Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q0Y0_LEIMA

TriTrypDb:

LmjF.36.4340 , LMJLV39_360054600 , LMJSD75_360054500

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0Y0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.569
CLV_NRD_NRD_1	235	237	PF00675	0.615
CLV_NRD_NRD_1	309	311	PF00675	0.576
CLV_NRD_NRD_1	347	349	PF00675	0.582
CLV_NRD_NRD_1	363	365	PF00675	0.406
CLV_NRD_NRD_1	445	447	PF00675	0.639
CLV_NRD_NRD_1	487	489	PF00675	0.646
CLV_NRD_NRD_1	498	500	PF00675	0.661
CLV_NRD_NRD_1	501	503	PF00675	0.645
CLV_PCSK_KEX2_1	235	237	PF00082	0.615
CLV_PCSK_KEX2_1	309	311	PF00082	0.527
CLV_PCSK_KEX2_1	331	333	PF00082	0.679
CLV_PCSK_KEX2_1	347	349	PF00082	0.462
CLV_PCSK_KEX2_1	362	364	PF00082	0.514
CLV_PCSK_KEX2_1	479	481	PF00082	0.725
CLV_PCSK_KEX2_1	487	489	PF00082	0.614
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.630
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.719
CLV_PCSK_SKI1_1	25	29	PF00082	0.643
CLV_PCSK_SKI1_1	283	287	PF00082	0.575
CLV_PCSK_SKI1_1	351	355	PF00082	0.640
CLV_PCSK_SKI1_1	446	450	PF00082	0.605
CLV_PCSK_SKI1_1	523	527	PF00082	0.616
CLV_PCSK_SKI1_1	99	103	PF00082	0.699
DEG_COP1_1	318	329	PF00400	0.626
DOC_CYCLIN_RxL_1	520	527	PF00134	0.603
DOC_CYCLIN_yClb5_NLxxxL_5	17	26	PF00134	0.696
DOC_PP1_RVXF_1	521	527	PF00149	0.602
DOC_PP2B_LxvP_1	286	289	PF13499	0.554
DOC_USP7_MATH_1	103	107	PF00917	0.757
DOC_USP7_MATH_1	138	142	PF00917	0.835
DOC_USP7_MATH_1	154	158	PF00917	0.668
DOC_USP7_MATH_1	163	167	PF00917	0.660
DOC_USP7_MATH_1	312	316	PF00917	0.639
DOC_USP7_MATH_1	40	44	PF00917	0.678
DOC_USP7_MATH_1	433	437	PF00917	0.565
DOC_USP7_MATH_1	473	477	PF00917	0.604
DOC_USP7_MATH_1	505	509	PF00917	0.620
DOC_USP7_MATH_1	531	535	PF00917	0.676
DOC_USP7_MATH_1	9	13	PF00917	0.646
DOC_WW_Pin1_4	122	127	PF00397	0.678
DOC_WW_Pin1_4	168	173	PF00397	0.645
DOC_WW_Pin1_4	225	230	PF00397	0.794
DOC_WW_Pin1_4	263	268	PF00397	0.662
DOC_WW_Pin1_4	435	440	PF00397	0.652
DOC_WW_Pin1_4	501	506	PF00397	0.657
LIG_14-3-3_CanoR_1	140	147	PF00244	0.724
LIG_14-3-3_CanoR_1	162	172	PF00244	0.771
LIG_14-3-3_CanoR_1	205	215	PF00244	0.683
LIG_14-3-3_CanoR_1	222	232	PF00244	0.728
LIG_14-3-3_CanoR_1	254	259	PF00244	0.674
LIG_14-3-3_CanoR_1	472	478	PF00244	0.749
LIG_14-3-3_CanoR_1	99	107	PF00244	0.646
LIG_Actin_WH2_2	265	280	PF00022	0.685
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_BRCT_BRCA1_1	425	429	PF00533	0.695
LIG_FHA_1	137	143	PF00498	0.690
LIG_FHA_1	169	175	PF00498	0.667
LIG_FHA_1	184	190	PF00498	0.548
LIG_FHA_1	321	327	PF00498	0.599
LIG_FHA_1	45	51	PF00498	0.556
LIG_FHA_1	530	536	PF00498	0.628
LIG_FHA_2	123	129	PF00498	0.811
LIG_FHA_2	341	347	PF00498	0.667
LIG_FHA_2	50	56	PF00498	0.565
LIG_FHA_2	60	66	PF00498	0.563
LIG_LIR_Apic_2	469	473	PF02991	0.689
LIG_LIR_Gen_1	180	189	PF02991	0.710
LIG_LIR_Gen_1	2	10	PF02991	0.642
LIG_LIR_Nem_3	180	185	PF02991	0.592
LIG_LIR_Nem_3	295	301	PF02991	0.524
LIG_LIR_Nem_3	335	340	PF02991	0.576
LIG_LIR_Nem_3	55	61	PF02991	0.614
LIG_PDZ_Class_1	531	536	PF00595	0.665
LIG_SH2_CRK	58	62	PF00017	0.617
LIG_SH2_NCK_1	182	186	PF00017	0.698
LIG_SH2_PTP2	339	342	PF00017	0.557
LIG_SH2_SRC	182	185	PF00017	0.740
LIG_SH2_SRC	293	296	PF00017	0.550
LIG_SH2_SRC	339	342	PF00017	0.557
LIG_SH2_STAP1	293	297	PF00017	0.545
LIG_SH2_STAT5	276	279	PF00017	0.589
LIG_SH2_STAT5	325	328	PF00017	0.675
LIG_SH2_STAT5	339	342	PF00017	0.496
LIG_SH2_STAT5	36	39	PF00017	0.759
LIG_SH3_2	160	165	PF14604	0.662
LIG_SH3_2	172	177	PF14604	0.644
LIG_SH3_3	157	163	PF00018	0.664
LIG_SH3_3	169	175	PF00018	0.657
LIG_TRAF2_1	271	274	PF00917	0.680
LIG_TRAF2_1	342	345	PF00917	0.613
LIG_TRAF2_1	357	360	PF00917	0.447
LIG_TYR_ITIM	56	61	PF00017	0.613
LIG_WRC_WIRS_1	517	522	PF05994	0.656
MOD_CDK_SPK_2	122	127	PF00069	0.661
MOD_CDK_SPK_2	168	173	PF00069	0.724
MOD_CDK_SPK_2	225	230	PF00069	0.794
MOD_CDK_SPxK_1	435	441	PF00069	0.695
MOD_CDK_SPxxK_3	263	270	PF00069	0.624
MOD_CDK_SPxxK_3	435	442	PF00069	0.756
MOD_CK1_1	136	142	PF00069	0.748
MOD_CK1_1	166	172	PF00069	0.837
MOD_CK1_1	211	217	PF00069	0.769
MOD_CK1_1	228	234	PF00069	0.555
MOD_CK1_1	239	245	PF00069	0.611
MOD_CK1_1	256	262	PF00069	0.782
MOD_CK1_1	303	309	PF00069	0.581
MOD_CK1_1	315	321	PF00069	0.669
MOD_CK1_1	43	49	PF00069	0.803
MOD_CK1_1	72	78	PF00069	0.739
MOD_CK1_1	8	14	PF00069	0.696
MOD_CK1_1	88	94	PF00069	0.645
MOD_CK2_1	103	109	PF00069	0.598
MOD_CK2_1	122	128	PF00069	0.809
MOD_CK2_1	153	159	PF00069	0.727
MOD_CK2_1	340	346	PF00069	0.544
MOD_CK2_1	450	456	PF00069	0.645
MOD_CK2_1	49	55	PF00069	0.580
MOD_CK2_1	501	507	PF00069	0.755
MOD_CK2_1	516	522	PF00069	0.529
MOD_CK2_1	70	76	PF00069	0.662
MOD_Cter_Amidation	477	480	PF01082	0.711
MOD_Cter_Amidation	500	503	PF01082	0.728
MOD_GlcNHglycan	225	228	PF01048	0.752
MOD_GlcNHglycan	238	241	PF01048	0.642
MOD_GlcNHglycan	244	247	PF01048	0.735
MOD_GlcNHglycan	306	309	PF01048	0.672
MOD_GlcNHglycan	38	41	PF01048	0.815
MOD_GlcNHglycan	397	400	PF01048	0.651
MOD_GlcNHglycan	429	432	PF01048	0.784
MOD_GlcNHglycan	443	446	PF01048	0.595
MOD_GlcNHglycan	452	455	PF01048	0.626
MOD_GlcNHglycan	480	483	PF01048	0.677
MOD_GlcNHglycan	507	510	PF01048	0.755
MOD_GlcNHglycan	7	10	PF01048	0.624
MOD_GlcNHglycan	86	90	PF01048	0.769
MOD_GlcNHglycan	92	95	PF01048	0.670
MOD_GSK3_1	136	143	PF00069	0.739
MOD_GSK3_1	163	170	PF00069	0.730
MOD_GSK3_1	206	213	PF00069	0.671
MOD_GSK3_1	221	228	PF00069	0.726
MOD_GSK3_1	249	256	PF00069	0.780
MOD_GSK3_1	259	266	PF00069	0.664
MOD_GSK3_1	30	37	PF00069	0.670
MOD_GSK3_1	300	307	PF00069	0.487
MOD_GSK3_1	312	319	PF00069	0.784
MOD_GSK3_1	395	402	PF00069	0.732
MOD_GSK3_1	40	47	PF00069	0.538
MOD_GSK3_1	423	430	PF00069	0.776
MOD_GSK3_1	433	440	PF00069	0.653
MOD_GSK3_1	5	12	PF00069	0.643
MOD_GSK3_1	501	508	PF00069	0.629
MOD_GSK3_1	99	106	PF00069	0.714
MOD_LATS_1	23	29	PF00433	0.643
MOD_N-GLC_1	211	216	PF02516	0.776
MOD_N-GLC_1	236	241	PF02516	0.703
MOD_N-GLC_1	301	306	PF02516	0.657
MOD_N-GLC_1	319	324	PF02516	0.735
MOD_N-GLC_1	395	400	PF02516	0.635
MOD_N-GLC_1	423	428	PF02516	0.696
MOD_NEK2_1	300	305	PF00069	0.492
MOD_NEK2_1	494	499	PF00069	0.617
MOD_PIKK_1	133	139	PF00454	0.788
MOD_PIKK_1	213	219	PF00454	0.733
MOD_PIKK_1	221	227	PF00454	0.646
MOD_PIKK_1	399	405	PF00454	0.672
MOD_PK_1	254	260	PF00069	0.617
MOD_PKA_1	441	447	PF00069	0.702
MOD_PKA_2	164	170	PF00069	0.797
MOD_PKA_2	192	198	PF00069	0.693
MOD_PKA_2	221	227	PF00069	0.726
MOD_PKA_2	242	248	PF00069	0.722
MOD_PKA_2	253	259	PF00069	0.710
MOD_PKA_2	40	46	PF00069	0.709
MOD_PKA_2	433	439	PF00069	0.732
MOD_PKA_2	494	500	PF00069	0.672
MOD_PKA_2	77	83	PF00069	0.788
MOD_PKB_1	247	255	PF00069	0.775
MOD_Plk_1	211	217	PF00069	0.734
MOD_Plk_1	351	357	PF00069	0.510
MOD_Plk_4	184	190	PF00069	0.585
MOD_Plk_4	480	486	PF00069	0.604
MOD_ProDKin_1	122	128	PF00069	0.677
MOD_ProDKin_1	168	174	PF00069	0.642
MOD_ProDKin_1	225	231	PF00069	0.793
MOD_ProDKin_1	263	269	PF00069	0.658
MOD_ProDKin_1	435	441	PF00069	0.652
MOD_ProDKin_1	501	507	PF00069	0.659
MOD_SUMO_rev_2	124	131	PF00179	0.623
TRG_DiLeu_BaEn_4	344	350	PF01217	0.500
TRG_DiLeu_BaEn_4	76	82	PF01217	0.718
TRG_ENDOCYTIC_2	182	185	PF00928	0.594
TRG_ENDOCYTIC_2	4	7	PF00928	0.644
TRG_ENDOCYTIC_2	58	61	PF00928	0.618
TRG_ER_diArg_1	309	311	PF00400	0.527
TRG_ER_diArg_1	347	349	PF00400	0.582
TRG_ER_diArg_1	361	364	PF00400	0.499
TRG_ER_diArg_1	388	391	PF00400	0.684
TRG_NLS_Bipartite_1	487	503	PF00514	0.614
TRG_NLS_MonoExtC_3	445	450	PF00514	0.602
TRG_NLS_MonoExtC_3	498	503	PF00514	0.613
TRG_NLS_MonoExtN_4	446	453	PF00514	0.630
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	347	352	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U4	Leptomonas seymouri	39%	100%
A0A3Q8IPF2	Leishmania donovani	84%	97%
A4HPV1	Leishmania braziliensis	54%	98%
A4IE40	Leishmania infantum	83%	97%
E9ATL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%