Spindle pole body component

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

gamma-tubulin complex component 2

Species:

Leishmania major

UniProt:

Q4Q0X5_LEIMA

TriTrypDb:

LmjF.36.4390 , LMJLV39_360055100 , LMJSD75_360055000

Length:

864

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	12
GO:0000923	equatorial microtubule organizing center	3	2
GO:0000930	gamma-tubulin complex	2	2
GO:0005737	cytoplasm	2	12
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	12
GO:0005874	microtubule	6	12
GO:0008275	gamma-tubulin small complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0036064	ciliary basal body	3	2
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q0X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0X5

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	12
GO:0000278	mitotic cell cycle	3	2
GO:0006996	organelle organization	4	12
GO:0007010	cytoskeleton organization	5	12
GO:0007017	microtubule-based process	2	12
GO:0007020	microtubule nucleation	4	12
GO:0007049	cell cycle	2	2
GO:0007051	spindle organization	3	2
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022402	cell cycle process	2	2
GO:0022414	reproductive process	1	2
GO:0022607	cellular component assembly	4	2
GO:0031122	cytoplasmic microtubule organization	4	2
GO:0051225	spindle assembly	4	2
GO:0051321	meiotic cell cycle	2	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	12
GO:0097435	supramolecular fiber organization	4	2
GO:0140694	non-membrane-bounded organelle assembly	6	2
GO:1904158	axonemal central apparatus assembly	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0043015	gamma-tubulin binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	484	488	PF00656	0.514
CLV_C14_Caspase3-7	549	553	PF00656	0.465
CLV_NRD_NRD_1	325	327	PF00675	0.254
CLV_NRD_NRD_1	413	415	PF00675	0.300
CLV_NRD_NRD_1	426	428	PF00675	0.199
CLV_NRD_NRD_1	633	635	PF00675	0.292
CLV_NRD_NRD_1	646	648	PF00675	0.147
CLV_PCSK_KEX2_1	16	18	PF00082	0.549
CLV_PCSK_KEX2_1	325	327	PF00082	0.254
CLV_PCSK_KEX2_1	412	414	PF00082	0.305
CLV_PCSK_KEX2_1	426	428	PF00082	0.193
CLV_PCSK_KEX2_1	633	635	PF00082	0.314
CLV_PCSK_KEX2_1	646	648	PF00082	0.156
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.591
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.285
CLV_PCSK_PC7_1	408	414	PF00082	0.285
CLV_PCSK_SKI1_1	260	264	PF00082	0.265
CLV_PCSK_SKI1_1	444	448	PF00082	0.264
CLV_PCSK_SKI1_1	533	537	PF00082	0.326
CLV_PCSK_SKI1_1	689	693	PF00082	0.236
CLV_Separin_Metazoa	248	252	PF03568	0.465
DEG_APCC_DBOX_1	645	653	PF00400	0.559
DEG_SCF_TRCP1_1	612	618	PF00400	0.559
DEG_SPOP_SBC_1	156	160	PF00917	0.544
DEG_SPOP_SBC_1	282	286	PF00917	0.544
DEG_SPOP_SBC_1	766	770	PF00917	0.536
DOC_ANK_TNKS_1	484	491	PF00023	0.426
DOC_CKS1_1	150	155	PF01111	0.536
DOC_CKS1_1	439	444	PF01111	0.559
DOC_CYCLIN_RxL_1	644	655	PF00134	0.536
DOC_CYCLIN_RxL_1	685	693	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	658	664	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	819	825	PF00134	0.471
DOC_MAPK_DCC_7	325	334	PF00069	0.495
DOC_MAPK_gen_1	258	267	PF00069	0.536
DOC_MAPK_gen_1	564	572	PF00069	0.520
DOC_MAPK_gen_1	646	654	PF00069	0.495
DOC_MAPK_HePTP_8	322	334	PF00069	0.454
DOC_MAPK_HePTP_8	666	678	PF00069	0.540
DOC_MAPK_MEF2A_6	325	334	PF00069	0.474
DOC_MAPK_MEF2A_6	432	439	PF00069	0.540
DOC_MAPK_MEF2A_6	566	574	PF00069	0.461
DOC_MAPK_MEF2A_6	669	678	PF00069	0.527
DOC_PP1_RVXF_1	15	22	PF00149	0.458
DOC_PP1_RVXF_1	534	540	PF00149	0.559
DOC_PP1_RVXF_1	677	684	PF00149	0.515
DOC_PP4_FxxP_1	287	290	PF00568	0.529
DOC_USP7_MATH_1	156	160	PF00917	0.542
DOC_USP7_MATH_1	282	286	PF00917	0.546
DOC_USP7_MATH_1	288	292	PF00917	0.550
DOC_USP7_MATH_1	360	364	PF00917	0.500
DOC_USP7_MATH_1	481	485	PF00917	0.546
DOC_USP7_MATH_1	629	633	PF00917	0.475
DOC_USP7_MATH_1	645	649	PF00917	0.535
DOC_USP7_MATH_1	855	859	PF00917	0.620
DOC_USP7_MATH_1	860	864	PF00917	0.625
DOC_USP7_MATH_1	98	102	PF00917	0.679
DOC_WW_Pin1_4	149	154	PF00397	0.537
DOC_WW_Pin1_4	160	165	PF00397	0.548
DOC_WW_Pin1_4	168	173	PF00397	0.527
DOC_WW_Pin1_4	286	291	PF00397	0.559
DOC_WW_Pin1_4	438	443	PF00397	0.559
DOC_WW_Pin1_4	520	525	PF00397	0.462
DOC_WW_Pin1_4	818	823	PF00397	0.446
LIG_14-3-3_CanoR_1	325	329	PF00244	0.472
LIG_14-3-3_CanoR_1	426	431	PF00244	0.448
LIG_14-3-3_CanoR_1	470	475	PF00244	0.470
LIG_14-3-3_CanoR_1	580	586	PF00244	0.517
LIG_14-3-3_CanoR_1	60	68	PF00244	0.665
LIG_14-3-3_CanoR_1	633	637	PF00244	0.506
LIG_14-3-3_CanoR_1	646	650	PF00244	0.425
LIG_14-3-3_CanoR_1	772	777	PF00244	0.446
LIG_14-3-3_CanoR_1	814	823	PF00244	0.532
LIG_Actin_WH2_2	245	262	PF00022	0.502
LIG_BIR_II_1	1	5	PF00653	0.528
LIG_BRCT_BRCA1_1	283	287	PF00533	0.529
LIG_Clathr_ClatBox_1	651	655	PF01394	0.454
LIG_deltaCOP1_diTrp_1	545	550	PF00928	0.454
LIG_deltaCOP1_diTrp_1	6	10	PF00928	0.537
LIG_DLG_GKlike_1	426	434	PF00625	0.540
LIG_EH1_1	567	575	PF00400	0.465
LIG_eIF4E_1	203	209	PF01652	0.465
LIG_FHA_1	133	139	PF00498	0.368
LIG_FHA_1	290	296	PF00498	0.527
LIG_FHA_1	319	325	PF00498	0.571
LIG_FHA_1	38	44	PF00498	0.482
LIG_FHA_1	6	12	PF00498	0.497
LIG_FHA_1	625	631	PF00498	0.558
LIG_FHA_1	661	667	PF00498	0.448
LIG_FHA_1	669	675	PF00498	0.451
LIG_FHA_1	695	701	PF00498	0.559
LIG_FHA_1	761	767	PF00498	0.555
LIG_FHA_1	795	801	PF00498	0.506
LIG_FHA_2	112	118	PF00498	0.458
LIG_FHA_2	597	603	PF00498	0.516
LIG_FHA_2	833	839	PF00498	0.446
LIG_Integrin_RGD_1	543	545	PF01839	0.265
LIG_Integrin_RGDW_4	543	546	PF00362	0.265
LIG_LIR_Apic_2	284	290	PF02991	0.529
LIG_LIR_Gen_1	190	198	PF02991	0.462
LIG_LIR_Gen_1	4	14	PF02991	0.456
LIG_LIR_Gen_1	584	595	PF02991	0.480
LIG_LIR_Gen_1	731	741	PF02991	0.509
LIG_LIR_Gen_1	783	791	PF02991	0.472
LIG_LIR_Gen_1	835	843	PF02991	0.446
LIG_LIR_Nem_3	190	195	PF02991	0.504
LIG_LIR_Nem_3	345	351	PF02991	0.488
LIG_LIR_Nem_3	4	10	PF02991	0.445
LIG_LIR_Nem_3	584	590	PF02991	0.480
LIG_LIR_Nem_3	731	737	PF02991	0.509
LIG_LIR_Nem_3	770	776	PF02991	0.481
LIG_LIR_Nem_3	783	789	PF02991	0.436
LIG_LIR_Nem_3	826	830	PF02991	0.455
LIG_LIR_Nem_3	835	839	PF02991	0.448
LIG_LYPXL_yS_3	827	830	PF13949	0.446
LIG_MYND_1	828	832	PF01753	0.446
LIG_NRBOX	318	324	PF00104	0.455
LIG_NRBOX	599	605	PF00104	0.540
LIG_PCNA_yPIPBox_3	597	611	PF02747	0.559
LIG_Pex14_1	546	550	PF04695	0.454
LIG_Pex14_2	424	428	PF04695	0.465
LIG_Pex14_2	717	721	PF04695	0.457
LIG_Rb_LxCxE_1	190	207	PF01857	0.540
LIG_REV1ctd_RIR_1	448	458	PF16727	0.540
LIG_SH2_CRK	455	459	PF00017	0.454
LIG_SH2_GRB2like	696	699	PF00017	0.536
LIG_SH2_NCK_1	151	155	PF00017	0.485
LIG_SH2_STAP1	224	228	PF00017	0.515
LIG_SH2_STAP1	696	700	PF00017	0.536
LIG_SH2_STAP1	724	728	PF00017	0.446
LIG_SH2_STAT3	224	227	PF00017	0.540
LIG_SH2_STAT3	538	541	PF00017	0.515
LIG_SH2_STAT3	849	852	PF00017	0.498
LIG_SH2_STAT5	151	154	PF00017	0.528
LIG_SH2_STAT5	331	334	PF00017	0.454
LIG_SH2_STAT5	455	458	PF00017	0.456
LIG_SH2_STAT5	538	541	PF00017	0.454
LIG_SH2_STAT5	696	699	PF00017	0.529
LIG_SH3_3	150	156	PF00018	0.559
LIG_SH3_3	169	175	PF00018	0.540
LIG_SH3_3	353	359	PF00018	0.522
LIG_SH3_3	483	489	PF00018	0.485
LIG_SH3_3	726	732	PF00018	0.446
LIG_SH3_3	819	825	PF00018	0.509
LIG_SUMO_SIM_anti_2	207	212	PF11976	0.540
LIG_SUMO_SIM_anti_2	318	324	PF11976	0.486
LIG_SUMO_SIM_anti_2	44	51	PF11976	0.425
LIG_SUMO_SIM_anti_2	525	530	PF11976	0.427
LIG_SUMO_SIM_anti_2	648	653	PF11976	0.515
LIG_SUMO_SIM_par_1	662	667	PF11976	0.533
LIG_SUMO_SIM_par_1	778	784	PF11976	0.459
LIG_TRAF2_1	599	602	PF00917	0.540
LIG_TRFH_1	728	732	PF08558	0.422
LIG_UBA3_1	528	536	PF00899	0.306
LIG_UBA3_1	676	685	PF00899	0.328
MOD_CDK_SPK_2	160	165	PF00069	0.391
MOD_CDK_SPxK_1	438	444	PF00069	0.453
MOD_CK1_1	119	125	PF00069	0.559
MOD_CK1_1	160	166	PF00069	0.395
MOD_CK1_1	177	183	PF00069	0.241
MOD_CK1_1	2	8	PF00069	0.554
MOD_CK1_1	204	210	PF00069	0.453
MOD_CK1_1	289	295	PF00069	0.426
MOD_CK1_1	386	392	PF00069	0.334
MOD_CK1_1	399	405	PF00069	0.422
MOD_CK1_1	553	559	PF00069	0.427
MOD_CK1_1	581	587	PF00069	0.392
MOD_CK1_1	632	638	PF00069	0.350
MOD_CK1_1	794	800	PF00069	0.356
MOD_CK2_1	111	117	PF00069	0.466
MOD_CK2_1	160	166	PF00069	0.405
MOD_CK2_1	177	183	PF00069	0.428
MOD_CK2_1	596	602	PF00069	0.348
MOD_CK2_1	636	642	PF00069	0.373
MOD_GlcNHglycan	100	103	PF01048	0.714
MOD_GlcNHglycan	159	162	PF01048	0.421
MOD_GlcNHglycan	269	272	PF01048	0.350
MOD_GlcNHglycan	310	313	PF01048	0.325
MOD_GlcNHglycan	340	343	PF01048	0.456
MOD_GlcNHglycan	362	365	PF01048	0.273
MOD_GlcNHglycan	385	388	PF01048	0.438
MOD_GlcNHglycan	398	401	PF01048	0.380
MOD_GlcNHglycan	496	499	PF01048	0.500
MOD_GlcNHglycan	513	516	PF01048	0.252
MOD_GlcNHglycan	552	555	PF01048	0.322
MOD_GlcNHglycan	612	615	PF01048	0.393
MOD_GlcNHglycan	62	65	PF01048	0.656
MOD_GlcNHglycan	638	641	PF01048	0.287
MOD_GlcNHglycan	703	707	PF01048	0.396
MOD_GlcNHglycan	73	76	PF01048	0.754
MOD_GlcNHglycan	857	860	PF01048	0.722
MOD_GSK3_1	1	8	PF00069	0.455
MOD_GSK3_1	128	135	PF00069	0.527
MOD_GSK3_1	156	163	PF00069	0.412
MOD_GSK3_1	177	184	PF00069	0.344
MOD_GSK3_1	215	222	PF00069	0.322
MOD_GSK3_1	282	289	PF00069	0.434
MOD_GSK3_1	37	44	PF00069	0.473
MOD_GSK3_1	396	403	PF00069	0.407
MOD_GSK3_1	426	433	PF00069	0.393
MOD_GSK3_1	506	513	PF00069	0.484
MOD_GSK3_1	610	617	PF00069	0.471
MOD_GSK3_1	625	632	PF00069	0.324
MOD_GSK3_1	748	755	PF00069	0.462
MOD_GSK3_1	790	797	PF00069	0.350
MOD_GSK3_1	814	821	PF00069	0.318
MOD_GSK3_1	98	105	PF00069	0.756
MOD_N-GLC_1	220	225	PF02516	0.401
MOD_N-GLC_1	430	435	PF02516	0.427
MOD_N-GLC_1	596	601	PF02516	0.425
MOD_NEK2_1	128	133	PF00069	0.539
MOD_NEK2_1	181	186	PF00069	0.370
MOD_NEK2_1	267	272	PF00069	0.398
MOD_NEK2_1	324	329	PF00069	0.427
MOD_NEK2_1	396	401	PF00069	0.394
MOD_NEK2_1	430	435	PF00069	0.355
MOD_NEK2_1	494	499	PF00069	0.470
MOD_NEK2_1	510	515	PF00069	0.320
MOD_NEK2_1	636	641	PF00069	0.467
MOD_NEK2_1	748	753	PF00069	0.347
MOD_NEK2_1	765	770	PF00069	0.197
MOD_NEK2_1	791	796	PF00069	0.365
MOD_PIKK_1	116	122	PF00454	0.611
MOD_PIKK_1	402	408	PF00454	0.453
MOD_PIKK_1	748	754	PF00454	0.419
MOD_PIKK_1	767	773	PF00454	0.199
MOD_PIKK_1	86	92	PF00454	0.744
MOD_PK_1	470	476	PF00069	0.226
MOD_PKA_1	426	432	PF00069	0.282
MOD_PKA_2	102	108	PF00069	0.752
MOD_PKA_2	324	330	PF00069	0.358
MOD_PKA_2	34	40	PF00069	0.561
MOD_PKA_2	426	432	PF00069	0.260
MOD_PKA_2	59	65	PF00069	0.671
MOD_PKA_2	610	616	PF00069	0.427
MOD_PKA_2	632	638	PF00069	0.289
MOD_PKA_2	645	651	PF00069	0.415
MOD_Plk_1	116	122	PF00069	0.589
MOD_Plk_1	220	226	PF00069	0.427
MOD_Plk_1	430	436	PF00069	0.412
MOD_Plk_1	5	11	PF00069	0.474
MOD_Plk_1	596	602	PF00069	0.341
MOD_Plk_1	801	807	PF00069	0.403
MOD_Plk_1	837	843	PF00069	0.383
MOD_Plk_4	128	134	PF00069	0.494
MOD_Plk_4	181	187	PF00069	0.311
MOD_Plk_4	204	210	PF00069	0.319
MOD_Plk_4	318	324	PF00069	0.449
MOD_Plk_4	430	436	PF00069	0.374
MOD_Plk_4	553	559	PF00069	0.427
MOD_Plk_4	660	666	PF00069	0.299
MOD_Plk_4	743	749	PF00069	0.311
MOD_Plk_4	832	838	PF00069	0.295
MOD_ProDKin_1	149	155	PF00069	0.423
MOD_ProDKin_1	160	166	PF00069	0.438
MOD_ProDKin_1	168	174	PF00069	0.409
MOD_ProDKin_1	286	292	PF00069	0.453
MOD_ProDKin_1	438	444	PF00069	0.453
MOD_ProDKin_1	520	526	PF00069	0.456
MOD_ProDKin_1	818	824	PF00069	0.295
TRG_DiLeu_BaEn_1	315	320	PF01217	0.322
TRG_DiLeu_BaLyEn_6	676	681	PF01217	0.378
TRG_DiLeu_BaLyEn_6	796	801	PF01217	0.422
TRG_DiLeu_BaLyEn_6	829	834	PF01217	0.295
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.746
TRG_ENDOCYTIC_2	331	334	PF00928	0.306
TRG_ENDOCYTIC_2	348	351	PF00928	0.306
TRG_ENDOCYTIC_2	455	458	PF00928	0.306
TRG_ENDOCYTIC_2	587	590	PF00928	0.341
TRG_ENDOCYTIC_2	827	830	PF00928	0.295
TRG_ER_diArg_1	257	260	PF00400	0.320
TRG_ER_diArg_1	324	326	PF00400	0.306
TRG_ER_diArg_1	426	428	PF00400	0.316
TRG_NES_CRM1_1	527	541	PF08389	0.427
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	689	693	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	814	818	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I635	Leptomonas seymouri	72%	98%
A0A0S4J3M1	Bodo saltans	41%	98%
A0A1X0P0Y3	Trypanosomatidae	47%	100%
A0A3R7RTV6	Trypanosoma rangeli	45%	100%
A0A3S7XBK0	Leishmania donovani	95%	100%
A4HPV6	Leishmania braziliensis	82%	100%
A4IDL8	Leishmania infantum	95%	100%
D0A4A5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ATM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q5R5J6	Pongo abelii	22%	96%
Q9BSJ2	Homo sapiens	22%	96%
Q9C5H9	Arabidopsis thaliana	22%	100%
V5DLM1	Trypanosoma cruzi	47%	100%