PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania major

UniProt:

Q4Q0V8_LEIMA

TriTrypDb:

LmjF.36.4560 , LMJLV39_360057100 , LMJSD75_360056900

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0V8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	580	584	PF00656	0.489
CLV_NRD_NRD_1	19	21	PF00675	0.531
CLV_NRD_NRD_1	409	411	PF00675	0.481
CLV_NRD_NRD_1	472	474	PF00675	0.643
CLV_NRD_NRD_1	519	521	PF00675	0.407
CLV_PCSK_KEX2_1	409	411	PF00082	0.500
CLV_PCSK_KEX2_1	474	476	PF00082	0.598
CLV_PCSK_KEX2_1	519	521	PF00082	0.407
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.500
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.598
CLV_PCSK_SKI1_1	379	383	PF00082	0.591
CLV_PCSK_SKI1_1	411	415	PF00082	0.475
CLV_PCSK_SKI1_1	548	552	PF00082	0.407
CLV_Separin_Metazoa	564	568	PF03568	0.407
DEG_APCC_DBOX_1	11	19	PF00400	0.663
DEG_SCF_FBW7_1	266	273	PF00400	0.582
DEG_SPOP_SBC_1	274	278	PF00917	0.646
DOC_CKS1_1	421	426	PF01111	0.371
DOC_CYCLIN_RxL_1	189	200	PF00134	0.720
DOC_CYCLIN_RxL_1	32	43	PF00134	0.545
DOC_MAPK_gen_1	375	383	PF00069	0.619
DOC_MAPK_gen_1	473	482	PF00069	0.540
DOC_MAPK_gen_1	571	581	PF00069	0.407
DOC_MAPK_JIP1_4	377	383	PF00069	0.616
DOC_MAPK_MEF2A_6	399	408	PF00069	0.459
DOC_MAPK_MEF2A_6	434	442	PF00069	0.456
DOC_MAPK_MEF2A_6	473	482	PF00069	0.540
DOC_PP1_RVXF_1	546	553	PF00149	0.407
DOC_PP4_MxPP_1	206	209	PF00568	0.735
DOC_USP7_MATH_1	127	131	PF00917	0.770
DOC_USP7_MATH_1	274	278	PF00917	0.633
DOC_USP7_MATH_1	398	402	PF00917	0.500
DOC_USP7_MATH_1	462	466	PF00917	0.674
DOC_USP7_MATH_1	469	473	PF00917	0.646
DOC_WW_Pin1_4	105	110	PF00397	0.757
DOC_WW_Pin1_4	115	120	PF00397	0.665
DOC_WW_Pin1_4	185	190	PF00397	0.698
DOC_WW_Pin1_4	200	205	PF00397	0.736
DOC_WW_Pin1_4	245	250	PF00397	0.725
DOC_WW_Pin1_4	266	271	PF00397	0.577
DOC_WW_Pin1_4	297	302	PF00397	0.710
DOC_WW_Pin1_4	320	325	PF00397	0.690
DOC_WW_Pin1_4	333	338	PF00397	0.564
DOC_WW_Pin1_4	387	392	PF00397	0.554
DOC_WW_Pin1_4	420	425	PF00397	0.376
DOC_WW_Pin1_4	60	65	PF00397	0.644
LIG_14-3-3_CanoR_1	263	271	PF00244	0.591
LIG_14-3-3_CanoR_1	399	406	PF00244	0.466
LIG_14-3-3_CanoR_1	500	507	PF00244	0.376
LIG_Actin_WH2_2	484	502	PF00022	0.530
LIG_BRCT_BRCA1_1	225	229	PF00533	0.711
LIG_BRCT_BRCA1_1	275	279	PF00533	0.793
LIG_FHA_1	126	132	PF00498	0.734
LIG_FHA_1	250	256	PF00498	0.647
LIG_FHA_1	364	370	PF00498	0.506
LIG_FHA_2	145	151	PF00498	0.646
LIG_FHA_2	511	517	PF00498	0.407
LIG_LIR_Apic_2	418	424	PF02991	0.491
LIG_LIR_Gen_1	278	288	PF02991	0.612
LIG_LIR_Gen_1	40	48	PF02991	0.534
LIG_LIR_Gen_1	426	433	PF02991	0.434
LIG_LIR_Gen_1	78	87	PF02991	0.697
LIG_LIR_LC3C_4	437	442	PF02991	0.430
LIG_LIR_Nem_3	278	284	PF02991	0.648
LIG_LIR_Nem_3	40	44	PF02991	0.542
LIG_LIR_Nem_3	426	430	PF02991	0.448
LIG_LIR_Nem_3	561	565	PF02991	0.379
LIG_LIR_Nem_3	78	83	PF02991	0.783
LIG_MYND_1	309	313	PF01753	0.773
LIG_PCNA_yPIPBox_3	153	162	PF02747	0.800
LIG_PDZ_Class_2	579	584	PF00595	0.476
LIG_SH2_GRB2like	72	75	PF00017	0.784
LIG_SH2_PTP2	421	424	PF00017	0.477
LIG_SH2_PTP2	427	430	PF00017	0.462
LIG_SH2_SRC	427	430	PF00017	0.462
LIG_SH2_STAT3	554	557	PF00017	0.407
LIG_SH2_STAT5	161	164	PF00017	0.792
LIG_SH2_STAT5	421	424	PF00017	0.432
LIG_SH2_STAT5	427	430	PF00017	0.386
LIG_SH2_STAT5	443	446	PF00017	0.549
LIG_SH2_STAT5	72	75	PF00017	0.574
LIG_SH3_3	116	122	PF00018	0.732
LIG_SH3_3	201	207	PF00018	0.661
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.737
LIG_SUMO_SIM_par_1	256	262	PF11976	0.737
LIG_SUMO_SIM_par_1	535	540	PF11976	0.407
LIG_TYR_ITIM	39	44	PF00017	0.545
LIG_WRC_WIRS_1	570	575	PF05994	0.407
MOD_CDK_SPxK_1	115	121	PF00069	0.731
MOD_CDK_SPxK_1	185	191	PF00069	0.794
MOD_CDK_SPxK_1	387	393	PF00069	0.658
MOD_CDK_SPxxK_3	185	192	PF00069	0.675
MOD_CDK_SPxxK_3	320	327	PF00069	0.738
MOD_CK1_1	151	157	PF00069	0.721
MOD_CK1_1	178	184	PF00069	0.788
MOD_CK1_1	197	203	PF00069	0.533
MOD_CK1_1	336	342	PF00069	0.719
MOD_CK1_1	78	84	PF00069	0.727
MOD_CK2_1	144	150	PF00069	0.645
MOD_CK2_1	253	259	PF00069	0.650
MOD_CK2_1	280	286	PF00069	0.613
MOD_CK2_1	37	43	PF00069	0.547
MOD_CK2_1	397	403	PF00069	0.528
MOD_CK2_1	510	516	PF00069	0.407
MOD_GlcNHglycan	109	112	PF01048	0.671
MOD_GlcNHglycan	150	153	PF01048	0.708
MOD_GlcNHglycan	225	228	PF01048	0.739
MOD_GlcNHglycan	342	345	PF01048	0.803
MOD_GlcNHglycan	459	462	PF01048	0.709
MOD_GlcNHglycan	469	472	PF01048	0.701
MOD_GlcNHglycan	5	8	PF01048	0.540
MOD_GlcNHglycan	80	83	PF01048	0.733
MOD_GlcNHglycan	94	97	PF01048	0.557
MOD_GSK3_1	107	114	PF00069	0.783
MOD_GSK3_1	121	128	PF00069	0.721
MOD_GSK3_1	142	149	PF00069	0.780
MOD_GSK3_1	237	244	PF00069	0.795
MOD_GSK3_1	245	252	PF00069	0.665
MOD_GSK3_1	266	273	PF00069	0.764
MOD_GSK3_1	291	298	PF00069	0.687
MOD_GSK3_1	336	343	PF00069	0.654
MOD_GSK3_1	60	67	PF00069	0.664
MOD_N-GLC_1	115	120	PF02516	0.733
MOD_N-GLC_1	200	205	PF02516	0.831
MOD_N-GLC_1	235	240	PF02516	0.753
MOD_N-GLC_1	264	269	PF02516	0.679
MOD_N-GLC_1	494	499	PF02516	0.503
MOD_NEK2_1	131	136	PF00069	0.709
MOD_NEK2_1	144	149	PF00069	0.720
MOD_NEK2_1	194	199	PF00069	0.716
MOD_NEK2_1	229	234	PF00069	0.770
MOD_NEK2_1	264	269	PF00069	0.645
MOD_NEK2_1	365	370	PF00069	0.497
MOD_NEK2_1	37	42	PF00069	0.549
MOD_NEK2_1	482	487	PF00069	0.602
MOD_NEK2_1	510	515	PF00069	0.403
MOD_NEK2_1	530	535	PF00069	0.180
MOD_NEK2_1	569	574	PF00069	0.407
MOD_NEK2_1	92	97	PF00069	0.653
MOD_NEK2_2	353	358	PF00069	0.601
MOD_PIKK_1	194	200	PF00454	0.730
MOD_PIKK_1	249	255	PF00454	0.661
MOD_PIKK_1	295	301	PF00454	0.778
MOD_PIKK_1	510	516	PF00454	0.383
MOD_PKA_1	548	554	PF00069	0.407
MOD_PKA_2	398	404	PF00069	0.485
MOD_Plk_1	530	536	PF00069	0.407
MOD_Plk_4	14	20	PF00069	0.550
MOD_Plk_4	216	222	PF00069	0.679
MOD_Plk_4	241	247	PF00069	0.737
MOD_Plk_4	253	259	PF00069	0.650
MOD_Plk_4	280	286	PF00069	0.613
MOD_Plk_4	423	429	PF00069	0.434
MOD_Plk_4	494	500	PF00069	0.383
MOD_Plk_4	548	554	PF00069	0.407
MOD_Plk_4	75	81	PF00069	0.714
MOD_ProDKin_1	105	111	PF00069	0.757
MOD_ProDKin_1	115	121	PF00069	0.663
MOD_ProDKin_1	185	191	PF00069	0.699
MOD_ProDKin_1	200	206	PF00069	0.736
MOD_ProDKin_1	245	251	PF00069	0.720
MOD_ProDKin_1	266	272	PF00069	0.579
MOD_ProDKin_1	297	303	PF00069	0.709
MOD_ProDKin_1	320	326	PF00069	0.692
MOD_ProDKin_1	333	339	PF00069	0.565
MOD_ProDKin_1	387	393	PF00069	0.559
MOD_ProDKin_1	420	426	PF00069	0.378
MOD_ProDKin_1	60	66	PF00069	0.651
MOD_SUMO_rev_2	540	550	PF00179	0.407
TRG_DiLeu_BaEn_1	436	441	PF01217	0.436
TRG_ENDOCYTIC_2	285	288	PF00928	0.617
TRG_ENDOCYTIC_2	41	44	PF00928	0.542
TRG_ENDOCYTIC_2	427	430	PF00928	0.462
TRG_ENDOCYTIC_2	570	573	PF00928	0.407
TRG_ENDOCYTIC_2	72	75	PF00928	0.685
TRG_ER_diArg_1	375	378	PF00400	0.531
TRG_ER_diArg_1	410	413	PF00400	0.505
TRG_ER_diArg_1	51	54	PF00400	0.518
TRG_ER_diArg_1	573	576	PF00400	0.407
TRG_NES_CRM1_1	13	28	PF08389	0.519
TRG_NES_CRM1_1	43	57	PF08389	0.533
TRG_NLS_MonoCore_2	408	413	PF00514	0.468
TRG_NLS_MonoCore_2	472	477	PF00514	0.630
TRG_NLS_MonoExtN_4	409	414	PF00514	0.474
TRG_NLS_MonoExtN_4	473	478	PF00514	0.606
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.675
TRG_Pf-PMV_PEXEL_1	412	417	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P823	Leptomonas seymouri	60%	95%
A0A3Q8ILF1	Leishmania donovani	93%	100%
A4HPX4	Leishmania braziliensis	78%	100%
E9ATP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%