Leucine-rich repeat-containing protein 34

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania major

UniProt:

Q4Q0Z1_LEIMA

TriTrypDb:

LmjF.36.4230 , LMJLV39_360053500 , LMJSD75_360053400

Length:

1123

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0031514	motile cilium	5	3

Expansion

Sequence features

Q4Q0Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.305
CLV_C14_Caspase3-7	888	892	PF00656	0.278
CLV_NRD_NRD_1	287	289	PF00675	0.432
CLV_NRD_NRD_1	536	538	PF00675	0.368
CLV_NRD_NRD_1	725	727	PF00675	0.370
CLV_PCSK_KEX2_1	333	335	PF00082	0.486
CLV_PCSK_KEX2_1	42	44	PF00082	0.456
CLV_PCSK_KEX2_1	536	538	PF00082	0.368
CLV_PCSK_KEX2_1	651	653	PF00082	0.430
CLV_PCSK_KEX2_1	813	815	PF00082	0.420
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.486
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.456
CLV_PCSK_PC1ET2_1	651	653	PF00082	0.430
CLV_PCSK_PC1ET2_1	813	815	PF00082	0.412
CLV_PCSK_SKI1_1	1057	1061	PF00082	0.471
CLV_PCSK_SKI1_1	1081	1085	PF00082	0.670
CLV_PCSK_SKI1_1	179	183	PF00082	0.365
CLV_PCSK_SKI1_1	202	206	PF00082	0.413
CLV_PCSK_SKI1_1	492	496	PF00082	0.476
CLV_PCSK_SKI1_1	52	56	PF00082	0.543
CLV_PCSK_SKI1_1	561	565	PF00082	0.371
CLV_PCSK_SKI1_1	620	624	PF00082	0.446
CLV_PCSK_SKI1_1	727	731	PF00082	0.521
CLV_PCSK_SKI1_1	813	817	PF00082	0.379
CLV_Separin_Metazoa	1009	1013	PF03568	0.498
CLV_Separin_Metazoa	203	207	PF03568	0.376
DEG_APCC_DBOX_1	1056	1064	PF00400	0.467
DEG_APCC_DBOX_1	491	499	PF00400	0.520
DEG_Nend_Nbox_1	1	3	PF02207	0.473
DOC_CYCLIN_RxL_1	202	212	PF00134	0.380
DOC_CYCLIN_RxL_1	530	544	PF00134	0.427
DOC_CYCLIN_RxL_1	854	865	PF00134	0.340
DOC_CYCLIN_RxL_1	941	951	PF00134	0.426
DOC_CYCLIN_RxL_1	987	998	PF00134	0.326
DOC_MAPK_gen_1	143	149	PF00069	0.517
DOC_MAPK_gen_1	333	339	PF00069	0.473
DOC_MAPK_gen_1	458	466	PF00069	0.391
DOC_MAPK_gen_1	490	497	PF00069	0.373
DOC_MAPK_gen_1	6	16	PF00069	0.463
DOC_MAPK_gen_1	813	819	PF00069	0.389
DOC_MAPK_MEF2A_6	458	466	PF00069	0.505
DOC_MAPK_MEF2A_6	503	510	PF00069	0.543
DOC_MAPK_MEF2A_6	561	568	PF00069	0.302
DOC_MAPK_MEF2A_6	6	15	PF00069	0.392
DOC_MAPK_MEF2A_6	929	938	PF00069	0.548
DOC_MAPK_NFAT4_5	561	569	PF00069	0.278
DOC_PP1_RVXF_1	911	918	PF00149	0.377
DOC_USP7_MATH_1	1026	1030	PF00917	0.302
DOC_USP7_MATH_1	115	119	PF00917	0.498
DOC_USP7_MATH_1	160	164	PF00917	0.466
DOC_USP7_MATH_1	369	373	PF00917	0.391
DOC_USP7_MATH_1	54	58	PF00917	0.411
DOC_USP7_MATH_1	590	594	PF00917	0.338
DOC_USP7_UBL2_3	144	148	PF12436	0.477
DOC_WW_Pin1_4	1069	1074	PF00397	0.515
DOC_WW_Pin1_4	309	314	PF00397	0.505
DOC_WW_Pin1_4	468	473	PF00397	0.536
DOC_WW_Pin1_4	668	673	PF00397	0.583
DOC_WW_Pin1_4	85	90	PF00397	0.430
LIG_14-3-3_CanoR_1	1012	1018	PF00244	0.323
LIG_14-3-3_CanoR_1	1095	1101	PF00244	0.682
LIG_14-3-3_CanoR_1	1115	1122	PF00244	0.456
LIG_14-3-3_CanoR_1	112	122	PF00244	0.360
LIG_14-3-3_CanoR_1	269	275	PF00244	0.425
LIG_14-3-3_CanoR_1	29	36	PF00244	0.348
LIG_14-3-3_CanoR_1	411	417	PF00244	0.371
LIG_14-3-3_CanoR_1	43	51	PF00244	0.402
LIG_14-3-3_CanoR_1	458	463	PF00244	0.481
LIG_14-3-3_CanoR_1	490	495	PF00244	0.467
LIG_14-3-3_CanoR_1	530	536	PF00244	0.405
LIG_14-3-3_CanoR_1	537	545	PF00244	0.417
LIG_14-3-3_CanoR_1	691	697	PF00244	0.400
LIG_14-3-3_CanoR_1	814	818	PF00244	0.398
LIG_14-3-3_CanoR_1	929	936	PF00244	0.411
LIG_14-3-3_CanoR_1	970	978	PF00244	0.543
LIG_Actin_WH2_2	389	405	PF00022	0.482
LIG_Actin_WH2_2	446	462	PF00022	0.334
LIG_APCC_ABBA_1	207	212	PF00400	0.375
LIG_APCC_ABBAyCdc20_2	206	212	PF00400	0.380
LIG_BRCT_BRCA1_1	215	219	PF00533	0.460
LIG_BRCT_BRCA1_1	272	276	PF00533	0.389
LIG_BRCT_BRCA1_1	291	295	PF00533	0.399
LIG_BRCT_BRCA1_1	444	448	PF00533	0.353
LIG_BRCT_BRCA1_1	913	917	PF00533	0.380
LIG_BRCT_BRCA1_1	995	999	PF00533	0.350
LIG_Clathr_ClatBox_1	208	212	PF01394	0.425
LIG_Clathr_ClatBox_1	884	888	PF01394	0.372
LIG_FHA_1	1102	1108	PF00498	0.666
LIG_FHA_1	114	120	PF00498	0.494
LIG_FHA_1	173	179	PF00498	0.539
LIG_FHA_1	300	306	PF00498	0.286
LIG_FHA_1	448	454	PF00498	0.389
LIG_FHA_1	459	465	PF00498	0.368
LIG_FHA_1	601	607	PF00498	0.478
LIG_FHA_1	720	726	PF00498	0.454
LIG_FHA_1	748	754	PF00498	0.407
LIG_FHA_1	777	783	PF00498	0.436
LIG_FHA_1	814	820	PF00498	0.523
LIG_FHA_2	194	200	PF00498	0.542
LIG_FHA_2	218	224	PF00498	0.401
LIG_FHA_2	291	297	PF00498	0.392
LIG_FHA_2	385	391	PF00498	0.432
LIG_FHA_2	560	566	PF00498	0.411
LIG_FHA_2	663	669	PF00498	0.503
LIG_FHA_2	692	698	PF00498	0.350
LIG_FHA_2	715	721	PF00498	0.385
LIG_FHA_2	750	756	PF00498	0.505
LIG_FHA_2	785	791	PF00498	0.581
LIG_FHA_2	949	955	PF00498	0.436
LIG_FHA_2	970	976	PF00498	0.467
LIG_GBD_Chelix_1	525	533	PF00786	0.273
LIG_IRF3_LxIS_1	373	380	PF10401	0.455
LIG_LIR_Gen_1	22	30	PF02991	0.464
LIG_LIR_Gen_1	312	319	PF02991	0.544
LIG_LIR_Nem_3	1033	1039	PF02991	0.376
LIG_LIR_Nem_3	1072	1077	PF02991	0.645
LIG_LIR_Nem_3	196	200	PF02991	0.467
LIG_LIR_Nem_3	22	27	PF02991	0.472
LIG_LIR_Nem_3	312	318	PF02991	0.501
LIG_LIR_Nem_3	780	786	PF02991	0.503
LIG_NRBOX	204	210	PF00104	0.480
LIG_NRBOX	978	984	PF00104	0.477
LIG_PCNA_yPIPBox_3	248	260	PF02747	0.473
LIG_PTB_Apo_2	264	271	PF02174	0.491
LIG_PTB_Phospho_1	264	270	PF10480	0.497
LIG_REV1ctd_RIR_1	13	22	PF16727	0.467
LIG_SH2_CRK	1074	1078	PF00017	0.592
LIG_SH2_CRK	315	319	PF00017	0.355
LIG_SH2_STAP1	315	319	PF00017	0.307
LIG_SH2_STAT3	1100	1103	PF00017	0.642
LIG_SH2_STAT5	1036	1039	PF00017	0.433
LIG_SH2_STAT5	109	112	PF00017	0.445
LIG_SH2_STAT5	1100	1103	PF00017	0.644
LIG_SH2_STAT5	113	116	PF00017	0.408
LIG_SH2_STAT5	363	366	PF00017	0.357
LIG_SH2_STAT5	367	370	PF00017	0.351
LIG_SH2_STAT5	552	555	PF00017	0.332
LIG_SH2_STAT5	556	559	PF00017	0.395
LIG_SH2_STAT5	873	876	PF00017	0.487
LIG_SH2_STAT5	947	950	PF00017	0.554
LIG_SH3_3	848	854	PF00018	0.546
LIG_SH3_3	86	92	PF00018	0.428
LIG_SUMO_SIM_anti_2	385	394	PF11976	0.393
LIG_SUMO_SIM_anti_2	504	509	PF11976	0.400
LIG_SUMO_SIM_anti_2	694	700	PF11976	0.417
LIG_SUMO_SIM_anti_2	793	800	PF11976	0.424
LIG_SUMO_SIM_par_1	1103	1108	PF11976	0.718
LIG_SUMO_SIM_par_1	228	234	PF11976	0.483
LIG_SUMO_SIM_par_1	504	509	PF11976	0.549
LIG_SUMO_SIM_par_1	609	615	PF11976	0.484
LIG_SUMO_SIM_par_1	697	702	PF11976	0.350
LIG_SUMO_SIM_par_1	815	820	PF11976	0.467
LIG_SUMO_SIM_par_1	873	880	PF11976	0.469
LIG_SUMO_SIM_par_1	883	888	PF11976	0.410
LIG_SUMO_SIM_par_1	93	98	PF11976	0.453
LIG_TRAF2_1	474	477	PF00917	0.482
LIG_TRAF2_1	672	675	PF00917	0.533
LIG_TRAF2_1	972	975	PF00917	0.494
LIG_TYR_ITSM	1070	1077	PF00017	0.555
LIG_UBA3_1	1	9	PF00899	0.463
LIG_UBA3_1	137	144	PF00899	0.305
LIG_UBA3_1	420	426	PF00899	0.393
LIG_WRC_WIRS_1	256	261	PF05994	0.516
LIG_WW_3	487	491	PF00397	0.375
MOD_CDK_SPxK_1	1069	1075	PF00069	0.524
MOD_CK1_1	1062	1068	PF00069	0.459
MOD_CK1_1	158	164	PF00069	0.474
MOD_CK1_1	242	248	PF00069	0.421
MOD_CK1_1	28	34	PF00069	0.407
MOD_CK1_1	471	477	PF00069	0.505
MOD_CK1_1	541	547	PF00069	0.417
MOD_CK1_1	692	698	PF00069	0.305
MOD_CK1_1	719	725	PF00069	0.539
MOD_CK1_1	883	889	PF00069	0.419
MOD_CK1_1	923	929	PF00069	0.518
MOD_CK1_1	98	104	PF00069	0.396
MOD_CK2_1	166	172	PF00069	0.478
MOD_CK2_1	193	199	PF00069	0.525
MOD_CK2_1	384	390	PF00069	0.495
MOD_CK2_1	471	477	PF00069	0.487
MOD_CK2_1	559	565	PF00069	0.390
MOD_CK2_1	662	668	PF00069	0.532
MOD_CK2_1	691	697	PF00069	0.417
MOD_CK2_1	714	720	PF00069	0.365
MOD_CK2_1	749	755	PF00069	0.523
MOD_CK2_1	788	794	PF00069	0.634
MOD_CK2_1	859	865	PF00069	0.205
MOD_CK2_1	87	93	PF00069	0.443
MOD_CK2_1	948	954	PF00069	0.351
MOD_CK2_1	969	975	PF00069	0.455
MOD_GlcNHglycan	103	106	PF01048	0.360
MOD_GlcNHglycan	157	160	PF01048	0.473
MOD_GlcNHglycan	179	182	PF01048	0.444
MOD_GlcNHglycan	241	244	PF01048	0.439
MOD_GlcNHglycan	36	39	PF01048	0.633
MOD_GlcNHglycan	453	456	PF01048	0.525
MOD_GlcNHglycan	509	513	PF01048	0.400
MOD_GlcNHglycan	606	609	PF01048	0.518
MOD_GlcNHglycan	68	71	PF01048	0.511
MOD_GlcNHglycan	700	704	PF01048	0.372
MOD_GlcNHglycan	711	714	PF01048	0.334
MOD_GlcNHglycan	868	871	PF01048	0.463
MOD_GlcNHglycan	895	899	PF01048	0.319
MOD_GlcNHglycan	922	925	PF01048	0.481
MOD_GSK3_1	1089	1096	PF00069	0.585
MOD_GSK3_1	168	175	PF00069	0.461
MOD_GSK3_1	177	184	PF00069	0.408
MOD_GSK3_1	213	220	PF00069	0.383
MOD_GSK3_1	270	277	PF00069	0.406
MOD_GSK3_1	291	298	PF00069	0.415
MOD_GSK3_1	307	314	PF00069	0.329
MOD_GSK3_1	447	454	PF00069	0.342
MOD_GSK3_1	541	548	PF00069	0.315
MOD_GSK3_1	590	597	PF00069	0.363
MOD_GSK3_1	600	607	PF00069	0.328
MOD_GSK3_1	681	688	PF00069	0.536
MOD_GSK3_1	784	791	PF00069	0.575
MOD_GSK3_1	834	841	PF00069	0.555
MOD_GSK3_1	855	862	PF00069	0.326
MOD_GSK3_1	883	890	PF00069	0.406
MOD_GSK3_1	907	914	PF00069	0.497
MOD_GSK3_1	965	972	PF00069	0.601
MOD_GSK3_1	984	991	PF00069	0.374
MOD_N-GLC_1	1013	1018	PF02516	0.342
MOD_N-GLC_1	1069	1074	PF02516	0.470
MOD_N-GLC_1	249	254	PF02516	0.490
MOD_N-GLC_1	340	345	PF02516	0.442
MOD_N-GLC_1	377	382	PF02516	0.365
MOD_N-GLC_1	398	403	PF02516	0.325
MOD_N-GLC_1	499	504	PF02516	0.488
MOD_N-GLC_1	531	536	PF02516	0.377
MOD_N-GLC_1	538	543	PF02516	0.354
MOD_N-GLC_1	559	564	PF02516	0.284
MOD_N-GLC_1	566	571	PF02516	0.261
MOD_N-GLC_1	66	71	PF02516	0.386
MOD_N-GLC_1	692	697	PF02516	0.439
MOD_N-GLC_1	761	766	PF02516	0.480
MOD_N-GLC_1	777	782	PF02516	0.396
MOD_N-GLC_1	794	799	PF02516	0.549
MOD_N-GLC_1	859	864	PF02516	0.373
MOD_N-GLC_1	962	967	PF02516	0.449
MOD_N-GLC_1	98	103	PF02516	0.421
MOD_N-GLC_1	984	989	PF02516	0.419
MOD_N-GLC_2	709	711	PF02516	0.326
MOD_NEK2_1	1050	1055	PF00069	0.416
MOD_NEK2_1	274	279	PF00069	0.386
MOD_NEK2_1	290	295	PF00069	0.264
MOD_NEK2_1	304	309	PF00069	0.325
MOD_NEK2_1	377	382	PF00069	0.433
MOD_NEK2_1	508	513	PF00069	0.508
MOD_NEK2_1	531	536	PF00069	0.310
MOD_NEK2_1	538	543	PF00069	0.264
MOD_NEK2_1	545	550	PF00069	0.236
MOD_NEK2_1	566	571	PF00069	0.311
MOD_NEK2_1	594	599	PF00069	0.374
MOD_NEK2_1	624	629	PF00069	0.402
MOD_NEK2_1	639	644	PF00069	0.337
MOD_NEK2_1	714	719	PF00069	0.455
MOD_NEK2_1	758	763	PF00069	0.411
MOD_NEK2_1	80	85	PF00069	0.459
MOD_NEK2_1	838	843	PF00069	0.397
MOD_NEK2_1	846	851	PF00069	0.370
MOD_NEK2_1	859	864	PF00069	0.264
MOD_NEK2_1	948	953	PF00069	0.518
MOD_NEK2_1	962	967	PF00069	0.501
MOD_NEK2_1	983	988	PF00069	0.466
MOD_NEK2_2	19	24	PF00069	0.470
MOD_NEK2_2	255	260	PF00069	0.238
MOD_PIKK_1	1089	1095	PF00454	0.540
MOD_PIKK_1	236	242	PF00454	0.442
MOD_PIKK_1	928	934	PF00454	0.473
MOD_PK_1	143	149	PF00069	0.467
MOD_PK_1	490	496	PF00069	0.545
MOD_PKA_1	143	149	PF00069	0.419
MOD_PKA_1	813	819	PF00069	0.389
MOD_PKA_2	1094	1100	PF00069	0.596
MOD_PKA_2	1114	1120	PF00069	0.586
MOD_PKA_2	236	242	PF00069	0.359
MOD_PKA_2	28	34	PF00069	0.349
MOD_PKA_2	410	416	PF00069	0.448
MOD_PKA_2	44	50	PF00069	0.403
MOD_PKA_2	813	819	PF00069	0.485
MOD_PKA_2	907	913	PF00069	0.500
MOD_PKA_2	928	934	PF00069	0.528
MOD_PKA_2	969	975	PF00069	0.374
MOD_Plk_1	1013	1019	PF00069	0.310
MOD_Plk_1	1050	1056	PF00069	0.517
MOD_Plk_1	1089	1095	PF00069	0.540
MOD_Plk_1	398	404	PF00069	0.320
MOD_Plk_1	518	524	PF00069	0.417
MOD_Plk_1	531	537	PF00069	0.313
MOD_Plk_1	559	565	PF00069	0.289
MOD_Plk_1	614	620	PF00069	0.450
MOD_Plk_1	624	630	PF00069	0.405
MOD_Plk_1	660	666	PF00069	0.457
MOD_Plk_1	679	685	PF00069	0.383
MOD_Plk_1	692	698	PF00069	0.450
MOD_Plk_1	776	782	PF00069	0.385
MOD_Plk_1	794	800	PF00069	0.393
MOD_Plk_1	834	840	PF00069	0.498
MOD_Plk_1	98	104	PF00069	0.396
MOD_Plk_1	984	990	PF00069	0.417
MOD_Plk_2-3	559	565	PF00069	0.440
MOD_Plk_4	1062	1068	PF00069	0.479
MOD_Plk_4	19	25	PF00069	0.469
MOD_Plk_4	255	261	PF00069	0.463
MOD_Plk_4	369	375	PF00069	0.392
MOD_Plk_4	379	385	PF00069	0.391
MOD_Plk_4	479	485	PF00069	0.418
MOD_Plk_4	518	524	PF00069	0.500
MOD_Plk_4	548	554	PF00069	0.370
MOD_Plk_4	614	620	PF00069	0.461
MOD_Plk_4	685	691	PF00069	0.470
MOD_Plk_4	777	783	PF00069	0.467
MOD_Plk_4	794	800	PF00069	0.442
MOD_Plk_4	846	852	PF00069	0.397
MOD_Plk_4	880	886	PF00069	0.403
MOD_ProDKin_1	1069	1075	PF00069	0.524
MOD_ProDKin_1	309	315	PF00069	0.504
MOD_ProDKin_1	468	474	PF00069	0.528
MOD_ProDKin_1	668	674	PF00069	0.588
MOD_ProDKin_1	85	91	PF00069	0.432
MOD_SUMO_for_1	622	625	PF00179	0.432
MOD_SUMO_rev_2	1112	1122	PF00179	0.646
MOD_SUMO_rev_2	615	624	PF00179	0.430
TRG_DiLeu_BaEn_1	794	799	PF01217	0.423
TRG_DiLeu_BaEn_2	202	208	PF01217	0.377
TRG_DiLeu_BaEn_2	973	979	PF01217	0.287
TRG_DiLeu_BaEn_3	776	782	PF01217	0.394
TRG_DiLeu_BaEn_4	974	980	PF01217	0.477
TRG_DiLeu_BaLyEn_6	493	498	PF01217	0.503
TRG_ENDOCYTIC_2	1036	1039	PF00928	0.392
TRG_ENDOCYTIC_2	1074	1077	PF00928	0.593
TRG_ENDOCYTIC_2	197	200	PF00928	0.439
TRG_ENDOCYTIC_2	315	318	PF00928	0.462
TRG_ENDOCYTIC_2	654	657	PF00928	0.459
TRG_ER_diArg_1	43	46	PF00400	0.431
TRG_ER_diArg_1	489	492	PF00400	0.455
TRG_ER_diArg_1	535	537	PF00400	0.278
TRG_ER_diArg_1	626	629	PF00400	0.491
TRG_ER_FFAT_2	442	454	PF00635	0.276
TRG_NES_CRM1_1	1058	1071	PF08389	0.423
TRG_NES_CRM1_1	199	212	PF08389	0.480
TRG_NLS_MonoExtN_4	40	46	PF00514	0.445
TRG_Pf-PMV_PEXEL_1	561	565	PF00026	0.229
TRG_Pf-PMV_PEXEL_1	751	755	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	773	777	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFA2	Leptomonas seymouri	54%	100%
A0A0S4JML5	Bodo saltans	30%	100%
A0A1X0P080	Trypanosomatidae	37%	100%
A0A3Q8IWA4	Leishmania donovani	92%	100%
A0A422MVT9	Trypanosoma rangeli	35%	100%
A4HPU2	Leishmania braziliensis	73%	100%
A4IE50	Leishmania infantum	92%	100%
D0A481	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ATK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DLP2	Trypanosoma cruzi	36%	100%