Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Arrestin (or S-antigen), N-terminal domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q0Z4_LEIMA

TriTrypDb:

LmjF.36.4200 , LMJLV39_360053100 , LMJSD75_360053000

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Z4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.663
CLV_C14_Caspase3-7	426	430	PF00656	0.671
CLV_C14_Caspase3-7	546	550	PF00656	0.469
CLV_C14_Caspase3-7	89	93	PF00656	0.481
CLV_NRD_NRD_1	101	103	PF00675	0.567
CLV_NRD_NRD_1	118	120	PF00675	0.243
CLV_NRD_NRD_1	2	4	PF00675	0.614
CLV_NRD_NRD_1	270	272	PF00675	0.562
CLV_NRD_NRD_1	299	301	PF00675	0.581
CLV_NRD_NRD_1	303	305	PF00675	0.542
CLV_NRD_NRD_1	336	338	PF00675	0.492
CLV_NRD_NRD_1	407	409	PF00675	0.693
CLV_NRD_NRD_1	494	496	PF00675	0.644
CLV_NRD_NRD_1	657	659	PF00675	0.457
CLV_NRD_NRD_1	668	670	PF00675	0.522
CLV_NRD_NRD_1	71	73	PF00675	0.455
CLV_PCSK_FUR_1	300	304	PF00082	0.549
CLV_PCSK_KEX2_1	101	103	PF00082	0.542
CLV_PCSK_KEX2_1	118	120	PF00082	0.243
CLV_PCSK_KEX2_1	270	272	PF00082	0.562
CLV_PCSK_KEX2_1	302	304	PF00082	0.576
CLV_PCSK_KEX2_1	336	338	PF00082	0.508
CLV_PCSK_KEX2_1	4	6	PF00082	0.602
CLV_PCSK_KEX2_1	406	408	PF00082	0.700
CLV_PCSK_KEX2_1	417	419	PF00082	0.604
CLV_PCSK_KEX2_1	493	495	PF00082	0.662
CLV_PCSK_KEX2_1	657	659	PF00082	0.457
CLV_PCSK_KEX2_1	667	669	PF00082	0.521
CLV_PCSK_KEX2_1	94	96	PF00082	0.491
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.591
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.670
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.643
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.528
CLV_PCSK_PC7_1	413	419	PF00082	0.643
CLV_PCSK_SKI1_1	407	411	PF00082	0.801
CLV_PCSK_SKI1_1	443	447	PF00082	0.545
CLV_PCSK_SKI1_1	522	526	PF00082	0.453
CLV_PCSK_SKI1_1	56	60	PF00082	0.432
CLV_PCSK_SKI1_1	593	597	PF00082	0.438
CLV_PCSK_SKI1_1	657	661	PF00082	0.467
CLV_PCSK_SKI1_1	675	679	PF00082	0.561
DEG_APCC_DBOX_1	527	535	PF00400	0.379
DEG_APCC_DBOX_1	55	63	PF00400	0.467
DEG_Nend_Nbox_1	1	3	PF02207	0.599
DEG_SPOP_SBC_1	375	379	PF00917	0.514
DEG_SPOP_SBC_1	581	585	PF00917	0.444
DOC_CKS1_1	445	450	PF01111	0.536
DOC_CYCLIN_RxL_1	517	529	PF00134	0.424
DOC_CYCLIN_RxL_1	654	663	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.658
DOC_MAPK_DCC_7	200	210	PF00069	0.420
DOC_MAPK_DCC_7	593	602	PF00069	0.436
DOC_MAPK_gen_1	200	208	PF00069	0.419
DOC_MAPK_gen_1	308	318	PF00069	0.552
DOC_MAPK_gen_1	517	527	PF00069	0.422
DOC_MAPK_gen_1	593	602	PF00069	0.436
DOC_MAPK_gen_1	739	749	PF00069	0.612
DOC_MAPK_MEF2A_6	202	210	PF00069	0.414
DOC_MAPK_MEF2A_6	517	525	PF00069	0.403
DOC_MAPK_MEF2A_6	528	536	PF00069	0.390
DOC_MAPK_MEF2A_6	593	602	PF00069	0.436
DOC_MAPK_MEF2A_6	742	751	PF00069	0.606
DOC_MAPK_MEF2A_6	9	17	PF00069	0.434
DOC_MAPK_RevD_3	81	95	PF00069	0.392
DOC_PP1_RVXF_1	441	447	PF00149	0.654
DOC_PP1_RVXF_1	656	663	PF00149	0.462
DOC_PP2B_LxvP_1	157	160	PF13499	0.312
DOC_PP2B_LxvP_1	373	376	PF13499	0.528
DOC_PP2B_LxvP_1	453	456	PF13499	0.650
DOC_PP2B_LxvP_1	602	605	PF13499	0.457
DOC_PP2B_LxvP_1	679	682	PF13499	0.543
DOC_PP2B_LxvP_1	762	765	PF13499	0.625
DOC_PP4_FxxP_1	446	449	PF00568	0.594
DOC_PP4_FxxP_1	498	501	PF00568	0.597
DOC_PP4_FxxP_1	787	790	PF00568	0.581
DOC_SPAK_OSR1_1	626	630	PF12202	0.287
DOC_USP7_MATH_1	183	187	PF00917	0.364
DOC_USP7_MATH_1	39	43	PF00917	0.465
DOC_USP7_MATH_1	473	477	PF00917	0.648
DOC_USP7_MATH_1	717	721	PF00917	0.638
DOC_USP7_UBL2_3	439	443	PF12436	0.555
DOC_WW_Pin1_4	427	432	PF00397	0.707
DOC_WW_Pin1_4	444	449	PF00397	0.642
DOC_WW_Pin1_4	526	531	PF00397	0.378
DOC_WW_Pin1_4	605	610	PF00397	0.452
LIG_14-3-3_CanoR_1	118	123	PF00244	0.336
LIG_14-3-3_CanoR_1	247	257	PF00244	0.615
LIG_14-3-3_CanoR_1	418	428	PF00244	0.662
LIG_14-3-3_CanoR_1	522	528	PF00244	0.499
LIG_14-3-3_CanoR_1	556	562	PF00244	0.442
LIG_14-3-3_CanoR_1	568	577	PF00244	0.381
LIG_14-3-3_CanoR_1	638	647	PF00244	0.464
LIG_14-3-3_CanoR_1	72	77	PF00244	0.394
LIG_14-3-3_CanoR_1	732	740	PF00244	0.622
LIG_Actin_WH2_2	504	519	PF00022	0.448
LIG_BRCT_BRCA1_1	151	155	PF00533	0.312
LIG_BRCT_BRCA1_1	623	627	PF00533	0.267
LIG_EH_1	784	788	PF12763	0.583
LIG_FHA_1	252	258	PF00498	0.522
LIG_FHA_1	432	438	PF00498	0.695
LIG_FHA_1	463	469	PF00498	0.683
LIG_FHA_1	516	522	PF00498	0.509
LIG_FHA_1	531	537	PF00498	0.310
LIG_FHA_1	540	546	PF00498	0.404
LIG_FHA_1	640	646	PF00498	0.376
LIG_FHA_1	681	687	PF00498	0.496
LIG_FHA_2	291	297	PF00498	0.507
LIG_FHA_2	567	573	PF00498	0.523
LIG_FHA_2	581	587	PF00498	0.414
LIG_FHA_2	73	79	PF00498	0.526
LIG_Integrin_isoDGR_2	392	394	PF01839	0.636
LIG_LIR_Apic_2	150	154	PF02991	0.291
LIG_LIR_Apic_2	496	501	PF02991	0.519
LIG_LIR_Apic_2	571	577	PF02991	0.453
LIG_LIR_Gen_1	152	163	PF02991	0.312
LIG_LIR_Gen_1	619	629	PF02991	0.356
LIG_LIR_Gen_1	74	83	PF02991	0.380
LIG_LIR_Nem_3	152	158	PF02991	0.317
LIG_LIR_Nem_3	619	625	PF02991	0.349
LIG_LIR_Nem_3	74	80	PF02991	0.395
LIG_LIR_Nem_3	802	807	PF02991	0.602
LIG_MAD2	522	530	PF02301	0.457
LIG_Pex14_1	503	507	PF04695	0.438
LIG_Pex14_1	662	666	PF04695	0.485
LIG_PTB_Apo_2	389	396	PF02174	0.660
LIG_REV1ctd_RIR_1	663	673	PF16727	0.595
LIG_SH2_CRK	151	155	PF00017	0.312
LIG_SH2_CRK	559	563	PF00017	0.354
LIG_SH2_CRK	574	578	PF00017	0.447
LIG_SH2_GRB2like	628	631	PF00017	0.358
LIG_SH2_NCK_1	559	563	PF00017	0.354
LIG_SH2_SRC	758	761	PF00017	0.751
LIG_SH2_STAP1	290	294	PF00017	0.512
LIG_SH2_STAP1	758	762	PF00017	0.638
LIG_SH2_STAP1	77	81	PF00017	0.371
LIG_SH2_STAT3	76	79	PF00017	0.393
LIG_SH2_STAT5	566	569	PF00017	0.390
LIG_SH2_STAT5	628	631	PF00017	0.378
LIG_SH3_3	33	39	PF00018	0.406
LIG_SH3_3	592	598	PF00018	0.438
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.466
LIG_SUMO_SIM_anti_2	641	648	PF11976	0.383
LIG_SUMO_SIM_par_1	32	37	PF11976	0.383
LIG_SUMO_SIM_par_1	42	48	PF11976	0.313
LIG_SUMO_SIM_par_1	523	529	PF11976	0.453
LIG_SUMO_SIM_par_1	541	546	PF11976	0.265
LIG_SUMO_SIM_par_1	641	648	PF11976	0.454
LIG_TRAF2_1	476	479	PF00917	0.669
LIG_TRFH_1	677	681	PF08558	0.559
LIG_TYR_ITIM	557	562	PF00017	0.356
LIG_UBA3_1	58	67	PF00899	0.565
LIG_WRC_WIRS_1	633	638	PF05994	0.426
MOD_CK1_1	251	257	PF00069	0.649
MOD_CK1_1	346	352	PF00069	0.690
MOD_CK1_1	399	405	PF00069	0.761
MOD_CK1_1	469	475	PF00069	0.640
MOD_CK1_1	510	516	PF00069	0.483
MOD_CK1_1	526	532	PF00069	0.424
MOD_CK1_1	548	554	PF00069	0.487
MOD_CK1_1	560	566	PF00069	0.304
MOD_CK1_1	585	591	PF00069	0.425
MOD_CK1_1	639	645	PF00069	0.393
MOD_CK1_1	711	717	PF00069	0.641
MOD_CK1_1	725	731	PF00069	0.697
MOD_CK1_1	93	99	PF00069	0.524
MOD_CK2_1	135	141	PF00069	0.261
MOD_CK2_1	231	237	PF00069	0.518
MOD_CK2_1	290	296	PF00069	0.510
MOD_CK2_1	4	10	PF00069	0.586
MOD_CK2_1	473	479	PF00069	0.714
MOD_CK2_1	566	572	PF00069	0.454
MOD_CK2_1	72	78	PF00069	0.530
MOD_Cter_Amidation	404	407	PF01082	0.664
MOD_GlcNHglycan	114	117	PF01048	0.572
MOD_GlcNHglycan	130	134	PF01048	0.262
MOD_GlcNHglycan	137	140	PF01048	0.331
MOD_GlcNHglycan	190	193	PF01048	0.421
MOD_GlcNHglycan	250	253	PF01048	0.665
MOD_GlcNHglycan	398	401	PF01048	0.786
MOD_GlcNHglycan	512	515	PF01048	0.523
MOD_GlcNHglycan	549	553	PF01048	0.381
MOD_GlcNHglycan	647	650	PF01048	0.482
MOD_GlcNHglycan	724	727	PF01048	0.575
MOD_GSK3_1	108	115	PF00069	0.720
MOD_GSK3_1	131	138	PF00069	0.313
MOD_GSK3_1	149	156	PF00069	0.277
MOD_GSK3_1	183	190	PF00069	0.388
MOD_GSK3_1	231	238	PF00069	0.685
MOD_GSK3_1	243	250	PF00069	0.607
MOD_GSK3_1	376	383	PF00069	0.678
MOD_GSK3_1	427	434	PF00069	0.739
MOD_GSK3_1	462	469	PF00069	0.672
MOD_GSK3_1	526	533	PF00069	0.394
MOD_GSK3_1	548	555	PF00069	0.395
MOD_GSK3_1	577	584	PF00069	0.469
MOD_GSK3_1	604	611	PF00069	0.457
MOD_GSK3_1	628	635	PF00069	0.414
MOD_GSK3_1	680	687	PF00069	0.545
MOD_GSK3_1	734	741	PF00069	0.654
MOD_GSK3_1	789	796	PF00069	0.595
MOD_N-GLC_1	235	240	PF02516	0.600
MOD_N-GLC_1	343	348	PF02516	0.563
MOD_N-GLC_1	357	362	PF02516	0.580
MOD_N-GLC_1	462	467	PF02516	0.665
MOD_N-GLC_1	653	658	PF02516	0.459
MOD_N-GLC_1	684	689	PF02516	0.536
MOD_NEK2_1	131	136	PF00069	0.345
MOD_NEK2_1	187	192	PF00069	0.468
MOD_NEK2_1	248	253	PF00069	0.670
MOD_NEK2_1	507	512	PF00069	0.444
MOD_NEK2_1	515	520	PF00069	0.531
MOD_NEK2_1	636	641	PF00069	0.437
MOD_NEK2_1	653	658	PF00069	0.358
MOD_NEK2_1	660	665	PF00069	0.481
MOD_NEK2_1	734	739	PF00069	0.581
MOD_NEK2_1	752	757	PF00069	0.503
MOD_NEK2_1	90	95	PF00069	0.497
MOD_PIKK_1	560	566	PF00454	0.395
MOD_PIKK_1	734	740	PF00454	0.656
MOD_PK_1	118	124	PF00069	0.243
MOD_PKA_1	118	124	PF00069	0.243
MOD_PKA_1	4	10	PF00069	0.632
MOD_PKA_1	493	499	PF00069	0.602
MOD_PKA_1	72	78	PF00069	0.439
MOD_PKA_2	118	124	PF00069	0.315
MOD_PKA_2	312	318	PF00069	0.565
MOD_PKA_2	4	10	PF00069	0.632
MOD_PKA_2	493	499	PF00069	0.666
MOD_PKA_2	660	666	PF00069	0.515
MOD_PKA_2	71	77	PF00069	0.550
MOD_PKA_2	734	740	PF00069	0.605
MOD_PKB_1	3	11	PF00069	0.604
MOD_Plk_1	320	326	PF00069	0.541
MOD_Plk_1	343	349	PF00069	0.576
MOD_Plk_1	505	511	PF00069	0.380
MOD_Plk_1	54	60	PF00069	0.465
MOD_Plk_1	585	591	PF00069	0.425
MOD_Plk_1	675	681	PF00069	0.545
MOD_Plk_1	717	723	PF00069	0.595
MOD_Plk_2-3	343	349	PF00069	0.600
MOD_Plk_4	131	137	PF00069	0.496
MOD_Plk_4	183	189	PF00069	0.428
MOD_Plk_4	312	318	PF00069	0.613
MOD_Plk_4	539	545	PF00069	0.539
MOD_Plk_4	557	563	PF00069	0.276
MOD_Plk_4	608	614	PF00069	0.395
MOD_Plk_4	618	624	PF00069	0.355
MOD_Plk_4	72	78	PF00069	0.397
MOD_ProDKin_1	427	433	PF00069	0.707
MOD_ProDKin_1	444	450	PF00069	0.642
MOD_ProDKin_1	526	532	PF00069	0.376
MOD_ProDKin_1	605	611	PF00069	0.449
MOD_SUMO_rev_2	476	486	PF00179	0.665
MOD_SUMO_rev_2	87	96	PF00179	0.497
TRG_DiLeu_BaEn_1	14	19	PF01217	0.390
TRG_DiLeu_BaEn_1	312	317	PF01217	0.613
TRG_DiLeu_BaEn_2	758	764	PF01217	0.649
TRG_DiLeu_BaLyEn_6	655	660	PF01217	0.458
TRG_DiLeu_BaLyEn_6	747	752	PF01217	0.617
TRG_ENDOCYTIC_2	275	278	PF00928	0.682
TRG_ENDOCYTIC_2	559	562	PF00928	0.355
TRG_ENDOCYTIC_2	77	80	PF00928	0.377
TRG_ENDOCYTIC_2	804	807	PF00928	0.603
TRG_ER_diArg_1	101	103	PF00400	0.530
TRG_ER_diArg_1	117	119	PF00400	0.243
TRG_ER_diArg_1	170	173	PF00400	0.436
TRG_ER_diArg_1	2	5	PF00400	0.598
TRG_ER_diArg_1	200	203	PF00400	0.417
TRG_ER_diArg_1	270	273	PF00400	0.570
TRG_ER_diArg_1	329	332	PF00400	0.497
TRG_ER_diArg_1	406	408	PF00400	0.660
TRG_ER_diArg_1	493	495	PF00400	0.616
TRG_ER_diArg_1	657	659	PF00400	0.457
TRG_ER_diArg_1	666	669	PF00400	0.515
TRG_NLS_Bipartite_1	406	420	PF00514	0.647
TRG_NLS_MonoCore_2	300	305	PF00514	0.546
TRG_NLS_MonoExtC_3	301	307	PF00514	0.593
TRG_NLS_MonoExtN_4	300	306	PF00514	0.592
TRG_NLS_MonoExtN_4	413	420	PF00514	0.707
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I967	Leptomonas seymouri	45%	95%
A0A3S7XBE9	Leishmania donovani	91%	100%
A4HPT9	Leishmania braziliensis	66%	97%
A4IE53	Leishmania infantum	91%	100%
E9ATK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%