Feruloyl esterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Feruloyl esterase

Gene product:

Esterase PHB depolymerase, putative

Species:

Leishmania major

UniProt:

Q4Q0V0_LEIMA

TriTrypDb:

LmjF.36.4640 , LMJLV39_360057900 , LMJSD75_360057700

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005576	extracellular region	2	6
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q0V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0V0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0008233	peptidase activity	3	1
GO:0008236	serine-type peptidase activity	4	1
GO:0017171	serine hydrolase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0030600	feruloyl esterase activity	5	1
GO:0052689	carboxylic ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.689
CLV_C14_Caspase3-7	78	82	PF00656	0.389
CLV_C14_Caspase3-7	91	95	PF00656	0.277
CLV_NRD_NRD_1	30	32	PF00675	0.472
CLV_NRD_NRD_1	359	361	PF00675	0.593
CLV_NRD_NRD_1	429	431	PF00675	0.707
CLV_NRD_NRD_1	470	472	PF00675	0.661
CLV_NRD_NRD_1	510	512	PF00675	0.717
CLV_PCSK_KEX2_1	168	170	PF00082	0.438
CLV_PCSK_KEX2_1	429	431	PF00082	0.708
CLV_PCSK_KEX2_1	448	450	PF00082	0.583
CLV_PCSK_KEX2_1	510	512	PF00082	0.697
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.431
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.659
CLV_PCSK_PC7_1	425	431	PF00082	0.680
CLV_PCSK_SKI1_1	168	172	PF00082	0.604
CLV_PCSK_SKI1_1	31	35	PF00082	0.452
CLV_PCSK_SKI1_1	42	46	PF00082	0.242
CLV_PCSK_SKI1_1	430	434	PF00082	0.713
CLV_PCSK_SKI1_1	455	459	PF00082	0.636
CLV_Separin_Metazoa	545	549	PF03568	0.390
DEG_SCF_SKP2-CKS1_1	15	22	PF00560	0.636
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.386
DOC_MAPK_gen_1	121	129	PF00069	0.322
DOC_MAPK_gen_1	510	517	PF00069	0.518
DOC_MAPK_gen_1	522	529	PF00069	0.431
DOC_MAPK_gen_1	66	75	PF00069	0.394
DOC_MAPK_JIP1_4	152	158	PF00069	0.296
DOC_MAPK_JIP1_4	511	517	PF00069	0.452
DOC_MAPK_MEF2A_6	152	160	PF00069	0.323
DOC_PP1_RVXF_1	314	321	PF00149	0.327
DOC_PP1_RVXF_1	556	563	PF00149	0.347
DOC_PP2B_LxvP_1	26	29	PF13499	0.698
DOC_PP2B_LxvP_1	308	311	PF13499	0.338
DOC_PP2B_LxvP_1	52	55	PF13499	0.386
DOC_USP7_MATH_1	263	267	PF00917	0.261
DOC_USP7_MATH_1	295	299	PF00917	0.279
DOC_USP7_MATH_1	516	520	PF00917	0.478
DOC_USP7_UBL2_3	18	22	PF12436	0.642
DOC_USP7_UBL2_3	458	462	PF12436	0.514
DOC_WW_Pin1_4	16	21	PF00397	0.683
LIG_14-3-3_CanoR_1	262	268	PF00244	0.328
LIG_14-3-3_CanoR_1	296	300	PF00244	0.317
LIG_14-3-3_CanoR_1	42	47	PF00244	0.324
LIG_14-3-3_CanoR_1	434	440	PF00244	0.434
LIG_APCC_ABBA_1	176	181	PF00400	0.253
LIG_BIR_II_1	1	5	PF00653	0.646
LIG_BIR_III_2	27	31	PF00653	0.679
LIG_BIR_III_4	10	14	PF00653	0.635
LIG_BRCT_BRCA1_1	480	484	PF00533	0.493
LIG_BRCT_BRCA1_1	79	83	PF00533	0.428
LIG_EH1_1	82	90	PF00400	0.397
LIG_FHA_1	172	178	PF00498	0.253
LIG_FHA_1	283	289	PF00498	0.334
LIG_FHA_1	295	301	PF00498	0.317
LIG_FHA_1	303	309	PF00498	0.234
LIG_FHA_1	539	545	PF00498	0.339
LIG_FHA_1	563	569	PF00498	0.286
LIG_FHA_2	133	139	PF00498	0.349
LIG_FHA_2	376	382	PF00498	0.503
LIG_FHA_2	399	405	PF00498	0.438
LIG_IBAR_NPY_1	383	385	PF08397	0.434
LIG_LIR_Gen_1	183	190	PF02991	0.296
LIG_LIR_Gen_1	418	427	PF02991	0.456
LIG_LIR_Gen_1	60	68	PF02991	0.369
LIG_LIR_Nem_3	128	132	PF02991	0.358
LIG_LIR_Nem_3	174	179	PF02991	0.275
LIG_LIR_Nem_3	183	188	PF02991	0.275
LIG_LIR_Nem_3	259	264	PF02991	0.312
LIG_LIR_Nem_3	418	424	PF02991	0.453
LIG_PCNA_yPIPBox_3	82	90	PF02747	0.365
LIG_PTAP_UEV_1	147	152	PF05743	0.231
LIG_PTB_Apo_2	348	355	PF02174	0.329
LIG_PTB_Phospho_1	348	354	PF10480	0.382
LIG_SH2_GRB2like	349	352	PF00017	0.329
LIG_SH2_GRB2like	354	357	PF00017	0.336
LIG_SH2_STAT5	100	103	PF00017	0.389
LIG_SH2_STAT5	142	145	PF00017	0.275
LIG_SH2_STAT5	196	199	PF00017	0.261
LIG_SH2_STAT5	349	352	PF00017	0.329
LIG_SH2_STAT5	354	357	PF00017	0.336
LIG_SH2_STAT5	421	424	PF00017	0.450
LIG_SH2_STAT5	491	494	PF00017	0.450
LIG_SH2_STAT5	567	570	PF00017	0.293
LIG_SH2_STAT5	57	60	PF00017	0.470
LIG_SH3_1	114	120	PF00018	0.385
LIG_SH3_3	114	120	PF00018	0.367
LIG_SH3_3	138	144	PF00018	0.261
LIG_SH3_3	145	151	PF00018	0.261
LIG_SH3_3	356	362	PF00018	0.342
LIG_SUMO_SIM_anti_2	541	548	PF11976	0.392
LIG_SUMO_SIM_anti_2	70	78	PF11976	0.442
LIG_SUMO_SIM_par_1	70	78	PF11976	0.449
LIG_TRFH_1	484	488	PF08558	0.503
LIG_TYR_ITIM	177	182	PF00017	0.280
LIG_UBA3_1	159	168	PF00899	0.328
LIG_WRC_WIRS_1	126	131	PF05994	0.374
LIG_WRC_WIRS_1	366	371	PF05994	0.436
LIG_WW_3	28	32	PF00397	0.694
MOD_CDK_SPxK_1	16	22	PF00069	0.637
MOD_CK1_1	103	109	PF00069	0.387
MOD_CK1_1	146	152	PF00069	0.275
MOD_CK1_1	16	22	PF00069	0.716
MOD_CK1_1	345	351	PF00069	0.389
MOD_CK1_1	74	80	PF00069	0.430
MOD_CK2_1	132	138	PF00069	0.301
MOD_CK2_1	33	39	PF00069	0.583
MOD_CK2_1	375	381	PF00069	0.483
MOD_CK2_1	397	403	PF00069	0.539
MOD_CK2_1	412	418	PF00069	0.410
MOD_CK2_1	539	545	PF00069	0.372
MOD_GlcNHglycan	267	270	PF01048	0.496
MOD_GSK3_1	128	135	PF00069	0.320
MOD_GSK3_1	142	149	PF00069	0.281
MOD_GSK3_1	186	193	PF00069	0.259
MOD_GSK3_1	290	297	PF00069	0.417
MOD_GSK3_1	334	341	PF00069	0.405
MOD_GSK3_1	345	352	PF00069	0.345
MOD_GSK3_1	398	405	PF00069	0.440
MOD_GSK3_1	71	78	PF00069	0.400
MOD_GSK3_1	9	16	PF00069	0.727
MOD_GSK3_1	99	106	PF00069	0.387
MOD_LATS_1	470	476	PF00433	0.458
MOD_N-GLC_1	355	360	PF02516	0.597
MOD_N-GLC_1	392	397	PF02516	0.703
MOD_N-GLC_1	538	543	PF02516	0.554
MOD_N-GLC_2	334	336	PF02516	0.548
MOD_NEK2_1	171	176	PF00069	0.275
MOD_NEK2_1	227	232	PF00069	0.328
MOD_NEK2_2	349	354	PF00069	0.298
MOD_PIKK_1	225	231	PF00454	0.253
MOD_PIKK_1	494	500	PF00454	0.511
MOD_PIKK_1	539	545	PF00454	0.365
MOD_PKA_1	31	37	PF00069	0.643
MOD_PKA_1	471	477	PF00069	0.449
MOD_PKA_2	295	301	PF00069	0.381
MOD_PKA_2	433	439	PF00069	0.483
MOD_Plk_1	233	239	PF00069	0.290
MOD_Plk_1	355	361	PF00069	0.406
MOD_Plk_1	402	408	PF00069	0.420
MOD_Plk_4	100	106	PF00069	0.357
MOD_Plk_4	122	128	PF00069	0.373
MOD_Plk_4	295	301	PF00069	0.317
MOD_Plk_4	319	325	PF00069	0.409
MOD_Plk_4	345	351	PF00069	0.369
MOD_ProDKin_1	16	22	PF00069	0.686
MOD_SUMO_rev_2	461	468	PF00179	0.512
TRG_DiLeu_BaEn_2	180	186	PF01217	0.261
TRG_ENDOCYTIC_2	179	182	PF00928	0.280
TRG_ENDOCYTIC_2	385	388	PF00928	0.491
TRG_ENDOCYTIC_2	421	424	PF00928	0.450
TRG_ER_diArg_1	510	512	PF00400	0.500
TRG_NES_CRM1_1	222	234	PF08389	0.223
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD17	Leptomonas seymouri	43%	100%
A0A3S7XBJ7	Leishmania donovani	84%	99%
A4HPY1	Leishmania braziliensis	57%	99%
A4IDP2	Leishmania infantum	84%	99%
E9ATP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%