Probable eukaryotic initiation factor 4A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent DEAD/H RNA helicase, putative

Species:

Leishmania major

UniProt:

Q4Q0X4_LEIMA

TriTrypDb:

LmjF.36.4400 , LMJLV39_360055300 , LMJSD75_360055100

Length:

964

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0X4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003676	nucleic acid binding	3	9
GO:0003724	RNA helicase activity	3	9
GO:0003743	translation initiation factor activity	4	9
GO:0003824	catalytic activity	1	9
GO:0004386	helicase activity	2	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0008135	translation factor activity, RNA binding	3	9
GO:0008186	ATP-dependent activity, acting on RNA	2	9
GO:0016787	hydrolase activity	2	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0045182	translation regulator activity	1	9
GO:0090079	translation regulator activity, nucleic acid binding	2	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9
GO:0140657	ATP-dependent activity	1	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	887	891	PF00656	0.499
CLV_NRD_NRD_1	12	14	PF00675	0.538
CLV_NRD_NRD_1	27	29	PF00675	0.598
CLV_NRD_NRD_1	35	37	PF00675	0.646
CLV_NRD_NRD_1	412	414	PF00675	0.291
CLV_NRD_NRD_1	549	551	PF00675	0.653
CLV_NRD_NRD_1	595	597	PF00675	0.673
CLV_NRD_NRD_1	632	634	PF00675	0.600
CLV_NRD_NRD_1	637	639	PF00675	0.603
CLV_NRD_NRD_1	718	720	PF00675	0.279
CLV_NRD_NRD_1	816	818	PF00675	0.502
CLV_NRD_NRD_1	824	826	PF00675	0.558
CLV_NRD_NRD_1	911	913	PF00675	0.560
CLV_PCSK_FUR_1	328	332	PF00082	0.305
CLV_PCSK_KEX2_1	119	121	PF00082	0.646
CLV_PCSK_KEX2_1	249	251	PF00082	0.773
CLV_PCSK_KEX2_1	29	31	PF00082	0.607
CLV_PCSK_KEX2_1	327	329	PF00082	0.258
CLV_PCSK_KEX2_1	330	332	PF00082	0.257
CLV_PCSK_KEX2_1	35	37	PF00082	0.582
CLV_PCSK_KEX2_1	412	414	PF00082	0.305
CLV_PCSK_KEX2_1	515	517	PF00082	0.714
CLV_PCSK_KEX2_1	632	634	PF00082	0.657
CLV_PCSK_KEX2_1	718	720	PF00082	0.279
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.622
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.773
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.540
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.285
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.273
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.714
CLV_PCSK_SKI1_1	353	357	PF00082	0.312
CLV_PCSK_SKI1_1	535	539	PF00082	0.735
CLV_PCSK_SKI1_1	551	555	PF00082	0.534
CLV_PCSK_SKI1_1	6	10	PF00082	0.738
CLV_PCSK_SKI1_1	614	618	PF00082	0.528
CLV_PCSK_SKI1_1	719	723	PF00082	0.280
CLV_PCSK_SKI1_1	74	78	PF00082	0.633
CLV_PCSK_SKI1_1	912	916	PF00082	0.579
CLV_PCSK_SKI1_1	921	925	PF00082	0.607
DEG_APCC_DBOX_1	740	748	PF00400	0.479
DEG_SCF_FBW7_1	296	301	PF00400	0.405
DEG_SCF_FBW7_1	544	549	PF00400	0.630
DEG_SCF_FBW7_2	214	219	PF00400	0.453
DEG_SCF_SKP2-CKS1_1	541	548	PF00560	0.632
DEG_SPOP_SBC_1	528	532	PF00917	0.626
DEG_SPOP_SBC_1	99	103	PF00917	0.703
DOC_CKS1_1	388	393	PF01111	0.454
DOC_CYCLIN_RxL_1	339	349	PF00134	0.489
DOC_MAPK_DCC_7	596	605	PF00069	0.722
DOC_MAPK_gen_1	18	25	PF00069	0.598
DOC_MAPK_gen_1	327	338	PF00069	0.482
DOC_MAPK_gen_1	412	419	PF00069	0.508
DOC_MAPK_gen_1	718	729	PF00069	0.501
DOC_MAPK_gen_1	749	757	PF00069	0.521
DOC_MAPK_gen_1	894	902	PF00069	0.516
DOC_MAPK_gen_1	943	951	PF00069	0.589
DOC_MAPK_HePTP_8	649	661	PF00069	0.474
DOC_MAPK_MEF2A_6	138	145	PF00069	0.654
DOC_MAPK_MEF2A_6	357	364	PF00069	0.495
DOC_MAPK_MEF2A_6	652	661	PF00069	0.473
DOC_MAPK_MEF2A_6	722	731	PF00069	0.521
DOC_MAPK_MEF2A_6	751	759	PF00069	0.521
DOC_PP1_RVXF_1	205	212	PF00149	0.529
DOC_PP1_RVXF_1	270	277	PF00149	0.479
DOC_PP1_RVXF_1	704	711	PF00149	0.481
DOC_PP1_RVXF_1	741	747	PF00149	0.479
DOC_PP1_RVXF_1	846	852	PF00149	0.447
DOC_PP2B_LxvP_1	151	154	PF13499	0.766
DOC_PP2B_PxIxI_1	383	389	PF00149	0.521
DOC_PP4_FxxP_1	211	214	PF00568	0.456
DOC_PP4_FxxP_1	276	279	PF00568	0.454
DOC_USP7_MATH_1	100	104	PF00917	0.670
DOC_USP7_MATH_1	105	109	PF00917	0.682
DOC_USP7_MATH_1	133	137	PF00917	0.588
DOC_USP7_MATH_1	254	258	PF00917	0.535
DOC_USP7_MATH_1	298	302	PF00917	0.437
DOC_USP7_MATH_1	464	468	PF00917	0.628
DOC_USP7_MATH_1	546	550	PF00917	0.674
DOC_USP7_MATH_1	553	557	PF00917	0.699
DOC_USP7_MATH_1	63	67	PF00917	0.638
DOC_USP7_MATH_1	637	641	PF00917	0.657
DOC_USP7_MATH_1	687	691	PF00917	0.426
DOC_USP7_MATH_1	93	97	PF00917	0.665
DOC_USP7_UBL2_3	14	18	PF12436	0.551
DOC_USP7_UBL2_3	243	247	PF12436	0.662
DOC_USP7_UBL2_3	489	493	PF12436	0.682
DOC_USP7_UBL2_3	5	9	PF12436	0.622
DOC_USP7_UBL2_3	535	539	PF12436	0.764
DOC_USP7_UBL2_3	554	558	PF12436	0.663
DOC_USP7_UBL2_3	745	749	PF12436	0.521
DOC_USP7_UBL2_3	858	862	PF12436	0.505
DOC_WW_Pin1_4	212	217	PF00397	0.470
DOC_WW_Pin1_4	294	299	PF00397	0.554
DOC_WW_Pin1_4	336	341	PF00397	0.479
DOC_WW_Pin1_4	387	392	PF00397	0.464
DOC_WW_Pin1_4	542	547	PF00397	0.629
DOC_WW_Pin1_4	83	88	PF00397	0.595
LIG_14-3-3_CanoR_1	292	298	PF00244	0.474
LIG_14-3-3_CanoR_1	331	337	PF00244	0.479
LIG_14-3-3_CanoR_1	614	619	PF00244	0.502
LIG_14-3-3_CanoR_1	665	670	PF00244	0.354
LIG_14-3-3_CanoR_1	74	83	PF00244	0.658
LIG_14-3-3_CanoR_1	783	789	PF00244	0.479
LIG_14-3-3_CanoR_1	925	931	PF00244	0.593
LIG_Actin_WH2_2	731	747	PF00022	0.472
LIG_Actin_WH2_2	832	850	PF00022	0.479
LIG_AP2alpha_1	746	750	PF02296	0.521
LIG_BIR_II_1	1	5	PF00653	0.615
LIG_BRCT_BRCA1_1	427	431	PF00533	0.521
LIG_FHA_1	288	294	PF00498	0.509
LIG_FHA_1	339	345	PF00498	0.484
LIG_FHA_1	539	545	PF00498	0.546
LIG_FHA_1	621	627	PF00498	0.499
LIG_FHA_1	649	655	PF00498	0.374
LIG_FHA_1	75	81	PF00498	0.630
LIG_FHA_1	946	952	PF00498	0.586
LIG_FHA_2	284	290	PF00498	0.457
LIG_FHA_2	434	440	PF00498	0.474
LIG_FHA_2	497	503	PF00498	0.621
LIG_FHA_2	584	590	PF00498	0.630
LIG_FHA_2	626	632	PF00498	0.591
LIG_FHA_2	699	705	PF00498	0.462
LIG_GBD_Chelix_1	839	847	PF00786	0.451
LIG_IRF3_LxIS_1	332	339	PF10401	0.509
LIG_LIR_Apic_2	208	214	PF02991	0.464
LIG_LIR_Apic_2	273	279	PF02991	0.454
LIG_LIR_Gen_1	428	438	PF02991	0.521
LIG_LIR_Nem_3	428	434	PF02991	0.521
LIG_LIR_Nem_3	474	480	PF02991	0.625
LIG_LIR_Nem_3	579	584	PF02991	0.682
LIG_LIR_Nem_3	692	697	PF02991	0.479
LIG_LIR_Nem_3	815	819	PF02991	0.449
LIG_NRBOX	280	286	PF00104	0.521
LIG_NRBOX	433	439	PF00104	0.521
LIG_NRBOX	719	725	PF00104	0.529
LIG_NRBOX	75	81	PF00104	0.592
LIG_NRBOX	802	808	PF00104	0.441
LIG_PCNA_yPIPBox_3	357	368	PF02747	0.517
LIG_Pex14_2	746	750	PF04695	0.479
LIG_SH2_CRK	581	585	PF00017	0.542
LIG_SH2_CRK	779	783	PF00017	0.521
LIG_SH2_NCK_1	41	45	PF00017	0.629
LIG_SH2_PTP2	416	419	PF00017	0.505
LIG_SH2_STAT5	190	193	PF00017	0.450
LIG_SH2_STAT5	405	408	PF00017	0.479
LIG_SH2_STAT5	416	419	PF00017	0.505
LIG_SH2_STAT5	618	621	PF00017	0.465
LIG_SH2_STAT5	683	686	PF00017	0.416
LIG_SH2_STAT5	694	697	PF00017	0.423
LIG_SH2_STAT5	775	778	PF00017	0.499
LIG_SH2_STAT5	788	791	PF00017	0.414
LIG_SH3_1	138	144	PF00018	0.660
LIG_SH3_3	138	144	PF00018	0.668
LIG_SH3_3	601	607	PF00018	0.676
LIG_SH3_3	67	73	PF00018	0.725
LIG_SH3_4	489	496	PF00018	0.621
LIG_SUMO_SIM_anti_2	801	807	PF11976	0.398
LIG_SUMO_SIM_par_1	148	156	PF11976	0.661
LIG_SUMO_SIM_par_1	620	628	PF11976	0.498
LIG_TRAF2_1	216	219	PF00917	0.459
LIG_TRAF2_1	572	575	PF00917	0.714
LIG_TRAF2_1	65	68	PF00917	0.661
LIG_TYR_ITIM	414	419	PF00017	0.505
LIG_UBA3_1	716	722	PF00899	0.521
LIG_UBA3_1	819	826	PF00899	0.511
LIG_WRC_WIRS_1	830	835	PF05994	0.466
MOD_CDC14_SPxK_1	339	342	PF00782	0.479
MOD_CDK_SPxK_1	336	342	PF00069	0.479
MOD_CDK_SPxK_1	387	393	PF00069	0.454
MOD_CDK_SPxK_1	542	548	PF00069	0.632
MOD_CK1_1	122	128	PF00069	0.646
MOD_CK1_1	265	271	PF00069	0.447
MOD_CK1_1	294	300	PF00069	0.505
MOD_CK1_1	529	535	PF00069	0.675
MOD_CK1_1	549	555	PF00069	0.639
MOD_CK1_1	625	631	PF00069	0.571
MOD_CK1_1	86	92	PF00069	0.608
MOD_CK2_1	225	231	PF00069	0.587
MOD_CK2_1	297	303	PF00069	0.539
MOD_CK2_1	433	439	PF00069	0.506
MOD_CK2_1	496	502	PF00069	0.611
MOD_CK2_1	583	589	PF00069	0.629
MOD_CK2_1	625	631	PF00069	0.630
MOD_CK2_1	665	671	PF00069	0.527
MOD_CK2_1	825	831	PF00069	0.549
MOD_Cter_Amidation	512	515	PF01082	0.697
MOD_Cter_Amidation	823	826	PF01082	0.547
MOD_Cter_Amidation	910	913	PF01082	0.524
MOD_Cter_Amidation	961	964	PF01082	0.544
MOD_GlcNHglycan	114	117	PF01048	0.575
MOD_GlcNHglycan	125	128	PF01048	0.625
MOD_GlcNHglycan	185	188	PF01048	0.639
MOD_GlcNHglycan	227	230	PF01048	0.642
MOD_GlcNHglycan	256	259	PF01048	0.606
MOD_GlcNHglycan	264	267	PF01048	0.251
MOD_GlcNHglycan	269	272	PF01048	0.249
MOD_GlcNHglycan	293	296	PF01048	0.222
MOD_GlcNHglycan	300	303	PF01048	0.201
MOD_GlcNHglycan	408	411	PF01048	0.313
MOD_GlcNHglycan	427	430	PF01048	0.321
MOD_GlcNHglycan	466	469	PF01048	0.646
MOD_GlcNHglycan	555	558	PF01048	0.704
MOD_GlcNHglycan	620	623	PF01048	0.469
MOD_GlcNHglycan	634	638	PF01048	0.673
MOD_GlcNHglycan	671	674	PF01048	0.572
MOD_GlcNHglycan	91	94	PF01048	0.700
MOD_GlcNHglycan	926	929	PF01048	0.601
MOD_GlcNHglycan	95	98	PF01048	0.681
MOD_GSK3_1	107	114	PF00069	0.638
MOD_GSK3_1	119	126	PF00069	0.593
MOD_GSK3_1	283	290	PF00069	0.503
MOD_GSK3_1	294	301	PF00069	0.513
MOD_GSK3_1	307	314	PF00069	0.562
MOD_GSK3_1	332	339	PF00069	0.507
MOD_GSK3_1	527	534	PF00069	0.570
MOD_GSK3_1	538	545	PF00069	0.622
MOD_GSK3_1	549	556	PF00069	0.595
MOD_GSK3_1	59	66	PF00069	0.665
MOD_GSK3_1	614	621	PF00069	0.436
MOD_GSK3_1	633	640	PF00069	0.734
MOD_GSK3_1	665	672	PF00069	0.564
MOD_GSK3_1	758	765	PF00069	0.464
MOD_GSK3_1	825	832	PF00069	0.509
MOD_GSK3_1	89	96	PF00069	0.662
MOD_N-GLC_1	679	684	PF02516	0.450
MOD_N-GLC_1	89	94	PF02516	0.634
MOD_N-GLC_2	111	113	PF02516	0.604
MOD_NEK2_1	128	133	PF00069	0.595
MOD_NEK2_1	209	214	PF00069	0.489
MOD_NEK2_1	406	411	PF00069	0.479
MOD_NEK2_1	425	430	PF00069	0.481
MOD_NEK2_1	669	674	PF00069	0.567
MOD_NEK2_1	698	703	PF00069	0.479
MOD_NEK2_1	734	739	PF00069	0.479
MOD_NEK2_1	819	824	PF00069	0.463
MOD_NEK2_1	835	840	PF00069	0.462
MOD_NEK2_1	924	929	PF00069	0.589
MOD_NEK2_2	507	512	PF00069	0.563
MOD_PIKK_1	63	69	PF00454	0.644
MOD_PK_1	40	46	PF00069	0.633
MOD_PKA_1	119	125	PF00069	0.709
MOD_PKA_1	4	10	PF00069	0.556
MOD_PKA_1	538	544	PF00069	0.542
MOD_PKA_1	825	831	PF00069	0.549
MOD_PKA_1	912	918	PF00069	0.532
MOD_PKA_2	119	125	PF00069	0.642
MOD_PKA_2	183	189	PF00069	0.724
MOD_PKA_2	236	242	PF00069	0.641
MOD_PKA_2	291	297	PF00069	0.474
MOD_PKA_2	549	555	PF00069	0.768
MOD_PKA_2	637	643	PF00069	0.607
MOD_PKA_2	782	788	PF00069	0.479
MOD_PKA_2	871	877	PF00069	0.472
MOD_PKA_2	924	930	PF00069	0.583
MOD_PKA_2	945	951	PF00069	0.587
MOD_PKB_1	38	46	PF00069	0.562
MOD_Plk_1	679	685	PF00069	0.426
MOD_Plk_2-3	433	439	PF00069	0.505
MOD_Plk_2-3	72	78	PF00069	0.628
MOD_Plk_2-3	878	884	PF00069	0.605
MOD_Plk_4	270	276	PF00069	0.479
MOD_Plk_4	332	338	PF00069	0.505
MOD_Plk_4	433	439	PF00069	0.509
MOD_Plk_4	473	479	PF00069	0.621
MOD_Plk_4	637	643	PF00069	0.597
MOD_Plk_4	679	685	PF00069	0.426
MOD_Plk_4	801	807	PF00069	0.379
MOD_Plk_4	835	841	PF00069	0.444
MOD_ProDKin_1	212	218	PF00069	0.462
MOD_ProDKin_1	294	300	PF00069	0.554
MOD_ProDKin_1	336	342	PF00069	0.479
MOD_ProDKin_1	387	393	PF00069	0.464
MOD_ProDKin_1	542	548	PF00069	0.632
MOD_ProDKin_1	83	89	PF00069	0.593
MOD_SUMO_for_1	563	566	PF00179	0.550
MOD_SUMO_rev_2	238	245	PF00179	0.636
MOD_SUMO_rev_2	748	755	PF00179	0.556
TRG_DiLeu_BaEn_1	433	438	PF01217	0.501
TRG_ENDOCYTIC_2	41	44	PF00928	0.625
TRG_ENDOCYTIC_2	416	419	PF00928	0.505
TRG_ENDOCYTIC_2	581	584	PF00928	0.543
TRG_ENDOCYTIC_2	696	699	PF00928	0.479
TRG_ER_diArg_1	27	30	PF00400	0.609
TRG_ER_diArg_1	35	38	PF00400	0.636
TRG_ER_diArg_1	412	414	PF00400	0.491
TRG_ER_diArg_1	717	719	PF00400	0.479
TRG_ER_diArg_1	741	744	PF00400	0.479
TRG_NLS_Bipartite_1	13	32	PF00514	0.530
TRG_NLS_MonoCore_2	953	958	PF00514	0.433
TRG_NLS_MonoExtC_3	245	250	PF00514	0.633
TRG_NLS_MonoExtC_3	326	331	PF00514	0.474
TRG_NLS_MonoExtC_3	513	518	PF00514	0.677
TRG_NLS_MonoExtC_3	534	539	PF00514	0.678
TRG_NLS_MonoExtN_4	243	250	PF00514	0.633
TRG_NLS_MonoExtN_4	325	331	PF00514	0.509
TRG_NLS_MonoExtN_4	512	518	PF00514	0.638
TRG_NLS_MonoExtN_4	533	539	PF00514	0.807
TRG_NLS_MonoExtN_4	954	959	PF00514	0.574
TRG_Pf-PMV_PEXEL_1	342	347	PF00026	0.254
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	766	771	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	817	821	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	901	906	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ87	Leptomonas seymouri	70%	100%
A0A0S4II81	Bodo saltans	26%	100%
A0A0S4J049	Bodo saltans	45%	100%
A0A3S7XBG9	Leishmania donovani	93%	100%
A4HPV7	Leishmania braziliensis	80%	99%
A4IDL9	Leishmania infantum	93%	100%
E9ATM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%