VPS9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar sorting protein 9 (VPS9) domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q0U8_LEIMA

TriTrypDb:

LmjF.36.4660 , LMJLV39_360058100 , LMJSD75_360057900

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0030139	endocytic vesicle	7	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0U8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0016192	vesicle-mediated transport	4	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7

Molecular functions
Term	Name	Level	Count
GO:0005085	guanyl-nucleotide exchange factor activity	3	7
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0031267	small GTPase binding	5	2
GO:0051020	GTPase binding	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7
GO:0140678	molecular function inhibitor activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.527
CLV_C14_Caspase3-7	5	9	PF00656	0.558
CLV_C14_Caspase3-7	816	820	PF00656	0.675
CLV_NRD_NRD_1	106	108	PF00675	0.582
CLV_NRD_NRD_1	428	430	PF00675	0.451
CLV_NRD_NRD_1	490	492	PF00675	0.436
CLV_NRD_NRD_1	529	531	PF00675	0.452
CLV_NRD_NRD_1	603	605	PF00675	0.312
CLV_PCSK_KEX2_1	106	108	PF00082	0.582
CLV_PCSK_KEX2_1	162	164	PF00082	0.384
CLV_PCSK_KEX2_1	428	430	PF00082	0.451
CLV_PCSK_KEX2_1	490	492	PF00082	0.436
CLV_PCSK_KEX2_1	529	531	PF00082	0.452
CLV_PCSK_KEX2_1	603	605	PF00082	0.312
CLV_PCSK_KEX2_1	607	609	PF00082	0.312
CLV_PCSK_KEX2_1	779	781	PF00082	0.584
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.384
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.340
CLV_PCSK_PC1ET2_1	779	781	PF00082	0.584
CLV_PCSK_PC7_1	603	609	PF00082	0.340
CLV_PCSK_SKI1_1	122	126	PF00082	0.378
CLV_PCSK_SKI1_1	401	405	PF00082	0.515
CLV_PCSK_SKI1_1	511	515	PF00082	0.368
CLV_PCSK_SKI1_1	604	608	PF00082	0.291
CLV_PCSK_SKI1_1	611	615	PF00082	0.291
CLV_PCSK_SKI1_1	718	722	PF00082	0.615
CLV_PCSK_SKI1_1	898	902	PF00082	0.489
CLV_PCSK_SKI1_1	924	928	PF00082	0.469
DEG_APCC_DBOX_1	223	231	PF00400	0.431
DEG_SCF_FBW7_1	489	496	PF00400	0.463
DEG_SPOP_SBC_1	405	409	PF00917	0.481
DOC_CDC14_PxL_1	251	259	PF14671	0.578
DOC_CYCLIN_RxL_1	534	543	PF00134	0.454
DOC_MAPK_gen_1	106	113	PF00069	0.478
DOC_MAPK_gen_1	339	348	PF00069	0.503
DOC_MAPK_gen_1	490	497	PF00069	0.468
DOC_MAPK_gen_1	894	902	PF00069	0.540
DOC_MAPK_MEF2A_6	490	497	PF00069	0.384
DOC_MAPK_MEF2A_6	587	596	PF00069	0.312
DOC_PP1_RVXF_1	643	650	PF00149	0.388
DOC_PP2B_LxvP_1	279	282	PF13499	0.674
DOC_PP2B_LxvP_1	844	847	PF13499	0.585
DOC_PP4_FxxP_1	42	45	PF00568	0.276
DOC_PP4_FxxP_1	575	578	PF00568	0.312
DOC_PP4_FxxP_1	659	662	PF00568	0.388
DOC_USP7_MATH_1	392	396	PF00917	0.727
DOC_USP7_MATH_1	406	410	PF00917	0.673
DOC_USP7_MATH_1	471	475	PF00917	0.471
DOC_USP7_MATH_1	663	667	PF00917	0.351
DOC_USP7_MATH_1	697	701	PF00917	0.531
DOC_USP7_MATH_1	773	777	PF00917	0.656
DOC_USP7_MATH_1	802	806	PF00917	0.641
DOC_USP7_MATH_1	813	817	PF00917	0.712
DOC_USP7_MATH_1	853	857	PF00917	0.568
DOC_USP7_UBL2_3	607	611	PF12436	0.315
DOC_WW_Pin1_4	489	494	PF00397	0.416
DOC_WW_Pin1_4	574	579	PF00397	0.313
DOC_WW_Pin1_4	842	847	PF00397	0.756
DOC_WW_Pin1_4	880	885	PF00397	0.714
DOC_WW_Pin1_4	91	96	PF00397	0.650
LIG_14-3-3_CanoR_1	246	252	PF00244	0.592
LIG_14-3-3_CanoR_1	339	348	PF00244	0.599
LIG_14-3-3_CanoR_1	444	449	PF00244	0.436
LIG_14-3-3_CanoR_1	46	51	PF00244	0.378
LIG_14-3-3_CanoR_1	494	498	PF00244	0.614
LIG_14-3-3_CanoR_1	511	518	PF00244	0.272
LIG_14-3-3_CanoR_1	645	650	PF00244	0.312
LIG_BIR_III_2	551	555	PF00653	0.390
LIG_BRCT_BRCA1_1	678	682	PF00533	0.369
LIG_BRCT_BRCA1_1	78	82	PF00533	0.571
LIG_Clathr_ClatBox_1	133	137	PF01394	0.374
LIG_Clathr_ClatBox_1	539	543	PF01394	0.501
LIG_CtBP_PxDLS_1	724	728	PF00389	0.601
LIG_DLG_GKlike_1	46	53	PF00625	0.394
LIG_FHA_1	106	112	PF00498	0.565
LIG_FHA_1	246	252	PF00498	0.663
LIG_FHA_1	304	310	PF00498	0.614
LIG_FHA_1	343	349	PF00498	0.529
LIG_FHA_1	490	496	PF00498	0.497
LIG_FHA_1	512	518	PF00498	0.469
LIG_FHA_2	248	254	PF00498	0.579
LIG_FHA_2	739	745	PF00498	0.605
LIG_FHA_2	785	791	PF00498	0.595
LIG_FHA_2	910	916	PF00498	0.444
LIG_GBD_Chelix_1	125	133	PF00786	0.337
LIG_Integrin_isoDGR_2	858	860	PF01839	0.549
LIG_LIR_Apic_2	40	45	PF02991	0.292
LIG_LIR_Apic_2	573	578	PF02991	0.312
LIG_LIR_Apic_2	657	662	PF02991	0.388
LIG_LIR_Gen_1	130	139	PF02991	0.408
LIG_LIR_Gen_1	436	446	PF02991	0.403
LIG_LIR_Gen_1	475	482	PF02991	0.520
LIG_LIR_Gen_1	515	524	PF02991	0.410
LIG_LIR_Gen_1	907	916	PF02991	0.433
LIG_LIR_Nem_3	130	134	PF02991	0.394
LIG_LIR_Nem_3	142	147	PF02991	0.427
LIG_LIR_Nem_3	426	430	PF02991	0.436
LIG_LIR_Nem_3	436	442	PF02991	0.418
LIG_LIR_Nem_3	475	481	PF02991	0.562
LIG_LIR_Nem_3	515	521	PF02991	0.403
LIG_LIR_Nem_3	907	911	PF02991	0.441
LIG_PCNA_yPIPBox_3	499	513	PF02747	0.471
LIG_Pex14_2	438	442	PF04695	0.467
LIG_Pex14_2	633	637	PF04695	0.312
LIG_PTB_Apo_2	138	145	PF02174	0.536
LIG_PTB_Apo_2	649	656	PF02174	0.312
LIG_PTB_Phospho_1	649	655	PF10480	0.312
LIG_REV1ctd_RIR_1	572	577	PF16727	0.312
LIG_SH2_CRK	131	135	PF00017	0.394
LIG_SH2_CRK	427	431	PF00017	0.426
LIG_SH2_CRK	518	522	PF00017	0.384
LIG_SH2_NCK_1	331	335	PF00017	0.638
LIG_SH2_STAP1	277	281	PF00017	0.627
LIG_SH2_STAT5	327	330	PF00017	0.695
LIG_SH2_STAT5	331	334	PF00017	0.630
LIG_SH2_STAT5	461	464	PF00017	0.558
LIG_SH2_STAT5	512	515	PF00017	0.366
LIG_SH2_STAT5	58	61	PF00017	0.461
LIG_SH2_STAT5	655	658	PF00017	0.342
LIG_SH2_STAT5	671	674	PF00017	0.312
LIG_SH3_3	108	114	PF00018	0.589
LIG_SH3_3	196	202	PF00018	0.501
LIG_SH3_3	249	255	PF00018	0.660
LIG_SH3_3	316	322	PF00018	0.675
LIG_SH3_3	385	391	PF00018	0.628
LIG_SH3_3	730	736	PF00018	0.613
LIG_SH3_3	879	885	PF00018	0.612
LIG_Sin3_3	637	644	PF02671	0.312
LIG_SUMO_SIM_anti_2	49	54	PF11976	0.446
LIG_SUMO_SIM_anti_2	787	793	PF11976	0.571
LIG_SUMO_SIM_par_1	306	313	PF11976	0.611
LIG_SUMO_SIM_par_1	342	351	PF11976	0.508
LIG_TRAF2_1	666	669	PF00917	0.332
LIG_TRAF2_2	95	100	PF00917	0.679
LIG_TYR_ITIM	129	134	PF00017	0.389
LIG_UBA3_1	207	212	PF00899	0.405
LIG_UBA3_1	29	36	PF00899	0.404
LIG_WW_3	845	849	PF00397	0.609
MOD_CDC14_SPxK_1	845	848	PF00782	0.644
MOD_CDK_SPK_2	489	494	PF00069	0.465
MOD_CDK_SPK_2	574	579	PF00069	0.312
MOD_CDK_SPxK_1	842	848	PF00069	0.659
MOD_CDK_SPxxK_3	574	581	PF00069	0.312
MOD_CK1_1	142	148	PF00069	0.412
MOD_CK1_1	233	239	PF00069	0.644
MOD_CK1_1	280	286	PF00069	0.644
MOD_CK1_1	3	9	PF00069	0.473
MOD_CK1_1	342	348	PF00069	0.609
MOD_CK1_1	373	379	PF00069	0.614
MOD_CK1_1	67	73	PF00069	0.678
MOD_CK1_1	827	833	PF00069	0.660
MOD_CK1_1	889	895	PF00069	0.720
MOD_CK2_1	150	156	PF00069	0.496
MOD_CK2_1	233	239	PF00069	0.511
MOD_CK2_1	28	34	PF00069	0.415
MOD_CK2_1	301	307	PF00069	0.627
MOD_CK2_1	344	350	PF00069	0.606
MOD_CK2_1	437	443	PF00069	0.492
MOD_CK2_1	522	528	PF00069	0.475
MOD_CK2_1	574	580	PF00069	0.312
MOD_CK2_1	663	669	PF00069	0.442
MOD_CK2_1	909	915	PF00069	0.455
MOD_Cter_Amidation	104	107	PF01082	0.564
MOD_Cter_Amidation	777	780	PF01082	0.588
MOD_GlcNHglycan	147	150	PF01048	0.495
MOD_GlcNHglycan	186	189	PF01048	0.608
MOD_GlcNHglycan	232	235	PF01048	0.534
MOD_GlcNHglycan	242	245	PF01048	0.581
MOD_GlcNHglycan	279	282	PF01048	0.617
MOD_GlcNHglycan	354	357	PF01048	0.630
MOD_GlcNHglycan	358	361	PF01048	0.513
MOD_GlcNHglycan	375	378	PF01048	0.681
MOD_GlcNHglycan	474	477	PF01048	0.529
MOD_GlcNHglycan	617	620	PF01048	0.332
MOD_GlcNHglycan	69	73	PF01048	0.621
MOD_GlcNHglycan	701	704	PF01048	0.775
MOD_GlcNHglycan	713	716	PF01048	0.544
MOD_GlcNHglycan	727	730	PF01048	0.613
MOD_GlcNHglycan	78	81	PF01048	0.548
MOD_GlcNHglycan	819	823	PF01048	0.672
MOD_GlcNHglycan	837	840	PF01048	0.628
MOD_GlcNHglycan	855	858	PF01048	0.594
MOD_GlcNHglycan	869	872	PF01048	0.553
MOD_GSK3_1	105	112	PF00069	0.565
MOD_GSK3_1	184	191	PF00069	0.627
MOD_GSK3_1	233	240	PF00069	0.562
MOD_GSK3_1	293	300	PF00069	0.626
MOD_GSK3_1	301	308	PF00069	0.603
MOD_GSK3_1	344	351	PF00069	0.561
MOD_GSK3_1	352	359	PF00069	0.625
MOD_GSK3_1	397	404	PF00069	0.543
MOD_GSK3_1	456	463	PF00069	0.454
MOD_GSK3_1	489	496	PF00069	0.494
MOD_GSK3_1	64	71	PF00069	0.574
MOD_GSK3_1	663	670	PF00069	0.388
MOD_GSK3_1	672	679	PF00069	0.486
MOD_GSK3_1	695	702	PF00069	0.619
MOD_GSK3_1	763	770	PF00069	0.627
MOD_GSK3_1	827	834	PF00069	0.732
MOD_GSK3_1	886	893	PF00069	0.682
MOD_N-GLC_1	145	150	PF02516	0.478
MOD_N-GLC_1	290	295	PF02516	0.620
MOD_N-GLC_1	352	357	PF02516	0.528
MOD_N-GLC_1	392	397	PF02516	0.595
MOD_N-GLC_1	522	527	PF02516	0.450
MOD_N-GLC_1	763	768	PF02516	0.650
MOD_N-GLC_1	889	894	PF02516	0.582
MOD_N-GLC_1	904	909	PF02516	0.450
MOD_N-GLC_2	299	301	PF02516	0.647
MOD_NEK2_1	20	25	PF00069	0.458
MOD_NEK2_1	230	235	PF00069	0.585
MOD_NEK2_1	247	252	PF00069	0.699
MOD_NEK2_1	352	357	PF00069	0.597
MOD_NEK2_1	370	375	PF00069	0.588
MOD_NEK2_1	59	64	PF00069	0.498
MOD_NEK2_1	676	681	PF00069	0.388
MOD_NEK2_2	406	411	PF00069	0.531
MOD_NEK2_2	713	718	PF00069	0.613
MOD_OFUCOSY	584	589	PF10250	0.388
MOD_PIKK_1	763	769	PF00454	0.615
MOD_PK_1	831	837	PF00069	0.639
MOD_PKA_2	105	111	PF00069	0.519
MOD_PKA_2	150	156	PF00069	0.496
MOD_PKA_2	223	229	PF00069	0.425
MOD_PKA_2	245	251	PF00069	0.704
MOD_PKA_2	493	499	PF00069	0.540
MOD_PKA_2	500	506	PF00069	0.420
MOD_PKA_2	64	70	PF00069	0.639
MOD_PKA_2	760	766	PF00069	0.612
MOD_PKA_2	824	830	PF00069	0.664
MOD_PKA_2	847	853	PF00069	0.660
MOD_PKB_1	337	345	PF00069	0.583
MOD_PKB_1	643	651	PF00069	0.312
MOD_Plk_1	342	348	PF00069	0.615
MOD_Plk_1	667	673	PF00069	0.321
MOD_Plk_1	865	871	PF00069	0.608
MOD_Plk_1	904	910	PF00069	0.449
MOD_Plk_2-3	784	790	PF00069	0.567
MOD_Plk_2-3	909	915	PF00069	0.451
MOD_Plk_4	20	26	PF00069	0.470
MOD_Plk_4	223	229	PF00069	0.337
MOD_Plk_4	247	253	PF00069	0.717
MOD_Plk_4	305	311	PF00069	0.598
MOD_Plk_4	500	506	PF00069	0.533
MOD_Plk_4	645	651	PF00069	0.314
MOD_Plk_4	676	682	PF00069	0.444
MOD_Plk_4	784	790	PF00069	0.647
MOD_ProDKin_1	489	495	PF00069	0.413
MOD_ProDKin_1	574	580	PF00069	0.313
MOD_ProDKin_1	842	848	PF00069	0.678
MOD_ProDKin_1	880	886	PF00069	0.717
MOD_ProDKin_1	91	97	PF00069	0.652
MOD_SUMO_rev_2	233	243	PF00179	0.573
MOD_SUMO_rev_2	355	365	PF00179	0.535
MOD_SUMO_rev_2	771	781	PF00179	0.628
TRG_DiLeu_BaEn_1	441	446	PF01217	0.456
TRG_DiLeu_BaEn_1	922	927	PF01217	0.640
TRG_DiLeu_BaEn_4	668	674	PF01217	0.340
TRG_ENDOCYTIC_2	131	134	PF00928	0.383
TRG_ENDOCYTIC_2	331	334	PF00928	0.671
TRG_ENDOCYTIC_2	427	430	PF00928	0.434
TRG_ENDOCYTIC_2	439	442	PF00928	0.383
TRG_ENDOCYTIC_2	478	481	PF00928	0.385
TRG_ENDOCYTIC_2	518	521	PF00928	0.463
TRG_ER_diArg_1	179	182	PF00400	0.567
TRG_ER_diArg_1	427	429	PF00400	0.424
TRG_ER_diArg_1	489	491	PF00400	0.425
TRG_ER_diArg_1	642	645	PF00400	0.312
TRG_ER_diArg_1	894	897	PF00400	0.535
TRG_Pf-PMV_PEXEL_1	924	929	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P3	Leptomonas seymouri	43%	92%
A0A3S7XBS1	Leishmania donovani	89%	100%
A4HPY3	Leishmania braziliensis	64%	100%
A4IDP4	Leishmania infantum	89%	100%
E9ATQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%