Putative ABC1 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC1 protein, putative

Species:

Leishmania major

UniProt:

Q4Q0W1_LEIMA

TriTrypDb:

LmjF.36.4530 , LMJLV39_360056600 , LMJSD75_360056400

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0W1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0W1

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	2
GO:0006744	ubiquinone biosynthetic process	6	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0042180	cellular ketone metabolic process	3	2
GO:0042181	ketone biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901661	quinone metabolic process	4	2
GO:1901663	quinone biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	444	448	PF00656	0.382
CLV_C14_Caspase3-7	51	55	PF00656	0.543
CLV_NRD_NRD_1	281	283	PF00675	0.389
CLV_NRD_NRD_1	502	504	PF00675	0.309
CLV_NRD_NRD_1	531	533	PF00675	0.380
CLV_PCSK_KEX2_1	345	347	PF00082	0.403
CLV_PCSK_KEX2_1	391	393	PF00082	0.391
CLV_PCSK_KEX2_1	502	504	PF00082	0.309
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.403
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.356
CLV_PCSK_SKI1_1	336	340	PF00082	0.327
CLV_PCSK_SKI1_1	367	371	PF00082	0.288
CLV_PCSK_SKI1_1	406	410	PF00082	0.191
CLV_PCSK_SKI1_1	430	434	PF00082	0.312
DOC_CKS1_1	83	88	PF01111	0.511
DOC_CYCLIN_yCln2_LP_2	70	76	PF00134	0.428
DOC_MAPK_gen_1	141	149	PF00069	0.339
DOC_MAPK_gen_1	389	398	PF00069	0.287
DOC_MAPK_gen_1	502	510	PF00069	0.313
DOC_MAPK_MEF2A_6	260	267	PF00069	0.208
DOC_MAPK_NFAT4_5	260	268	PF00069	0.224
DOC_PP1_RVXF_1	520	526	PF00149	0.300
DOC_PP2B_LxvP_1	490	493	PF13499	0.375
DOC_PP2B_LxvP_1	70	73	PF13499	0.414
DOC_PP4_FxxP_1	177	180	PF00568	0.375
DOC_PP4_FxxP_1	315	318	PF00568	0.242
DOC_USP7_MATH_1	211	215	PF00917	0.260
DOC_USP7_MATH_1	310	314	PF00917	0.261
DOC_USP7_MATH_1	66	70	PF00917	0.364
DOC_WW_Pin1_4	205	210	PF00397	0.435
DOC_WW_Pin1_4	492	497	PF00397	0.349
DOC_WW_Pin1_4	82	87	PF00397	0.499
LIG_14-3-3_CanoR_1	220	224	PF00244	0.296
LIG_14-3-3_CanoR_1	290	294	PF00244	0.375
LIG_14-3-3_CanoR_1	3	7	PF00244	0.693
LIG_14-3-3_CanoR_1	373	379	PF00244	0.260
LIG_14-3-3_CanoR_1	64	74	PF00244	0.533
LIG_Actin_WH2_2	132	150	PF00022	0.371
LIG_Actin_WH2_2	211	226	PF00022	0.375
LIG_BRCT_BRCA1_1	311	315	PF00533	0.375
LIG_BRCT_BRCA1_1	404	408	PF00533	0.285
LIG_EVH1_2	269	273	PF00568	0.242
LIG_FHA_1	116	122	PF00498	0.459
LIG_FHA_1	29	35	PF00498	0.594
LIG_FHA_1	324	330	PF00498	0.243
LIG_FHA_1	505	511	PF00498	0.326
LIG_FHA_1	69	75	PF00498	0.509
LIG_FHA_2	202	208	PF00498	0.191
LIG_FHA_2	363	369	PF00498	0.245
LIG_FHA_2	436	442	PF00498	0.343
LIG_FHA_2	83	89	PF00498	0.500
LIG_GSK3_LRP6_1	492	497	PF00069	0.349
LIG_LIR_Apic_2	174	180	PF02991	0.260
LIG_LIR_Apic_2	312	318	PF02991	0.264
LIG_LIR_Gen_1	107	117	PF02991	0.394
LIG_LIR_Gen_1	199	210	PF02991	0.262
LIG_LIR_Gen_1	359	369	PF02991	0.441
LIG_LIR_Gen_1	378	388	PF02991	0.129
LIG_LIR_Gen_1	410	420	PF02991	0.255
LIG_LIR_Nem_3	107	112	PF02991	0.305
LIG_LIR_Nem_3	199	205	PF02991	0.250
LIG_LIR_Nem_3	359	364	PF02991	0.448
LIG_LIR_Nem_3	378	384	PF02991	0.198
LIG_LIR_Nem_3	410	415	PF02991	0.255
LIG_LIR_Nem_3	88	94	PF02991	0.489
LIG_LYPXL_yS_3	245	248	PF13949	0.242
LIG_PCNA_TLS_4	406	413	PF02747	0.191
LIG_PCNA_yPIPBox_3	328	336	PF02747	0.296
LIG_Pex14_2	105	109	PF04695	0.373
LIG_Pex14_2	370	374	PF04695	0.242
LIG_PTB_Apo_2	380	387	PF02174	0.242
LIG_PTB_Phospho_1	380	386	PF10480	0.375
LIG_SH2_CRK	321	325	PF00017	0.296
LIG_SH2_SRC	412	415	PF00017	0.260
LIG_SH2_STAP1	291	295	PF00017	0.272
LIG_SH2_STAP1	404	408	PF00017	0.260
LIG_SH2_STAT3	316	319	PF00017	0.179
LIG_SH2_STAT5	291	294	PF00017	0.347
LIG_SH2_STAT5	316	319	PF00017	0.338
LIG_SH2_STAT5	334	337	PF00017	0.413
LIG_SH2_STAT5	356	359	PF00017	0.260
LIG_SH2_STAT5	394	397	PF00017	0.375
LIG_SH2_STAT5	412	415	PF00017	0.260
LIG_SH3_3	229	235	PF00018	0.375
LIG_SH3_3	240	246	PF00018	0.242
LIG_SH3_3	264	270	PF00018	0.321
LIG_SH3_3	344	350	PF00018	0.324
LIG_SH3_3	490	496	PF00018	0.385
LIG_SH3_3	80	86	PF00018	0.551
LIG_SUMO_SIM_anti_2	410	417	PF11976	0.265
LIG_SUMO_SIM_anti_2	452	457	PF11976	0.292
LIG_SUMO_SIM_par_1	151	160	PF11976	0.411
LIG_SUMO_SIM_par_1	505	512	PF11976	0.280
LIG_SUMO_SIM_par_1	71	79	PF11976	0.428
LIG_TRAF2_1	438	441	PF00917	0.396
LIG_TYR_ITIM	243	248	PF00017	0.242
LIG_UBA3_1	108	116	PF00899	0.503
LIG_UBA3_1	277	283	PF00899	0.285
LIG_WRC_WIRS_1	202	207	PF05994	0.339
MOD_CDK_SPK_2	82	87	PF00069	0.499
MOD_CK1_1	251	257	PF00069	0.242
MOD_CK1_1	40	46	PF00069	0.587
MOD_CK1_1	68	74	PF00069	0.472
MOD_CK1_1	81	87	PF00069	0.588
MOD_CK2_1	362	368	PF00069	0.238
MOD_CK2_1	435	441	PF00069	0.336
MOD_Cter_Amidation	343	346	PF01082	0.307
MOD_GlcNHglycan	123	126	PF01048	0.600
MOD_GlcNHglycan	24	27	PF01048	0.575
MOD_GlcNHglycan	284	288	PF01048	0.307
MOD_GlcNHglycan	39	42	PF01048	0.580
MOD_GlcNHglycan	43	46	PF01048	0.545
MOD_GlcNHglycan	504	507	PF01048	0.301
MOD_GlcNHglycan	51	54	PF01048	0.505
MOD_GlcNHglycan	519	522	PF01048	0.279
MOD_GSK3_1	117	124	PF00069	0.562
MOD_GSK3_1	201	208	PF00069	0.339
MOD_GSK3_1	289	296	PF00069	0.354
MOD_GSK3_1	37	44	PF00069	0.592
MOD_GSK3_1	398	405	PF00069	0.462
MOD_GSK3_1	414	421	PF00069	0.321
MOD_GSK3_1	492	499	PF00069	0.356
MOD_GSK3_1	64	71	PF00069	0.546
MOD_GSK3_1	78	85	PF00069	0.535
MOD_N-GLC_1	379	384	PF02516	0.260
MOD_NEK2_1	117	122	PF00069	0.509
MOD_NEK2_1	184	189	PF00069	0.253
MOD_NEK2_1	2	7	PF00069	0.579
MOD_NEK2_1	261	266	PF00069	0.285
MOD_NEK2_1	27	32	PF00069	0.565
MOD_NEK2_1	293	298	PF00069	0.261
MOD_NEK2_1	362	367	PF00069	0.242
MOD_NEK2_1	504	509	PF00069	0.337
MOD_NEK2_1	514	519	PF00069	0.351
MOD_NEK2_2	104	109	PF00069	0.371
MOD_NEK2_2	310	315	PF00069	0.261
MOD_NEK2_2	496	501	PF00069	0.349
MOD_PIKK_1	2	8	PF00454	0.704
MOD_PIKK_1	78	84	PF00454	0.447
MOD_PKA_1	502	508	PF00069	0.302
MOD_PKA_2	2	8	PF00069	0.588
MOD_PKA_2	219	225	PF00069	0.296
MOD_PKA_2	289	295	PF00069	0.321
MOD_PKA_2	423	429	PF00069	0.197
MOD_PKA_2	502	508	PF00069	0.302
MOD_PKA_2	514	520	PF00069	0.284
MOD_Plk_1	156	162	PF00069	0.502
MOD_Plk_4	104	110	PF00069	0.360
MOD_Plk_4	310	316	PF00069	0.432
MOD_Plk_4	357	363	PF00069	0.429
MOD_Plk_4	423	429	PF00069	0.237
MOD_Plk_4	449	455	PF00069	0.308
MOD_Plk_4	473	479	PF00069	0.364
MOD_Plk_4	481	487	PF00069	0.343
MOD_Plk_4	504	510	PF00069	0.303
MOD_ProDKin_1	205	211	PF00069	0.435
MOD_ProDKin_1	492	498	PF00069	0.349
MOD_ProDKin_1	82	88	PF00069	0.504
TRG_ENDOCYTIC_2	245	248	PF00928	0.242
TRG_ENDOCYTIC_2	301	304	PF00928	0.242
TRG_ENDOCYTIC_2	321	324	PF00928	0.121
TRG_ENDOCYTIC_2	412	415	PF00928	0.242
TRG_ENDOCYTIC_2	91	94	PF00928	0.453
TRG_ER_diArg_1	488	491	PF00400	0.406
TRG_ER_diArg_1	502	504	PF00400	0.327
TRG_NES_CRM1_1	355	368	PF08389	0.179
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6U2	Leptomonas seymouri	71%	100%
A0A1X0P0M1	Trypanosomatidae	55%	95%
A0A3Q8IPG5	Leishmania donovani	94%	100%
A0A3R7RTW5	Trypanosoma rangeli	60%	100%
A3QJU3	Danio rerio	38%	85%
A4H590	Leishmania braziliensis	25%	100%
A4HPX0	Leishmania braziliensis	86%	100%
A4IDN2	Leishmania infantum	94%	100%
D0A4C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	95%
O04212	Arabidopsis thaliana	24%	99%
P27697	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P73121	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	94%
Q18486	Caenorhabditis elegans	45%	71%
Q29RI0	Bos taurus	43%	82%
Q4QIE6	Leishmania major	25%	100%
Q54IH6	Dictyostelium discoideum	38%	94%
Q55680	Synechocystis sp. (strain PCC 6803 / Kazusa)	26%	78%
Q566J8	Mus musculus	43%	100%
Q5BJQ0	Rattus norvegicus	43%	82%
Q5RGU1	Danio rerio	42%	86%
Q60936	Mus musculus	43%	83%
Q6AY19	Rattus norvegicus	43%	100%
Q8NI60	Homo sapiens	43%	82%
Q8RWG1	Arabidopsis thaliana	26%	78%
Q92338	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	87%
Q94BU1	Arabidopsis thaliana	25%	77%
Q96D53	Homo sapiens	42%	98%
Q9D0L4	Mus musculus	26%	100%
Q9MA15	Arabidopsis thaliana	24%	75%
Q9SBB2	Arabidopsis thaliana	40%	86%
V5BCS0	Trypanosoma cruzi	26%	84%
V5BQ67	Trypanosoma cruzi	60%	100%