Putative chaperone protein DNAj

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania major

UniProt:

Q4Q0W7_LEIMA

TriTrypDb:

LmjF.36.4470 , LMJLV39_360056000 , LMJSD75_360055800

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0W7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0031072	heat shock protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.531
CLV_NRD_NRD_1	258	260	PF00675	0.661
CLV_NRD_NRD_1	268	270	PF00675	0.708
CLV_NRD_NRD_1	61	63	PF00675	0.310
CLV_PCSK_KEX2_1	249	251	PF00082	0.635
CLV_PCSK_KEX2_1	61	63	PF00082	0.309
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.635
CLV_PCSK_PC7_1	245	251	PF00082	0.655
CLV_PCSK_SKI1_1	21	25	PF00082	0.293
CLV_PCSK_SKI1_1	236	240	PF00082	0.570
CLV_PCSK_SKI1_1	99	103	PF00082	0.550
DOC_MAPK_gen_1	127	136	PF00069	0.420
DOC_PP2B_LxvP_1	12	15	PF13499	0.320
DOC_USP7_MATH_1	15	19	PF00917	0.304
DOC_USP7_MATH_1	165	169	PF00917	0.581
DOC_USP7_MATH_1	244	248	PF00917	0.754
DOC_USP7_MATH_1	75	79	PF00917	0.604
DOC_USP7_UBL2_3	17	21	PF12436	0.192
DOC_USP7_UBL2_3	236	240	PF12436	0.627
DOC_USP7_UBL2_3	266	270	PF12436	0.739
DOC_WW_Pin1_4	158	163	PF00397	0.591
DOC_WW_Pin1_4	168	173	PF00397	0.557
LIG_14-3-3_CanoR_1	149	155	PF00244	0.540
LIG_14-3-3_CanoR_1	221	227	PF00244	0.631
LIG_Clathr_ClatBox_1	175	179	PF01394	0.382
LIG_FHA_1	66	72	PF00498	0.475
LIG_FHA_1	9	15	PF00498	0.369
LIG_FHA_2	151	157	PF00498	0.435
LIG_Integrin_RGD_1	123	125	PF01839	0.505
LIG_LIR_Gen_1	132	140	PF02991	0.538
LIG_LIR_Gen_1	224	233	PF02991	0.579
LIG_LIR_Gen_1	50	59	PF02991	0.380
LIG_LIR_Nem_3	100	105	PF02991	0.446
LIG_LIR_Nem_3	132	136	PF02991	0.546
LIG_LIR_Nem_3	24	30	PF02991	0.301
LIG_LIR_Nem_3	44	49	PF02991	0.280
LIG_LIR_Nem_3	50	56	PF02991	0.269
LIG_SH2_CRK	53	57	PF00017	0.290
LIG_SH2_CRK	9	13	PF00017	0.306
LIG_SH2_STAP1	226	230	PF00017	0.589
LIG_SH2_STAT5	133	136	PF00017	0.549
LIG_SH2_STAT5	237	240	PF00017	0.567
LIG_SUMO_SIM_anti_2	110	117	PF11976	0.311
LIG_TRAF2_1	108	111	PF00917	0.399
LIG_UBA3_1	175	180	PF00899	0.506
LIG_UBA3_1	229	236	PF00899	0.527
LIG_WRC_WIRS_1	98	103	PF05994	0.367
MOD_CDK_SPxxK_3	160	167	PF00069	0.351
MOD_CK1_1	168	174	PF00069	0.550
MOD_CK1_1	225	231	PF00069	0.630
MOD_CK1_1	248	254	PF00069	0.704
MOD_CK1_1	74	80	PF00069	0.670
MOD_CK2_1	105	111	PF00069	0.401
MOD_CK2_1	150	156	PF00069	0.517
MOD_CK2_1	167	173	PF00069	0.484
MOD_CK2_1	221	227	PF00069	0.676
MOD_CK2_1	54	60	PF00069	0.372
MOD_GlcNHglycan	107	110	PF01048	0.543
MOD_GlcNHglycan	198	201	PF01048	0.609
MOD_GlcNHglycan	73	76	PF01048	0.593
MOD_GlcNHglycan	90	93	PF01048	0.445
MOD_GSK3_1	221	228	PF00069	0.629
MOD_GSK3_1	232	239	PF00069	0.605
MOD_GSK3_1	244	251	PF00069	0.683
MOD_GSK3_1	65	72	PF00069	0.519
MOD_GSK3_1	75	82	PF00069	0.547
MOD_GSK3_1	97	104	PF00069	0.492
MOD_N-GLC_1	158	163	PF02516	0.534
MOD_NEK2_1	101	106	PF00069	0.458
MOD_NEK2_1	150	155	PF00069	0.454
MOD_NEK2_1	16	21	PF00069	0.420
MOD_NEK2_1	196	201	PF00069	0.610
MOD_NEK2_1	8	13	PF00069	0.445
MOD_PK_1	45	51	PF00069	0.319
MOD_PKA_1	269	275	PF00069	0.747
MOD_PKA_2	244	250	PF00069	0.716
MOD_PKB_1	219	227	PF00069	0.614
MOD_Plk_1	209	215	PF00069	0.689
MOD_Plk_4	150	156	PF00069	0.505
MOD_Plk_4	225	231	PF00069	0.623
MOD_ProDKin_1	158	164	PF00069	0.598
MOD_ProDKin_1	168	174	PF00069	0.555
MOD_SUMO_rev_2	120	129	PF00179	0.519
MOD_SUMO_rev_2	228	238	PF00179	0.565
TRG_ENDOCYTIC_2	133	136	PF00928	0.537
TRG_ENDOCYTIC_2	226	229	PF00928	0.611
TRG_ENDOCYTIC_2	27	30	PF00928	0.267
TRG_ENDOCYTIC_2	53	56	PF00928	0.290
TRG_ENDOCYTIC_2	9	12	PF00928	0.286
TRG_ER_diArg_1	218	221	PF00400	0.585
TRG_NLS_Bipartite_1	249	270	PF00514	0.664
TRG_NLS_MonoExtC_3	265	270	PF00514	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P699	Leptomonas seymouri	66%	100%
A0A0S4J0E0	Bodo saltans	42%	100%
A0A1X0P0E8	Trypanosomatidae	40%	97%
A0A3Q8IIZ8	Leishmania donovani	91%	100%
A0A3S5ISR2	Trypanosoma rangeli	45%	100%
A4HPW4	Leishmania braziliensis	78%	100%
A4IDM6	Leishmania infantum	91%	100%
D0A4B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D0AAU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	89%
E9ATN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q8WXX5	Homo sapiens	28%	100%
Q91WN1	Mus musculus	28%	100%
Q9VGR7	Drosophila melanogaster	25%	92%
V5BL40	Trypanosoma cruzi	32%	90%
V5BUT9	Trypanosoma cruzi	45%	100%