MTS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial N(5)-glutamine methyltransferase MTQ1, putative

Species:

Leishmania major

UniProt:

Q4Q0W5_LEIMA

TriTrypDb:

LmjF.36.4490 , LMJLV39_360056200 , LMJSD75_360056000

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0W5

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0032259	methylation	2	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0043414	macromolecule methylation	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008276	protein methyltransferase activity	3	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.606
CLV_C14_Caspase3-7	390	394	PF00656	0.509
CLV_C14_Caspase3-7	93	97	PF00656	0.574
CLV_MEL_PAP_1	368	374	PF00089	0.374
CLV_NRD_NRD_1	153	155	PF00675	0.499
CLV_NRD_NRD_1	229	231	PF00675	0.390
CLV_NRD_NRD_1	29	31	PF00675	0.596
CLV_NRD_NRD_1	460	462	PF00675	0.423
CLV_PCSK_FUR_1	458	462	PF00082	0.410
CLV_PCSK_KEX2_1	229	231	PF00082	0.375
CLV_PCSK_KEX2_1	233	235	PF00082	0.354
CLV_PCSK_KEX2_1	29	31	PF00082	0.636
CLV_PCSK_KEX2_1	460	462	PF00082	0.426
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.488
CLV_PCSK_PC7_1	229	235	PF00082	0.446
CLV_PCSK_SKI1_1	175	179	PF00082	0.358
CLV_PCSK_SKI1_1	230	234	PF00082	0.353
CLV_PCSK_SKI1_1	427	431	PF00082	0.361
CLV_PCSK_SKI1_1	453	457	PF00082	0.402
CLV_PCSK_SKI1_1	506	510	PF00082	0.369
CLV_PCSK_SKI1_1	67	71	PF00082	0.441
DEG_APCC_DBOX_1	233	241	PF00400	0.396
DEG_SCF_TRCP1_1	60	66	PF00400	0.523
DOC_ANK_TNKS_1	124	131	PF00023	0.607
DOC_CYCLIN_RxL_1	172	179	PF00134	0.411
DOC_CYCLIN_RxL_1	229	241	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.307
DOC_MAPK_gen_1	436	444	PF00069	0.474
DOC_MAPK_gen_1	490	499	PF00069	0.474
DOC_MAPK_MEF2A_6	466	475	PF00069	0.424
DOC_MAPK_MEF2A_6	490	499	PF00069	0.425
DOC_PP2B_LxvP_1	40	43	PF13499	0.583
DOC_PP2B_PxIxI_1	468	474	PF00149	0.457
DOC_USP7_MATH_1	288	292	PF00917	0.463
DOC_USP7_MATH_1	358	362	PF00917	0.502
DOC_USP7_MATH_1	376	380	PF00917	0.699
DOC_USP7_MATH_1	47	51	PF00917	0.628
DOC_WW_Pin1_4	289	294	PF00397	0.712
DOC_WW_Pin1_4	295	300	PF00397	0.651
DOC_WW_Pin1_4	349	354	PF00397	0.446
LIG_14-3-3_CanoR_1	355	363	PF00244	0.478
LIG_14-3-3_CanoR_1	46	52	PF00244	0.542
LIG_14-3-3_CanoR_1	506	513	PF00244	0.344
LIG_14-3-3_CanoR_1	56	63	PF00244	0.609
LIG_Actin_WH2_2	14	31	PF00022	0.551
LIG_Actin_WH2_2	65	82	PF00022	0.696
LIG_APCC_ABBA_1	495	500	PF00400	0.308
LIG_BRCT_BRCA1_1	138	142	PF00533	0.486
LIG_BRCT_BRCA1_1	251	255	PF00533	0.455
LIG_BRCT_BRCA1_1	360	364	PF00533	0.431
LIG_CtBP_PxDLS_1	15	19	PF00389	0.542
LIG_deltaCOP1_diTrp_1	206	213	PF00928	0.330
LIG_deltaCOP1_diTrp_1	274	279	PF00928	0.310
LIG_EH1_1	479	487	PF00400	0.474
LIG_FHA_1	311	317	PF00498	0.431
LIG_FHA_1	396	402	PF00498	0.374
LIG_FHA_1	426	432	PF00498	0.489
LIG_FHA_1	46	52	PF00498	0.658
LIG_FHA_2	146	152	PF00498	0.591
LIG_FHA_2	328	334	PF00498	0.525
LIG_FHA_2	388	394	PF00498	0.433
LIG_FHA_2	420	426	PF00498	0.428
LIG_FHA_2	91	97	PF00498	0.629
LIG_Integrin_RGD_1	125	127	PF01839	0.609
LIG_LIR_Gen_1	139	147	PF02991	0.470
LIG_LIR_Gen_1	398	407	PF02991	0.350
LIG_LIR_Gen_1	438	449	PF02991	0.414
LIG_LIR_Gen_1	90	98	PF02991	0.526
LIG_LIR_Nem_3	139	145	PF02991	0.681
LIG_LIR_Nem_3	184	189	PF02991	0.524
LIG_LIR_Nem_3	277	282	PF02991	0.476
LIG_LIR_Nem_3	361	367	PF02991	0.537
LIG_LIR_Nem_3	398	402	PF02991	0.299
LIG_LIR_Nem_3	438	444	PF02991	0.404
LIG_LIR_Nem_3	489	495	PF02991	0.341
LIG_LIR_Nem_3	90	94	PF02991	0.573
LIG_MYND_1	265	269	PF01753	0.311
LIG_PTB_Apo_2	402	409	PF02174	0.301
LIG_PTB_Phospho_1	402	408	PF10480	0.299
LIG_SH2_CRK	399	403	PF00017	0.361
LIG_SH2_NCK_1	91	95	PF00017	0.508
LIG_SH2_PTP2	408	411	PF00017	0.336
LIG_SH2_PTP2	414	417	PF00017	0.370
LIG_SH2_SRC	248	251	PF00017	0.312
LIG_SH2_STAP1	183	187	PF00017	0.463
LIG_SH2_STAP1	399	403	PF00017	0.361
LIG_SH2_STAT3	501	504	PF00017	0.386
LIG_SH2_STAT5	102	105	PF00017	0.532
LIG_SH2_STAT5	248	251	PF00017	0.337
LIG_SH2_STAT5	408	411	PF00017	0.356
LIG_SH2_STAT5	414	417	PF00017	0.401
LIG_SH2_STAT5	441	444	PF00017	0.315
LIG_SH2_STAT5	71	74	PF00017	0.462
LIG_SH3_3	191	197	PF00018	0.545
LIG_SH3_3	369	375	PF00018	0.437
LIG_SH3_3	400	406	PF00018	0.303
LIG_SH3_3	412	418	PF00018	0.372
LIG_SUMO_SIM_anti_2	330	337	PF11976	0.498
LIG_SUMO_SIM_par_1	1	6	PF11976	0.487
LIG_TRAF2_1	502	505	PF00917	0.426
LIG_TRAF2_2	411	416	PF00917	0.371
LIG_UBA3_1	177	185	PF00899	0.394
MOD_CDC14_SPxK_1	302	305	PF00782	0.503
MOD_CDC14_SPxK_1	352	355	PF00782	0.446
MOD_CDK_SPxK_1	299	305	PF00069	0.553
MOD_CDK_SPxK_1	349	355	PF00069	0.446
MOD_CK1_1	107	113	PF00069	0.514
MOD_CK1_1	132	138	PF00069	0.563
MOD_CK1_1	90	96	PF00069	0.761
MOD_CK2_1	135	141	PF00069	0.540
MOD_CK2_1	145	151	PF00069	0.534
MOD_CK2_1	168	174	PF00069	0.381
MOD_CK2_1	221	227	PF00069	0.459
MOD_CK2_1	232	238	PF00069	0.276
MOD_CK2_1	354	360	PF00069	0.550
MOD_CK2_1	419	425	PF00069	0.431
MOD_CK2_1	81	87	PF00069	0.641
MOD_CMANNOS	276	279	PF00535	0.312
MOD_GlcNHglycan	138	141	PF01048	0.551
MOD_GlcNHglycan	325	328	PF01048	0.320
MOD_GlcNHglycan	356	359	PF01048	0.380
MOD_GlcNHglycan	372	375	PF01048	0.664
MOD_GlcNHglycan	378	381	PF01048	0.582
MOD_GlcNHglycan	60	63	PF01048	0.654
MOD_GlcNHglycan	84	87	PF01048	0.633
MOD_GlcNHglycan	98	101	PF01048	0.607
MOD_GSK3_1	132	139	PF00069	0.701
MOD_GSK3_1	270	277	PF00069	0.342
MOD_GSK3_1	288	295	PF00069	0.502
MOD_GSK3_1	323	330	PF00069	0.548
MOD_GSK3_1	354	361	PF00069	0.547
MOD_GSK3_1	376	383	PF00069	0.601
MOD_GSK3_1	419	426	PF00069	0.430
MOD_GSK3_1	47	54	PF00069	0.627
MOD_N-GLC_1	107	112	PF02516	0.741
MOD_N-GLC_1	136	141	PF02516	0.575
MOD_N-GLC_1	380	385	PF02516	0.606
MOD_NEK2_1	486	491	PF00069	0.379
MOD_NEK2_1	51	56	PF00069	0.556
MOD_NEK2_1	63	68	PF00069	0.481
MOD_NEK2_2	387	392	PF00069	0.420
MOD_PIKK_1	249	255	PF00454	0.451
MOD_PKA_2	221	227	PF00069	0.476
MOD_PKA_2	339	345	PF00069	0.478
MOD_PKA_2	354	360	PF00069	0.434
MOD_PKA_2	370	376	PF00069	0.460
MOD_PKA_2	435	441	PF00069	0.488
MOD_PKA_2	45	51	PF00069	0.602
MOD_PKB_1	56	64	PF00069	0.542
MOD_Plk_1	132	138	PF00069	0.557
MOD_Plk_2-3	146	152	PF00069	0.697
MOD_Plk_2-3	221	227	PF00069	0.437
MOD_Plk_2-3	87	93	PF00069	0.532
MOD_Plk_4	190	196	PF00069	0.581
MOD_Plk_4	244	250	PF00069	0.398
MOD_Plk_4	47	53	PF00069	0.623
MOD_ProDKin_1	289	295	PF00069	0.716
MOD_ProDKin_1	299	305	PF00069	0.520
MOD_ProDKin_1	349	355	PF00069	0.446
MOD_SUMO_rev_2	144	153	PF00179	0.644
MOD_SUMO_rev_2	484	491	PF00179	0.278
TRG_AP2beta_CARGO_1	362	371	PF09066	0.443
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.321
TRG_ENDOCYTIC_2	183	186	PF00928	0.466
TRG_ENDOCYTIC_2	282	285	PF00928	0.515
TRG_ENDOCYTIC_2	399	402	PF00928	0.388
TRG_ENDOCYTIC_2	414	417	PF00928	0.296
TRG_ENDOCYTIC_2	441	444	PF00928	0.315
TRG_ENDOCYTIC_2	91	94	PF00928	0.575
TRG_ER_diArg_1	21	24	PF00400	0.572
TRG_ER_diArg_1	28	30	PF00400	0.592
TRG_ER_diArg_1	457	460	PF00400	0.445
TRG_ER_diArg_1	55	58	PF00400	0.721
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXT0	Leptomonas seymouri	55%	100%
A0A0S4K087	Bodo saltans	48%	100%
A0A1X0P0C0	Trypanosomatidae	49%	100%
A0A3R7N4Z4	Trypanosoma rangeli	53%	100%
A0A3S7XBK9	Leishmania donovani	93%	100%
A4HPW6	Leishmania braziliensis	73%	100%
A4IDM8	Leishmania infantum	93%	100%
D0A4B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ATN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DLL0	Trypanosoma cruzi	50%	100%