCSK_SKI1_1	320	324	PF00082	0.384
CLV_PCSK_SKI1_1	370	374	PF00082	0.507
CLV_PCSK_SKI1_1	454	458	PF00082	0.312
CLV_PCSK_SKI1_1	46	50	PF00082	0.362
CLV_PCSK_SKI1_1	51	55	PF00082	0.353
DEG_APCC_DBOX_1	183	191	PF00400	0.351
DOC_CDC14_PxL_1	384	392	PF14671	0.384
DOC_CKS1_1	295	300	PF01111	0.268
DOC_CYCLIN_RxL_1	43	50	PF00134	0.555
DOC_MAPK_gen_1	151	158	PF00069	0.446
DOC_MAPK_gen_1	318	325	PF00069	0.212
DOC_MAPK_gen_1	337	347	PF00069	0.524
DOC_PP1_RVXF_1	432	438	PF00149	0.562
DOC_PP2B_PxIxI_1	326	332	PF00149	0.335
DOC_PP4_FxxP_1	185	188	PF00568	0.323
DOC_PP4_FxxP_1	375	378	PF00568	0.314
DOC_USP7_MATH_1	124	128	PF00917	0.327
DOC_USP7_MATH_1	279	283	PF00917	0.384
DOC_USP7_MATH_1	299	303	PF00917	0.115
DOC_USP7_MATH_1	360	364	PF00917	0.419
DOC_USP7_UBL2_3	151	155	PF12436	0.532
DOC_USP7_UBL2_3	68	72	PF12436	0.599
DOC_USP7_UBL2_3	81	85	PF12436	0.624
DOC_WW_Pin1_4	294	299	PF00397	0.268
LIG_14-3-3_CanoR_1	212	216	PF00244	0.351
LIG_14-3-3_CanoR_1	454	462	PF00244	0.575
LIG_14-3-3_CanoR_1	74	83	PF00244	0.633
LIG_APCC_ABBA_1	424	429	PF00400	0.582
LIG_BRCT_BRCA1_1	216	220	PF00533	0.335
LIG_CaM_NSCaTE_8	196	203	PF13499	0.240
LIG_CtBP_PxDLS_1	89	93	PF00389	0.476
LIG_eIF4E_1	368	374	PF01652	0.339
LIG_FHA_1	106	112	PF00498	0.414
LIG_FHA_1	132	138	PF00498	0.302
LIG_FHA_1	142	148	PF00498	0.309
LIG_FHA_1	187	193	PF00498	0.331
LIG_FHA_1	208	214	PF00498	0.328
LIG_FHA_1	235	241	PF00498	0.252
LIG_FHA_1	256	262	PF00498	0.313
LIG_FHA_1	295	301	PF00498	0.322
LIG_FHA_1	369	375	PF00498	0.244
LIG_FHA_1	406	412	PF00498	0.595
LIG_FHA_1	434	440	PF00498	0.457
LIG_FHA_2	114	120	PF00498	0.294
LIG_FHA_2	45	51	PF00498	0.565
LIG_GBD_Chelix_1	103	111	PF00786	0.445
LIG_GBD_Chelix_1	422	430	PF00786	0.309
LIG_IBAR_NPY_1	123	125	PF08397	0.367
LIG_LIR_Gen_1	122	133	PF02991	0.334
LIG_LIR_Gen_1	217	224	PF02991	0.268
LIG_LIR_Gen_1	228	234	PF02991	0.309
LIG_LIR_Gen_1	282	292	PF02991	0.366
LIG_LIR_Gen_1	349	359	PF02991	0.298
LIG_LIR_Gen_1	414	425	PF02991	0.482
LIG_LIR_Gen_1	436	445	PF02991	0.402
LIG_LIR_Nem_3	122	128	PF02991	0.403
LIG_LIR_Nem_3	217	223	PF02991	0.343
LIG_LIR_Nem_3	228	232	PF02991	0.299
LIG_LIR_Nem_3	282	288	PF02991	0.366
LIG_LIR_Nem_3	349	354	PF02991	0.298
LIG_LIR_Nem_3	414	420	PF02991	0.483
LIG_LIR_Nem_3	436	440	PF02991	0.419
LIG_LIR_Nem_3	459	465	PF02991	0.353
LIG_NRBOX	136	142	PF00104	0.329
LIG_NRBOX	318	324	PF00104	0.419
LIG_SH2_CRK	125	129	PF00017	0.328
LIG_SH2_CRK	417	421	PF00017	0.475
LIG_SH2_PTP2	229	232	PF00017	0.338
LIG_SH2_SRC	462	465	PF00017	0.418
LIG_SH2_STAP1	351	355	PF00017	0.298
LIG_SH2_STAP1	368	372	PF00017	0.273
LIG_SH2_STAT5	100	103	PF00017	0.298
LIG_SH2_STAT5	222	225	PF00017	0.318
LIG_SH2_STAT5	229	232	PF00017	0.274
LIG_SH2_STAT5	241	244	PF00017	0.236
LIG_SH2_STAT5	246	249	PF00017	0.188
LIG_SH2_STAT5	34	37	PF00017	0.303
LIG_SH2_STAT5	351	354	PF00017	0.291
LIG_SH2_STAT5	40	43	PF00017	0.485
LIG_SH2_STAT5	417	420	PF00017	0.477
LIG_SH2_STAT5	425	428	PF00017	0.517
LIG_SH2_STAT5	455	458	PF00017	0.301
LIG_SH3_3	15	21	PF00018	0.346
LIG_SH3_3	173	179	PF00018	0.303
LIG_SH3_3	210	216	PF00018	0.328
LIG_SH3_3	391	397	PF00018	0.421
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.349
LIG_SUMO_SIM_anti_2	134	139	PF11976	0.302
LIG_SUMO_SIM_anti_2	173	178	PF11976	0.384
LIG_SUMO_SIM_par_1	102	108	PF11976	0.366
LIG_SUMO_SIM_par_1	24	30	PF11976	0.419
LIG_SUMO_SIM_par_1	275	282	PF11976	0.357
LIG_SUMO_SIM_par_1	357	363	PF11976	0.384
LIG_UBA3_1	426	434	PF00899	0.538
LIG_UBA3_1	53	60	PF00899	0.595
LIG_WRC_WIRS_1	457	462	PF05994	0.533
MOD_CK1_1	225	231	PF00069	0.184
MOD_CK1_1	362	368	PF00069	0.384
MOD_CK2_1	113	119	PF00069	0.361
MOD_CK2_1	44	50	PF00069	0.545
MOD_GlcNHglycan	234	237	PF01048	0.535
MOD_GSK3_1	156	163	PF00069	0.314
MOD_GSK3_1	166	173	PF00069	0.314
MOD_GSK3_1	186	193	PF00069	0.323
MOD_GSK3_1	207	214	PF00069	0.330
MOD_GSK3_1	218	225	PF00069	0.337
MOD_GSK3_1	230	237	PF00069	0.309
MOD_GSK3_1	294	301	PF00069	0.310
MOD_GSK3_1	362	369	PF00069	0.333
MOD_GSK3_1	405	412	PF00069	0.519
MOD_N-GLC_1	190	195	PF02516	0.528
MOD_N-GLC_1	415	420	PF02516	0.274
MOD_NEK2_1	105	110	PF00069	0.396
MOD_NEK2_1	113	118	PF00069	0.502
MOD_NEK2_1	133	138	PF00069	0.389
MOD_NEK2_1	190	195	PF00069	0.322
MOD_NEK2_1	211	216	PF00069	0.332
MOD_NEK2_1	27	32	PF00069	0.397
MOD_NEK2_1	354	359	PF00069	0.298
MOD_NEK2_1	383	388	PF00069	0.298
MOD_NEK2_1	411	416	PF00069	0.480
MOD_NEK2_1	5	10	PF00069	0.432
MOD_NEK2_2	207	212	PF00069	0.296
MOD_NEK2_2	34	39	PF00069	0.344
MOD_PKA_2	211	217	PF00069	0.351
MOD_PKB_1	398	406	PF00069	0.568
MOD_Plk_1	415	421	PF00069	0.483
MOD_Plk_4	172	178	PF00069	0.392
MOD_Plk_4	192	198	PF00069	0.184
MOD_Plk_4	215	221	PF00069	0.351
MOD_Plk_4	234	240	PF00069	0.218
MOD_Plk_4	248	254	PF00069	0.378
MOD_Plk_4	27	33	PF00069	0.361
MOD_Plk_4	272	278	PF00069	0.314
MOD_Plk_4	279	285	PF00069	0.314
MOD_Plk_4	349	355	PF00069	0.311
MOD_Plk_4	368	374	PF00069	0.278
MOD_Plk_4	415	421	PF00069	0.472
MOD_Plk_4	456	462	PF00069	0.434
MOD_Plk_4	99	105	PF00069	0.411
MOD_ProDKin_1	294	300	PF00069	0.268
MOD_SUMO_rev_2	429	436	PF00179	0.579
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.358
TRG_ENDOCYTIC_2	100	103	PF00928	0.333
TRG_ENDOCYTIC_2	125	128	PF00928	0.332
TRG_ENDOCYTIC_2	229	232	PF00928	0.327
TRG_ENDOCYTIC_2	249	252	PF00928	0.115
TRG_ENDOCYTIC_2	285	288	PF00928	0.310
TRG_ENDOCYTIC_2	351	354	PF00928	0.298
TRG_ENDOCYTIC_2	417	420	PF00928	0.477
TRG_ENDOCYTIC_2	462	465	PF00928	0.386
TRG_ER_diArg_1	397	400	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUV1	Leptomonas seymouri	72%	100%
A0A0S4IKK6	Bodo saltans	48%	100%
A0A1X0P351	Trypanosomatidae	47%	100%
A0A3Q8IJH0	Leishmania donovani	96%	100%
A0A3R7MVB5	Trypanosoma rangeli	49%	100%
A4HPT7	Leishmania braziliensis	84%	100%
A4IE55	Leishmania infantum	96%	100%
D0A8Q1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ATK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P07286	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P0CD61	Dictyostelium discoideum	36%	100%
P23338	Cricetulus longicaudatus	33%	100%
P24140	Cricetulus griseus	33%	100%
P42864	Leishmania amazonensis	92%	100%
P42867	Mus musculus	33%	100%
P42881	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q5EA65	Bos taurus	33%	100%
Q9H3H5	Homo sapiens	34%	100%
V5B6U2	Trypanosoma cruzi	49%	100%