t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0V3_LEIMA

TriTrypDb:

LmjF.36.4610 , LMJLV39_360057600 , LMJSD75_360057400

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q0V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0V3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.708
CLV_C14_Caspase3-7	386	390	PF00656	0.654
CLV_NRD_NRD_1	121	123	PF00675	0.452
CLV_NRD_NRD_1	15	17	PF00675	0.498
CLV_NRD_NRD_1	220	222	PF00675	0.474
CLV_NRD_NRD_1	252	254	PF00675	0.617
CLV_NRD_NRD_1	30	32	PF00675	0.423
CLV_NRD_NRD_1	329	331	PF00675	0.541
CLV_PCSK_FUR_1	119	123	PF00082	0.355
CLV_PCSK_KEX2_1	119	121	PF00082	0.464
CLV_PCSK_KEX2_1	15	17	PF00082	0.493
CLV_PCSK_KEX2_1	176	178	PF00082	0.418
CLV_PCSK_KEX2_1	252	254	PF00082	0.604
CLV_PCSK_KEX2_1	30	32	PF00082	0.418
CLV_PCSK_KEX2_1	329	331	PF00082	0.539
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.429
CLV_PCSK_PC7_1	172	178	PF00082	0.429
CLV_PCSK_SKI1_1	16	20	PF00082	0.452
CLV_PCSK_SKI1_1	308	312	PF00082	0.515
CLV_PCSK_SKI1_1	376	380	PF00082	0.477
DEG_Nend_UBRbox_2	1	3	PF02207	0.708
DEG_SCF_FBW7_2	336	342	PF00400	0.620
DOC_CKS1_1	336	341	PF01111	0.620
DOC_CYCLIN_RxL_1	304	315	PF00134	0.709
DOC_CYCLIN_RxL_1	370	380	PF00134	0.657
DOC_MAPK_gen_1	176	182	PF00069	0.570
DOC_PP4_FxxP_1	446	449	PF00568	0.650
DOC_USP7_MATH_1	14	18	PF00917	0.693
DOC_USP7_MATH_1	223	227	PF00917	0.590
DOC_USP7_MATH_1	287	291	PF00917	0.737
DOC_USP7_MATH_1	40	44	PF00917	0.665
DOC_WW_Pin1_4	17	22	PF00397	0.666
DOC_WW_Pin1_4	257	262	PF00397	0.798
DOC_WW_Pin1_4	335	340	PF00397	0.699
DOC_WW_Pin1_4	74	79	PF00397	0.618
LIG_14-3-3_CanoR_1	15	21	PF00244	0.751
LIG_14-3-3_CanoR_1	163	173	PF00244	0.659
LIG_14-3-3_CanoR_1	252	261	PF00244	0.821
LIG_14-3-3_CanoR_1	61	69	PF00244	0.590
LIG_BRCT_BRCA1_1	418	422	PF00533	0.520
LIG_eIF4E_1	5	11	PF01652	0.704
LIG_FHA_1	104	110	PF00498	0.605
LIG_FHA_1	268	274	PF00498	0.697
LIG_FHA_1	313	319	PF00498	0.708
LIG_FHA_1	39	45	PF00498	0.677
LIG_FHA_1	448	454	PF00498	0.575
LIG_FHA_1	61	67	PF00498	0.621
LIG_FHA_2	131	137	PF00498	0.699
LIG_FHA_2	32	38	PF00498	0.698
LIG_FHA_2	362	368	PF00498	0.657
LIG_GBD_Chelix_1	453	461	PF00786	0.484
LIG_LIR_Apic_2	444	449	PF02991	0.679
LIG_LIR_Gen_1	415	422	PF02991	0.582
LIG_LIR_Nem_3	269	274	PF02991	0.709
LIG_LIR_Nem_3	415	421	PF02991	0.581
LIG_MYND_1	356	360	PF01753	0.732
LIG_NRBOX	452	458	PF00104	0.428
LIG_Pex14_2	267	271	PF04695	0.738
LIG_Pex14_2	418	422	PF04695	0.520
LIG_SH3_3	350	356	PF00018	0.736
LIG_SH3_3	436	442	PF00018	0.663
LIG_SH3_4	146	153	PF00018	0.765
LIG_SUMO_SIM_par_1	94	101	PF11976	0.586
LIG_TRAF2_1	183	186	PF00917	0.616
LIG_TRAF2_1	34	37	PF00917	0.633
LIG_TRAF2_1	364	367	PF00917	0.611
LIG_Vh1_VBS_1	202	220	PF01044	0.584
MOD_CK1_1	130	136	PF00069	0.747
MOD_CK1_1	17	23	PF00069	0.634
MOD_CK1_1	257	263	PF00069	0.741
MOD_CK1_1	29	35	PF00069	0.573
MOD_CK1_1	401	407	PF00069	0.577
MOD_CK1_1	43	49	PF00069	0.674
MOD_CK1_1	97	103	PF00069	0.609
MOD_CK2_1	31	37	PF00069	0.689
MOD_CK2_1	314	320	PF00069	0.710
MOD_CK2_1	361	367	PF00069	0.639
MOD_CK2_1	6	12	PF00069	0.631
MOD_CK2_1	88	94	PF00069	0.590
MOD_GlcNHglycan	155	158	PF01048	0.531
MOD_GlcNHglycan	16	19	PF01048	0.465
MOD_GlcNHglycan	243	246	PF01048	0.517
MOD_GlcNHglycan	293	296	PF01048	0.443
MOD_GlcNHglycan	385	388	PF01048	0.367
MOD_GlcNHglycan	443	446	PF01048	0.449
MOD_GlcNHglycan	66	69	PF01048	0.430
MOD_GSK3_1	103	110	PF00069	0.495
MOD_GSK3_1	128	135	PF00069	0.707
MOD_GSK3_1	17	24	PF00069	0.678
MOD_GSK3_1	253	260	PF00069	0.804
MOD_GSK3_1	287	294	PF00069	0.667
MOD_GSK3_1	31	38	PF00069	0.686
MOD_GSK3_1	340	347	PF00069	0.696
MOD_GSK3_1	398	405	PF00069	0.576
MOD_GSK3_1	40	47	PF00069	0.630
MOD_GSK3_1	412	419	PF00069	0.573
MOD_GSK3_1	60	67	PF00069	0.425
MOD_GSK3_1	84	91	PF00069	0.587
MOD_GSK3_1	94	101	PF00069	0.553
MOD_N-GLC_1	334	339	PF02516	0.536
MOD_NEK2_1	1	6	PF00069	0.669
MOD_NEK2_1	105	110	PF00069	0.526
MOD_NEK2_1	267	272	PF00069	0.726
MOD_NEK2_1	344	349	PF00069	0.751
MOD_NEK2_1	44	49	PF00069	0.600
MOD_NEK2_1	84	89	PF00069	0.593
MOD_NEK2_1	96	101	PF00069	0.524
MOD_NEK2_2	281	286	PF00069	0.710
MOD_PIKK_1	35	41	PF00454	0.692
MOD_PIKK_1	398	404	PF00454	0.576
MOD_PIKK_1	45	51	PF00454	0.594
MOD_PKA_1	329	335	PF00069	0.697
MOD_PKA_2	14	20	PF00069	0.752
MOD_PKA_2	29	35	PF00069	0.632
MOD_PKA_2	329	335	PF00069	0.716
MOD_PKA_2	60	66	PF00069	0.565
MOD_Plk_1	1	7	PF00069	0.722
MOD_Plk_1	398	404	PF00069	0.590
MOD_Plk_4	340	346	PF00069	0.623
MOD_Plk_4	40	46	PF00069	0.662
MOD_Plk_4	402	408	PF00069	0.579
MOD_Plk_4	84	90	PF00069	0.666
MOD_ProDKin_1	17	23	PF00069	0.670
MOD_ProDKin_1	257	263	PF00069	0.796
MOD_ProDKin_1	335	341	PF00069	0.701
MOD_ProDKin_1	74	80	PF00069	0.613
MOD_SUMO_for_1	183	186	PF00179	0.611
MOD_SUMO_rev_2	386	393	PF00179	0.586
TRG_DiLeu_BaEn_1	416	421	PF01217	0.635
TRG_DiLeu_BaEn_4	366	372	PF01217	0.599
TRG_ER_diArg_1	119	122	PF00400	0.703
TRG_ER_diArg_1	30	33	PF00400	0.645
TRG_ER_diArg_1	328	330	PF00400	0.696
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	398	402	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ6	Leptomonas seymouri	53%	100%
A0A1X0P0B8	Trypanosomatidae	33%	100%
A0A3Q8IJ09	Leishmania donovani	89%	100%
A4HPX8	Leishmania braziliensis	71%	100%
A4IDP0	Leishmania infantum	89%	100%
D0A4C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ATP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BUS9	Trypanosoma cruzi	33%	100%