Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0X9_LEIMA

TriTrypDb:

LmjF.36.4350 , LMJLV39_360054700 , LMJSD75_360054600

Length:

889

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0X9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.661
CLV_C14_Caspase3-7	237	241	PF00656	0.593
CLV_C14_Caspase3-7	424	428	PF00656	0.594
CLV_C14_Caspase3-7	447	451	PF00656	0.542
CLV_C14_Caspase3-7	714	718	PF00656	0.509
CLV_C14_Caspase3-7	740	744	PF00656	0.629
CLV_MEL_PAP_1	599	605	PF00089	0.636
CLV_NRD_NRD_1	149	151	PF00675	0.677
CLV_NRD_NRD_1	238	240	PF00675	0.657
CLV_NRD_NRD_1	459	461	PF00675	0.608
CLV_NRD_NRD_1	624	626	PF00675	0.659
CLV_NRD_NRD_1	686	688	PF00675	0.570
CLV_NRD_NRD_1	753	755	PF00675	0.602
CLV_NRD_NRD_1	758	760	PF00675	0.599
CLV_PCSK_FUR_1	751	755	PF00082	0.537
CLV_PCSK_KEX2_1	149	151	PF00082	0.677
CLV_PCSK_KEX2_1	238	240	PF00082	0.657
CLV_PCSK_KEX2_1	590	592	PF00082	0.614
CLV_PCSK_KEX2_1	624	626	PF00082	0.662
CLV_PCSK_KEX2_1	688	690	PF00082	0.569
CLV_PCSK_KEX2_1	750	752	PF00082	0.586
CLV_PCSK_KEX2_1	753	755	PF00082	0.571
CLV_PCSK_KEX2_1	758	760	PF00082	0.590
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.614
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.569
CLV_PCSK_PC1ET2_1	750	752	PF00082	0.586
CLV_PCSK_PC7_1	754	760	PF00082	0.567
CLV_PCSK_SKI1_1	374	378	PF00082	0.685
CLV_PCSK_SKI1_1	429	433	PF00082	0.669
CLV_PCSK_SKI1_1	591	595	PF00082	0.608
DEG_APCC_DBOX_1	758	766	PF00400	0.662
DEG_SCF_FBW7_1	873	879	PF00400	0.679
DEG_SPOP_SBC_1	219	223	PF00917	0.620
DEG_SPOP_SBC_1	265	269	PF00917	0.533
DEG_SPOP_SBC_1	565	569	PF00917	0.624
DOC_ANK_TNKS_1	615	622	PF00023	0.606
DOC_CKS1_1	24	29	PF01111	0.691
DOC_CKS1_1	731	736	PF01111	0.620
DOC_CKS1_1	835	840	PF01111	0.614
DOC_CKS1_1	873	878	PF01111	0.688
DOC_CKS1_1	94	99	PF01111	0.600
DOC_CYCLIN_RxL_1	584	598	PF00134	0.610
DOC_CYCLIN_yClb1_LxF_4	589	594	PF00134	0.677
DOC_CYCLIN_yCln2_LP_2	611	617	PF00134	0.584
DOC_PP1_RVXF_1	33	40	PF00149	0.683
DOC_PP1_RVXF_1	588	595	PF00149	0.599
DOC_PP2B_LxvP_1	359	362	PF13499	0.587
DOC_PP2B_LxvP_1	531	534	PF13499	0.526
DOC_PP4_FxxP_1	21	24	PF00568	0.718
DOC_USP7_MATH_1	124	128	PF00917	0.632
DOC_USP7_MATH_1	159	163	PF00917	0.627
DOC_USP7_MATH_1	166	170	PF00917	0.674
DOC_USP7_MATH_1	179	183	PF00917	0.527
DOC_USP7_MATH_1	215	219	PF00917	0.764
DOC_USP7_MATH_1	247	251	PF00917	0.667
DOC_USP7_MATH_1	416	420	PF00917	0.700
DOC_USP7_MATH_1	445	449	PF00917	0.681
DOC_USP7_MATH_1	505	509	PF00917	0.745
DOC_USP7_MATH_1	637	641	PF00917	0.595
DOC_USP7_MATH_1	727	731	PF00917	0.534
DOC_USP7_MATH_1	790	794	PF00917	0.577
DOC_USP7_MATH_1	839	843	PF00917	0.752
DOC_USP7_MATH_1	883	887	PF00917	0.716
DOC_WW_Pin1_4	131	136	PF00397	0.596
DOC_WW_Pin1_4	191	196	PF00397	0.618
DOC_WW_Pin1_4	200	205	PF00397	0.587
DOC_WW_Pin1_4	23	28	PF00397	0.699
DOC_WW_Pin1_4	281	286	PF00397	0.627
DOC_WW_Pin1_4	377	382	PF00397	0.654
DOC_WW_Pin1_4	42	47	PF00397	0.486
DOC_WW_Pin1_4	467	472	PF00397	0.645
DOC_WW_Pin1_4	475	480	PF00397	0.636
DOC_WW_Pin1_4	542	547	PF00397	0.600
DOC_WW_Pin1_4	583	588	PF00397	0.573
DOC_WW_Pin1_4	605	610	PF00397	0.596
DOC_WW_Pin1_4	730	735	PF00397	0.787
DOC_WW_Pin1_4	766	771	PF00397	0.586
DOC_WW_Pin1_4	834	839	PF00397	0.679
DOC_WW_Pin1_4	872	877	PF00397	0.686
DOC_WW_Pin1_4	90	95	PF00397	0.625
LIG_14-3-3_CanoR_1	149	155	PF00244	0.619
LIG_14-3-3_CanoR_1	167	171	PF00244	0.530
LIG_14-3-3_CanoR_1	185	190	PF00244	0.496
LIG_14-3-3_CanoR_1	275	285	PF00244	0.695
LIG_14-3-3_CanoR_1	295	300	PF00244	0.487
LIG_14-3-3_CanoR_1	335	343	PF00244	0.574
LIG_14-3-3_CanoR_1	351	359	PF00244	0.599
LIG_14-3-3_CanoR_1	659	664	PF00244	0.626
LIG_14-3-3_CanoR_1	728	732	PF00244	0.537
LIG_14-3-3_CanoR_1	800	804	PF00244	0.639
LIG_BRCT_BRCA1_1	17	21	PF00533	0.712
LIG_BRCT_BRCA1_1	511	515	PF00533	0.610
LIG_CtBP_PxDLS_1	498	504	PF00389	0.619
LIG_FHA_1	137	143	PF00498	0.569
LIG_FHA_1	149	155	PF00498	0.603
LIG_FHA_1	185	191	PF00498	0.610
LIG_FHA_1	211	217	PF00498	0.640
LIG_FHA_1	220	226	PF00498	0.577
LIG_FHA_1	438	444	PF00498	0.609
LIG_FHA_1	707	713	PF00498	0.623
LIG_FHA_2	225	231	PF00498	0.564
LIG_FHA_2	232	238	PF00498	0.554
LIG_FHA_2	302	308	PF00498	0.635
LIG_FHA_2	351	357	PF00498	0.546
LIG_FHA_2	422	428	PF00498	0.638
LIG_FHA_2	567	573	PF00498	0.638
LIG_FHA_2	731	737	PF00498	0.683
LIG_FHA_2	770	776	PF00498	0.674
LIG_FHA_2	817	823	PF00498	0.692
LIG_Integrin_isoDGR_2	372	374	PF01839	0.655
LIG_LIR_Apic_2	18	24	PF02991	0.715
LIG_LIR_Apic_2	717	723	PF02991	0.720
LIG_LIR_Apic_2	832	838	PF02991	0.661
LIG_LIR_Gen_1	733	741	PF02991	0.684
LIG_LIR_Gen_1	826	835	PF02991	0.627
LIG_LIR_Nem_3	158	163	PF02991	0.521
LIG_LIR_Nem_3	450	455	PF02991	0.669
LIG_LIR_Nem_3	733	738	PF02991	0.686
LIG_LIR_Nem_3	826	830	PF02991	0.592
LIG_MYND_1	609	613	PF01753	0.660
LIG_Pex14_1	660	664	PF04695	0.666
LIG_SH2_CRK	160	164	PF00017	0.517
LIG_SH2_PTP2	835	838	PF00017	0.618
LIG_SH2_STAT3	259	262	PF00017	0.672
LIG_SH2_STAT5	259	262	PF00017	0.638
LIG_SH2_STAT5	720	723	PF00017	0.612
LIG_SH2_STAT5	835	838	PF00017	0.618
LIG_SH3_3	209	215	PF00018	0.538
LIG_SH3_3	21	27	PF00018	0.705
LIG_SH3_3	282	288	PF00018	0.628
LIG_SH3_3	337	343	PF00018	0.626
LIG_SH3_3	381	387	PF00018	0.570
LIG_SH3_3	550	556	PF00018	0.682
LIG_SH3_3	764	770	PF00018	0.546
LIG_SH3_3	91	97	PF00018	0.608
LIG_SxIP_EBH_1	605	616	PF03271	0.607
LIG_TRAF2_1	352	355	PF00917	0.617
LIG_TRAF2_1	419	422	PF00917	0.661
LIG_TRAF2_1	57	60	PF00917	0.647
LIG_TRAF2_1	593	596	PF00917	0.607
LIG_TRAF2_1	66	69	PF00917	0.542
LIG_WW_3	470	474	PF00397	0.654
MOD_CDK_SPK_2	585	590	PF00069	0.653
MOD_CDK_SPK_2	93	98	PF00069	0.676
MOD_CDK_SPxK_1	467	473	PF00069	0.657
MOD_CDK_SPxK_1	585	591	PF00069	0.658
MOD_CDK_SPxxK_3	542	549	PF00069	0.674
MOD_CDK_SPxxK_3	583	590	PF00069	0.579
MOD_CK1_1	120	126	PF00069	0.700
MOD_CK1_1	134	140	PF00069	0.518
MOD_CK1_1	15	21	PF00069	0.655
MOD_CK1_1	155	161	PF00069	0.663
MOD_CK1_1	191	197	PF00069	0.556
MOD_CK1_1	205	211	PF00069	0.571
MOD_CK1_1	218	224	PF00069	0.657
MOD_CK1_1	277	283	PF00069	0.623
MOD_CK1_1	347	353	PF00069	0.653
MOD_CK1_1	448	454	PF00069	0.770
MOD_CK1_1	567	573	PF00069	0.553
MOD_CK1_1	582	588	PF00069	0.586
MOD_CK1_1	7	13	PF00069	0.649
MOD_CK1_1	730	736	PF00069	0.648
MOD_CK1_1	769	775	PF00069	0.661
MOD_CK1_1	792	798	PF00069	0.579
MOD_CK1_1	828	834	PF00069	0.621
MOD_CK1_1	840	846	PF00069	0.608
MOD_CK1_1	866	872	PF00069	0.615
MOD_CK1_1	93	99	PF00069	0.639
MOD_CK2_1	224	230	PF00069	0.569
MOD_CK2_1	231	237	PF00069	0.549
MOD_CK2_1	350	356	PF00069	0.548
MOD_CK2_1	416	422	PF00069	0.680
MOD_CK2_1	566	572	PF00069	0.647
MOD_CK2_1	730	736	PF00069	0.802
MOD_GlcNHglycan	117	120	PF01048	0.612
MOD_GlcNHglycan	126	129	PF01048	0.566
MOD_GlcNHglycan	157	160	PF01048	0.662
MOD_GlcNHglycan	17	20	PF01048	0.597
MOD_GlcNHglycan	175	178	PF01048	0.500
MOD_GlcNHglycan	190	193	PF01048	0.588
MOD_GlcNHglycan	204	207	PF01048	0.552
MOD_GlcNHglycan	217	220	PF01048	0.761
MOD_GlcNHglycan	280	283	PF01048	0.687
MOD_GlcNHglycan	336	339	PF01048	0.570
MOD_GlcNHglycan	394	397	PF01048	0.671
MOD_GlcNHglycan	400	404	PF01048	0.645
MOD_GlcNHglycan	412	415	PF01048	0.518
MOD_GlcNHglycan	418	421	PF01048	0.550
MOD_GlcNHglycan	467	470	PF01048	0.679
MOD_GlcNHglycan	495	498	PF01048	0.632
MOD_GlcNHglycan	524	527	PF01048	0.613
MOD_GlcNHglycan	6	9	PF01048	0.677
MOD_GlcNHglycan	603	606	PF01048	0.624
MOD_GlcNHglycan	655	658	PF01048	0.744
MOD_GlcNHglycan	666	669	PF01048	0.598
MOD_GlcNHglycan	678	681	PF01048	0.519
MOD_GlcNHglycan	868	871	PF01048	0.604
MOD_GSK3_1	120	127	PF00069	0.671
MOD_GSK3_1	134	141	PF00069	0.528
MOD_GSK3_1	148	155	PF00069	0.698
MOD_GSK3_1	184	191	PF00069	0.683
MOD_GSK3_1	215	222	PF00069	0.778
MOD_GSK3_1	274	281	PF00069	0.623
MOD_GSK3_1	350	357	PF00069	0.560
MOD_GSK3_1	390	397	PF00069	0.686
MOD_GSK3_1	463	470	PF00069	0.651
MOD_GSK3_1	471	478	PF00069	0.673
MOD_GSK3_1	505	512	PF00069	0.649
MOD_GSK3_1	579	586	PF00069	0.759
MOD_GSK3_1	601	608	PF00069	0.609
MOD_GSK3_1	672	679	PF00069	0.626
MOD_GSK3_1	706	713	PF00069	0.786
MOD_GSK3_1	789	796	PF00069	0.746
MOD_GSK3_1	825	832	PF00069	0.623
MOD_GSK3_1	837	844	PF00069	0.619
MOD_GSK3_1	868	875	PF00069	0.596
MOD_GSK3_1	96	103	PF00069	0.736
MOD_N-GLC_1	289	294	PF02516	0.691
MOD_N-GLC_1	448	453	PF02516	0.607
MOD_N-GLC_2	199	201	PF02516	0.647
MOD_NEK2_1	117	122	PF00069	0.662
MOD_NEK2_1	12	17	PF00069	0.667
MOD_NEK2_1	220	225	PF00069	0.614
MOD_NEK2_1	255	260	PF00069	0.617
MOD_NEK2_1	276	281	PF00069	0.745
MOD_NEK2_1	344	349	PF00069	0.608
MOD_NEK2_1	394	399	PF00069	0.625
MOD_NEK2_1	515	520	PF00069	0.639
MOD_NEK2_1	653	658	PF00069	0.600
MOD_NEK2_1	664	669	PF00069	0.578
MOD_NEK2_1	672	677	PF00069	0.627
MOD_NEK2_1	683	688	PF00069	0.562
MOD_NEK2_2	579	584	PF00069	0.640
MOD_PIKK_1	258	264	PF00454	0.667
MOD_PIKK_1	328	334	PF00454	0.594
MOD_PIKK_1	394	400	PF00454	0.694
MOD_PIKK_1	696	702	PF00454	0.592
MOD_PIKK_1	806	812	PF00454	0.593
MOD_PIKK_1	825	831	PF00454	0.580
MOD_PIKK_1	837	843	PF00454	0.601
MOD_PIKK_1	852	858	PF00454	0.539
MOD_PIKK_1	868	874	PF00454	0.513
MOD_PK_1	659	665	PF00069	0.531
MOD_PKA_2	148	154	PF00069	0.604
MOD_PKA_2	15	21	PF00069	0.685
MOD_PKA_2	166	172	PF00069	0.600
MOD_PKA_2	184	190	PF00069	0.494
MOD_PKA_2	210	216	PF00069	0.548
MOD_PKA_2	274	280	PF00069	0.616
MOD_PKA_2	294	300	PF00069	0.622
MOD_PKA_2	301	307	PF00069	0.600
MOD_PKA_2	334	340	PF00069	0.583
MOD_PKA_2	350	356	PF00069	0.613
MOD_PKA_2	559	565	PF00069	0.647
MOD_PKA_2	601	607	PF00069	0.649
MOD_PKA_2	727	733	PF00069	0.549
MOD_PKA_2	799	805	PF00069	0.594
MOD_PKB_1	150	158	PF00069	0.674
MOD_Plk_1	289	295	PF00069	0.709
MOD_Plk_1	354	360	PF00069	0.668
MOD_Plk_1	448	454	PF00069	0.531
MOD_Plk_1	629	635	PF00069	0.546
MOD_Plk_1	716	722	PF00069	0.610
MOD_Plk_4	185	191	PF00069	0.759
MOD_Plk_4	322	328	PF00069	0.613
MOD_Plk_4	354	360	PF00069	0.630
MOD_Plk_4	448	454	PF00069	0.603
MOD_Plk_4	607	613	PF00069	0.640
MOD_Plk_4	659	665	PF00069	0.561
MOD_Plk_4	703	709	PF00069	0.639
MOD_Plk_4	716	722	PF00069	0.545
MOD_ProDKin_1	131	137	PF00069	0.595
MOD_ProDKin_1	191	197	PF00069	0.617
MOD_ProDKin_1	200	206	PF00069	0.586
MOD_ProDKin_1	23	29	PF00069	0.695
MOD_ProDKin_1	281	287	PF00069	0.626
MOD_ProDKin_1	377	383	PF00069	0.655
MOD_ProDKin_1	42	48	PF00069	0.488
MOD_ProDKin_1	467	473	PF00069	0.647
MOD_ProDKin_1	475	481	PF00069	0.636
MOD_ProDKin_1	542	548	PF00069	0.599
MOD_ProDKin_1	583	589	PF00069	0.574
MOD_ProDKin_1	605	611	PF00069	0.596
MOD_ProDKin_1	730	736	PF00069	0.791
MOD_ProDKin_1	766	772	PF00069	0.586
MOD_ProDKin_1	834	840	PF00069	0.679
MOD_ProDKin_1	872	878	PF00069	0.686
MOD_ProDKin_1	90	96	PF00069	0.625
MOD_SUMO_rev_2	318	325	PF00179	0.631
TRG_DiLeu_BaEn_1	354	359	PF01217	0.653
TRG_DiLeu_BaEn_1	595	600	PF01217	0.658
TRG_DiLeu_BaEn_4	354	360	PF01217	0.655
TRG_ENDOCYTIC_2	160	163	PF00928	0.519
TRG_ER_diArg_1	148	150	PF00400	0.679
TRG_ER_diArg_1	299	302	PF00400	0.686
TRG_ER_diArg_1	528	531	PF00400	0.534
TRG_ER_diArg_1	684	687	PF00400	0.587
TRG_ER_diArg_1	751	754	PF00400	0.632
TRG_ER_diArg_1	758	761	PF00400	0.575
TRG_NLS_MonoExtC_3	686	692	PF00514	0.467
TRG_NLS_MonoExtC_3	749	754	PF00514	0.562
TRG_NLS_MonoExtN_4	685	691	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	689	693	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P766	Leptomonas seymouri	32%	100%
A0A3S7XBG5	Leishmania donovani	86%	100%
A4HPV2	Leishmania braziliensis	59%	100%
A4IE39	Leishmania infantum	86%	100%
E9ATL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%