Putative amino acid transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid transporter, putative

Species:

Leishmania major

UniProt:

Q4Q0W6_LEIMA

TriTrypDb:

LmjF.36.4480 , LMJLV39_360056100 , LMJSD75_360055900

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q0W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0W6

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	2
GO:0006810	transport	3	2
GO:0006865	amino acid transport	5	2
GO:0009987	cellular process	1	2
GO:0015849	organic acid transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0015171	amino acid transmembrane transporter activity	5	2
GO:0015179	L-amino acid transmembrane transporter activity	6	2
GO:0022857	transmembrane transporter activity	2	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.753
CLV_C14_Caspase3-7	309	313	PF00656	0.260
CLV_NRD_NRD_1	128	130	PF00675	0.453
CLV_NRD_NRD_1	210	212	PF00675	0.525
CLV_NRD_NRD_1	220	222	PF00675	0.495
CLV_NRD_NRD_1	268	270	PF00675	0.352
CLV_NRD_NRD_1	271	273	PF00675	0.347
CLV_NRD_NRD_1	377	379	PF00675	0.471
CLV_NRD_NRD_1	418	420	PF00675	0.275
CLV_NRD_NRD_1	496	498	PF00675	0.275
CLV_NRD_NRD_1	569	571	PF00675	0.243
CLV_NRD_NRD_1	604	606	PF00675	0.381
CLV_PCSK_FUR_1	266	270	PF00082	0.330
CLV_PCSK_KEX2_1	210	212	PF00082	0.516
CLV_PCSK_KEX2_1	219	221	PF00082	0.496
CLV_PCSK_KEX2_1	266	268	PF00082	0.360
CLV_PCSK_KEX2_1	271	273	PF00082	0.344
CLV_PCSK_KEX2_1	367	369	PF00082	0.533
CLV_PCSK_KEX2_1	377	379	PF00082	0.450
CLV_PCSK_KEX2_1	418	420	PF00082	0.275
CLV_PCSK_KEX2_1	496	498	PF00082	0.275
CLV_PCSK_KEX2_1	569	571	PF00082	0.243
CLV_PCSK_KEX2_1	604	606	PF00082	0.381
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.495
CLV_PCSK_PC7_1	216	222	PF00082	0.527
CLV_PCSK_PC7_1	262	268	PF00082	0.375
CLV_PCSK_SKI1_1	272	276	PF00082	0.303
DEG_APCC_DBOX_1	495	503	PF00400	0.475
DEG_APCC_DBOX_1	739	747	PF00400	0.610
DEG_Nend_UBRbox_3	1	3	PF02207	0.694
DEG_SCF_FBW7_1	170	176	PF00400	0.668
DEG_SCF_FBW7_2	573	578	PF00400	0.494
DEG_SPOP_SBC_1	159	163	PF00917	0.725
DEG_SPOP_SBC_1	247	251	PF00917	0.571
DOC_CKS1_1	170	175	PF01111	0.667
DOC_CYCLIN_yCln2_LP_2	66	72	PF00134	0.312
DOC_MAPK_gen_1	377	387	PF00069	0.226
DOC_MAPK_gen_1	418	429	PF00069	0.451
DOC_MAPK_gen_1	742	752	PF00069	0.533
DOC_MAPK_MEF2A_6	422	431	PF00069	0.451
DOC_MAPK_MEF2A_6	477	484	PF00069	0.340
DOC_PP1_RVXF_1	379	385	PF00149	0.243
DOC_PP2B_LxvP_1	118	121	PF13499	0.498
DOC_PP2B_LxvP_1	66	69	PF13499	0.312
DOC_PP4_FxxP_1	245	248	PF00568	0.695
DOC_SPAK_OSR1_1	386	390	PF12202	0.267
DOC_USP7_MATH_1	154	158	PF00917	0.702
DOC_USP7_MATH_1	248	252	PF00917	0.532
DOC_USP7_MATH_1	303	307	PF00917	0.275
DOC_USP7_MATH_1	5	9	PF00917	0.641
DOC_USP7_MATH_1	510	514	PF00917	0.468
DOC_USP7_MATH_1	520	524	PF00917	0.488
DOC_USP7_MATH_1	534	538	PF00917	0.427
DOC_USP7_MATH_1	619	623	PF00917	0.607
DOC_USP7_MATH_1	711	715	PF00917	0.580
DOC_WW_Pin1_4	169	174	PF00397	0.706
DOC_WW_Pin1_4	561	566	PF00397	0.475
DOC_WW_Pin1_4	571	576	PF00397	0.475
DOC_WW_Pin1_4	581	586	PF00397	0.448
DOC_WW_Pin1_4	596	601	PF00397	0.383
DOC_WW_Pin1_4	645	650	PF00397	0.464
DOC_WW_Pin1_4	704	709	PF00397	0.479
LIG_14-3-3_CanoR_1	107	116	PF00244	0.514
LIG_14-3-3_CanoR_1	16	23	PF00244	0.622
LIG_14-3-3_CanoR_1	164	170	PF00244	0.702
LIG_14-3-3_CanoR_1	271	281	PF00244	0.475
LIG_14-3-3_CanoR_1	34	38	PF00244	0.642
LIG_14-3-3_CanoR_1	362	371	PF00244	0.287
LIG_14-3-3_CanoR_1	386	390	PF00244	0.305
LIG_14-3-3_CanoR_1	422	428	PF00244	0.525
LIG_14-3-3_CanoR_1	501	505	PF00244	0.475
LIG_14-3-3_CanoR_1	604	613	PF00244	0.471
LIG_14-3-3_CanoR_1	7	11	PF00244	0.638
LIG_BIR_III_4	103	107	PF00653	0.530
LIG_BIR_III_4	620	624	PF00653	0.556
LIG_BRCT_BRCA1_1	316	320	PF00533	0.359
LIG_BRCT_BRCA1_1	708	712	PF00533	0.583
LIG_BRCT_BRCA1_1	737	741	PF00533	0.579
LIG_deltaCOP1_diTrp_1	339	349	PF00928	0.502
LIG_EH1_1	353	361	PF00400	0.305
LIG_eIF4E_1	466	472	PF01652	0.268
LIG_FHA_1	109	115	PF00498	0.491
LIG_FHA_1	395	401	PF00498	0.334
LIG_FHA_1	439	445	PF00498	0.340
LIG_FHA_1	44	50	PF00498	0.608
LIG_FHA_1	538	544	PF00498	0.493
LIG_FHA_1	561	567	PF00498	0.468
LIG_FHA_1	622	628	PF00498	0.523
LIG_FHA_1	637	643	PF00498	0.456
LIG_FHA_1	650	656	PF00498	0.462
LIG_FHA_1	665	671	PF00498	0.312
LIG_FHA_2	135	141	PF00498	0.658
LIG_FHA_2	179	185	PF00498	0.719
LIG_FHA_2	235	241	PF00498	0.657
LIG_FHA_2	307	313	PF00498	0.275
LIG_FHA_2	506	512	PF00498	0.502
LIG_FHA_2	526	532	PF00498	0.383
LIG_GBD_Chelix_1	49	57	PF00786	0.278
LIG_LIR_Apic_2	242	248	PF02991	0.700
LIG_LIR_Apic_2	403	409	PF02991	0.312
LIG_LIR_Apic_2	772	778	PF02991	0.393
LIG_LIR_Gen_1	250	261	PF02991	0.523
LIG_LIR_Gen_1	340	350	PF02991	0.475
LIG_LIR_Gen_1	351	361	PF02991	0.312
LIG_LIR_Gen_1	574	585	PF02991	0.529
LIG_LIR_Gen_1	660	671	PF02991	0.291
LIG_LIR_Gen_1	687	697	PF02991	0.312
LIG_LIR_Gen_1	768	779	PF02991	0.455
LIG_LIR_Gen_1	88	98	PF02991	0.306
LIG_LIR_Nem_3	242	247	PF02991	0.685
LIG_LIR_Nem_3	250	256	PF02991	0.547
LIG_LIR_Nem_3	285	290	PF02991	0.341
LIG_LIR_Nem_3	317	323	PF02991	0.316
LIG_LIR_Nem_3	340	346	PF02991	0.498
LIG_LIR_Nem_3	351	357	PF02991	0.365
LIG_LIR_Nem_3	370	374	PF02991	0.301
LIG_LIR_Nem_3	574	580	PF02991	0.529
LIG_LIR_Nem_3	660	666	PF02991	0.334
LIG_LIR_Nem_3	687	692	PF02991	0.312
LIG_LIR_Nem_3	738	744	PF02991	0.566
LIG_LIR_Nem_3	768	774	PF02991	0.427
LIG_LIR_Nem_3	88	93	PF02991	0.400
LIG_LIR_Nem_3	94	99	PF02991	0.496
LIG_LYPXL_yS_3	371	374	PF13949	0.275
LIG_MLH1_MIPbox_1	316	320	PF16413	0.302
LIG_NRBOX	748	754	PF00104	0.340
LIG_NRBOX	80	86	PF00104	0.312
LIG_Pex14_2	484	488	PF04695	0.312
LIG_SH2_CRK	253	257	PF00017	0.538
LIG_SH2_CRK	270	274	PF00017	0.610
LIG_SH2_CRK	287	291	PF00017	0.277
LIG_SH2_CRK	293	297	PF00017	0.312
LIG_SH2_CRK	369	373	PF00017	0.372
LIG_SH2_CRK	406	410	PF00017	0.475
LIG_SH2_CRK	96	100	PF00017	0.388
LIG_SH2_NCK_1	406	410	PF00017	0.475
LIG_SH2_PTP2	354	357	PF00017	0.302
LIG_SH2_SRC	369	372	PF00017	0.329
LIG_SH2_STAP1	293	297	PF00017	0.312
LIG_SH2_STAP1	577	581	PF00017	0.529
LIG_SH2_STAP1	771	775	PF00017	0.372
LIG_SH2_STAT3	119	122	PF00017	0.519
LIG_SH2_STAT3	363	366	PF00017	0.275
LIG_SH2_STAT5	127	130	PF00017	0.584
LIG_SH2_STAT5	208	211	PF00017	0.655
LIG_SH2_STAT5	307	310	PF00017	0.350
LIG_SH2_STAT5	319	322	PF00017	0.299
LIG_SH2_STAT5	354	357	PF00017	0.317
LIG_SH2_STAT5	410	413	PF00017	0.475
LIG_SH2_STAT5	446	449	PF00017	0.312
LIG_SH2_STAT5	73	76	PF00017	0.423
LIG_SH2_STAT5	96	99	PF00017	0.312
LIG_SH3_3	167	173	PF00018	0.714
LIG_SH3_3	426	432	PF00018	0.476
LIG_SH3_3	450	456	PF00018	0.342
LIG_SH3_3	643	649	PF00018	0.466
LIG_SH3_3	702	708	PF00018	0.388
LIG_SUMO_SIM_anti_2	652	660	PF11976	0.475
LIG_SUMO_SIM_par_1	489	495	PF11976	0.312
LIG_SUMO_SIM_par_1	503	508	PF11976	0.475
LIG_SUMO_SIM_par_1	638	643	PF11976	0.475
LIG_SUMO_SIM_par_1	82	89	PF11976	0.307
LIG_TRAF2_1	138	141	PF00917	0.670
LIG_TRAF2_1	197	200	PF00917	0.689
LIG_TRAF2_1	261	264	PF00917	0.535
LIG_TRFH_1	116	120	PF08558	0.492
LIG_TRFH_1	244	248	PF08558	0.588
LIG_TYR_ITIM	291	296	PF00017	0.312
LIG_TYR_ITIM	352	357	PF00017	0.302
LIG_WRC_WIRS_1	395	400	PF05994	0.312
LIG_WRC_WIRS_1	446	451	PF05994	0.312
LIG_WRC_WIRS_1	771	776	PF05994	0.379
LIG_WRC_WIRS_1	87	92	PF05994	0.340
MOD_CK1_1	163	169	PF00069	0.791
MOD_CK1_1	202	208	PF00069	0.767
MOD_CK1_1	249	255	PF00069	0.557
MOD_CK1_1	3	9	PF00069	0.576
MOD_CK1_1	306	312	PF00069	0.275
MOD_CK1_1	33	39	PF00069	0.621
MOD_CK1_1	492	498	PF00069	0.312
MOD_CK1_1	537	543	PF00069	0.499
MOD_CK1_1	599	605	PF00069	0.501
MOD_CK1_1	735	741	PF00069	0.567
MOD_CK2_1	106	112	PF00069	0.515
MOD_CK2_1	134	140	PF00069	0.740
MOD_CK2_1	194	200	PF00069	0.745
MOD_CK2_1	223	229	PF00069	0.787
MOD_CK2_1	525	531	PF00069	0.460
MOD_CK2_1	619	625	PF00069	0.495
MOD_Cter_Amidation	602	605	PF01082	0.278
MOD_GlcNHglycan	156	159	PF01048	0.646
MOD_GlcNHglycan	167	170	PF01048	0.602
MOD_GlcNHglycan	181	184	PF01048	0.465
MOD_GlcNHglycan	188	191	PF01048	0.477
MOD_GlcNHglycan	196	199	PF01048	0.604
MOD_GlcNHglycan	511	515	PF01048	0.267
MOD_GlcNHglycan	522	525	PF01048	0.290
MOD_GlcNHglycan	601	604	PF01048	0.300
MOD_GlcNHglycan	617	620	PF01048	0.245
MOD_GlcNHglycan	621	624	PF01048	0.238
MOD_GlcNHglycan	675	678	PF01048	0.529
MOD_GlcNHglycan	708	711	PF01048	0.394
MOD_GlcNHglycan	713	716	PF01048	0.389
MOD_GlcNHglycan	722	725	PF01048	0.411
MOD_GlcNHglycan	728	732	PF01048	0.409
MOD_GlcNHglycan	734	737	PF01048	0.368
MOD_GSK3_1	102	109	PF00069	0.527
MOD_GSK3_1	15	22	PF00069	0.666
MOD_GSK3_1	154	161	PF00069	0.841
MOD_GSK3_1	165	172	PF00069	0.703
MOD_GSK3_1	230	237	PF00069	0.746
MOD_GSK3_1	45	52	PF00069	0.533
MOD_GSK3_1	537	544	PF00069	0.518
MOD_GSK3_1	599	606	PF00069	0.540
MOD_GSK3_1	615	622	PF00069	0.503
MOD_GSK3_1	627	634	PF00069	0.577
MOD_GSK3_1	645	652	PF00069	0.421
MOD_GSK3_1	732	739	PF00069	0.624
MOD_N-GLC_1	581	586	PF02516	0.285
MOD_NEK2_1	282	287	PF00069	0.267
MOD_NEK2_1	314	319	PF00069	0.296
MOD_NEK2_1	330	335	PF00069	0.369
MOD_NEK2_1	341	346	PF00069	0.535
MOD_NEK2_1	385	390	PF00069	0.297
MOD_NEK2_1	400	405	PF00069	0.256
MOD_NEK2_1	423	428	PF00069	0.475
MOD_NEK2_1	580	585	PF00069	0.559
MOD_NEK2_1	664	669	PF00069	0.430
MOD_NEK2_1	684	689	PF00069	0.183
MOD_NEK2_1	72	77	PF00069	0.341
MOD_NEK2_1	85	90	PF00069	0.250
MOD_NEK2_2	91	96	PF00069	0.388
MOD_PIKK_1	15	21	PF00454	0.617
MOD_PIKK_1	362	368	PF00454	0.275
MOD_PIKK_1	627	633	PF00454	0.460
MOD_PKA_1	604	610	PF00069	0.478
MOD_PKA_2	106	112	PF00069	0.521
MOD_PKA_2	15	21	PF00069	0.565
MOD_PKA_2	159	165	PF00069	0.746
MOD_PKA_2	25	31	PF00069	0.515
MOD_PKA_2	33	39	PF00069	0.645
MOD_PKA_2	385	391	PF00069	0.260
MOD_PKA_2	500	506	PF00069	0.475
MOD_PKA_2	520	526	PF00069	0.469
MOD_PKA_2	6	12	PF00069	0.659
MOD_PKA_2	603	609	PF00069	0.475
MOD_PKA_2	613	619	PF00069	0.453
MOD_Plk_1	202	208	PF00069	0.790
MOD_Plk_1	510	516	PF00069	0.475
MOD_Plk_1	649	655	PF00069	0.529
MOD_Plk_2-3	199	205	PF00069	0.765
MOD_Plk_4	303	309	PF00069	0.379
MOD_Plk_4	342	348	PF00069	0.480
MOD_Plk_4	49	55	PF00069	0.488
MOD_Plk_4	500	506	PF00069	0.475
MOD_Plk_4	56	62	PF00069	0.279
MOD_Plk_4	6	12	PF00069	0.590
MOD_Plk_4	650	656	PF00069	0.558
MOD_Plk_4	665	671	PF00069	0.227
MOD_Plk_4	684	690	PF00069	0.312
MOD_Plk_4	73	79	PF00069	0.312
MOD_Plk_4	765	771	PF00069	0.340
MOD_ProDKin_1	169	175	PF00069	0.702
MOD_ProDKin_1	561	567	PF00069	0.475
MOD_ProDKin_1	571	577	PF00069	0.475
MOD_ProDKin_1	581	587	PF00069	0.448
MOD_ProDKin_1	596	602	PF00069	0.383
MOD_ProDKin_1	645	651	PF00069	0.464
MOD_ProDKin_1	704	710	PF00069	0.480
MOD_SUMO_rev_2	335	344	PF00179	0.472
TRG_DiLeu_BaEn_1	660	665	PF01217	0.312
TRG_DiLeu_BaLyEn_6	739	744	PF01217	0.600
TRG_DiLeu_LyEn_5	562	567	PF01217	0.475
TRG_ENDOCYTIC_2	253	256	PF00928	0.540
TRG_ENDOCYTIC_2	270	273	PF00928	0.612
TRG_ENDOCYTIC_2	287	290	PF00928	0.277
TRG_ENDOCYTIC_2	293	296	PF00928	0.312
TRG_ENDOCYTIC_2	319	322	PF00928	0.312
TRG_ENDOCYTIC_2	354	357	PF00928	0.339
TRG_ENDOCYTIC_2	371	374	PF00928	0.282
TRG_ENDOCYTIC_2	412	415	PF00928	0.475
TRG_ENDOCYTIC_2	421	424	PF00928	0.490
TRG_ENDOCYTIC_2	446	449	PF00928	0.313
TRG_ENDOCYTIC_2	577	580	PF00928	0.529
TRG_ENDOCYTIC_2	771	774	PF00928	0.404
TRG_ENDOCYTIC_2	96	99	PF00928	0.312
TRG_ER_diArg_1	209	211	PF00400	0.711
TRG_ER_diArg_1	219	221	PF00400	0.696
TRG_ER_diArg_1	265	268	PF00400	0.523
TRG_ER_diArg_1	270	272	PF00400	0.533
TRG_ER_diArg_1	376	378	PF00400	0.260
TRG_ER_diArg_1	418	420	PF00400	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ5	Leptomonas seymouri	57%	98%
A0A3S7XBM8	Leishmania donovani	88%	99%
A4HPW5	Leishmania braziliensis	68%	100%
A4IDM7	Leishmania infantum	87%	99%
E9ATN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%