Trypanothione synthetase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

trypanothione synthetase-like protein

Species:

Leishmania major

UniProt:

Q4Q0Y4_LEIMA

TriTrypDb:

LmjF.36.4300 , LMJLV39_360054200 , LMJSD75_360054100

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Y4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016874	ligase activity	2	5
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	5
GO:0016880	acid-ammonia (or amide) ligase activity	4	5
GO:0047479	trypanothione synthase activity	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.483
CLV_C14_Caspase3-7	197	201	PF00656	0.520
CLV_C14_Caspase3-7	680	684	PF00656	0.414
CLV_NRD_NRD_1	392	394	PF00675	0.589
CLV_NRD_NRD_1	59	61	PF00675	0.478
CLV_NRD_NRD_1	659	661	PF00675	0.429
CLV_NRD_NRD_1	686	688	PF00675	0.423
CLV_PCSK_KEX2_1	394	396	PF00082	0.591
CLV_PCSK_KEX2_1	59	61	PF00082	0.495
CLV_PCSK_KEX2_1	659	661	PF00082	0.429
CLV_PCSK_KEX2_1	686	688	PF00082	0.423
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.591
CLV_PCSK_PC7_1	390	396	PF00082	0.559
CLV_PCSK_SKI1_1	455	459	PF00082	0.535
CLV_PCSK_SKI1_1	548	552	PF00082	0.555
CLV_PCSK_SKI1_1	59	63	PF00082	0.495
CLV_PCSK_SKI1_1	599	603	PF00082	0.608
DEG_APCC_DBOX_1	274	282	PF00400	0.415
DOC_CKS1_1	210	215	PF01111	0.598
DOC_CKS1_1	476	481	PF01111	0.527
DOC_CYCLIN_RxL_1	269	277	PF00134	0.473
DOC_CYCLIN_RxL_1	57	66	PF00134	0.295
DOC_CYCLIN_RxL_1	653	666	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	425	431	PF00134	0.426
DOC_MAPK_FxFP_2	744	747	PF00069	0.612
DOC_MAPK_gen_1	272	282	PF00069	0.372
DOC_MAPK_MEF2A_6	275	282	PF00069	0.428
DOC_MAPK_NFAT4_5	275	283	PF00069	0.515
DOC_PP1_RVXF_1	270	277	PF00149	0.472
DOC_PP1_RVXF_1	546	553	PF00149	0.530
DOC_PP4_FxxP_1	152	155	PF00568	0.424
DOC_PP4_FxxP_1	242	245	PF00568	0.519
DOC_PP4_FxxP_1	348	351	PF00568	0.443
DOC_PP4_FxxP_1	619	622	PF00568	0.390
DOC_PP4_FxxP_1	744	747	PF00568	0.612
DOC_USP7_MATH_1	155	159	PF00917	0.512
DOC_USP7_MATH_1	188	192	PF00917	0.537
DOC_USP7_MATH_1	307	311	PF00917	0.640
DOC_USP7_MATH_1	371	375	PF00917	0.537
DOC_USP7_MATH_1	380	384	PF00917	0.509
DOC_USP7_MATH_1	412	416	PF00917	0.759
DOC_USP7_MATH_1	559	563	PF00917	0.627
DOC_WW_Pin1_4	121	126	PF00397	0.316
DOC_WW_Pin1_4	151	156	PF00397	0.432
DOC_WW_Pin1_4	209	214	PF00397	0.545
DOC_WW_Pin1_4	220	225	PF00397	0.459
DOC_WW_Pin1_4	333	338	PF00397	0.585
DOC_WW_Pin1_4	413	418	PF00397	0.774
DOC_WW_Pin1_4	475	480	PF00397	0.488
DOC_WW_Pin1_4	557	562	PF00397	0.542
DOC_WW_Pin1_4	643	648	PF00397	0.692
DOC_WW_Pin1_4	663	668	PF00397	0.484
DOC_WW_Pin1_4	696	701	PF00397	0.695
LIG_14-3-3_CanoR_1	275	279	PF00244	0.385
LIG_14-3-3_CanoR_1	455	463	PF00244	0.538
LIG_14-3-3_CanoR_1	482	491	PF00244	0.619
LIG_14-3-3_CanoR_1	640	650	PF00244	0.650
LIG_14-3-3_CanoR_1	75	82	PF00244	0.314
LIG_APCC_ABBA_1	11	16	PF00400	0.464
LIG_BRCT_BRCA1_1	221	225	PF00533	0.562
LIG_BRCT_BRCA1_1	650	654	PF00533	0.393
LIG_deltaCOP1_diTrp_1	441	451	PF00928	0.444
LIG_eIF4E_1	57	63	PF01652	0.319
LIG_FHA_1	178	184	PF00498	0.485
LIG_FHA_1	275	281	PF00498	0.529
LIG_FHA_1	294	300	PF00498	0.307
LIG_FHA_1	404	410	PF00498	0.691
LIG_FHA_1	469	475	PF00498	0.545
LIG_FHA_1	509	515	PF00498	0.543
LIG_FHA_1	64	70	PF00498	0.295
LIG_FHA_1	671	677	PF00498	0.655
LIG_FHA_1	722	728	PF00498	0.732
LIG_FHA_2	171	177	PF00498	0.550
LIG_FHA_2	221	227	PF00498	0.473
LIG_FHA_2	300	306	PF00498	0.601
LIG_FHA_2	333	339	PF00498	0.562
LIG_FHA_2	344	350	PF00498	0.393
LIG_FHA_2	428	434	PF00498	0.625
LIG_FHA_2	84	90	PF00498	0.319
LIG_LIR_Apic_2	346	351	PF02991	0.495
LIG_LIR_Apic_2	396	402	PF02991	0.642
LIG_LIR_Apic_2	616	622	PF02991	0.429
LIG_LIR_Gen_1	508	514	PF02991	0.447
LIG_LIR_Nem_3	124	129	PF02991	0.353
LIG_LIR_Nem_3	20	24	PF02991	0.417
LIG_LIR_Nem_3	318	324	PF02991	0.502
LIG_LIR_Nem_3	346	350	PF02991	0.488
LIG_LIR_Nem_3	374	379	PF02991	0.487
LIG_LIR_Nem_3	44	50	PF02991	0.364
LIG_LIR_Nem_3	492	496	PF02991	0.452
LIG_LIR_Nem_3	508	513	PF02991	0.446
LIG_LIR_Nem_3	591	595	PF02991	0.415
LIG_LIR_Nem_3	651	657	PF02991	0.384
LIG_LYPXL_S_1	375	379	PF13949	0.511
LIG_LYPXL_yS_3	376	379	PF13949	0.514
LIG_MAD2	498	506	PF02301	0.530
LIG_MYND_1	121	125	PF01753	0.353
LIG_PCNA_PIPBox_1	369	378	PF02747	0.568
LIG_Rb_LxCxE_1	591	612	PF01857	0.407
LIG_SH2_CRK	169	173	PF00017	0.494
LIG_SH2_SRC	159	162	PF00017	0.476
LIG_SH2_STAP1	57	61	PF00017	0.319
LIG_SH2_STAP1	581	585	PF00017	0.473
LIG_SH2_STAT5	148	151	PF00017	0.529
LIG_SH2_STAT5	159	162	PF00017	0.415
LIG_SH2_STAT5	34	37	PF00017	0.467
LIG_SH2_STAT5	347	350	PF00017	0.486
LIG_SH2_STAT5	41	44	PF00017	0.418
LIG_SH2_STAT5	47	50	PF00017	0.263
LIG_SH2_STAT5	496	499	PF00017	0.442
LIG_SH2_STAT5	626	629	PF00017	0.412
LIG_SH2_STAT5	662	665	PF00017	0.489
LIG_SH2_STAT5	94	97	PF00017	0.334
LIG_SH3_1	292	298	PF00018	0.537
LIG_SH3_2	199	204	PF14604	0.451
LIG_SH3_3	115	121	PF00018	0.319
LIG_SH3_3	196	202	PF00018	0.433
LIG_SH3_3	207	213	PF00018	0.462
LIG_SH3_3	292	298	PF00018	0.489
LIG_SH3_3	500	506	PF00018	0.475
LIG_SH3_3	535	541	PF00018	0.572
LIG_SH3_3	644	650	PF00018	0.545
LIG_SH3_3	733	739	PF00018	0.576
LIG_SUMO_SIM_anti_2	471	478	PF11976	0.576
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.458
LIG_SUMO_SIM_par_1	170	176	PF11976	0.356
LIG_SUMO_SIM_par_1	420	426	PF11976	0.751
LIG_SUMO_SIM_par_1	471	478	PF11976	0.544
LIG_SUMO_SIM_par_1	510	517	PF11976	0.416
LIG_SUMO_SIM_par_1	723	730	PF11976	0.762
LIG_TRAF2_1	430	433	PF00917	0.563
LIG_UBA3_1	171	179	PF00899	0.377
LIG_WRC_WIRS_1	131	136	PF05994	0.389
LIG_WRC_WIRS_1	372	377	PF05994	0.560
MOD_CDK_SPK_2	643	648	PF00069	0.692
MOD_CDK_SPxK_1	333	339	PF00069	0.577
MOD_CDK_SPxxK_3	475	482	PF00069	0.573
MOD_CDK_SPxxK_3	646	653	PF00069	0.382
MOD_CK1_1	45	51	PF00069	0.461
MOD_CK1_1	562	568	PF00069	0.634
MOD_CK1_1	570	576	PF00069	0.654
MOD_CK1_1	646	652	PF00069	0.541
MOD_CK1_1	7	13	PF00069	0.657
MOD_CK1_1	726	732	PF00069	0.684
MOD_CK2_1	151	157	PF00069	0.523
MOD_CK2_1	170	176	PF00069	0.507
MOD_CK2_1	299	305	PF00069	0.619
MOD_CK2_1	427	433	PF00069	0.641
MOD_CK2_1	83	89	PF00069	0.319
MOD_GlcNHglycan	190	193	PF01048	0.507
MOD_GlcNHglycan	245	248	PF01048	0.586
MOD_GlcNHglycan	267	270	PF01048	0.485
MOD_GlcNHglycan	35	38	PF01048	0.441
MOD_GlcNHglycan	382	385	PF01048	0.542
MOD_GlcNHglycan	395	398	PF01048	0.448
MOD_GlcNHglycan	561	564	PF01048	0.687
MOD_GlcNHglycan	577	580	PF01048	0.646
MOD_GlcNHglycan	628	631	PF01048	0.421
MOD_GSK3_1	151	158	PF00069	0.487
MOD_GSK3_1	403	410	PF00069	0.722
MOD_GSK3_1	41	48	PF00069	0.509
MOD_GSK3_1	423	430	PF00069	0.662
MOD_GSK3_1	508	515	PF00069	0.449
MOD_GSK3_1	622	629	PF00069	0.387
MOD_GSK3_1	83	90	PF00069	0.316
MOD_N-GLC_1	256	261	PF02516	0.530
MOD_N-GLC_1	299	304	PF02516	0.640
MOD_N-GLC_1	330	335	PF02516	0.637
MOD_N-GLC_1	632	637	PF02516	0.633
MOD_N-GLC_2	533	535	PF02516	0.567
MOD_NEK2_1	274	279	PF00069	0.467
MOD_NEK2_1	299	304	PF00069	0.623
MOD_NEK2_1	423	428	PF00069	0.722
MOD_NEK2_1	470	475	PF00069	0.487
MOD_NEK2_1	484	489	PF00069	0.594
MOD_NEK2_1	527	532	PF00069	0.533
MOD_NEK2_1	62	67	PF00069	0.295
MOD_NEK2_1	712	717	PF00069	0.493
MOD_NEK2_2	371	376	PF00069	0.512
MOD_NEK2_2	681	686	PF00069	0.495
MOD_NEK2_2	92	97	PF00069	0.389
MOD_PIKK_1	103	109	PF00454	0.391
MOD_PIKK_1	458	464	PF00454	0.595
MOD_PIKK_1	484	490	PF00454	0.589
MOD_PIKK_1	665	671	PF00454	0.432
MOD_PK_1	648	654	PF00069	0.494
MOD_PKA_1	393	399	PF00069	0.594
MOD_PKA_2	274	280	PF00069	0.383
MOD_PKA_2	74	80	PF00069	0.319
MOD_PKB_1	393	401	PF00069	0.613
MOD_Plk_1	299	305	PF00069	0.640
MOD_Plk_1	42	48	PF00069	0.508
MOD_Plk_1	458	464	PF00069	0.524
MOD_Plk_1	548	554	PF00069	0.451
MOD_Plk_1	7	13	PF00069	0.570
MOD_Plk_4	155	161	PF00069	0.535
MOD_Plk_4	259	265	PF00069	0.528
MOD_Plk_4	343	349	PF00069	0.491
MOD_Plk_4	371	377	PF00069	0.511
MOD_Plk_4	42	48	PF00069	0.512
MOD_Plk_4	548	554	PF00069	0.518
MOD_Plk_4	7	13	PF00069	0.613
MOD_Plk_4	704	710	PF00069	0.436
MOD_ProDKin_1	121	127	PF00069	0.316
MOD_ProDKin_1	151	157	PF00069	0.441
MOD_ProDKin_1	209	215	PF00069	0.552
MOD_ProDKin_1	220	226	PF00069	0.457
MOD_ProDKin_1	333	339	PF00069	0.578
MOD_ProDKin_1	413	419	PF00069	0.773
MOD_ProDKin_1	475	481	PF00069	0.486
MOD_ProDKin_1	557	563	PF00069	0.561
MOD_ProDKin_1	643	649	PF00069	0.677
MOD_ProDKin_1	663	669	PF00069	0.493
MOD_ProDKin_1	696	702	PF00069	0.689
MOD_SUMO_for_1	363	366	PF00179	0.617
MOD_SUMO_rev_2	675	684	PF00179	0.475
TRG_DiLeu_BaEn_1	472	477	PF01217	0.495
TRG_DiLeu_BaEn_4	420	426	PF01217	0.501
TRG_ENDOCYTIC_2	169	172	PF00928	0.407
TRG_ENDOCYTIC_2	347	350	PF00928	0.486
TRG_ENDOCYTIC_2	376	379	PF00928	0.514
TRG_ENDOCYTIC_2	47	50	PF00928	0.305
TRG_ENDOCYTIC_2	496	499	PF00928	0.523
TRG_ENDOCYTIC_2	52	55	PF00928	0.293
TRG_ER_diArg_1	284	287	PF00400	0.452
TRG_ER_diArg_1	59	61	PF00400	0.295
TRG_ER_diArg_1	659	661	PF00400	0.456
TRG_ER_diArg_1	686	688	PF00400	0.505
TRG_NES_CRM1_1	338	353	PF08389	0.554
TRG_NLS_MonoExtN_4	390	397	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCF5	Leptomonas seymouri	65%	99%
A0A1X0P094	Trypanosomatidae	41%	100%
A0A3Q8IRG9	Leishmania donovani	93%	100%
A4IE44	Leishmania infantum	94%	100%
E9ATL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BQ93	Trypanosoma cruzi	39%	100%