Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0Z2_LEIMA

TriTrypDb:

LmjF.36.4220 , LMJLV39_360053300 , LMJSD75_360053200

Length:

669

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Z2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.702
CLV_C14_Caspase3-7	367	371	PF00656	0.839
CLV_MEL_PAP_1	242	248	PF00089	0.626
CLV_MEL_PAP_1	634	640	PF00089	0.606
CLV_NRD_NRD_1	151	153	PF00675	0.806
CLV_NRD_NRD_1	165	167	PF00675	0.548
CLV_NRD_NRD_1	345	347	PF00675	0.838
CLV_NRD_NRD_1	442	444	PF00675	0.821
CLV_NRD_NRD_1	506	508	PF00675	0.827
CLV_NRD_NRD_1	563	565	PF00675	0.692
CLV_NRD_NRD_1	604	606	PF00675	0.639
CLV_NRD_NRD_1	73	75	PF00675	0.756
CLV_NRD_NRD_1	92	94	PF00675	0.752
CLV_PCSK_FUR_1	440	444	PF00082	0.720
CLV_PCSK_FUR_1	71	75	PF00082	0.743
CLV_PCSK_KEX2_1	151	153	PF00082	0.806
CLV_PCSK_KEX2_1	165	167	PF00082	0.548
CLV_PCSK_KEX2_1	211	213	PF00082	0.711
CLV_PCSK_KEX2_1	345	347	PF00082	0.838
CLV_PCSK_KEX2_1	442	444	PF00082	0.821
CLV_PCSK_KEX2_1	467	469	PF00082	0.814
CLV_PCSK_KEX2_1	471	473	PF00082	0.808
CLV_PCSK_KEX2_1	506	508	PF00082	0.827
CLV_PCSK_KEX2_1	563	565	PF00082	0.692
CLV_PCSK_KEX2_1	73	75	PF00082	0.756
CLV_PCSK_KEX2_1	92	94	PF00082	0.630
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.711
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.814
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.808
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.642
CLV_PCSK_PC7_1	161	167	PF00082	0.566
CLV_PCSK_SKI1_1	195	199	PF00082	0.627
CLV_PCSK_SKI1_1	35	39	PF00082	0.537
CLV_PCSK_SKI1_1	464	468	PF00082	0.820
CLV_PCSK_SKI1_1	606	610	PF00082	0.640
CLV_PCSK_SKI1_1	622	626	PF00082	0.630
DEG_APCC_DBOX_1	34	42	PF00400	0.535
DEG_APCC_DBOX_1	604	612	PF00400	0.587
DEG_MDM2_SWIB_1	225	233	PF02201	0.697
DEG_SPOP_SBC_1	306	310	PF00917	0.805
DEG_SPOP_SBC_1	315	319	PF00917	0.724
DOC_CYCLIN_RxL_1	603	612	PF00134	0.659
DOC_CYCLIN_yCln2_LP_2	27	30	PF00134	0.541
DOC_MAPK_gen_1	165	172	PF00069	0.740
DOC_MAPK_gen_1	440	450	PF00069	0.716
DOC_MAPK_gen_1	605	613	PF00069	0.582
DOC_MAPK_MEF2A_6	35	43	PF00069	0.538
DOC_MAPK_MEF2A_6	605	613	PF00069	0.593
DOC_PP2B_LxvP_1	26	29	PF13499	0.552
DOC_SPAK_OSR1_1	637	641	PF12202	0.557
DOC_USP7_MATH_1	30	34	PF00917	0.526
DOC_USP7_MATH_1	306	310	PF00917	0.818
DOC_USP7_MATH_1	325	329	PF00917	0.560
DOC_USP7_MATH_1	335	339	PF00917	0.691
DOC_USP7_MATH_1	349	353	PF00917	0.572
DOC_USP7_MATH_1	364	368	PF00917	0.691
DOC_USP7_MATH_1	369	373	PF00917	0.545
DOC_USP7_MATH_1	413	417	PF00917	0.773
DOC_USP7_MATH_1	428	432	PF00917	0.607
DOC_USP7_MATH_1	436	440	PF00917	0.761
DOC_USP7_MATH_1	45	49	PF00917	0.480
DOC_USP7_MATH_1	452	456	PF00917	0.796
DOC_USP7_MATH_1	527	531	PF00917	0.730
DOC_USP7_MATH_1	578	582	PF00917	0.740
DOC_USP7_UBL2_3	467	471	PF12436	0.814
DOC_WW_Pin1_4	1	6	PF00397	0.525
DOC_WW_Pin1_4	109	114	PF00397	0.811
DOC_WW_Pin1_4	17	22	PF00397	0.544
DOC_WW_Pin1_4	183	188	PF00397	0.735
DOC_WW_Pin1_4	234	239	PF00397	0.796
DOC_WW_Pin1_4	249	254	PF00397	0.603
DOC_WW_Pin1_4	259	264	PF00397	0.681
DOC_WW_Pin1_4	308	313	PF00397	0.761
DOC_WW_Pin1_4	331	336	PF00397	0.838
DOC_WW_Pin1_4	382	387	PF00397	0.712
DOC_WW_Pin1_4	395	400	PF00397	0.603
DOC_WW_Pin1_4	41	46	PF00397	0.531
DOC_WW_Pin1_4	415	420	PF00397	0.486
DOC_WW_Pin1_4	422	427	PF00397	0.619
DOC_WW_Pin1_4	491	496	PF00397	0.609
DOC_WW_Pin1_4	574	579	PF00397	0.691
LIG_14-3-3_CanoR_1	230	238	PF00244	0.699
LIG_14-3-3_CanoR_1	239	249	PF00244	0.664
LIG_14-3-3_CanoR_1	307	312	PF00244	0.764
LIG_14-3-3_CanoR_1	358	368	PF00244	0.646
LIG_14-3-3_CanoR_1	414	418	PF00244	0.743
LIG_14-3-3_CanoR_1	442	452	PF00244	0.814
LIG_14-3-3_CanoR_1	507	517	PF00244	0.798
LIG_14-3-3_CanoR_1	572	580	PF00244	0.616
LIG_APCC_ABBAyCdc20_2	606	612	PF00400	0.632
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_Clathr_ClatBox_1	608	612	PF01394	0.626
LIG_deltaCOP1_diTrp_1	128	134	PF00928	0.712
LIG_FHA_1	171	177	PF00498	0.628
LIG_FHA_1	468	474	PF00498	0.807
LIG_FHA_1	499	505	PF00498	0.743
LIG_FHA_1	655	661	PF00498	0.601
LIG_FHA_2	120	126	PF00498	0.640
LIG_FHA_2	208	214	PF00498	0.711
LIG_FHA_2	460	466	PF00498	0.642
LIG_FHA_2	554	560	PF00498	0.719
LIG_FHA_2	625	631	PF00498	0.575
LIG_FHA_2	79	85	PF00498	0.741
LIG_LIR_Nem_3	480	486	PF02991	0.713
LIG_Pex14_2	221	225	PF04695	0.679
LIG_Pex14_2	6	10	PF04695	0.528
LIG_PTB_Apo_2	485	492	PF02174	0.720
LIG_PTB_Phospho_1	485	491	PF10480	0.718
LIG_RPA_C_Fungi	437	449	PF08784	0.718
LIG_SH2_PTP2	610	613	PF00017	0.617
LIG_SH2_SRC	610	613	PF00017	0.617
LIG_SH2_STAP1	272	276	PF00017	0.639
LIG_SH2_STAT5	171	174	PF00017	0.697
LIG_SH2_STAT5	223	226	PF00017	0.678
LIG_SH2_STAT5	610	613	PF00017	0.462
LIG_SH2_STAT5	626	629	PF00017	0.479
LIG_SH3_3	235	241	PF00018	0.789
LIG_SH3_3	243	249	PF00018	0.738
LIG_SH3_3	26	32	PF00018	0.541
LIG_SH3_3	398	404	PF00018	0.786
LIG_SH3_3	44	50	PF00018	0.480
LIG_SH3_3	594	600	PF00018	0.810
LIG_SH3_3	601	607	PF00018	0.686
LIG_SH3_3	610	616	PF00018	0.501
LIG_SH3_CIN85_PxpxPR_1	600	605	PF14604	0.686
LIG_SUMO_SIM_par_1	406	412	PF11976	0.638
LIG_TYR_ITIM	608	613	PF00017	0.621
LIG_WW_3	248	252	PF00397	0.617
LIG_WW_3	28	32	PF00397	0.528
MOD_CDK_SPK_2	183	188	PF00069	0.673
MOD_CDK_SPK_2	234	239	PF00069	0.669
MOD_CDK_SPK_2	415	420	PF00069	0.753
MOD_CDK_SPK_2	574	579	PF00069	0.691
MOD_CDK_SPxxK_3	1	8	PF00069	0.524
MOD_CK1_1	207	213	PF00069	0.718
MOD_CK1_1	240	246	PF00069	0.751
MOD_CK1_1	297	303	PF00069	0.827
MOD_CK1_1	305	311	PF00069	0.673
MOD_CK1_1	334	340	PF00069	0.845
MOD_CK1_1	362	368	PF00069	0.693
MOD_CK1_1	385	391	PF00069	0.762
MOD_CK1_1	412	418	PF00069	0.788
MOD_CK1_1	459	465	PF00069	0.762
MOD_CK1_1	48	54	PF00069	0.538
MOD_CK1_1	494	500	PF00069	0.715
MOD_CK1_1	586	592	PF00069	0.652
MOD_CK2_1	314	320	PF00069	0.788
MOD_CK2_1	325	331	PF00069	0.720
MOD_CK2_1	459	465	PF00069	0.638
MOD_CK2_1	486	492	PF00069	0.743
MOD_CK2_1	553	559	PF00069	0.732
MOD_CK2_1	78	84	PF00069	0.751
MOD_CMANNOS	131	134	PF00535	0.704
MOD_DYRK1A_RPxSP_1	574	578	PF00069	0.684
MOD_GlcNHglycan	22	25	PF01048	0.563
MOD_GlcNHglycan	246	249	PF01048	0.704
MOD_GlcNHglycan	296	299	PF01048	0.838
MOD_GlcNHglycan	301	304	PF01048	0.760
MOD_GlcNHglycan	312	315	PF01048	0.565
MOD_GlcNHglycan	331	334	PF01048	0.595
MOD_GlcNHglycan	390	394	PF01048	0.728
MOD_GlcNHglycan	411	414	PF01048	0.663
MOD_GlcNHglycan	434	437	PF01048	0.705
MOD_GlcNHglycan	588	591	PF01048	0.689
MOD_GlcNHglycan	93	96	PF01048	0.761
MOD_GSK3_1	16	23	PF00069	0.538
MOD_GSK3_1	237	244	PF00069	0.663
MOD_GSK3_1	270	277	PF00069	0.706
MOD_GSK3_1	289	296	PF00069	0.747
MOD_GSK3_1	302	309	PF00069	0.588
MOD_GSK3_1	310	317	PF00069	0.656
MOD_GSK3_1	325	332	PF00069	0.581
MOD_GSK3_1	359	366	PF00069	0.799
MOD_GSK3_1	378	385	PF00069	0.560
MOD_GSK3_1	408	415	PF00069	0.699
MOD_GSK3_1	41	48	PF00069	0.530
MOD_GSK3_1	418	425	PF00069	0.622
MOD_GSK3_1	428	435	PF00069	0.639
MOD_GSK3_1	438	445	PF00069	0.672
MOD_GSK3_1	452	459	PF00069	0.801
MOD_GSK3_1	494	501	PF00069	0.682
MOD_GSK3_1	509	516	PF00069	0.587
MOD_GSK3_1	553	560	PF00069	0.724
MOD_GSK3_1	574	581	PF00069	0.763
MOD_N-GLC_1	16	21	PF02516	0.539
MOD_N-GLC_1	359	364	PF02516	0.663
MOD_NEK2_1	133	138	PF00069	0.605
MOD_NEK2_1	182	187	PF00069	0.726
MOD_NEK2_1	356	361	PF00069	0.828
MOD_NEK2_1	444	449	PF00069	0.757
MOD_NEK2_1	457	462	PF00069	0.807
MOD_NEK2_1	498	503	PF00069	0.786
MOD_NEK2_1	644	649	PF00069	0.500
MOD_NEK2_2	593	598	PF00069	0.590
MOD_PIKK_1	45	51	PF00454	0.528
MOD_PIKK_1	518	524	PF00454	0.712
MOD_PIKK_1	572	578	PF00454	0.712
MOD_PK_1	152	158	PF00069	0.799
MOD_PKA_1	442	448	PF00069	0.778
MOD_PKA_1	467	473	PF00069	0.811
MOD_PKA_2	142	148	PF00069	0.688
MOD_PKA_2	244	250	PF00069	0.642
MOD_PKA_2	30	36	PF00069	0.528
MOD_PKA_2	306	312	PF00069	0.766
MOD_PKA_2	344	350	PF00069	0.771
MOD_PKA_2	413	419	PF00069	0.758
MOD_PKA_2	442	448	PF00069	0.719
MOD_PKA_2	467	473	PF00069	0.811
MOD_PKA_2	527	533	PF00069	0.621
MOD_PKA_2	578	584	PF00069	0.726
MOD_PKA_2	636	642	PF00069	0.619
MOD_PKA_2	91	97	PF00069	0.649
MOD_PKB_1	440	448	PF00069	0.718
MOD_Plk_1	479	485	PF00069	0.776
MOD_Plk_4	126	132	PF00069	0.615
MOD_Plk_4	22	28	PF00069	0.562
MOD_Plk_4	224	230	PF00069	0.684
MOD_Plk_4	486	492	PF00069	0.681
MOD_ProDKin_1	1	7	PF00069	0.523
MOD_ProDKin_1	109	115	PF00069	0.811
MOD_ProDKin_1	17	23	PF00069	0.547
MOD_ProDKin_1	183	189	PF00069	0.730
MOD_ProDKin_1	234	240	PF00069	0.800
MOD_ProDKin_1	249	255	PF00069	0.606
MOD_ProDKin_1	259	265	PF00069	0.679
MOD_ProDKin_1	308	314	PF00069	0.763
MOD_ProDKin_1	331	337	PF00069	0.840
MOD_ProDKin_1	382	388	PF00069	0.710
MOD_ProDKin_1	395	401	PF00069	0.602
MOD_ProDKin_1	41	47	PF00069	0.529
MOD_ProDKin_1	415	421	PF00069	0.483
MOD_ProDKin_1	422	428	PF00069	0.618
MOD_ProDKin_1	491	497	PF00069	0.610
MOD_ProDKin_1	574	580	PF00069	0.697
MOD_SUMO_rev_2	459	469	PF00179	0.817
TRG_DiLeu_BaEn_1	34	39	PF01217	0.535
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.577
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.661
TRG_ENDOCYTIC_2	610	613	PF00928	0.457
TRG_ER_diArg_1	150	152	PF00400	0.803
TRG_ER_diArg_1	165	168	PF00400	0.524
TRG_ER_diArg_1	440	443	PF00400	0.720
TRG_ER_diArg_1	562	564	PF00400	0.685
TRG_ER_diArg_1	70	73	PF00400	0.736
TRG_NES_CRM1_1	190	203	PF08389	0.732
TRG_PTS2	1	43	PF00400	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJR0	Leishmania donovani	91%	100%
A4HPU1	Leishmania braziliensis	68%	100%
A4IE51	Leishmania infantum	91%	100%
E9ATK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%