PHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q0V5_LEIMA

TriTrypDb:

LmjF.36.4590 , LMJLV39_360057400 , LMJSD75_360057200

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0V5

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.697
CLV_C14_Caspase3-7	258	262	PF00656	0.701
CLV_C14_Caspase3-7	430	434	PF00656	0.785
CLV_C14_Caspase3-7	50	54	PF00656	0.690
CLV_C14_Caspase3-7	569	573	PF00656	0.749
CLV_C14_Caspase3-7	62	66	PF00656	0.719
CLV_C14_Caspase3-7	636	640	PF00656	0.743
CLV_NRD_NRD_1	250	252	PF00675	0.714
CLV_NRD_NRD_1	404	406	PF00675	0.601
CLV_NRD_NRD_1	481	483	PF00675	0.346
CLV_NRD_NRD_1	498	500	PF00675	0.346
CLV_NRD_NRD_1	601	603	PF00675	0.621
CLV_NRD_NRD_1	646	648	PF00675	0.696
CLV_NRD_NRD_1	679	681	PF00675	0.509
CLV_NRD_NRD_1	683	685	PF00675	0.573
CLV_NRD_NRD_1	755	757	PF00675	0.674
CLV_NRD_NRD_1	762	764	PF00675	0.669
CLV_NRD_NRD_1	798	800	PF00675	0.587
CLV_NRD_NRD_1	93	95	PF00675	0.752
CLV_PCSK_FUR_1	796	800	PF00082	0.586
CLV_PCSK_KEX2_1	110	112	PF00082	0.798
CLV_PCSK_KEX2_1	249	251	PF00082	0.718
CLV_PCSK_KEX2_1	343	345	PF00082	0.758
CLV_PCSK_KEX2_1	403	405	PF00082	0.599
CLV_PCSK_KEX2_1	481	483	PF00082	0.362
CLV_PCSK_KEX2_1	498	500	PF00082	0.346
CLV_PCSK_KEX2_1	648	650	PF00082	0.691
CLV_PCSK_KEX2_1	679	681	PF00082	0.509
CLV_PCSK_KEX2_1	683	685	PF00082	0.573
CLV_PCSK_KEX2_1	762	764	PF00082	0.647
CLV_PCSK_KEX2_1	798	800	PF00082	0.587
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.796
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.681
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.691
CLV_PCSK_PC7_1	679	685	PF00082	0.544
CLV_PCSK_SKI1_1	158	162	PF00082	0.538
CLV_PCSK_SKI1_1	181	185	PF00082	0.534
CLV_PCSK_SKI1_1	196	200	PF00082	0.650
CLV_PCSK_SKI1_1	201	205	PF00082	0.495
CLV_PCSK_SKI1_1	343	347	PF00082	0.680
CLV_PCSK_SKI1_1	72	76	PF00082	0.585
DEG_APCC_DBOX_1	481	489	PF00400	0.619
DEG_SCF_FBW7_1	202	208	PF00400	0.717
DEG_SCF_TRCP1_1	207	213	PF00400	0.681
DEG_SPOP_SBC_1	309	313	PF00917	0.747
DOC_CKS1_1	202	207	PF01111	0.751
DOC_CYCLIN_yCln2_LP_2	338	341	PF00134	0.618
DOC_MAPK_gen_1	717	726	PF00069	0.597
DOC_PP2B_LxvP_1	338	341	PF13499	0.773
DOC_PP2B_LxvP_1	466	469	PF13499	0.619
DOC_PP2B_LxvP_1	742	745	PF13499	0.651
DOC_PP2B_PxIxI_1	474	480	PF00149	0.452
DOC_PP4_FxxP_1	126	129	PF00568	0.683
DOC_PP4_FxxP_1	381	384	PF00568	0.641
DOC_USP7_MATH_1	189	193	PF00917	0.531
DOC_USP7_MATH_1	205	209	PF00917	0.720
DOC_USP7_MATH_1	212	216	PF00917	0.693
DOC_USP7_MATH_1	268	272	PF00917	0.519
DOC_USP7_MATH_1	309	313	PF00917	0.735
DOC_USP7_MATH_1	354	358	PF00917	0.652
DOC_USP7_MATH_1	422	426	PF00917	0.560
DOC_USP7_MATH_1	440	444	PF00917	0.665
DOC_USP7_MATH_1	85	89	PF00917	0.672
DOC_WW_Pin1_4	196	201	PF00397	0.657
DOC_WW_Pin1_4	230	235	PF00397	0.795
DOC_WW_Pin1_4	310	315	PF00397	0.809
DOC_WW_Pin1_4	423	428	PF00397	0.481
DOC_WW_Pin1_4	436	441	PF00397	0.700
DOC_WW_Pin1_4	553	558	PF00397	0.694
DOC_WW_Pin1_4	583	588	PF00397	0.672
DOC_WW_Pin1_4	595	600	PF00397	0.487
DOC_WW_Pin1_4	640	645	PF00397	0.686
DOC_WW_Pin1_4	74	79	PF00397	0.745
LIG_14-3-3_CanoR_1	131	139	PF00244	0.539
LIG_14-3-3_CanoR_1	181	186	PF00244	0.529
LIG_14-3-3_CanoR_1	328	333	PF00244	0.646
LIG_14-3-3_CanoR_1	366	373	PF00244	0.478
LIG_14-3-3_CanoR_1	403	412	PF00244	0.538
LIG_14-3-3_CanoR_1	448	456	PF00244	0.626
LIG_14-3-3_CanoR_1	683	690	PF00244	0.548
LIG_14-3-3_CanoR_1	719	727	PF00244	0.593
LIG_14-3-3_CanoR_1	796	806	PF00244	0.571
LIG_Actin_WH2_2	483	500	PF00022	0.619
LIG_Actin_WH2_2	784	800	PF00022	0.569
LIG_BIR_II_1	1	5	PF00653	0.745
LIG_BIR_III_3	1	5	PF00653	0.745
LIG_CtBP_PxDLS_1	577	581	PF00389	0.735
LIG_deltaCOP1_diTrp_1	729	732	PF00928	0.565
LIG_DLG_GKlike_1	282	290	PF00625	0.577
LIG_FHA_1	197	203	PF00498	0.676
LIG_FHA_1	211	217	PF00498	0.718
LIG_FHA_1	573	579	PF00498	0.820
LIG_FHA_1	630	636	PF00498	0.518
LIG_FHA_1	640	646	PF00498	0.613
LIG_FHA_1	765	771	PF00498	0.620
LIG_FHA_2	182	188	PF00498	0.531
LIG_FHA_2	202	208	PF00498	0.500
LIG_FHA_2	32	38	PF00498	0.660
LIG_FHA_2	634	640	PF00498	0.719
LIG_FHA_2	798	804	PF00498	0.539
LIG_GBD_Chelix_1	627	635	PF00786	0.557
LIG_Integrin_isoDGR_2	242	244	PF01839	0.736
LIG_LIR_Gen_1	721	728	PF02991	0.622
LIG_LIR_Gen_1	729	738	PF02991	0.533
LIG_LIR_Gen_1	746	755	PF02991	0.546
LIG_LIR_Gen_1	769	779	PF02991	0.593
LIG_LIR_Nem_3	721	726	PF02991	0.628
LIG_LIR_Nem_3	729	735	PF02991	0.531
LIG_LIR_Nem_3	746	752	PF02991	0.539
LIG_NRBOX	630	636	PF00104	0.568
LIG_SH2_CRK	145	149	PF00017	0.661
LIG_SH2_NCK_1	49	53	PF00017	0.687
LIG_SH2_NCK_1	749	753	PF00017	0.646
LIG_SH2_SRC	20	23	PF00017	0.676
LIG_SH2_SRC	399	402	PF00017	0.595
LIG_SH2_SRC	49	52	PF00017	0.684
LIG_SH2_SRC	493	496	PF00017	0.591
LIG_SH2_SRC	749	752	PF00017	0.640
LIG_SH2_STAP1	190	194	PF00017	0.536
LIG_SH2_STAP1	27	31	PF00017	0.670
LIG_SH2_STAT5	159	162	PF00017	0.549
LIG_SH2_STAT5	185	188	PF00017	0.542
LIG_SH2_STAT5	20	23	PF00017	0.676
LIG_SH2_STAT5	423	426	PF00017	0.549
LIG_SH2_STAT5	493	496	PF00017	0.546
LIG_SH2_STAT5	600	603	PF00017	0.494
LIG_SH3_3	199	205	PF00018	0.814
LIG_SH3_3	382	388	PF00018	0.535
LIG_SH3_3	416	422	PF00018	0.478
LIG_SH3_3	434	440	PF00018	0.703
LIG_SH3_3	546	552	PF00018	0.698
LIG_SH3_3	638	644	PF00018	0.656
LIG_SUMO_SIM_par_1	31	38	PF11976	0.660
LIG_SUMO_SIM_par_1	574	583	PF11976	0.619
LIG_SUMO_SIM_par_1	733	739	PF11976	0.585
LIG_TRAF2_1	745	748	PF00917	0.647
MOD_CDC14_SPxK_1	426	429	PF00782	0.506
MOD_CDC14_SPxK_1	556	559	PF00782	0.677
MOD_CDK_SPK_2	196	201	PF00069	0.735
MOD_CDK_SPxK_1	423	429	PF00069	0.460
MOD_CDK_SPxK_1	553	559	PF00069	0.669
MOD_CDK_SPxxK_3	310	317	PF00069	0.734
MOD_CDK_SPxxK_3	595	602	PF00069	0.595
MOD_CDK_SPxxK_3	640	647	PF00069	0.689
MOD_CK1_1	127	133	PF00069	0.553
MOD_CK1_1	215	221	PF00069	0.713
MOD_CK1_1	226	232	PF00069	0.779
MOD_CK1_1	312	318	PF00069	0.730
MOD_CK1_1	439	445	PF00069	0.691
MOD_CK1_1	571	577	PF00069	0.625
MOD_CK1_1	579	585	PF00069	0.684
MOD_CK1_1	612	618	PF00069	0.707
MOD_CK1_1	764	770	PF00069	0.642
MOD_CK1_1	96	102	PF00069	0.728
MOD_CK2_1	181	187	PF00069	0.530
MOD_CK2_1	31	37	PF00069	0.721
MOD_CK2_1	464	470	PF00069	0.619
MOD_CK2_1	797	803	PF00069	0.544
MOD_CK2_1	98	104	PF00069	0.626
MOD_DYRK1A_RPxSP_1	196	200	PF00069	0.674
MOD_DYRK1A_RPxSP_1	201	205	PF00069	0.684
MOD_GlcNHglycan	206	210	PF01048	0.766
MOD_GlcNHglycan	257	260	PF01048	0.678
MOD_GlcNHglycan	282	285	PF01048	0.823
MOD_GlcNHglycan	298	301	PF01048	0.641
MOD_GlcNHglycan	305	308	PF01048	0.595
MOD_GlcNHglycan	330	333	PF01048	0.710
MOD_GlcNHglycan	348	352	PF01048	0.659
MOD_GlcNHglycan	405	408	PF01048	0.563
MOD_GlcNHglycan	442	445	PF01048	0.717
MOD_GlcNHglycan	450	453	PF01048	0.714
MOD_GlcNHglycan	560	563	PF01048	0.717
MOD_GlcNHglycan	614	617	PF01048	0.613
MOD_GlcNHglycan	686	689	PF01048	0.595
MOD_GlcNHglycan	713	716	PF01048	0.613
MOD_GlcNHglycan	763	766	PF01048	0.658
MOD_GlcNHglycan	812	815	PF01048	0.638
MOD_GlcNHglycan	88	91	PF01048	0.654
MOD_GlcNHglycan	98	101	PF01048	0.816
MOD_GSK3_1	201	208	PF00069	0.746
MOD_GSK3_1	224	231	PF00069	0.798
MOD_GSK3_1	276	283	PF00069	0.745
MOD_GSK3_1	296	303	PF00069	0.501
MOD_GSK3_1	308	315	PF00069	0.713
MOD_GSK3_1	436	443	PF00069	0.692
MOD_GSK3_1	5	12	PF00069	0.606
MOD_GSK3_1	553	560	PF00069	0.734
MOD_GSK3_1	567	574	PF00069	0.756
MOD_GSK3_1	576	583	PF00069	0.660
MOD_GSK3_1	588	595	PF00069	0.600
MOD_GSK3_1	605	612	PF00069	0.512
MOD_GSK3_1	629	636	PF00069	0.564
MOD_GSK3_1	684	691	PF00069	0.456
MOD_GSK3_1	718	725	PF00069	0.597
MOD_LATS_1	326	332	PF00433	0.737
MOD_LATS_1	401	407	PF00433	0.617
MOD_LATS_1	446	452	PF00433	0.660
MOD_N-GLC_1	592	597	PF02516	0.561
MOD_NEK2_1	276	281	PF00069	0.639
MOD_NEK2_1	286	291	PF00069	0.629
MOD_NEK2_1	531	536	PF00069	0.546
MOD_NEK2_1	580	585	PF00069	0.690
MOD_NEK2_1	588	593	PF00069	0.575
MOD_NEK2_1	629	634	PF00069	0.520
MOD_NEK2_1	797	802	PF00069	0.603
MOD_PIKK_1	276	282	PF00454	0.733
MOD_PIKK_1	572	578	PF00454	0.746
MOD_PK_1	798	804	PF00069	0.677
MOD_PKA_1	14	20	PF00069	0.681
MOD_PKA_1	403	409	PF00069	0.548
MOD_PKA_1	683	689	PF00069	0.586
MOD_PKA_1	798	804	PF00069	0.576
MOD_PKA_2	127	133	PF00069	0.635
MOD_PKA_2	243	249	PF00069	0.849
MOD_PKA_2	287	293	PF00069	0.707
MOD_PKA_2	296	302	PF00069	0.628
MOD_PKA_2	365	371	PF00069	0.524
MOD_PKA_2	403	409	PF00069	0.516
MOD_PKA_2	447	453	PF00069	0.651
MOD_PKA_2	558	564	PF00069	0.720
MOD_PKA_2	683	689	PF00069	0.586
MOD_PKA_2	718	724	PF00069	0.597
MOD_PKA_2	761	767	PF00069	0.656
MOD_PKA_2	797	803	PF00069	0.558
MOD_PKA_2	86	92	PF00069	0.760
MOD_PKA_2	93	99	PF00069	0.688
MOD_PKB_1	796	804	PF00069	0.578
MOD_Plk_1	702	708	PF00069	0.572
MOD_Plk_2-3	538	544	PF00069	0.546
MOD_Plk_4	181	187	PF00069	0.573
MOD_Plk_4	190	196	PF00069	0.515
MOD_Plk_4	212	218	PF00069	0.833
MOD_Plk_4	31	37	PF00069	0.662
MOD_Plk_4	394	400	PF00069	0.548
MOD_Plk_4	722	728	PF00069	0.582
MOD_ProDKin_1	196	202	PF00069	0.666
MOD_ProDKin_1	230	236	PF00069	0.795
MOD_ProDKin_1	310	316	PF00069	0.807
MOD_ProDKin_1	423	429	PF00069	0.495
MOD_ProDKin_1	436	442	PF00069	0.700
MOD_ProDKin_1	553	559	PF00069	0.699
MOD_ProDKin_1	583	589	PF00069	0.671
MOD_ProDKin_1	595	601	PF00069	0.482
MOD_ProDKin_1	640	646	PF00069	0.688
MOD_ProDKin_1	74	80	PF00069	0.741
MOD_SUMO_for_1	109	112	PF00179	0.684
MOD_SUMO_rev_2	77	85	PF00179	0.670
TRG_DiLeu_BaLyEn_6	584	589	PF01217	0.551
TRG_ENDOCYTIC_2	145	148	PF00928	0.662
TRG_ENDOCYTIC_2	49	52	PF00928	0.684
TRG_ENDOCYTIC_2	749	752	PF00928	0.640
TRG_ENDOCYTIC_2	771	774	PF00928	0.705
TRG_ER_diArg_1	249	251	PF00400	0.659
TRG_ER_diArg_1	403	405	PF00400	0.483
TRG_ER_diArg_1	480	482	PF00400	0.546
TRG_ER_diArg_1	497	499	PF00400	0.546
TRG_ER_diArg_1	646	649	PF00400	0.695
TRG_ER_diArg_1	651	654	PF00400	0.656
TRG_ER_diArg_1	697	700	PF00400	0.701
TRG_ER_diArg_1	796	799	PF00400	0.595
TRG_NES_CRM1_1	733	748	PF08389	0.607
TRG_NLS_MonoExtC_3	646	651	PF00514	0.692
TRG_NLS_MonoExtN_4	644	651	PF00514	0.692
TRG_Pf-PMV_PEXEL_1	699	703	PF00026	0.705
TRG_Pf-PMV_PEXEL_1	768	772	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA05	Leptomonas seymouri	54%	97%
A0A3Q8IHQ6	Leishmania donovani	89%	100%
A4HPX7	Leishmania braziliensis	71%	100%
A4IDN8	Leishmania infantum	91%	100%
E9ATP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%