Transmembrane protein 17B

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Predicted membrane protein, putative

Species:

Leishmania major

UniProt:

Q4Q0V4_LEIMA

TriTrypDb:

LmjF.36.4600 , LMJLV39_360057500 , LMJSD75_360057300

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q0V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0V4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	109	111	PF00082	0.297
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.297
CLV_PCSK_SKI1_1	110	114	PF00082	0.295
CLV_Separin_Metazoa	97	101	PF03568	0.310
DEG_APCC_DBOX_1	71	79	PF00400	0.241
DEG_APCC_DBOX_1	99	107	PF00400	0.540
DOC_CDC14_PxL_1	122	130	PF14671	0.369
DOC_CYCLIN_yCln2_LP_2	16	22	PF00134	0.567
DOC_MAPK_gen_1	169	178	PF00069	0.596
DOC_MAPK_MEF2A_6	83	91	PF00069	0.418
DOC_WW_Pin1_4	181	186	PF00397	0.640
DOC_WW_Pin1_4	40	45	PF00397	0.623
LIG_14-3-3_CanoR_1	30	35	PF00244	0.609
LIG_Actin_WH2_2	10	28	PF00022	0.566
LIG_APCC_ABBAyCdc20_2	109	115	PF00400	0.532
LIG_BRCT_BRCA1_1	10	14	PF00533	0.568
LIG_Clathr_ClatBox_1	155	159	PF01394	0.397
LIG_FHA_1	119	125	PF00498	0.369
LIG_FHA_1	149	155	PF00498	0.294
LIG_FHA_1	7	13	PF00498	0.616
LIG_GBD_Chelix_1	116	124	PF00786	0.397
LIG_GBD_Chelix_1	130	138	PF00786	0.397
LIG_LIR_Apic_2	57	63	PF02991	0.335
LIG_LIR_Gen_1	11	22	PF02991	0.567
LIG_LIR_Gen_1	111	120	PF02991	0.413
LIG_LIR_Gen_1	177	186	PF02991	0.656
LIG_LIR_Gen_1	54	64	PF02991	0.373
LIG_LIR_Nem_3	11	17	PF02991	0.567
LIG_LIR_Nem_3	111	116	PF02991	0.532
LIG_LIR_Nem_3	177	182	PF02991	0.574
LIG_LIR_Nem_3	54	59	PF02991	0.335
LIG_NRBOX	45	51	PF00104	0.540
LIG_PALB2_WD40_1	61	69	PF16756	0.397
LIG_SH2_CRK	60	64	PF00017	0.382
LIG_SH2_PTP2	179	182	PF00017	0.611
LIG_SH2_STAT5	179	182	PF00017	0.569
LIG_SH2_STAT5	68	71	PF00017	0.444
LIG_SH3_3	16	22	PF00018	0.567
LIG_SUMO_SIM_anti_2	151	157	PF11976	0.315
LIG_SUMO_SIM_par_1	127	132	PF11976	0.241
LIG_SUMO_SIM_par_1	153	159	PF11976	0.311
LIG_SUMO_SIM_par_1	48	54	PF11976	0.455
LIG_SUMO_SIM_par_1	8	13	PF11976	0.620
LIG_SxIP_EBH_1	91	100	PF03271	0.241
MOD_CK1_1	181	187	PF00069	0.687
MOD_CK1_1	6	12	PF00069	0.566
MOD_CK1_1	77	83	PF00069	0.324
MOD_CK2_1	21	27	PF00069	0.564
MOD_GlcNHglycan	5	8	PF01048	0.364
MOD_GlcNHglycan	60	63	PF01048	0.397
MOD_GSK3_1	144	151	PF00069	0.340
MOD_GSK3_1	54	61	PF00069	0.397
MOD_GSK3_1	6	13	PF00069	0.566
MOD_GSK3_1	64	71	PF00069	0.413
MOD_NEK2_1	120	125	PF00069	0.325
MOD_NEK2_1	129	134	PF00069	0.454
MOD_NEK2_1	144	149	PF00069	0.324
MOD_NEK2_1	168	173	PF00069	0.605
MOD_NEK2_1	178	183	PF00069	0.614
MOD_NEK2_1	8	13	PF00069	0.614
MOD_NEK2_2	48	53	PF00069	0.402
MOD_NMyristoyl	1	7	PF02799	0.569
MOD_PIKK_1	148	154	PF00454	0.418
MOD_PIKK_1	77	83	PF00454	0.308
MOD_PKA_2	168	174	PF00069	0.626
MOD_Plk_1	144	150	PF00069	0.340
MOD_Plk_2-3	21	27	PF00069	0.564
MOD_Plk_4	120	126	PF00069	0.320
MOD_Plk_4	129	135	PF00069	0.479
MOD_Plk_4	51	57	PF00069	0.379
MOD_ProDKin_1	181	187	PF00069	0.643
MOD_ProDKin_1	40	46	PF00069	0.615
TRG_DiLeu_BaEn_2	114	120	PF01217	0.532
TRG_ENDOCYTIC_2	179	182	PF00928	0.611
TRG_ER_diArg_1	29	32	PF00400	0.653
TRG_NES_CRM1_1	115	127	PF08389	0.407
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM58	Leptomonas seymouri	64%	100%
A0A0S4JJP3	Bodo saltans	30%	100%
A0A1X0P0F4	Trypanosomatidae	34%	100%
A0A3R7LEN3	Trypanosoma rangeli	38%	100%
A0A3S7XBP1	Leishmania donovani	93%	100%
A4IDN9	Leishmania infantum	92%	100%
D0A4C5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ATP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%