HRDC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2870), putative

Species:

Leishmania major

UniProt:

Q4Q0W4_LEIMA

TriTrypDb:

LmjF.36.4500 , LMJLV39_360056300 , LMJSD75_360056100

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0W4

Function

Biological processes
Term	Name	Level	Count
GO:0003352	regulation of cilium movement	6	15
GO:0032886	regulation of microtubule-based process	4	15
GO:0050789	regulation of biological process	2	15
GO:0050794	regulation of cellular process	3	15
GO:0060632	regulation of microtubule-based movement	5	15
GO:0065007	biological regulation	1	15

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.422
CLV_C14_Caspase3-7	33	37	PF00656	0.470
CLV_C14_Caspase3-7	97	101	PF00656	0.418
CLV_NRD_NRD_1	223	225	PF00675	0.283
CLV_NRD_NRD_1	90	92	PF00675	0.539
CLV_PCSK_KEX2_1	7	9	PF00082	0.377
CLV_PCSK_KEX2_1	90	92	PF00082	0.511
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.377
DEG_APCC_DBOX_1	44	52	PF00400	0.430
DOC_CYCLIN_RxL_1	78	89	PF00134	0.498
DOC_MAPK_gen_1	186	196	PF00069	0.455
DOC_MAPK_gen_1	87	95	PF00069	0.473
DOC_MAPK_MEF2A_6	189	196	PF00069	0.454
DOC_PP1_RVXF_1	162	169	PF00149	0.534
DOC_PP1_RVXF_1	45	51	PF00149	0.366
DOC_USP7_MATH_1	116	120	PF00917	0.448
DOC_USP7_MATH_1	175	179	PF00917	0.467
DOC_USP7_MATH_1	198	202	PF00917	0.555
DOC_USP7_MATH_2	10	16	PF00917	0.554
DOC_USP7_UBL2_3	182	186	PF12436	0.457
DOC_USP7_UBL2_3	191	195	PF12436	0.450
DOC_USP7_UBL2_3	56	60	PF12436	0.412
DOC_USP7_UBL2_3	7	11	PF12436	0.414
LIG_14-3-3_CanoR_1	146	151	PF00244	0.399
LIG_14-3-3_CanoR_1	45	51	PF00244	0.473
LIG_14-3-3_CanoR_1	81	86	PF00244	0.513
LIG_CaM_IQ_9	216	232	PF13499	0.552
LIG_EH1_1	144	152	PF00400	0.485
LIG_FHA_1	191	197	PF00498	0.470
LIG_FHA_1	26	32	PF00498	0.497
LIG_FHA_1	33	39	PF00498	0.386
LIG_FHA_1	71	77	PF00498	0.454
LIG_FHA_2	133	139	PF00498	0.508
LIG_LIR_Apic_2	243	248	PF02991	0.470
LIG_LIR_Gen_1	15	26	PF02991	0.393
LIG_LIR_Gen_1	79	89	PF02991	0.428
LIG_LIR_Nem_3	15	21	PF02991	0.407
LIG_LIR_Nem_3	177	183	PF02991	0.489
LIG_LIR_Nem_3	79	85	PF02991	0.410
LIG_PCNA_PIPBox_1	215	224	PF02747	0.459
LIG_PCNA_yPIPBox_3	224	233	PF02747	0.505
LIG_PCNA_yPIPBox_3	90	103	PF02747	0.449
LIG_SH2_STAP1	14	18	PF00017	0.457
LIG_SH2_STAT3	223	226	PF00017	0.523
LIG_SH2_STAT5	183	186	PF00017	0.472
LIG_SH2_STAT5	71	74	PF00017	0.532
LIG_SH2_STAT5	82	85	PF00017	0.456
LIG_SH3_3	199	205	PF00018	0.455
LIG_TRAF2_1	10	13	PF00917	0.544
LIG_WW_3	203	207	PF00397	0.459
MOD_CK2_1	134	140	PF00069	0.470
MOD_GlcNHglycan	117	121	PF01048	0.414
MOD_GlcNHglycan	161	164	PF01048	0.484
MOD_GlcNHglycan	169	172	PF01048	0.243
MOD_GlcNHglycan	242	245	PF01048	0.264
MOD_GSK3_1	130	137	PF00069	0.541
MOD_GSK3_1	153	160	PF00069	0.526
MOD_GSK3_1	21	28	PF00069	0.410
MOD_GSK3_1	236	243	PF00069	0.453
MOD_GSK3_1	81	88	PF00069	0.536
MOD_NEK2_1	167	172	PF00069	0.460
MOD_NEK2_1	21	26	PF00069	0.359
MOD_NEK2_1	240	245	PF00069	0.532
MOD_NEK2_1	41	46	PF00069	0.385
MOD_NEK2_2	257	262	PF00069	0.489
MOD_PKA_2	175	181	PF00069	0.467
MOD_PKA_2	46	52	PF00069	0.406
MOD_Plk_1	157	163	PF00069	0.414
MOD_Plk_1	236	242	PF00069	0.466
MOD_Plk_2-3	134	140	PF00069	0.469
MOD_Plk_4	146	152	PF00069	0.391
MOD_Plk_4	46	52	PF00069	0.500
MOD_SUMO_for_1	10	13	PF00179	0.470
MOD_SUMO_rev_2	207	214	PF00179	0.459
MOD_SUMO_rev_2	227	232	PF00179	0.449
TRG_DiLeu_BaEn_1	228	233	PF01217	0.517
TRG_DiLeu_BaEn_1	98	103	PF01217	0.426
TRG_ENDOCYTIC_2	18	21	PF00928	0.373
TRG_ENDOCYTIC_2	82	85	PF00928	0.416
TRG_ER_diArg_1	45	48	PF00400	0.354
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.288
TRG_Pf-PMV_PEXEL_1	81	86	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY2	Leptomonas seymouri	84%	100%
A0A0S4JE13	Bodo saltans	26%	92%
A0A0S4JRV9	Bodo saltans	56%	100%
A0A1X0P0N8	Trypanosomatidae	65%	100%
A0A3Q8IRH9	Leishmania donovani	97%	100%
A0A3R7NWF2	Trypanosoma rangeli	66%	100%
A4HPL6	Leishmania braziliensis	25%	79%
A4HPW7	Leishmania braziliensis	95%	100%
A4IDM9	Leishmania infantum	97%	100%
D0A4B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9ATN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5B520	Trypanosoma cruzi	68%	100%
V5B6Z0	Trypanosoma cruzi	24%	94%