Alternative oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Alternative oxidase

Gene product:

alternative oxidase, putative

Species:

Leishmania major

UniProt:

Q4Q0X6_LEIMA

TriTrypDb:

LmjF.36.4380 , LMJLV39_360055000 , LMJSD75_360054900

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	7
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0070469	respirasome	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q0X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0X6

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	2
GO:0008152	metabolic process	1	2
GO:0009060	aerobic respiration	6	2
GO:0009987	cellular process	1	2
GO:0010230	alternative respiration	7	2
GO:0015980	energy derivation by oxidation of organic compounds	4	2
GO:0044237	cellular metabolic process	2	2
GO:0045333	cellular respiration	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0009916	alternative oxidase activity	5	7
GO:0016491	oxidoreductase activity	2	7
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	3	7
GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.583
CLV_NRD_NRD_1	27	29	PF00675	0.502
CLV_NRD_NRD_1	425	427	PF00675	0.298
CLV_PCSK_KEX2_1	169	171	PF00082	0.615
CLV_PCSK_KEX2_1	27	29	PF00082	0.500
CLV_PCSK_PC7_1	165	171	PF00082	0.568
CLV_PCSK_SKI1_1	165	169	PF00082	0.473
CLV_PCSK_SKI1_1	17	21	PF00082	0.496
CLV_PCSK_SKI1_1	247	251	PF00082	0.497
CLV_PCSK_SKI1_1	354	358	PF00082	0.237
CLV_PCSK_SKI1_1	397	401	PF00082	0.370
DEG_APCC_DBOX_1	16	24	PF00400	0.671
DOC_MAPK_MEF2A_6	115	124	PF00069	0.489
DOC_MAPK_MEF2A_6	13	20	PF00069	0.715
DOC_MAPK_MEF2A_6	143	150	PF00069	0.332
DOC_MAPK_MEF2A_6	404	413	PF00069	0.524
DOC_PP1_RVXF_1	124	131	PF00149	0.491
DOC_USP7_MATH_1	156	160	PF00917	0.332
DOC_USP7_MATH_1	187	191	PF00917	0.362
DOC_USP7_MATH_1	19	23	PF00917	0.695
DOC_USP7_MATH_1	195	199	PF00917	0.271
DOC_USP7_MATH_1	218	222	PF00917	0.395
DOC_USP7_MATH_1	238	242	PF00917	0.302
DOC_USP7_MATH_1	307	311	PF00917	0.492
DOC_USP7_MATH_1	389	393	PF00917	0.525
DOC_USP7_MATH_1	402	406	PF00917	0.432
DOC_USP7_MATH_1	415	419	PF00917	0.464
DOC_USP7_MATH_1	46	50	PF00917	0.762
DOC_USP7_MATH_1	54	58	PF00917	0.741
DOC_USP7_MATH_1	63	67	PF00917	0.670
DOC_WW_Pin1_4	1	6	PF00397	0.613
DOC_WW_Pin1_4	109	114	PF00397	0.489
DOC_WW_Pin1_4	188	193	PF00397	0.289
DOC_WW_Pin1_4	196	201	PF00397	0.289
DOC_WW_Pin1_4	385	390	PF00397	0.562
DOC_WW_Pin1_4	397	402	PF00397	0.427
DOC_WW_Pin1_4	83	88	PF00397	0.522
LIG_14-3-3_CanoR_1	143	147	PF00244	0.332
LIG_14-3-3_CanoR_1	484	490	PF00244	0.637
LIG_14-3-3_CanoR_1	97	107	PF00244	0.568
LIG_BRCT_BRCA1_1	189	193	PF00533	0.368
LIG_BRCT_BRCA1_1	409	413	PF00533	0.464
LIG_BRCT_BRCA1_1	60	64	PF00533	0.658
LIG_BRCT_BRCA1_1	84	88	PF00533	0.560
LIG_eIF4E_1	288	294	PF01652	0.332
LIG_FHA_1	143	149	PF00498	0.332
LIG_FHA_1	284	290	PF00498	0.332
LIG_FHA_1	313	319	PF00498	0.489
LIG_FHA_1	353	359	PF00498	0.440
LIG_FHA_1	480	486	PF00498	0.653
LIG_FHA_2	183	189	PF00498	0.353
LIG_FHA_2	268	274	PF00498	0.291
LIG_FHA_2	355	361	PF00498	0.484
LIG_FHA_2	447	453	PF00498	0.518
LIG_FHA_2	99	105	PF00498	0.489
LIG_HCF-1_HBM_1	239	242	PF13415	0.368
LIG_LIR_Gen_1	190	200	PF02991	0.346
LIG_LIR_Gen_1	286	296	PF02991	0.336
LIG_LIR_Gen_1	311	321	PF02991	0.489
LIG_LIR_Gen_1	4	14	PF02991	0.594
LIG_LIR_Gen_1	85	95	PF02991	0.562
LIG_LIR_Nem_3	190	196	PF02991	0.346
LIG_LIR_Nem_3	286	291	PF02991	0.356
LIG_LIR_Nem_3	388	393	PF02991	0.437
LIG_LIR_Nem_3	461	467	PF02991	0.489
LIG_LIR_Nem_3	75	81	PF02991	0.721
LIG_LIR_Nem_3	85	91	PF02991	0.551
LIG_LYPXL_S_1	294	298	PF13949	0.332
LIG_LYPXL_yS_3	295	298	PF13949	0.489
LIG_NRBOX	245	251	PF00104	0.273
LIG_NRBOX	275	281	PF00104	0.517
LIG_REV1ctd_RIR_1	165	174	PF16727	0.241
LIG_SH2_CRK	260	264	PF00017	0.368
LIG_SH2_STAT5	140	143	PF00017	0.489
LIG_SH2_STAT5	163	166	PF00017	0.289
LIG_SH2_STAT5	242	245	PF00017	0.273
LIG_SH2_STAT5	288	291	PF00017	0.332
LIG_SH2_STAT5	29	32	PF00017	0.733
LIG_SH2_STAT5	76	79	PF00017	0.726
LIG_SH3_3	203	209	PF00018	0.404
LIG_SH3_3	326	332	PF00018	0.524
LIG_SH3_3	406	412	PF00018	0.568
LIG_SH3_3	53	59	PF00018	0.673
LIG_SUMO_SIM_anti_2	268	273	PF11976	0.273
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.309
LIG_SUMO_SIM_anti_2	452	457	PF11976	0.489
LIG_SUMO_SIM_par_1	354	360	PF11976	0.437
LIG_SUMO_SIM_par_1	446	452	PF11976	0.507
LIG_TRAF2_1	306	309	PF00917	0.489
LIG_TRAF2_1	357	360	PF00917	0.568
LIG_TYR_ITIM	258	263	PF00017	0.336
LIG_TYR_ITIM	336	341	PF00017	0.332
LIG_UBA3_1	485	493	PF00899	0.593
LIG_WW_1	73	76	PF00397	0.524
MOD_CDK_SPxK_1	109	115	PF00069	0.332
MOD_CDK_SPxxK_3	397	404	PF00069	0.381
MOD_CK1_1	171	177	PF00069	0.377
MOD_CK1_1	198	204	PF00069	0.317
MOD_CK1_1	22	28	PF00069	0.657
MOD_CK1_1	225	231	PF00069	0.479
MOD_CK1_1	385	391	PF00069	0.378
MOD_CK1_1	446	452	PF00069	0.375
MOD_CK1_1	48	54	PF00069	0.665
MOD_CK1_1	57	63	PF00069	0.590
MOD_CK2_1	182	188	PF00069	0.309
MOD_CK2_1	267	273	PF00069	0.359
MOD_CK2_1	354	360	PF00069	0.397
MOD_CK2_1	98	104	PF00069	0.332
MOD_DYRK1A_RPxSP_1	397	401	PF00069	0.381
MOD_GlcNHglycan	227	230	PF01048	0.451
MOD_GlcNHglycan	384	387	PF01048	0.437
MOD_GlcNHglycan	397	400	PF01048	0.368
MOD_GlcNHglycan	404	407	PF01048	0.502
MOD_GlcNHglycan	41	44	PF01048	0.568
MOD_GlcNHglycan	420	424	PF01048	0.441
MOD_GlcNHglycan	48	51	PF01048	0.702
MOD_GlcNHglycan	52	55	PF01048	0.698
MOD_GlcNHglycan	56	59	PF01048	0.615
MOD_GSK3_1	142	149	PF00069	0.333
MOD_GSK3_1	171	178	PF00069	0.340
MOD_GSK3_1	18	25	PF00069	0.638
MOD_GSK3_1	183	190	PF00069	0.317
MOD_GSK3_1	218	225	PF00069	0.491
MOD_GSK3_1	227	234	PF00069	0.296
MOD_GSK3_1	308	315	PF00069	0.340
MOD_GSK3_1	37	44	PF00069	0.620
MOD_GSK3_1	385	392	PF00069	0.318
MOD_GSK3_1	415	422	PF00069	0.436
MOD_GSK3_1	46	53	PF00069	0.664
MOD_GSK3_1	54	61	PF00069	0.688
MOD_N-GLC_1	171	176	PF02516	0.377
MOD_N-GLC_1	434	439	PF02516	0.259
MOD_N-GLC_2	175	177	PF02516	0.259
MOD_NEK2_1	108	113	PF00069	0.441
MOD_NEK2_1	124	129	PF00069	0.195
MOD_NEK2_1	146	151	PF00069	0.346
MOD_NEK2_1	168	173	PF00069	0.381
MOD_NEK2_1	222	227	PF00069	0.340
MOD_NEK2_1	23	28	PF00069	0.588
MOD_NEK2_1	231	236	PF00069	0.183
MOD_NEK2_1	272	277	PF00069	0.331
MOD_NEK2_1	37	42	PF00069	0.550
MOD_NEK2_1	485	490	PF00069	0.610
MOD_NEK2_1	64	69	PF00069	0.726
MOD_NEK2_1	82	87	PF00069	0.383
MOD_NEK2_2	65	70	PF00069	0.529
MOD_PIKK_1	178	184	PF00454	0.353
MOD_PIKK_1	312	318	PF00454	0.332
MOD_PIKK_1	41	47	PF00454	0.704
MOD_PIKK_1	479	485	PF00454	0.586
MOD_PIKK_1	98	104	PF00454	0.441
MOD_PKA_1	426	432	PF00069	0.289
MOD_PKA_2	142	148	PF00069	0.332
MOD_PKA_2	168	174	PF00069	0.378
MOD_PKA_2	218	224	PF00069	0.446
MOD_Plk_1	238	244	PF00069	0.441
MOD_Plk_1	267	273	PF00069	0.332
MOD_Plk_1	307	313	PF00069	0.346
MOD_Plk_4	142	148	PF00069	0.332
MOD_Plk_4	218	224	PF00069	0.331
MOD_Plk_4	238	244	PF00069	0.336
MOD_Plk_4	308	314	PF00069	0.344
MOD_Plk_4	443	449	PF00069	0.441
MOD_Plk_4	72	78	PF00069	0.665
MOD_ProDKin_1	1	7	PF00069	0.502
MOD_ProDKin_1	109	115	PF00069	0.332
MOD_ProDKin_1	188	194	PF00069	0.332
MOD_ProDKin_1	196	202	PF00069	0.332
MOD_ProDKin_1	385	391	PF00069	0.433
MOD_ProDKin_1	397	403	PF00069	0.244
MOD_ProDKin_1	83	89	PF00069	0.382
MOD_SUMO_rev_2	420	429	PF00179	0.411
TRG_DiLeu_BaEn_1	245	250	PF01217	0.309
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.556
TRG_ENDOCYTIC_2	163	166	PF00928	0.332
TRG_ENDOCYTIC_2	260	263	PF00928	0.336
TRG_ENDOCYTIC_2	288	291	PF00928	0.332
TRG_ENDOCYTIC_2	295	298	PF00928	0.332
TRG_ENDOCYTIC_2	338	341	PF00928	0.332
TRG_ENDOCYTIC_2	78	81	PF00928	0.644
TRG_ER_diArg_1	168	170	PF00400	0.381
TRG_ER_diArg_1	27	29	PF00400	0.595
TRG_NES_CRM1_1	268	281	PF08389	0.346
TRG_NES_CRM1_1	466	478	PF08389	0.381
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	247	252	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	465	470	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P770	Leptomonas seymouri	55%	100%
A0A3Q8IWB1	Leishmania donovani	90%	100%
A4HPV5	Leishmania braziliensis	69%	100%
A4IDL7	Leishmania infantum	90%	100%
E9ATM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%