Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0Y8_LEIMA

TriTrypDb:

LmjF.36.4260 , LMJLV39_360053800 , LMJSD75_360053700

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Y8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.530
CLV_NRD_NRD_1	197	199	PF00675	0.514
CLV_NRD_NRD_1	309	311	PF00675	0.420
CLV_NRD_NRD_1	332	334	PF00675	0.424
CLV_NRD_NRD_1	339	341	PF00675	0.418
CLV_NRD_NRD_1	355	357	PF00675	0.442
CLV_NRD_NRD_1	36	38	PF00675	0.578
CLV_NRD_NRD_1	405	407	PF00675	0.493
CLV_NRD_NRD_1	52	54	PF00675	0.559
CLV_NRD_NRD_1	90	92	PF00675	0.730
CLV_PCSK_KEX2_1	197	199	PF00082	0.514
CLV_PCSK_KEX2_1	309	311	PF00082	0.439
CLV_PCSK_KEX2_1	332	334	PF00082	0.419
CLV_PCSK_KEX2_1	35	37	PF00082	0.738
CLV_PCSK_KEX2_1	355	357	PF00082	0.468
CLV_PCSK_KEX2_1	405	407	PF00082	0.476
CLV_PCSK_KEX2_1	52	54	PF00082	0.559
CLV_PCSK_KEX2_1	90	92	PF00082	0.670
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.729
CLV_PCSK_SKI1_1	127	131	PF00082	0.470
CLV_PCSK_SKI1_1	187	191	PF00082	0.439
CLV_PCSK_SKI1_1	197	201	PF00082	0.423
CLV_PCSK_SKI1_1	260	264	PF00082	0.435
DEG_APCC_DBOX_1	126	134	PF00400	0.447
DEG_MDM2_SWIB_1	211	219	PF02201	0.388
DEG_Nend_UBRbox_3	1	3	PF02207	0.635
DOC_CKS1_1	22	27	PF01111	0.621
DOC_CYCLIN_RxL_1	172	183	PF00134	0.398
DOC_CYCLIN_RxL_1	254	265	PF00134	0.444
DOC_MAPK_gen_1	338	348	PF00069	0.432
DOC_MAPK_gen_1	366	374	PF00069	0.436
DOC_MAPK_MEF2A_6	340	348	PF00069	0.424
DOC_USP7_MATH_1	102	106	PF00917	0.599
DOC_USP7_MATH_1	11	15	PF00917	0.684
DOC_USP7_MATH_1	129	133	PF00917	0.513
DOC_USP7_MATH_1	302	306	PF00917	0.522
DOC_USP7_MATH_1	354	358	PF00917	0.457
DOC_USP7_MATH_1	421	425	PF00917	0.643
DOC_USP7_MATH_1	60	64	PF00917	0.757
DOC_WW_Pin1_4	21	26	PF00397	0.709
DOC_WW_Pin1_4	414	419	PF00397	0.494
DOC_WW_Pin1_4	46	51	PF00397	0.553
LIG_14-3-3_CanoR_1	187	194	PF00244	0.515
LIG_14-3-3_CanoR_1	21	25	PF00244	0.744
LIG_14-3-3_CanoR_1	257	263	PF00244	0.516
LIG_14-3-3_CanoR_1	303	307	PF00244	0.511
LIG_14-3-3_CanoR_1	355	359	PF00244	0.533
LIG_Actin_WH2_2	241	259	PF00022	0.481
LIG_AP_GAE_1	116	122	PF02883	0.596
LIG_BIR_III_2	93	97	PF00653	0.538
LIG_BRCT_BRCA1_1	395	399	PF00533	0.483
LIG_eIF4E_1	164	170	PF01652	0.405
LIG_FHA_1	2	8	PF00498	0.675
LIG_FHA_1	25	31	PF00498	0.634
LIG_FHA_1	367	373	PF00498	0.417
LIG_FHA_1	385	391	PF00498	0.331
LIG_FHA_2	133	139	PF00498	0.657
LIG_FHA_2	154	160	PF00498	0.484
LIG_FHA_2	325	331	PF00498	0.465
LIG_Integrin_RGD_1	85	87	PF01839	0.744
LIG_Integrin_RGD_1	91	93	PF01839	0.657
LIG_LIR_Gen_1	116	126	PF02991	0.462
LIG_LIR_Nem_3	116	122	PF02991	0.475
LIG_LIR_Nem_3	207	211	PF02991	0.400
LIG_NRBOX	343	349	PF00104	0.425
LIG_Pex14_2	211	215	PF04695	0.383
LIG_SH2_GRB2like	351	354	PF00017	0.412
LIG_SH2_SRC	351	354	PF00017	0.437
LIG_SH2_STAP1	258	262	PF00017	0.470
LIG_SH2_STAP1	409	413	PF00017	0.518
LIG_SH2_STAT3	168	171	PF00017	0.518
LIG_SH2_STAT3	339	342	PF00017	0.511
LIG_SH2_STAT5	168	171	PF00017	0.426
LIG_SH2_STAT5	278	281	PF00017	0.546
LIG_SH2_STAT5	335	338	PF00017	0.496
LIG_SH2_STAT5	351	354	PF00017	0.330
LIG_SH3_1	52	58	PF00018	0.523
LIG_SH3_3	104	110	PF00018	0.706
LIG_SH3_3	27	33	PF00018	0.654
LIG_SH3_3	52	58	PF00018	0.536
LIG_SUMO_SIM_anti_2	230	235	PF11976	0.525
LIG_SUMO_SIM_anti_2	343	348	PF11976	0.396
LIG_TRAF2_1	221	224	PF00917	0.435
MOD_CDC14_SPxK_1	49	52	PF00782	0.547
MOD_CDK_SPxK_1	46	52	PF00069	0.553
MOD_CDK_SPxxK_3	46	53	PF00069	0.556
MOD_CK1_1	132	138	PF00069	0.557
MOD_CK1_1	153	159	PF00069	0.504
MOD_CK1_1	20	26	PF00069	0.691
MOD_CK1_1	3	9	PF00069	0.731
MOD_CK1_1	357	363	PF00069	0.539
MOD_CK1_1	384	390	PF00069	0.473
MOD_CK1_1	393	399	PF00069	0.512
MOD_CK1_1	63	69	PF00069	0.619
MOD_CK2_1	132	138	PF00069	0.594
MOD_CK2_1	153	159	PF00069	0.525
MOD_CK2_1	258	264	PF00069	0.505
MOD_CK2_1	302	308	PF00069	0.537
MOD_CK2_1	324	330	PF00069	0.476
MOD_GlcNHglycan	383	387	PF01048	0.509
MOD_GlcNHglycan	392	395	PF01048	0.504
MOD_GlcNHglycan	421	424	PF01048	0.698
MOD_GlcNHglycan	427	431	PF01048	0.662
MOD_GlcNHglycan	66	69	PF01048	0.766
MOD_GlcNHglycan	7	10	PF01048	0.598
MOD_GSK3_1	1	8	PF00069	0.744
MOD_GSK3_1	17	24	PF00069	0.706
MOD_GSK3_1	258	265	PF00069	0.434
MOD_GSK3_1	324	331	PF00069	0.524
MOD_GSK3_1	60	67	PF00069	0.764
MOD_LATS_1	185	191	PF00433	0.438
MOD_N-GLC_1	1	6	PF02516	0.623
MOD_N-GLC_1	366	371	PF02516	0.495
MOD_NEK2_1	1	6	PF00069	0.658
MOD_NEK2_1	211	216	PF00069	0.506
MOD_NEK2_1	256	261	PF00069	0.520
MOD_NEK2_1	262	267	PF00069	0.444
MOD_NEK2_1	390	395	PF00069	0.522
MOD_NEK2_1	71	76	PF00069	0.721
MOD_NEK2_2	302	307	PF00069	0.514
MOD_NEK2_2	421	426	PF00069	0.600
MOD_PIKK_1	357	363	PF00454	0.531
MOD_PKA_2	20	26	PF00069	0.739
MOD_PKA_2	256	262	PF00069	0.519
MOD_PKA_2	302	308	PF00069	0.518
MOD_PKA_2	354	360	PF00069	0.537
MOD_Plk_4	26	32	PF00069	0.755
MOD_Plk_4	302	308	PF00069	0.518
MOD_Plk_4	368	374	PF00069	0.434
MOD_Plk_4	398	404	PF00069	0.578
MOD_ProDKin_1	21	27	PF00069	0.708
MOD_ProDKin_1	414	420	PF00069	0.495
MOD_ProDKin_1	46	52	PF00069	0.553
TRG_DiLeu_BaEn_1	343	348	PF01217	0.421
TRG_DiLeu_BaEn_4	195	201	PF01217	0.516
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.584
TRG_ER_diArg_1	125	128	PF00400	0.538
TRG_ER_diArg_1	197	199	PF00400	0.559
TRG_ER_diArg_1	332	334	PF00400	0.427
TRG_NLS_MonoExtN_4	33	39	PF00514	0.527
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	332	337	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J8	Leptomonas seymouri	67%	100%
A0A0S4JG62	Bodo saltans	51%	100%
A0A1X0P1T1	Trypanosomatidae	54%	100%
A0A3Q8ILB9	Leishmania donovani	93%	100%
A0A422P583	Trypanosoma rangeli	56%	100%
A4HPU5	Leishmania braziliensis	79%	100%
A4IE48	Leishmania infantum	94%	100%
E9ATL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BQ98	Trypanosoma cruzi	58%	100%