Sld5 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GINS complex protein, putative

Species:

Leishmania major

UniProt:

Q4Q0Z5_LEIMA

TriTrypDb:

LmjF.36.4190 , LMJLV39_360053000 , LMJSD75_360052900

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000811	GINS complex	4	2
GO:0031261	DNA replication preinitiation complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0032993	protein-DNA complex	2	2
GO:0140513	nuclear protein-containing complex	2	2
GO:0000228	nuclear chromosome	6	8
GO:0005694	chromosome	5	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q0Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Z5

Function

Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0000727	double-strand break repair via break-induced replication	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006260	DNA replication	5	10
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.717
CLV_NRD_NRD_1	337	339	PF00675	0.610
CLV_PCSK_KEX2_1	336	338	PF00082	0.624
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.609
CLV_PCSK_SKI1_1	131	135	PF00082	0.344
DEG_APCC_DBOX_1	223	231	PF00400	0.628
DEG_SPOP_SBC_1	257	261	PF00917	0.788
DOC_MAPK_gen_1	170	180	PF00069	0.464
DOC_MAPK_gen_1	222	230	PF00069	0.611
DOC_MAPK_RevD_3	324	338	PF00069	0.698
DOC_USP7_MATH_1	24	28	PF00917	0.617
DOC_USP7_MATH_1	302	306	PF00917	0.665
DOC_USP7_MATH_1	311	315	PF00917	0.787
DOC_WW_Pin1_4	183	188	PF00397	0.464
DOC_WW_Pin1_4	234	239	PF00397	0.576
DOC_WW_Pin1_4	265	270	PF00397	0.770
DOC_WW_Pin1_4	324	329	PF00397	0.627
LIG_14-3-3_CanoR_1	207	211	PF00244	0.410
LIG_14-3-3_CanoR_1	240	246	PF00244	0.712
LIG_14-3-3_CanoR_1	247	251	PF00244	0.725
LIG_14-3-3_CanoR_1	258	264	PF00244	0.731
LIG_14-3-3_CanoR_1	337	341	PF00244	0.603
LIG_14-3-3_CanoR_1	87	97	PF00244	0.471
LIG_14-3-3_CterR_2	341	343	PF00244	0.621
LIG_Actin_WH2_2	191	209	PF00022	0.464
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BRCT_BRCA1_1	120	124	PF00533	0.544
LIG_BRCT_BRCA1_1	185	189	PF00533	0.507
LIG_BRCT_BRCA1_1	283	287	PF00533	0.646
LIG_deltaCOP1_diTrp_1	30	34	PF00928	0.595
LIG_FHA_1	194	200	PF00498	0.482
LIG_FHA_1	258	264	PF00498	0.757
LIG_FHA_1	316	322	PF00498	0.611
LIG_FHA_1	89	95	PF00498	0.464
LIG_FHA_2	177	183	PF00498	0.538
LIG_LIR_Gen_1	116	127	PF02991	0.378
LIG_LIR_Gen_1	40	49	PF02991	0.366
LIG_LIR_Gen_1	98	105	PF02991	0.531
LIG_LIR_Nem_3	116	122	PF02991	0.378
LIG_LIR_Nem_3	209	213	PF02991	0.418
LIG_LIR_Nem_3	31	37	PF02991	0.440
LIG_LIR_Nem_3	98	102	PF02991	0.531
LIG_PCNA_yPIPBox_3	170	178	PF02747	0.550
LIG_Pex14_1	81	85	PF04695	0.544
LIG_Rb_LxCxE_1	196	209	PF01857	0.591
LIG_SH2_SRC	127	130	PF00017	0.495
LIG_SH2_STAT3	85	88	PF00017	0.544
LIG_SH2_STAT5	104	107	PF00017	0.368
LIG_SH2_STAT5	125	128	PF00017	0.464
LIG_SH2_STAT5	85	88	PF00017	0.527
LIG_SH2_STAT5	99	102	PF00017	0.417
LIG_SH3_1	66	72	PF00018	0.312
LIG_SH3_3	66	72	PF00018	0.383
LIG_WRC_WIRS_1	39	44	PF05994	0.333
LIG_WW_1	96	99	PF00397	0.507
MOD_CDK_SPxK_1	234	240	PF00069	0.581
MOD_CK1_1	2	8	PF00069	0.663
MOD_CK1_1	234	240	PF00069	0.659
MOD_CK1_1	252	258	PF00069	0.658
MOD_CK1_1	265	271	PF00069	0.658
MOD_CK1_1	295	301	PF00069	0.688
MOD_CK1_1	305	311	PF00069	0.651
MOD_CK2_1	176	182	PF00069	0.474
MOD_CK2_1	311	317	PF00069	0.627
MOD_GlcNHglycan	141	144	PF01048	0.277
MOD_GlcNHglycan	233	236	PF01048	0.709
MOD_GlcNHglycan	251	254	PF01048	0.623
MOD_GlcNHglycan	297	300	PF01048	0.669
MOD_GSK3_1	176	183	PF00069	0.432
MOD_GSK3_1	241	248	PF00069	0.627
MOD_GSK3_1	249	256	PF00069	0.582
MOD_GSK3_1	257	264	PF00069	0.526
MOD_GSK3_1	273	280	PF00069	0.562
MOD_GSK3_1	298	305	PF00069	0.635
MOD_GSK3_1	311	318	PF00069	0.606
MOD_GSK3_1	336	343	PF00069	0.653
MOD_N-GLC_2	90	92	PF02516	0.303
MOD_NEK2_1	1	6	PF00069	0.704
MOD_NEK2_1	206	211	PF00069	0.401
MOD_NEK2_1	241	246	PF00069	0.636
MOD_NEK2_1	263	268	PF00069	0.690
MOD_NEK2_1	300	305	PF00069	0.706
MOD_NEK2_1	86	91	PF00069	0.577
MOD_PIKK_1	292	298	PF00454	0.693
MOD_PIKK_1	315	321	PF00454	0.635
MOD_PKA_1	131	137	PF00069	0.544
MOD_PKA_1	336	342	PF00069	0.601
MOD_PKA_2	206	212	PF00069	0.407
MOD_PKA_2	239	245	PF00069	0.562
MOD_PKA_2	246	252	PF00069	0.623
MOD_PKA_2	257	263	PF00069	0.763
MOD_PKA_2	336	342	PF00069	0.617
MOD_PKA_2	86	92	PF00069	0.476
MOD_Plk_4	176	182	PF00069	0.474
MOD_Plk_4	283	289	PF00069	0.705
MOD_Plk_4	38	44	PF00069	0.398
MOD_Plk_4	47	53	PF00069	0.336
MOD_ProDKin_1	183	189	PF00069	0.464
MOD_ProDKin_1	234	240	PF00069	0.581
MOD_ProDKin_1	265	271	PF00069	0.771
MOD_ProDKin_1	324	330	PF00069	0.625
TRG_DiLeu_BaEn_1	158	163	PF01217	0.464
TRG_ENDOCYTIC_2	67	70	PF00928	0.373
TRG_ENDOCYTIC_2	99	102	PF00928	0.517
TRG_NES_CRM1_1	202	216	PF08389	0.463
TRG_NLS_MonoCore_2	334	339	PF00514	0.601
TRG_NLS_MonoExtN_4	332	339	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.264
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H9	Leptomonas seymouri	66%	100%
A0A3Q8IPD7	Leishmania donovani	91%	100%
A0A3R7KS72	Trypanosoma rangeli	44%	100%
A4HPT8	Leishmania braziliensis	81%	98%
A4IE54	Leishmania infantum	91%	100%
D0A8Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ATK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BMD4	Trypanosoma cruzi	46%	83%