WD domain, G-beta repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0Z0_LEIMA

TriTrypDb:

LmjF.36.4240 , LMJLV39_360053600 , LMJSD75_360053500

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Z0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.614
CLV_C14_Caspase3-7	568	572	PF00656	0.465
CLV_NRD_NRD_1	184	186	PF00675	0.785
CLV_NRD_NRD_1	419	421	PF00675	0.591
CLV_NRD_NRD_1	507	509	PF00675	0.463
CLV_NRD_NRD_1	541	543	PF00675	0.514
CLV_NRD_NRD_1	58	60	PF00675	0.501
CLV_PCSK_KEX2_1	184	186	PF00082	0.785
CLV_PCSK_KEX2_1	237	239	PF00082	0.435
CLV_PCSK_KEX2_1	419	421	PF00082	0.591
CLV_PCSK_KEX2_1	507	509	PF00082	0.463
CLV_PCSK_KEX2_1	58	60	PF00082	0.501
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.435
CLV_PCSK_SKI1_1	489	493	PF00082	0.469
CLV_PCSK_SKI1_1	507	511	PF00082	0.261
CLV_PCSK_SKI1_1	631	635	PF00082	0.528
DEG_APCC_DBOX_1	686	694	PF00400	0.482
DEG_SCF_FBW7_1	655	660	PF00400	0.548
DEG_SPOP_SBC_1	324	328	PF00917	0.667
DEG_SPOP_SBC_1	408	412	PF00917	0.515
DEG_SPOP_SBC_1	657	661	PF00917	0.666
DOC_MAPK_gen_1	542	550	PF00069	0.454
DOC_MAPK_gen_1	58	64	PF00069	0.483
DOC_MAPK_MEF2A_6	251	259	PF00069	0.503
DOC_MAPK_MEF2A_6	431	440	PF00069	0.471
DOC_MAPK_MEF2A_6	687	694	PF00069	0.489
DOC_MAPK_NFAT4_5	687	695	PF00069	0.493
DOC_PP1_RVXF_1	58	65	PF00149	0.483
DOC_PP2B_LxvP_1	259	262	PF13499	0.477
DOC_PP2B_LxvP_1	284	287	PF13499	0.474
DOC_USP7_MATH_1	150	154	PF00917	0.706
DOC_USP7_MATH_1	156	160	PF00917	0.630
DOC_USP7_MATH_1	187	191	PF00917	0.793
DOC_USP7_MATH_1	268	272	PF00917	0.478
DOC_USP7_MATH_1	287	291	PF00917	0.323
DOC_USP7_MATH_1	324	328	PF00917	0.716
DOC_USP7_MATH_1	382	386	PF00917	0.643
DOC_USP7_MATH_1	450	454	PF00917	0.458
DOC_USP7_MATH_1	479	483	PF00917	0.636
DOC_USP7_MATH_1	5	9	PF00917	0.526
DOC_USP7_MATH_1	511	515	PF00917	0.444
DOC_USP7_MATH_1	627	631	PF00917	0.664
DOC_USP7_MATH_1	657	661	PF00917	0.783
DOC_USP7_MATH_1	675	679	PF00917	0.271
DOC_USP7_MATH_2	268	274	PF00917	0.487
DOC_USP7_UBL2_3	365	369	PF12436	0.570
DOC_WW_Pin1_4	124	129	PF00397	0.620
DOC_WW_Pin1_4	212	217	PF00397	0.600
DOC_WW_Pin1_4	244	249	PF00397	0.557
DOC_WW_Pin1_4	380	385	PF00397	0.574
DOC_WW_Pin1_4	641	646	PF00397	0.677
DOC_WW_Pin1_4	651	656	PF00397	0.581
DOC_WW_Pin1_4	7	12	PF00397	0.407
LIG_14-3-3_CanoR_1	167	175	PF00244	0.625
LIG_14-3-3_CanoR_1	189	199	PF00244	0.584
LIG_14-3-3_CanoR_1	308	315	PF00244	0.618
LIG_14-3-3_CanoR_1	325	333	PF00244	0.573
LIG_14-3-3_CanoR_1	419	425	PF00244	0.608
LIG_14-3-3_CanoR_1	437	441	PF00244	0.284
LIG_14-3-3_CanoR_1	59	65	PF00244	0.482
LIG_14-3-3_CanoR_1	84	94	PF00244	0.538
LIG_Actin_WH2_2	528	544	PF00022	0.426
LIG_BIR_III_4	45	49	PF00653	0.447
LIG_BRCT_BRCA1_1	116	120	PF00533	0.451
LIG_BRCT_BRCA1_1	23	27	PF00533	0.421
LIG_BRCT_BRCA1_1	37	41	PF00533	0.368
LIG_BRCT_BRCA1_1	384	388	PF00533	0.652
LIG_BRCT_BRCA1_1	412	416	PF00533	0.556
LIG_CtBP_PxDLS_1	122	126	PF00389	0.535
LIG_EH_1	276	280	PF12763	0.417
LIG_FHA_1	101	107	PF00498	0.554
LIG_FHA_1	17	23	PF00498	0.326
LIG_FHA_1	186	192	PF00498	0.705
LIG_FHA_1	199	205	PF00498	0.526
LIG_FHA_1	561	567	PF00498	0.513
LIG_FHA_1	680	686	PF00498	0.431
LIG_FHA_1	87	93	PF00498	0.545
LIG_FHA_2	293	299	PF00498	0.478
LIG_FHA_2	582	588	PF00498	0.475
LIG_FHA_2	695	701	PF00498	0.457
LIG_FHA_2	86	92	PF00498	0.525
LIG_LIR_Apic_2	169	175	PF02991	0.695
LIG_LIR_Apic_2	298	304	PF02991	0.532
LIG_LIR_Gen_1	280	287	PF02991	0.487
LIG_LIR_Gen_1	63	70	PF02991	0.467
LIG_LIR_LC3C_4	689	694	PF02991	0.499
LIG_LIR_Nem_3	117	123	PF02991	0.464
LIG_LIR_Nem_3	280	286	PF02991	0.531
LIG_LIR_Nem_3	63	67	PF02991	0.464
LIG_RPA_C_Fungi	350	362	PF08784	0.489
LIG_SH2_PTP2	404	407	PF00017	0.493
LIG_SH2_SRC	404	407	PF00017	0.541
LIG_SH2_STAP1	521	525	PF00017	0.475
LIG_SH2_STAT3	611	614	PF00017	0.504
LIG_SH2_STAT5	223	226	PF00017	0.464
LIG_SH2_STAT5	232	235	PF00017	0.437
LIG_SH2_STAT5	283	286	PF00017	0.477
LIG_SH2_STAT5	404	407	PF00017	0.614
LIG_SH2_STAT5	650	653	PF00017	0.658
LIG_SH2_STAT5	672	675	PF00017	0.431
LIG_SH3_3	172	178	PF00018	0.728
LIG_SH3_3	602	608	PF00018	0.588
LIG_SUMO_SIM_par_1	121	127	PF11976	0.539
LIG_SUMO_SIM_par_1	254	260	PF11976	0.485
LIG_SUMO_SIM_par_1	48	54	PF11976	0.293
LIG_SUMO_SIM_par_1	573	579	PF11976	0.482
LIG_TRAF2_1	357	360	PF00917	0.548
LIG_TRAF2_1	665	668	PF00917	0.629
LIG_WRC_WIRS_1	421	426	PF05994	0.474
LIG_WRC_WIRS_1	61	66	PF05994	0.467
MOD_CDC14_SPxK_1	644	647	PF00782	0.689
MOD_CDK_SPxK_1	641	647	PF00069	0.690
MOD_CDK_SPxxK_3	244	251	PF00069	0.554
MOD_CK1_1	114	120	PF00069	0.513
MOD_CK1_1	124	130	PF00069	0.529
MOD_CK1_1	190	196	PF00069	0.796
MOD_CK1_1	197	203	PF00069	0.682
MOD_CK1_1	247	253	PF00069	0.590
MOD_CK1_1	374	380	PF00069	0.686
MOD_CK1_1	391	397	PF00069	0.442
MOD_CK1_1	414	420	PF00069	0.486
MOD_CK1_1	576	582	PF00069	0.508
MOD_CK1_1	65	71	PF00069	0.530
MOD_CK1_1	660	666	PF00069	0.632
MOD_CK2_1	145	151	PF00069	0.634
MOD_CK2_1	287	293	PF00069	0.493
MOD_CK2_1	308	314	PF00069	0.593
MOD_CK2_1	329	335	PF00069	0.569
MOD_CK2_1	391	397	PF00069	0.654
MOD_CK2_1	581	587	PF00069	0.428
MOD_CK2_1	694	700	PF00069	0.458
MOD_Cter_Amidation	505	508	PF01082	0.489
MOD_GlcNHglycan	154	157	PF01048	0.713
MOD_GlcNHglycan	158	161	PF01048	0.697
MOD_GlcNHglycan	206	209	PF01048	0.679
MOD_GlcNHglycan	289	292	PF01048	0.481
MOD_GlcNHglycan	305	308	PF01048	0.502
MOD_GlcNHglycan	327	330	PF01048	0.692
MOD_GlcNHglycan	343	346	PF01048	0.447
MOD_GlcNHglycan	373	376	PF01048	0.647
MOD_GlcNHglycan	384	387	PF01048	0.622
MOD_GlcNHglycan	42	45	PF01048	0.426
MOD_GlcNHglycan	424	427	PF01048	0.439
MOD_GlcNHglycan	452	455	PF01048	0.458
MOD_GlcNHglycan	497	500	PF01048	0.442
MOD_GlcNHglycan	504	507	PF01048	0.413
MOD_GlcNHglycan	522	526	PF01048	0.300
MOD_GlcNHglycan	64	67	PF01048	0.460
MOD_GlcNHglycan	660	663	PF01048	0.704
MOD_GlcNHglycan	675	678	PF01048	0.354
MOD_GSK3_1	1	8	PF00069	0.604
MOD_GSK3_1	124	131	PF00069	0.551
MOD_GSK3_1	152	159	PF00069	0.625
MOD_GSK3_1	163	170	PF00069	0.546
MOD_GSK3_1	185	192	PF00069	0.653
MOD_GSK3_1	194	201	PF00069	0.561
MOD_GSK3_1	212	219	PF00069	0.516
MOD_GSK3_1	23	30	PF00069	0.378
MOD_GSK3_1	243	250	PF00069	0.567
MOD_GSK3_1	303	310	PF00069	0.610
MOD_GSK3_1	325	332	PF00069	0.572
MOD_GSK3_1	36	43	PF00069	0.438
MOD_GSK3_1	367	374	PF00069	0.677
MOD_GSK3_1	407	414	PF00069	0.524
MOD_GSK3_1	422	429	PF00069	0.485
MOD_GSK3_1	627	634	PF00069	0.581
MOD_GSK3_1	653	660	PF00069	0.665
MOD_GSK3_1	675	682	PF00069	0.343
MOD_N-GLC_1	329	334	PF02516	0.609
MOD_N-GLC_1	341	346	PF02516	0.534
MOD_N-GLC_1	414	419	PF02516	0.523
MOD_N-GLC_1	489	494	PF02516	0.462
MOD_NEK2_1	100	105	PF00069	0.517
MOD_NEK2_1	123	128	PF00069	0.579
MOD_NEK2_1	180	185	PF00069	0.721
MOD_NEK2_1	23	28	PF00069	0.312
MOD_NEK2_1	279	284	PF00069	0.517
MOD_NEK2_1	436	441	PF00069	0.456
MOD_NEK2_1	495	500	PF00069	0.449
MOD_NEK2_1	535	540	PF00069	0.474
MOD_NEK2_1	646	651	PF00069	0.638
MOD_NEK2_1	673	678	PF00069	0.421
MOD_NEK2_2	329	334	PF00069	0.568
MOD_NEK2_2	537	542	PF00069	0.474
MOD_NEK2_2	544	549	PF00069	0.365
MOD_NEK2_2	560	565	PF00069	0.286
MOD_PIKK_1	109	115	PF00454	0.466
MOD_PIKK_1	631	637	PF00454	0.734
MOD_PIKK_1	75	81	PF00454	0.599
MOD_PK_1	573	579	PF00069	0.482
MOD_PKA_2	145	151	PF00069	0.688
MOD_PKA_2	166	172	PF00069	0.626
MOD_PKA_2	180	186	PF00069	0.718
MOD_PKA_2	307	313	PF00069	0.653
MOD_PKA_2	324	330	PF00069	0.584
MOD_PKA_2	371	377	PF00069	0.744
MOD_PKA_2	397	403	PF00069	0.566
MOD_PKA_2	436	442	PF00069	0.486
MOD_PKA_2	581	587	PF00069	0.476
MOD_PKA_2	646	652	PF00069	0.662
MOD_PKA_2	83	89	PF00069	0.516
MOD_PKB_1	420	428	PF00069	0.338
MOD_PKB_1	487	495	PF00069	0.394
MOD_PKB_1	82	90	PF00069	0.514
MOD_Plk_1	292	298	PF00069	0.477
MOD_Plk_1	329	335	PF00069	0.567
MOD_Plk_1	35	41	PF00069	0.509
MOD_Plk_1	414	420	PF00069	0.523
MOD_Plk_1	5	11	PF00069	0.578
MOD_Plk_1	560	566	PF00069	0.447
MOD_Plk_4	111	117	PF00069	0.557
MOD_Plk_4	23	29	PF00069	0.360
MOD_Plk_4	292	298	PF00069	0.477
MOD_Plk_4	329	335	PF00069	0.567
MOD_Plk_4	36	42	PF00069	0.445
MOD_Plk_4	388	394	PF00069	0.651
MOD_Plk_4	397	403	PF00069	0.496
MOD_Plk_4	544	550	PF00069	0.437
MOD_Plk_4	573	579	PF00069	0.584
MOD_Plk_4	646	652	PF00069	0.658
MOD_ProDKin_1	124	130	PF00069	0.628
MOD_ProDKin_1	212	218	PF00069	0.586
MOD_ProDKin_1	244	250	PF00069	0.560
MOD_ProDKin_1	380	386	PF00069	0.572
MOD_ProDKin_1	641	647	PF00069	0.680
MOD_ProDKin_1	651	657	PF00069	0.596
MOD_ProDKin_1	7	13	PF00069	0.397
MOD_SUMO_rev_2	311	320	PF00179	0.667
TRG_DiLeu_BaEn_1	95	100	PF01217	0.613
TRG_DiLeu_BaEn_2	36	42	PF01217	0.484
TRG_ENDOCYTIC_2	283	286	PF00928	0.477
TRG_ER_diArg_1	177	180	PF00400	0.776
TRG_ER_diArg_1	418	420	PF00400	0.518
TRG_ER_diArg_1	507	509	PF00400	0.463
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGF7	Leishmania donovani	89%	100%
A4HPU3	Leishmania braziliensis	73%	100%
E9AHX8	Leishmania infantum	89%	100%
E9ATK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%