Elongation factor-2 kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

elongation factor-2 kinase-like protein

Species:

Leishmania major

UniProt:

Q4Q0W0_LEIMA

TriTrypDb:

LmjF.36.4540 , LMJLV39_360056700 , LMJSD75_360056500

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0W0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	18
GO:0006793	phosphorus metabolic process	3	18
GO:0006796	phosphate-containing compound metabolic process	4	18
GO:0006807	nitrogen compound metabolic process	2	18
GO:0008152	metabolic process	1	18
GO:0009987	cellular process	1	18
GO:0016310	phosphorylation	5	18
GO:0019538	protein metabolic process	3	18
GO:0036211	protein modification process	4	18
GO:0043170	macromolecule metabolic process	3	18
GO:0043412	macromolecule modification	4	18
GO:0044237	cellular metabolic process	2	18
GO:0044238	primary metabolic process	2	18
GO:0071704	organic substance metabolic process	2	18
GO:1901564	organonitrogen compound metabolic process	3	18

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003676	nucleic acid binding	3	6
GO:0003746	translation elongation factor activity	4	6
GO:0003824	catalytic activity	1	18
GO:0004672	protein kinase activity	3	18
GO:0004674	protein serine/threonine kinase activity	4	18
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0008135	translation factor activity, RNA binding	3	6
GO:0016301	kinase activity	4	18
GO:0016740	transferase activity	2	18
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	18
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	18
GO:0017076	purine nucleotide binding	4	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0045182	translation regulator activity	1	6
GO:0090079	translation regulator activity, nucleic acid binding	2	6
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:0140096	catalytic activity, acting on a protein	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18
GO:0004683	calmodulin-dependent protein kinase activity	5	5
GO:0016905	myosin heavy chain kinase activity	6	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	216	218	PF00675	0.372
CLV_PCSK_KEX2_1	172	174	PF00082	0.430
CLV_PCSK_KEX2_1	215	217	PF00082	0.368
CLV_PCSK_KEX2_1	224	226	PF00082	0.343
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.462
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.341
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.336
DOC_CYCLIN_RxL_1	169	178	PF00134	0.211
DOC_CYCLIN_yCln2_LP_2	344	350	PF00134	0.481
DOC_MAPK_gen_1	223	232	PF00069	0.365
DOC_PP1_RVXF_1	170	177	PF00149	0.453
DOC_PP1_RVXF_1	83	89	PF00149	0.424
DOC_WW_Pin1_4	25	30	PF00397	0.521
DOC_WW_Pin1_4	331	336	PF00397	0.498
LIG_14-3-3_CanoR_1	147	153	PF00244	0.297
LIG_14-3-3_CanoR_1	180	188	PF00244	0.415
LIG_14-3-3_CanoR_1	216	220	PF00244	0.261
LIG_14-3-3_CanoR_1	319	323	PF00244	0.431
LIG_14-3-3_CanoR_1	77	86	PF00244	0.452
LIG_BRCT_BRCA1_1	116	120	PF00533	0.457
LIG_Clathr_ClatBox_1	188	192	PF01394	0.361
LIG_Clathr_ClatBox_1	229	233	PF01394	0.496
LIG_FHA_1	155	161	PF00498	0.439
LIG_FHA_1	31	37	PF00498	0.515
LIG_FHA_1	81	87	PF00498	0.440
LIG_FHA_2	237	243	PF00498	0.351
LIG_LIR_Gen_1	134	143	PF02991	0.490
LIG_LIR_Gen_1	233	241	PF02991	0.340
LIG_LIR_Gen_1	321	330	PF02991	0.548
LIG_LIR_Nem_3	134	139	PF02991	0.427
LIG_LIR_Nem_3	196	202	PF02991	0.385
LIG_LIR_Nem_3	203	209	PF02991	0.359
LIG_LIR_Nem_3	233	238	PF02991	0.340
LIG_LIR_Nem_3	321	326	PF02991	0.587
LIG_MLH1_MIPbox_1	116	120	PF16413	0.415
LIG_NRBOX	362	368	PF00104	0.503
LIG_Pex14_2	23	27	PF04695	0.483
LIG_REV1ctd_RIR_1	174	184	PF16727	0.341
LIG_SH2_CRK	323	327	PF00017	0.451
LIG_SH2_GRB2like	119	122	PF00017	0.422
LIG_SH2_GRB2like	202	205	PF00017	0.431
LIG_SH2_STAP1	202	206	PF00017	0.296
LIG_SH2_STAP1	359	363	PF00017	0.656
LIG_SH2_STAT5	119	122	PF00017	0.328
LIG_SH2_STAT5	202	205	PF00017	0.418
LIG_SH2_STAT5	54	57	PF00017	0.396
LIG_SH3_3	136	142	PF00018	0.404
LIG_SH3_3	332	338	PF00018	0.524
LIG_SH3_3	44	50	PF00018	0.455
LIG_SH3_3	69	75	PF00018	0.344
LIG_SH3_CIN85_PxpxPR_1	16	21	PF14604	0.473
LIG_TRAF2_1	218	221	PF00917	0.415
LIG_TRAF2_1	89	92	PF00917	0.309
LIG_TYR_ITIM	320	325	PF00017	0.418
LIG_UBA3_1	299	305	PF00899	0.368
LIG_UBA3_1	341	346	PF00899	0.524
LIG_WRC_WIRS_1	149	154	PF05994	0.296
MOD_CDK_SPxK_1	331	337	PF00069	0.597
MOD_CK1_1	178	184	PF00069	0.343
MOD_CK1_1	236	242	PF00069	0.338
MOD_CK1_1	243	249	PF00069	0.328
MOD_CK1_1	318	324	PF00069	0.586
MOD_CK1_1	349	355	PF00069	0.529
MOD_CK1_1	80	86	PF00069	0.479
MOD_CK2_1	215	221	PF00069	0.426
MOD_CK2_1	236	242	PF00069	0.370
MOD_CK2_1	349	355	PF00069	0.533
MOD_CK2_1	38	44	PF00069	0.480
MOD_DYRK1A_RPxSP_1	331	335	PF00069	0.419
MOD_GlcNHglycan	183	186	PF01048	0.321
MOD_GlcNHglycan	242	245	PF01048	0.370
MOD_GlcNHglycan	363	366	PF01048	0.500
MOD_GSK3_1	175	182	PF00069	0.369
MOD_GSK3_1	193	200	PF00069	0.336
MOD_GSK3_1	236	243	PF00069	0.332
MOD_GSK3_1	325	332	PF00069	0.537
MOD_GSK3_1	361	368	PF00069	0.395
MOD_GSK3_1	93	100	PF00069	0.485
MOD_N-GLC_1	197	202	PF02516	0.422
MOD_N-GLC_1	315	320	PF02516	0.470
MOD_NEK2_1	240	245	PF00069	0.322
MOD_NEK2_1	361	366	PF00069	0.602
MOD_NEK2_1	93	98	PF00069	0.455
MOD_PIKK_1	329	335	PF00454	0.607
MOD_PIKK_1	77	83	PF00454	0.395
MOD_PIKK_1	97	103	PF00454	0.158
MOD_PKA_1	215	221	PF00069	0.471
MOD_PKA_2	179	185	PF00069	0.420
MOD_PKA_2	193	199	PF00069	0.465
MOD_PKA_2	215	221	PF00069	0.469
MOD_PKA_2	318	324	PF00069	0.593
MOD_PKA_2	361	367	PF00069	0.547
MOD_Plk_1	109	115	PF00069	0.241
MOD_Plk_1	315	321	PF00069	0.473
MOD_Plk_4	148	154	PF00069	0.415
MOD_Plk_4	243	249	PF00069	0.335
MOD_Plk_4	318	324	PF00069	0.472
MOD_Plk_4	346	352	PF00069	0.656
MOD_ProDKin_1	25	31	PF00069	0.520
MOD_ProDKin_1	331	337	PF00069	0.503
MOD_SUMO_rev_2	267	272	PF00179	0.388
TRG_DiLeu_BaEn_1	44	49	PF01217	0.390
TRG_ENDOCYTIC_2	210	213	PF00928	0.393
TRG_ENDOCYTIC_2	322	325	PF00928	0.493
TRG_ER_diArg_1	225	228	PF00400	0.385
TRG_NLS_MonoExtN_4	223	228	PF00514	0.314
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.201
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L4	Leptomonas seymouri	54%	100%
A0A0S4IVQ7	Bodo saltans	31%	85%
A0A0S4J072	Bodo saltans	54%	86%
A0A1X0NJ27	Trypanosomatidae	46%	100%
A0A3Q8IGH4	Leishmania donovani	54%	100%
A0A3Q8IJS7	Leishmania donovani	89%	100%
A4HPX1	Leishmania braziliensis	82%	100%
A4HPX3	Leishmania braziliensis	57%	100%
A4IDN3	Leishmania infantum	89%	100%
A4IDN5	Leishmania infantum	54%	100%
C9ZME6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
C9ZWN7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ATN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9ATN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
Q4Q0U3	Leishmania major	53%	100%
V5AN54	Trypanosoma cruzi	47%	100%