Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat/Utp21 specific WD40 associated putative domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q0Z3_LEIMA

TriTrypDb:

LmjF.36.4210 , LMJLV39_360053200 , LMJSD75_360053100

Length:

976

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0005840	ribosome	5	11
GO:0030684	preribosome	3	11
GO:0032040	small-subunit processome	4	11
GO:0032991	protein-containing complex	1	12
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	3	2
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4Q0Z3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Z3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.507
CLV_C14_Caspase3-7	328	332	PF00656	0.440
CLV_C14_Caspase3-7	54	58	PF00656	0.460
CLV_C14_Caspase3-7	611	615	PF00656	0.557
CLV_MEL_PAP_1	931	937	PF00089	0.425
CLV_NRD_NRD_1	340	342	PF00675	0.365
CLV_NRD_NRD_1	748	750	PF00675	0.592
CLV_NRD_NRD_1	821	823	PF00675	0.425
CLV_NRD_NRD_1	831	833	PF00675	0.425
CLV_NRD_NRD_1	909	911	PF00675	0.342
CLV_PCSK_FUR_1	338	342	PF00082	0.384
CLV_PCSK_KEX2_1	116	118	PF00082	0.320
CLV_PCSK_KEX2_1	340	342	PF00082	0.365
CLV_PCSK_KEX2_1	388	390	PF00082	0.435
CLV_PCSK_KEX2_1	747	749	PF00082	0.593
CLV_PCSK_KEX2_1	830	832	PF00082	0.218
CLV_PCSK_KEX2_1	874	876	PF00082	0.339
CLV_PCSK_KEX2_1	909	911	PF00082	0.361
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.320
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.556
CLV_PCSK_PC1ET2_1	830	832	PF00082	0.218
CLV_PCSK_PC1ET2_1	874	876	PF00082	0.339
CLV_PCSK_SKI1_1	152	156	PF00082	0.389
CLV_PCSK_SKI1_1	487	491	PF00082	0.422
CLV_PCSK_SKI1_1	898	902	PF00082	0.389
CLV_Separin_Metazoa	673	677	PF03568	0.369
DEG_APCC_DBOX_1	283	291	PF00400	0.613
DEG_Nend_UBRbox_2	1	3	PF02207	0.462
DEG_SCF_FBW7_2	841	846	PF00400	0.374
DEG_SPOP_SBC_1	608	612	PF00917	0.557
DOC_ANK_TNKS_1	188	195	PF00023	0.218
DOC_ANK_TNKS_1	68	75	PF00023	0.355
DOC_CKS1_1	25	30	PF01111	0.503
DOC_CKS1_1	581	586	PF01111	0.432
DOC_CYCLIN_RxL_1	149	159	PF00134	0.425
DOC_CYCLIN_RxL_1	453	462	PF00134	0.480
DOC_CYCLIN_RxL_1	892	905	PF00134	0.393
DOC_CYCLIN_yClb1_LxF_4	772	777	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	581	587	PF00134	0.259
DOC_CYCLIN_yCln2_LP_2	792	795	PF00134	0.320
DOC_MAPK_gen_1	247	255	PF00069	0.468
DOC_MAPK_gen_1	796	802	PF00069	0.320
DOC_MAPK_gen_1	909	916	PF00069	0.339
DOC_MAPK_HePTP_8	861	873	PF00069	0.389
DOC_MAPK_JIP1_4	811	817	PF00069	0.361
DOC_MAPK_MEF2A_6	632	640	PF00069	0.393
DOC_MAPK_MEF2A_6	864	873	PF00069	0.389
DOC_MAPK_MEF2A_6	96	103	PF00069	0.451
DOC_PP1_RVXF_1	115	122	PF00149	0.425
DOC_PP1_RVXF_1	772	778	PF00149	0.393
DOC_PP1_RVXF_1	910	917	PF00149	0.448
DOC_PP2B_LxvP_1	792	795	PF13499	0.320
DOC_PP4_FxxP_1	304	307	PF00568	0.527
DOC_PP4_FxxP_1	633	636	PF00568	0.455
DOC_PP4_FxxP_1	802	805	PF00568	0.320
DOC_USP7_MATH_1	240	244	PF00917	0.416
DOC_USP7_MATH_1	499	503	PF00917	0.477
DOC_USP7_MATH_1	609	613	PF00917	0.501
DOC_USP7_MATH_1	702	706	PF00917	0.690
DOC_USP7_MATH_1	711	715	PF00917	0.763
DOC_WW_Pin1_4	17	22	PF00397	0.436
DOC_WW_Pin1_4	24	29	PF00397	0.502
DOC_WW_Pin1_4	580	585	PF00397	0.433
DOC_WW_Pin1_4	590	595	PF00397	0.454
DOC_WW_Pin1_4	632	637	PF00397	0.354
DOC_WW_Pin1_4	674	679	PF00397	0.553
DOC_WW_Pin1_4	839	844	PF00397	0.316
LIG_14-3-3_CanoR_1	376	380	PF00244	0.400
LIG_14-3-3_CanoR_1	712	719	PF00244	0.756
LIG_14-3-3_CanoR_1	954	958	PF00244	0.348
LIG_Actin_WH2_2	520	538	PF00022	0.469
LIG_Actin_WH2_2	797	813	PF00022	0.320
LIG_Actin_WH2_2	939	956	PF00022	0.374
LIG_AP2alpha_2	5	7	PF02296	0.532
LIG_APCC_ABBAyCdc20_2	831	837	PF00400	0.218
LIG_BRCT_BRCA1_1	242	246	PF00533	0.439
LIG_BRCT_BRCA1_1	553	557	PF00533	0.370
LIG_BRCT_BRCA1_1	638	642	PF00533	0.347
LIG_CaM_NSCaTE_8	531	538	PF13499	0.549
LIG_Clathr_ClatBox_1	301	305	PF01394	0.482
LIG_EH1_1	954	962	PF00400	0.316
LIG_eIF4E_1	149	155	PF01652	0.304
LIG_eIF4E_1	25	31	PF01652	0.374
LIG_eIF4E_1	353	359	PF01652	0.357
LIG_eIF4E_1	416	422	PF01652	0.442
LIG_FHA_1	123	129	PF00498	0.341
LIG_FHA_1	135	141	PF00498	0.297
LIG_FHA_1	159	165	PF00498	0.368
LIG_FHA_1	224	230	PF00498	0.418
LIG_FHA_1	240	246	PF00498	0.364
LIG_FHA_1	25	31	PF00498	0.420
LIG_FHA_1	308	314	PF00498	0.508
LIG_FHA_1	346	352	PF00498	0.395
LIG_FHA_1	35	41	PF00498	0.311
LIG_FHA_1	353	359	PF00498	0.373
LIG_FHA_1	512	518	PF00498	0.470
LIG_FHA_1	530	536	PF00498	0.316
LIG_FHA_1	562	568	PF00498	0.403
LIG_FHA_1	805	811	PF00498	0.320
LIG_FHA_1	903	909	PF00498	0.403
LIG_FHA_1	98	104	PF00498	0.425
LIG_FHA_2	229	235	PF00498	0.406
LIG_FHA_2	246	252	PF00498	0.303
LIG_FHA_2	52	58	PF00498	0.538
LIG_FHA_2	575	581	PF00498	0.542
LIG_FHA_2	609	615	PF00498	0.557
LIG_FHA_2	699	705	PF00498	0.729
LIG_FHA_2	718	724	PF00498	0.694
LIG_FHA_2	778	784	PF00498	0.320
LIG_FHA_2	804	810	PF00498	0.320
LIG_FHA_2	884	890	PF00498	0.351
LIG_IRF3_LxIS_1	13	20	PF10401	0.235
LIG_LIR_Apic_2	22	28	PF02991	0.394
LIG_LIR_Apic_2	413	419	PF02991	0.299
LIG_LIR_Apic_2	799	805	PF02991	0.320
LIG_LIR_Gen_1	308	314	PF02991	0.519
LIG_LIR_Gen_1	685	694	PF02991	0.584
LIG_LIR_Gen_1	813	818	PF02991	0.361
LIG_LIR_Gen_1	858	868	PF02991	0.415
LIG_LIR_Nem_3	2	7	PF02991	0.378
LIG_LIR_Nem_3	204	209	PF02991	0.321
LIG_LIR_Nem_3	308	312	PF02991	0.543
LIG_LIR_Nem_3	37	41	PF02991	0.345
LIG_LIR_Nem_3	603	608	PF02991	0.477
LIG_LIR_Nem_3	685	691	PF02991	0.584
LIG_LIR_Nem_3	858	863	PF02991	0.385
LIG_LRP6_Inhibitor_1	661	667	PF00058	0.505
LIG_MAD2	8	16	PF02301	0.469
LIG_MYND_1	791	795	PF01753	0.320
LIG_MYND_3	940	944	PF01753	0.381
LIG_PCNA_yPIPBox_3	892	901	PF02747	0.421
LIG_PCNA_yPIPBox_3	912	925	PF02747	0.121
LIG_PDZ_Class_1	971	976	PF00595	0.491
LIG_Pex14_2	903	907	PF04695	0.339
LIG_PTB_Apo_2	662	669	PF02174	0.499
LIG_PTB_Phospho_1	662	668	PF10480	0.492
LIG_Rb_pABgroove_1	484	492	PF01858	0.453
LIG_SH2_CRK	25	29	PF00017	0.409
LIG_SH2_CRK	309	313	PF00017	0.518
LIG_SH2_CRK	466	470	PF00017	0.447
LIG_SH2_CRK	605	609	PF00017	0.477
LIG_SH2_CRK	668	672	PF00017	0.434
LIG_SH2_CRK	68	72	PF00017	0.362
LIG_SH2_GRB2like	149	152	PF00017	0.339
LIG_SH2_NCK_1	466	470	PF00017	0.447
LIG_SH2_NCK_1	885	889	PF00017	0.413
LIG_SH2_SRC	80	83	PF00017	0.543
LIG_SH2_STAP1	149	153	PF00017	0.339
LIG_SH2_STAP1	309	313	PF00017	0.515
LIG_SH2_STAT5	149	152	PF00017	0.339
LIG_SH2_STAT5	309	312	PF00017	0.530
LIG_SH2_STAT5	607	610	PF00017	0.463
LIG_SH2_STAT5	660	663	PF00017	0.431
LIG_SH2_STAT5	670	673	PF00017	0.509
LIG_SH2_STAT5	80	83	PF00017	0.543
LIG_SH2_STAT5	859	862	PF00017	0.337
LIG_SH2_STAT5	879	882	PF00017	0.322
LIG_SH2_STAT5	885	888	PF00017	0.317
LIG_SH3_1	788	794	PF00018	0.320
LIG_SH3_2	791	796	PF14604	0.320
LIG_SH3_3	15	21	PF00018	0.516
LIG_SH3_3	397	403	PF00018	0.532
LIG_SH3_3	672	678	PF00018	0.455
LIG_SH3_3	788	794	PF00018	0.320
LIG_SH3_3	958	964	PF00018	0.347
LIG_SUMO_SIM_anti_2	141	147	PF11976	0.420
LIG_SUMO_SIM_anti_2	98	103	PF11976	0.374
LIG_SUMO_SIM_par_1	27	34	PF11976	0.363
LIG_SUMO_SIM_par_1	513	518	PF11976	0.513
LIG_SUMO_SIM_par_1	813	820	PF11976	0.451
LIG_TRAF2_1	577	580	PF00917	0.522
LIG_TRAF2_1	697	700	PF00917	0.668
LIG_TRAF2_1	701	704	PF00917	0.729
LIG_TRAF2_1	722	725	PF00917	0.684
LIG_TRAF2_1	806	809	PF00917	0.339
LIG_TRAF2_1	843	846	PF00917	0.374
LIG_TRAF2_1	942	945	PF00917	0.425
LIG_TYR_ITIM	666	671	PF00017	0.428
LIG_WRC_WIRS_1	1	6	PF05994	0.415
LIG_WRC_WIRS_1	230	235	PF05994	0.421
LIG_WRC_WIRS_1	900	905	PF05994	0.361
MOD_CDK_SPK_2	674	679	PF00069	0.514
MOD_CDK_SPxK_1	580	586	PF00069	0.435
MOD_CK1_1	188	194	PF00069	0.400
MOD_CK1_1	256	262	PF00069	0.371
MOD_CK1_1	420	426	PF00069	0.346
MOD_CK1_1	451	457	PF00069	0.431
MOD_CK1_1	593	599	PF00069	0.514
MOD_CK1_1	862	868	PF00069	0.339
MOD_CK1_1	881	887	PF00069	0.393
MOD_CK1_1	902	908	PF00069	0.425
MOD_CK2_1	256	262	PF00069	0.362
MOD_CK2_1	282	288	PF00069	0.527
MOD_CK2_1	499	505	PF00069	0.470
MOD_CK2_1	574	580	PF00069	0.518
MOD_CK2_1	698	704	PF00069	0.719
MOD_CK2_1	717	723	PF00069	0.680
MOD_CK2_1	803	809	PF00069	0.320
MOD_CK2_1	86	92	PF00069	0.442
MOD_CK2_1	883	889	PF00069	0.343
MOD_CMANNOS	528	531	PF00535	0.377
MOD_Cter_Amidation	386	389	PF01082	0.432
MOD_GlcNHglycan	168	171	PF01048	0.362
MOD_GlcNHglycan	183	186	PF01048	0.447
MOD_GlcNHglycan	255	258	PF01048	0.370
MOD_GlcNHglycan	427	430	PF01048	0.416
MOD_GlcNHglycan	445	448	PF01048	0.386
MOD_GlcNHglycan	450	453	PF01048	0.428
MOD_GlcNHglycan	472	475	PF01048	0.351
MOD_GlcNHglycan	611	614	PF01048	0.254
MOD_GlcNHglycan	703	707	PF01048	0.739
MOD_GlcNHglycan	713	716	PF01048	0.705
MOD_GlcNHglycan	880	883	PF01048	0.218
MOD_GlcNHglycan	971	974	PF01048	0.463
MOD_GSK3_1	130	137	PF00069	0.367
MOD_GSK3_1	154	161	PF00069	0.361
MOD_GSK3_1	181	188	PF00069	0.427
MOD_GSK3_1	229	236	PF00069	0.511
MOD_GSK3_1	273	280	PF00069	0.531
MOD_GSK3_1	308	315	PF00069	0.441
MOD_GSK3_1	367	374	PF00069	0.369
MOD_GSK3_1	375	382	PF00069	0.382
MOD_GSK3_1	443	450	PF00069	0.397
MOD_GSK3_1	51	58	PF00069	0.527
MOD_GSK3_1	511	518	PF00069	0.463
MOD_GSK3_1	632	639	PF00069	0.355
MOD_GSK3_1	698	705	PF00069	0.743
MOD_GSK3_1	706	713	PF00069	0.749
MOD_GSK3_1	949	956	PF00069	0.330
MOD_GSK3_1	967	974	PF00069	0.401
MOD_N-GLC_1	179	184	PF02516	0.179
MOD_N-GLC_1	482	487	PF02516	0.426
MOD_N-GLC_1	706	711	PF02516	0.685
MOD_N-GLC_1	777	782	PF02516	0.361
MOD_N-GLC_1	823	828	PF02516	0.363
MOD_N-GLC_2	270	272	PF02516	0.424
MOD_NEK2_1	108	113	PF00069	0.425
MOD_NEK2_1	173	178	PF00069	0.402
MOD_NEK2_1	201	206	PF00069	0.339
MOD_NEK2_1	253	258	PF00069	0.430
MOD_NEK2_1	273	278	PF00069	0.432
MOD_NEK2_1	31	36	PF00069	0.359
MOD_NEK2_1	312	317	PF00069	0.423
MOD_NEK2_1	357	362	PF00069	0.334
MOD_NEK2_1	367	372	PF00069	0.356
MOD_NEK2_1	443	448	PF00069	0.469
MOD_NEK2_1	545	550	PF00069	0.400
MOD_NEK2_1	55	60	PF00069	0.486
MOD_NEK2_1	638	643	PF00069	0.383
MOD_NEK2_1	648	653	PF00069	0.310
MOD_NEK2_1	777	782	PF00069	0.339
MOD_NEK2_1	86	91	PF00069	0.451
MOD_NEK2_1	967	972	PF00069	0.476
MOD_NEK2_2	859	864	PF00069	0.425
MOD_PIKK_1	379	385	PF00454	0.403
MOD_PIKK_1	737	743	PF00454	0.639
MOD_PIKK_1	804	810	PF00454	0.330
MOD_PKA_1	748	754	PF00069	0.624
MOD_PKA_2	188	194	PF00069	0.424
MOD_PKA_2	367	373	PF00069	0.361
MOD_PKA_2	375	381	PF00069	0.376
MOD_PKA_2	711	717	PF00069	0.761
MOD_PKA_2	748	754	PF00069	0.564
MOD_PKA_2	810	816	PF00069	0.320
MOD_PKA_2	953	959	PF00069	0.328
MOD_Plk_1	307	313	PF00069	0.540
MOD_Plk_1	482	488	PF00069	0.415
MOD_Plk_1	500	506	PF00069	0.401
MOD_Plk_1	551	557	PF00069	0.476
MOD_Plk_1	777	783	PF00069	0.320
MOD_Plk_2-3	375	381	PF00069	0.394
MOD_Plk_4	124	130	PF00069	0.451
MOD_Plk_4	19	25	PF00069	0.378
MOD_Plk_4	240	246	PF00069	0.392
MOD_Plk_4	297	303	PF00069	0.354
MOD_Plk_4	308	314	PF00069	0.399
MOD_Plk_4	417	423	PF00069	0.353
MOD_Plk_4	511	517	PF00069	0.457
MOD_Plk_4	552	558	PF00069	0.385
MOD_Plk_4	777	783	PF00069	0.325
MOD_Plk_4	810	816	PF00069	0.320
MOD_Plk_4	899	905	PF00069	0.375
MOD_ProDKin_1	17	23	PF00069	0.443
MOD_ProDKin_1	24	30	PF00069	0.493
MOD_ProDKin_1	580	586	PF00069	0.434
MOD_ProDKin_1	590	596	PF00069	0.454
MOD_ProDKin_1	632	638	PF00069	0.357
MOD_ProDKin_1	674	680	PF00069	0.560
MOD_ProDKin_1	839	845	PF00069	0.316
MOD_SUMO_rev_2	437	446	PF00179	0.385
MOD_SUMO_rev_2	870	876	PF00179	0.339
TRG_DiLeu_BaEn_1	308	313	PF01217	0.529
TRG_DiLeu_BaLyEn_6	788	793	PF01217	0.320
TRG_ENDOCYTIC_2	206	209	PF00928	0.320
TRG_ENDOCYTIC_2	309	312	PF00928	0.532
TRG_ENDOCYTIC_2	466	469	PF00928	0.448
TRG_ENDOCYTIC_2	605	608	PF00928	0.477
TRG_ENDOCYTIC_2	660	663	PF00928	0.391
TRG_ENDOCYTIC_2	668	671	PF00928	0.372
TRG_ENDOCYTIC_2	68	71	PF00928	0.364
TRG_ER_diArg_1	747	749	PF00400	0.630
TRG_ER_diArg_1	831	833	PF00400	0.218
TRG_ER_diArg_1	908	910	PF00400	0.389
TRG_NES_CRM1_1	839	851	PF08389	0.365
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7H8	Leptomonas seymouri	82%	100%
A0A0S4IK94	Bodo saltans	51%	100%
A0A1X0P3D2	Trypanosomatidae	62%	99%
A0A3R7KJ70	Trypanosoma rangeli	64%	100%
A0A3S7XBK1	Leishmania donovani	95%	99%
A4HPU0	Leishmania braziliensis	88%	99%
A4IE52	Leishmania infantum	95%	99%
D0A8Q5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	88%
E9ATK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
O14053	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q06078	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q8NI36	Homo sapiens	24%	100%
V5BS01	Trypanosoma cruzi	62%	100%