LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q0U7_LEIMA
TriTrypDb:
LmjF.36.4670 , LMJLV39_360058200 , LMJSD75_360058000
Length:
128

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4Q0U7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0U7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 36 38 PF00082 0.490
CLV_PCSK_PC1ET2_1 36 38 PF00082 0.548
CLV_PCSK_SKI1_1 112 116 PF00082 0.475
CLV_PCSK_SKI1_1 36 40 PF00082 0.538
CLV_PCSK_SKI1_1 70 74 PF00082 0.453
DEG_APCC_DBOX_1 69 77 PF00400 0.471
DEG_Nend_Nbox_1 1 3 PF02207 0.718
DOC_CYCLIN_RxL_1 106 119 PF00134 0.475
DOC_MAPK_gen_1 68 75 PF00069 0.455
DOC_USP7_MATH_1 58 62 PF00917 0.658
LIG_14-3-3_CanoR_1 37 45 PF00244 0.530
LIG_14-3-3_CanoR_1 6 11 PF00244 0.499
LIG_EH1_1 108 116 PF00400 0.454
LIG_eIF4E_1 109 115 PF01652 0.453
LIG_FHA_2 115 121 PF00498 0.469
LIG_FHA_2 37 43 PF00498 0.545
LIG_NRBOX 68 74 PF00104 0.457
LIG_SH3_3 121 127 PF00018 0.465
LIG_SUMO_SIM_par_1 5 11 PF11976 0.460
LIG_TRAF2_1 117 120 PF00917 0.564
LIG_UBA3_1 114 123 PF00899 0.534
MOD_CK2_1 114 120 PF00069 0.522
MOD_CK2_1 36 42 PF00069 0.519
MOD_CK2_1 58 64 PF00069 0.433
MOD_GlcNHglycan 10 13 PF01048 0.677
MOD_GlcNHglycan 21 24 PF01048 0.547
MOD_GlcNHglycan 39 42 PF01048 0.490
MOD_GlcNHglycan 60 63 PF01048 0.594
MOD_GSK3_1 10 17 PF00069 0.580
MOD_GSK3_1 2 9 PF00069 0.588
MOD_NEK2_1 10 15 PF00069 0.600
MOD_PKA_1 36 42 PF00069 0.537
MOD_PKA_2 2 8 PF00069 0.476
MOD_PKA_2 36 42 PF00069 0.526
MOD_Plk_4 10 16 PF00069 0.567
MOD_SUMO_for_1 105 108 PF00179 0.515
MOD_SUMO_for_1 50 53 PF00179 0.671
TRG_DiLeu_BaEn_1 71 76 PF01217 0.448
TRG_DiLeu_BaEn_4 95 101 PF01217 0.469
TRG_ER_diArg_1 67 70 PF00400 0.493
TRG_Pf-PMV_PEXEL_1 116 120 PF00026 0.466

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I6T4 Leptomonas seymouri 82% 100%
A0A0S4JQY9 Bodo saltans 60% 100%
A0A1X0P0D5 Trypanosomatidae 59% 100%
A0A3Q8IJL8 Leishmania donovani 90% 100%
A0A3S5ISR3 Trypanosoma rangeli 61% 100%
A4HPY4 Leishmania braziliensis 73% 100%
A4IDP5 Leishmania infantum 90% 100%
D0A4D5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9ATQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS