TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0Y6_LEIMA

TriTrypDb:

LmjF.36.4280 , LMJLV39_360054000 , LMJSD75_360053900

Length:

824

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	2
GO:0005681	spliceosomal complex	3	2
GO:0005684	U2-type spliceosomal complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0071007	U2-type catalytic step 2 spliceosome	4	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0071014	post-mRNA release spliceosomal complex	4	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q0Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Y6

Function

Biological processes
Term	Name	Level	Count
GO:0000245	spliceosomal complex assembly	7	2
GO:0000375	RNA splicing, via transesterification reactions	8	12
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	12
GO:0000398	mRNA splicing, via spliceosome	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008380	RNA splicing	7	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	2
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0065003	protein-containing complex assembly	5	2
GO:0071704	organic substance metabolic process	2	12
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.697
CLV_C14_Caspase3-7	606	610	PF00656	0.426
CLV_NRD_NRD_1	20	22	PF00675	0.591
CLV_NRD_NRD_1	207	209	PF00675	0.556
CLV_NRD_NRD_1	217	219	PF00675	0.442
CLV_NRD_NRD_1	445	447	PF00675	0.551
CLV_NRD_NRD_1	483	485	PF00675	0.465
CLV_NRD_NRD_1	621	623	PF00675	0.462
CLV_NRD_NRD_1	632	634	PF00675	0.565
CLV_NRD_NRD_1	758	760	PF00675	0.535
CLV_NRD_NRD_1	76	78	PF00675	0.500
CLV_NRD_NRD_1	815	817	PF00675	0.555
CLV_NRD_NRD_1	85	87	PF00675	0.521
CLV_NRD_NRD_1	9	11	PF00675	0.603
CLV_PCSK_FUR_1	73	77	PF00082	0.480
CLV_PCSK_KEX2_1	19	21	PF00082	0.577
CLV_PCSK_KEX2_1	2	4	PF00082	0.617
CLV_PCSK_KEX2_1	207	209	PF00082	0.556
CLV_PCSK_KEX2_1	217	219	PF00082	0.442
CLV_PCSK_KEX2_1	445	447	PF00082	0.551
CLV_PCSK_KEX2_1	483	485	PF00082	0.541
CLV_PCSK_KEX2_1	621	623	PF00082	0.446
CLV_PCSK_KEX2_1	632	634	PF00082	0.558
CLV_PCSK_KEX2_1	75	77	PF00082	0.477
CLV_PCSK_KEX2_1	758	760	PF00082	0.569
CLV_PCSK_KEX2_1	814	816	PF00082	0.552
CLV_PCSK_KEX2_1	85	87	PF00082	0.401
CLV_PCSK_KEX2_1	9	11	PF00082	0.591
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.617
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.477
CLV_PCSK_PC1ET2_1	814	816	PF00082	0.578
CLV_PCSK_PC7_1	213	219	PF00082	0.431
CLV_PCSK_PC7_1	5	11	PF00082	0.677
CLV_PCSK_PC7_1	628	634	PF00082	0.532
CLV_PCSK_PC7_1	754	760	PF00082	0.566
CLV_PCSK_SKI1_1	150	154	PF00082	0.411
CLV_PCSK_SKI1_1	179	183	PF00082	0.390
CLV_PCSK_SKI1_1	213	217	PF00082	0.433
CLV_PCSK_SKI1_1	288	292	PF00082	0.513
CLV_PCSK_SKI1_1	330	334	PF00082	0.315
CLV_PCSK_SKI1_1	404	408	PF00082	0.523
CLV_PCSK_SKI1_1	424	428	PF00082	0.198
CLV_PCSK_SKI1_1	483	487	PF00082	0.452
CLV_PCSK_SKI1_1	563	567	PF00082	0.464
CLV_PCSK_SKI1_1	743	747	PF00082	0.415
CLV_PCSK_SKI1_1	811	815	PF00082	0.593
CLV_PCSK_SKI1_1	818	822	PF00082	0.595
CLV_PCSK_SKI1_1	86	90	PF00082	0.548
CLV_Separin_Metazoa	573	577	PF03568	0.549
DEG_APCC_DBOX_1	742	750	PF00400	0.529
DEG_Nend_UBRbox_1	1	4	PF02207	0.624
DOC_ANK_TNKS_1	316	323	PF00023	0.518
DOC_CKS1_1	223	228	PF01111	0.498
DOC_CYCLIN_RxL_1	480	490	PF00134	0.536
DOC_MAPK_gen_1	775	784	PF00069	0.501
DOC_PP1_RVXF_1	757	764	PF00149	0.607
DOC_PP2B_LxvP_1	411	414	PF13499	0.579
DOC_PP4_FxxP_1	223	226	PF00568	0.499
DOC_PP4_FxxP_1	49	52	PF00568	0.654
DOC_USP7_MATH_1	154	158	PF00917	0.430
DOC_USP7_MATH_1	369	373	PF00917	0.674
DOC_USP7_MATH_1	400	404	PF00917	0.513
DOC_USP7_MATH_1	52	56	PF00917	0.673
DOC_WW_Pin1_4	222	227	PF00397	0.513
DOC_WW_Pin1_4	398	403	PF00397	0.592
DOC_WW_Pin1_4	48	53	PF00397	0.623
DOC_WW_Pin1_4	522	527	PF00397	0.596
DOC_WW_Pin1_4	702	707	PF00397	0.501
DOC_WW_Pin1_4	782	787	PF00397	0.381
LIG_14-3-3_CanoR_1	150	159	PF00244	0.476
LIG_14-3-3_CanoR_1	342	352	PF00244	0.556
LIG_14-3-3_CanoR_1	445	449	PF00244	0.568
LIG_14-3-3_CanoR_1	475	485	PF00244	0.466
LIG_14-3-3_CanoR_1	594	599	PF00244	0.449
LIG_14-3-3_CanoR_1	710	718	PF00244	0.520
LIG_14-3-3_CanoR_1	758	762	PF00244	0.592
LIG_APCC_ABBA_1	118	123	PF00400	0.539
LIG_APCC_ABBA_1	334	339	PF00400	0.511
LIG_APCC_ABBAyCdc20_2	20	26	PF00400	0.576
LIG_BIR_III_2	189	193	PF00653	0.547
LIG_BRCT_BRCA1_1	136	140	PF00533	0.568
LIG_BRCT_BRCA1_1	677	681	PF00533	0.555
LIG_deltaCOP1_diTrp_1	789	794	PF00928	0.519
LIG_FHA_1	331	337	PF00498	0.470
LIG_FHA_1	737	743	PF00498	0.501
LIG_FHA_2	585	591	PF00498	0.501
LIG_FHA_2	766	772	PF00498	0.595
LIG_GBD_Chelix_1	328	336	PF00786	0.312
LIG_LIR_Apic_2	221	226	PF02991	0.513
LIG_LIR_Gen_1	106	114	PF02991	0.434
LIG_LIR_Gen_1	130	136	PF02991	0.395
LIG_LIR_Gen_1	311	319	PF02991	0.431
LIG_LIR_Gen_1	349	358	PF02991	0.429
LIG_LIR_Gen_1	767	776	PF02991	0.483
LIG_LIR_Gen_1	789	796	PF02991	0.508
LIG_LIR_Nem_3	130	134	PF02991	0.380
LIG_LIR_Nem_3	160	165	PF02991	0.373
LIG_LIR_Nem_3	228	232	PF02991	0.380
LIG_LIR_Nem_3	311	315	PF02991	0.406
LIG_LIR_Nem_3	345	351	PF02991	0.429
LIG_LIR_Nem_3	353	358	PF02991	0.375
LIG_LIR_Nem_3	664	669	PF02991	0.367
LIG_LIR_Nem_3	767	773	PF02991	0.497
LIG_LIR_Nem_3	778	782	PF02991	0.412
LIG_LIR_Nem_3	789	794	PF02991	0.364
LIG_LRP6_Inhibitor_1	90	96	PF00058	0.503
LIG_LYPXL_S_1	657	661	PF13949	0.278
LIG_MLH1_MIPbox_1	677	681	PF16413	0.555
LIG_PCNA_PIPBox_1	33	42	PF02747	0.612
LIG_PCNA_PIPBox_1	651	660	PF02747	0.497
LIG_PCNA_yPIPBox_3	28	40	PF02747	0.632
LIG_PCNA_yPIPBox_3	644	658	PF02747	0.512
LIG_Pex14_1	560	564	PF04695	0.452
LIG_Pex14_1	676	680	PF04695	0.518
LIG_Pex14_2	556	560	PF04695	0.413
LIG_Pex14_2	677	681	PF04695	0.555
LIG_PTB_Apo_2	451	458	PF02174	0.523
LIG_RPA_C_Fungi	617	629	PF08784	0.551
LIG_RPA_C_Fungi	639	651	PF08784	0.350
LIG_SH2_CRK	602	606	PF00017	0.497
LIG_SH2_GRB2like	547	550	PF00017	0.490
LIG_SH2_NCK_1	196	200	PF00017	0.484
LIG_SH2_SRC	547	550	PF00017	0.490
LIG_SH2_STAP1	196	200	PF00017	0.489
LIG_SH2_STAP1	337	341	PF00017	0.469
LIG_SH2_STAT3	202	205	PF00017	0.505
LIG_SH2_STAT3	358	361	PF00017	0.493
LIG_SH2_STAT3	419	422	PF00017	0.530
LIG_SH2_STAT5	165	168	PF00017	0.368
LIG_SH2_STAT5	351	354	PF00017	0.399
LIG_SH2_STAT5	539	542	PF00017	0.513
LIG_SH2_STAT5	680	683	PF00017	0.516
LIG_SUMO_SIM_par_1	270	276	PF11976	0.463
LIG_SUMO_SIM_par_1	300	306	PF11976	0.567
LIG_TRAF2_1	471	474	PF00917	0.516
LIG_TRAF2_1	649	652	PF00917	0.527
LIG_TRAF2_1	65	68	PF00917	0.464
LIG_TYR_ITIM	562	567	PF00017	0.482
LIG_WRC_WIRS_1	585	590	PF05994	0.431
LIG_WRC_WIRS_1	595	600	PF05994	0.480
LIG_WRC_WIRS_1	658	663	PF05994	0.276
MOD_CDC14_SPxK_1	401	404	PF00782	0.554
MOD_CDK_SPxK_1	398	404	PF00069	0.599
MOD_CK1_1	370	376	PF00069	0.551
MOD_CK1_1	490	496	PF00069	0.532
MOD_CK2_1	310	316	PF00069	0.415
MOD_CK2_1	509	515	PF00069	0.378
MOD_CK2_1	525	531	PF00069	0.657
MOD_CK2_1	62	68	PF00069	0.458
MOD_CK2_1	745	751	PF00069	0.500
MOD_CK2_1	789	795	PF00069	0.516
MOD_GlcNHglycan	369	372	PF01048	0.652
MOD_GlcNHglycan	388	391	PF01048	0.470
MOD_GlcNHglycan	527	530	PF01048	0.592
MOD_GlcNHglycan	54	57	PF01048	0.654
MOD_GlcNHglycan	685	689	PF01048	0.626
MOD_GlcNHglycan	725	728	PF01048	0.506
MOD_GSK3_1	146	153	PF00069	0.434
MOD_GSK3_1	48	55	PF00069	0.659
MOD_GSK3_1	521	528	PF00069	0.627
MOD_GSK3_1	696	703	PF00069	0.621
MOD_GSK3_1	705	712	PF00069	0.526
MOD_GSK3_1	732	739	PF00069	0.662
MOD_GSK3_1	757	764	PF00069	0.571
MOD_GSK3_1	794	801	PF00069	0.548
MOD_N-GLC_1	343	348	PF02516	0.568
MOD_N-GLC_1	52	57	PF02516	0.571
MOD_NEK2_1	1	6	PF00069	0.722
MOD_NEK2_1	134	139	PF00069	0.544
MOD_NEK2_1	367	372	PF00069	0.667
MOD_NEK2_1	392	397	PF00069	0.626
MOD_NEK2_1	794	799	PF00069	0.453
MOD_NEK2_1	80	85	PF00069	0.526
MOD_NEK2_2	350	355	PF00069	0.490
MOD_PIKK_1	487	493	PF00454	0.550
MOD_PIKK_1	765	771	PF00454	0.620
MOD_PKA_1	814	820	PF00069	0.585
MOD_PKA_2	362	368	PF00069	0.556
MOD_PKA_2	444	450	PF00069	0.566
MOD_PKA_2	509	515	PF00069	0.343
MOD_PKA_2	709	715	PF00069	0.501
MOD_PKA_2	723	729	PF00069	0.505
MOD_PKA_2	757	763	PF00069	0.576
MOD_PKA_2	814	820	PF00069	0.567
MOD_PKB_1	340	348	PF00069	0.567
MOD_Plk_1	80	86	PF00069	0.533
MOD_Plk_4	225	231	PF00069	0.417
MOD_Plk_4	350	356	PF00069	0.498
MOD_Plk_4	509	515	PF00069	0.343
MOD_Plk_4	657	663	PF00069	0.360
MOD_Plk_4	745	751	PF00069	0.532
MOD_ProDKin_1	222	228	PF00069	0.507
MOD_ProDKin_1	398	404	PF00069	0.582
MOD_ProDKin_1	48	54	PF00069	0.626
MOD_ProDKin_1	522	528	PF00069	0.590
MOD_ProDKin_1	702	708	PF00069	0.498
MOD_ProDKin_1	782	788	PF00069	0.380
MOD_SUMO_for_1	565	568	PF00179	0.371
TRG_DiLeu_BaEn_1	778	783	PF01217	0.506
TRG_DiLeu_BaEn_4	652	658	PF01217	0.539
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.534
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.542
TRG_DiLeu_BaLyEn_6	783	788	PF01217	0.483
TRG_ENDOCYTIC_2	131	134	PF00928	0.392
TRG_ENDOCYTIC_2	165	168	PF00928	0.368
TRG_ENDOCYTIC_2	312	315	PF00928	0.399
TRG_ENDOCYTIC_2	351	354	PF00928	0.414
TRG_ENDOCYTIC_2	564	567	PF00928	0.359
TRG_ENDOCYTIC_2	602	605	PF00928	0.374
TRG_ENDOCYTIC_2	658	661	PF00928	0.367
TRG_ER_diArg_1	18	21	PF00400	0.591
TRG_ER_diArg_1	216	218	PF00400	0.430
TRG_ER_diArg_1	483	485	PF00400	0.520
TRG_ER_diArg_1	621	624	PF00400	0.479
TRG_ER_diArg_1	757	759	PF00400	0.585
TRG_ER_diArg_1	815	818	PF00400	0.560
TRG_ER_diArg_1	84	86	PF00400	0.547
TRG_ER_diArg_1	9	11	PF00400	0.607
TRG_NES_CRM1_1	108	123	PF08389	0.556
TRG_NLS_MonoExtC_3	1	7	PF00514	0.653
TRG_NLS_MonoExtC_3	813	818	PF00514	0.556
TRG_NLS_MonoExtN_4	811	818	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	330	335	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	624	629	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P767	Leptomonas seymouri	74%	99%
A0A0S4JKT1	Bodo saltans	29%	95%
A0A1X0P0C5	Trypanosomatidae	43%	100%
A0A3Q8IHN6	Leishmania donovani	95%	100%
A0A3R7P515	Trypanosoma rangeli	43%	100%
A4HPU7	Leishmania braziliensis	87%	100%
A4IE46	Leishmania infantum	95%	100%
D0A493	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ATL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P63154	Mus musculus	23%	100%
P63155	Rattus norvegicus	23%	100%
P87312	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q4PB37	Ustilago maydis (strain 521 / FGSC 9021)	28%	100%
Q4WT84	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q5BDX1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	100%
Q5K654	Paracoccidioides brasiliensis	25%	100%
Q6CJK2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	100%
Q7SGD2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
Q9BZJ0	Homo sapiens	23%	97%
V5B545	Trypanosoma cruzi	43%	100%