AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania major

UniProt:

Q4Q0U4_LEIMA

TriTrypDb:

LmjF.36.4690 , LMJLV39_360058500 , LMJSD75_360058300

Length:

993

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q0U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0U4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	585	589	PF00656	0.621
CLV_C14_Caspase3-7	591	595	PF00656	0.568
CLV_C14_Caspase3-7	600	604	PF00656	0.467
CLV_C14_Caspase3-7	699	703	PF00656	0.451
CLV_C14_Caspase3-7	771	775	PF00656	0.617
CLV_NRD_NRD_1	189	191	PF00675	0.723
CLV_NRD_NRD_1	383	385	PF00675	0.539
CLV_NRD_NRD_1	394	396	PF00675	0.440
CLV_NRD_NRD_1	567	569	PF00675	0.811
CLV_NRD_NRD_1	59	61	PF00675	0.734
CLV_NRD_NRD_1	742	744	PF00675	0.715
CLV_NRD_NRD_1	75	77	PF00675	0.585
CLV_NRD_NRD_1	790	792	PF00675	0.713
CLV_NRD_NRD_1	877	879	PF00675	0.520
CLV_NRD_NRD_1	948	950	PF00675	0.332
CLV_PCSK_FUR_1	381	385	PF00082	0.553
CLV_PCSK_KEX2_1	189	191	PF00082	0.723
CLV_PCSK_KEX2_1	371	373	PF00082	0.542
CLV_PCSK_KEX2_1	381	383	PF00082	0.536
CLV_PCSK_KEX2_1	396	398	PF00082	0.430
CLV_PCSK_KEX2_1	61	63	PF00082	0.727
CLV_PCSK_KEX2_1	741	743	PF00082	0.724
CLV_PCSK_KEX2_1	75	77	PF00082	0.609
CLV_PCSK_KEX2_1	877	879	PF00082	0.520
CLV_PCSK_KEX2_1	929	931	PF00082	0.472
CLV_PCSK_KEX2_1	947	949	PF00082	0.296
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.542
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.420
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.727
CLV_PCSK_PC1ET2_1	741	743	PF00082	0.724
CLV_PCSK_PC1ET2_1	929	931	PF00082	0.472
CLV_PCSK_PC7_1	943	949	PF00082	0.330
CLV_PCSK_SKI1_1	100	104	PF00082	0.818
CLV_PCSK_SKI1_1	217	221	PF00082	0.530
CLV_PCSK_SKI1_1	396	400	PF00082	0.389
CLV_PCSK_SKI1_1	469	473	PF00082	0.736
CLV_PCSK_SKI1_1	517	521	PF00082	0.699
CLV_PCSK_SKI1_1	742	746	PF00082	0.693
CLV_PCSK_SKI1_1	838	842	PF00082	0.441
CLV_PCSK_SKI1_1	930	934	PF00082	0.397
DEG_APCC_DBOX_1	394	402	PF00400	0.605
DEG_APCC_DBOX_1	816	824	PF00400	0.377
DEG_Nend_UBRbox_3	1	3	PF02207	0.421
DEG_SCF_FBW7_1	839	845	PF00400	0.639
DEG_SCF_FBW7_2	441	448	PF00400	0.514
DEG_SPOP_SBC_1	728	732	PF00917	0.539
DEG_SPOP_SBC_1	760	764	PF00917	0.506
DOC_ANK_TNKS_1	647	654	PF00023	0.463
DOC_CDC14_PxL_1	349	357	PF14671	0.737
DOC_CDC14_PxL_1	518	526	PF14671	0.513
DOC_CKS1_1	442	447	PF01111	0.514
DOC_CKS1_1	839	844	PF01111	0.638
DOC_CKS1_1	880	885	PF01111	0.737
DOC_CKS1_1	987	992	PF01111	0.691
DOC_CYCLIN_yCln2_LP_2	472	478	PF00134	0.620
DOC_CYCLIN_yCln2_LP_2	917	923	PF00134	0.636
DOC_MAPK_gen_1	395	402	PF00069	0.558
DOC_MAPK_HePTP_8	909	921	PF00069	0.616
DOC_MAPK_MEF2A_6	395	402	PF00069	0.546
DOC_MAPK_MEF2A_6	469	476	PF00069	0.541
DOC_MAPK_MEF2A_6	912	921	PF00069	0.597
DOC_MAPK_NFAT4_5	469	477	PF00069	0.559
DOC_PIKK_1	51	59	PF02985	0.473
DOC_PP1_RVXF_1	702	709	PF00149	0.527
DOC_PP1_RVXF_1	927	934	PF00149	0.667
DOC_PP2B_LxvP_1	412	415	PF13499	0.515
DOC_PP2B_LxvP_1	472	475	PF13499	0.620
DOC_PP2B_LxvP_1	917	920	PF13499	0.646
DOC_PP4_FxxP_1	131	134	PF00568	0.569
DOC_USP7_MATH_1	111	115	PF00917	0.579
DOC_USP7_MATH_1	184	188	PF00917	0.514
DOC_USP7_MATH_1	236	240	PF00917	0.496
DOC_USP7_MATH_1	266	270	PF00917	0.745
DOC_USP7_MATH_1	360	364	PF00917	0.671
DOC_USP7_MATH_1	365	369	PF00917	0.645
DOC_USP7_MATH_1	427	431	PF00917	0.474
DOC_USP7_MATH_1	485	489	PF00917	0.603
DOC_USP7_MATH_1	606	610	PF00917	0.595
DOC_USP7_MATH_1	666	670	PF00917	0.562
DOC_USP7_MATH_1	760	764	PF00917	0.626
DOC_USP7_MATH_1	807	811	PF00917	0.528
DOC_USP7_MATH_1	829	833	PF00917	0.308
DOC_USP7_MATH_1	840	844	PF00917	0.734
DOC_USP7_MATH_1	87	91	PF00917	0.591
DOC_USP7_MATH_1	881	885	PF00917	0.718
DOC_USP7_MATH_1	887	891	PF00917	0.692
DOC_USP7_UBL2_3	969	973	PF12436	0.607
DOC_WW_Pin1_4	123	128	PF00397	0.541
DOC_WW_Pin1_4	279	284	PF00397	0.755
DOC_WW_Pin1_4	344	349	PF00397	0.721
DOC_WW_Pin1_4	441	446	PF00397	0.517
DOC_WW_Pin1_4	483	488	PF00397	0.618
DOC_WW_Pin1_4	761	766	PF00397	0.455
DOC_WW_Pin1_4	794	799	PF00397	0.576
DOC_WW_Pin1_4	805	810	PF00397	0.470
DOC_WW_Pin1_4	838	843	PF00397	0.633
DOC_WW_Pin1_4	879	884	PF00397	0.734
DOC_WW_Pin1_4	986	991	PF00397	0.645
LIG_14-3-3_CanoR_1	100	109	PF00244	0.622
LIG_14-3-3_CanoR_1	144	148	PF00244	0.485
LIG_14-3-3_CanoR_1	342	348	PF00244	0.744
LIG_14-3-3_CanoR_1	372	380	PF00244	0.742
LIG_14-3-3_CanoR_1	432	438	PF00244	0.592
LIG_14-3-3_CanoR_1	549	556	PF00244	0.537
LIG_14-3-3_CanoR_1	777	781	PF00244	0.560
LIG_14-3-3_CanoR_1	783	787	PF00244	0.554
LIG_14-3-3_CanoR_1	862	868	PF00244	0.720
LIG_Actin_WH2_2	813	828	PF00022	0.363
LIG_APCC_ABBA_1	520	525	PF00400	0.488
LIG_APCC_ABBAyCdc20_2	578	584	PF00400	0.546
LIG_BIR_III_2	350	354	PF00653	0.734
LIG_BRCT_BRCA1_1	762	766	PF00533	0.622
LIG_eIF4E_1	215	221	PF01652	0.330
LIG_EVH1_2	97	101	PF00568	0.441
LIG_FHA_1	21	27	PF00498	0.386
LIG_FHA_1	214	220	PF00498	0.483
LIG_FHA_1	335	341	PF00498	0.768
LIG_FHA_1	344	350	PF00498	0.671
LIG_FHA_1	444	450	PF00498	0.505
LIG_FHA_1	645	651	PF00498	0.598
LIG_FHA_1	66	72	PF00498	0.391
LIG_FHA_1	723	729	PF00498	0.539
LIG_FHA_1	820	826	PF00498	0.436
LIG_FHA_1	880	886	PF00498	0.732
LIG_FHA_2	155	161	PF00498	0.396
LIG_FHA_2	163	169	PF00498	0.398
LIG_FHA_2	589	595	PF00498	0.468
LIG_FHA_2	609	615	PF00498	0.589
LIG_FHA_2	697	703	PF00498	0.453
LIG_FHA_2	987	993	PF00498	0.702
LIG_GBD_Chelix_1	975	983	PF00786	0.386
LIG_Integrin_isoDGR_2	547	549	PF01839	0.771
LIG_Integrin_RGD_1	62	64	PF01839	0.640
LIG_IRF3_LxIS_1	174	181	PF10401	0.411
LIG_LIR_Apic_2	169	175	PF02991	0.437
LIG_LIR_Apic_2	214	218	PF02991	0.413
LIG_LIR_Apic_2	910	916	PF02991	0.614
LIG_LIR_Gen_1	151	159	PF02991	0.403
LIG_LIR_Gen_1	239	249	PF02991	0.541
LIG_LIR_Gen_1	424	434	PF02991	0.372
LIG_LIR_Gen_1	638	645	PF02991	0.480
LIG_LIR_Gen_1	665	675	PF02991	0.590
LIG_LIR_Gen_1	810	820	PF02991	0.348
LIG_LIR_Nem_3	151	155	PF02991	0.409
LIG_LIR_Nem_3	239	244	PF02991	0.521
LIG_LIR_Nem_3	38	42	PF02991	0.377
LIG_LIR_Nem_3	424	429	PF02991	0.349
LIG_LIR_Nem_3	638	643	PF02991	0.618
LIG_LIR_Nem_3	665	670	PF02991	0.604
LIG_LIR_Nem_3	810	816	PF02991	0.437
LIG_LIR_Nem_3	873	879	PF02991	0.755
LIG_LIR_Nem_3	936	941	PF02991	0.601
LIG_NRBOX	154	160	PF00104	0.468
LIG_PDZ_Class_2	988	993	PF00595	0.692
LIG_Pex14_2	143	147	PF04695	0.496
LIG_Pex14_2	16	20	PF04695	0.379
LIG_REV1ctd_RIR_1	456	462	PF16727	0.539
LIG_REV1ctd_RIR_1	963	974	PF16727	0.601
LIG_SH2_CRK	172	176	PF00017	0.470
LIG_SH2_CRK	215	219	PF00017	0.479
LIG_SH2_CRK	39	43	PF00017	0.370
LIG_SH2_CRK	667	671	PF00017	0.619
LIG_SH2_CRK	746	750	PF00017	0.455
LIG_SH2_CRK	876	880	PF00017	0.764
LIG_SH2_NCK_1	667	671	PF00017	0.564
LIG_SH2_STAP1	231	235	PF00017	0.411
LIG_SH2_STAT3	437	440	PF00017	0.504
LIG_SH2_STAT3	941	944	PF00017	0.587
LIG_SH2_STAT5	172	175	PF00017	0.498
LIG_SH2_STAT5	215	218	PF00017	0.415
LIG_SH2_STAT5	252	255	PF00017	0.661
LIG_SH2_STAT5	502	505	PF00017	0.537
LIG_SH2_STAT5	523	526	PF00017	0.500
LIG_SH2_STAT5	667	670	PF00017	0.538
LIG_SH2_STAT5	815	818	PF00017	0.411
LIG_SH2_STAT5	913	916	PF00017	0.598
LIG_SH2_STAT5	941	944	PF00017	0.603
LIG_SH3_1	795	801	PF00018	0.539
LIG_SH3_1	877	883	PF00018	0.728
LIG_SH3_3	105	111	PF00018	0.465
LIG_SH3_3	173	179	PF00018	0.584
LIG_SH3_3	41	47	PF00018	0.446
LIG_SH3_3	439	445	PF00018	0.516
LIG_SH3_3	505	511	PF00018	0.528
LIG_SH3_3	746	752	PF00018	0.475
LIG_SH3_3	795	801	PF00018	0.550
LIG_SH3_3	836	842	PF00018	0.617
LIG_SH3_3	877	883	PF00018	0.728
LIG_SH3_3	984	990	PF00018	0.653
LIG_SUMO_SIM_anti_2	154	160	PF11976	0.465
LIG_SUMO_SIM_anti_2	337	342	PF11976	0.789
LIG_SUMO_SIM_par_1	154	160	PF11976	0.465
LIG_SUMO_SIM_par_1	242	248	PF11976	0.561
LIG_SUMO_SIM_par_1	462	467	PF11976	0.495
LIG_SUMO_SIM_par_1	680	687	PF11976	0.549
LIG_SUMO_SIM_par_1	826	832	PF11976	0.436
LIG_TYR_ITIM	229	234	PF00017	0.411
LIG_TYR_ITIM	744	749	PF00017	0.458
LIG_UBA3_1	518	526	PF00899	0.568
LIG_UBA3_1	921	929	PF00899	0.565
LIG_WW_1	212	215	PF00397	0.474
MOD_CDC14_SPxK_1	797	800	PF00782	0.539
MOD_CDK_SPxK_1	794	800	PF00069	0.538
MOD_CK1_1	10	16	PF00069	0.379
MOD_CK1_1	114	120	PF00069	0.568
MOD_CK1_1	199	205	PF00069	0.584
MOD_CK1_1	239	245	PF00069	0.505
MOD_CK1_1	363	369	PF00069	0.789
MOD_CK1_1	373	379	PF00069	0.661
MOD_CK1_1	486	492	PF00069	0.596
MOD_CK1_1	535	541	PF00069	0.555
MOD_CK1_1	570	576	PF00069	0.586
MOD_CK1_1	586	592	PF00069	0.512
MOD_CK1_1	609	615	PF00069	0.587
MOD_CK1_1	729	735	PF00069	0.562
MOD_CK1_1	755	761	PF00069	0.538
MOD_CK1_1	775	781	PF00069	0.634
MOD_CK1_1	793	799	PF00069	0.471
MOD_CK1_1	861	867	PF00069	0.737
MOD_CK2_1	154	160	PF00069	0.395
MOD_CK2_1	162	168	PF00069	0.389
MOD_CK2_1	301	307	PF00069	0.811
MOD_CK2_1	657	663	PF00069	0.626
MOD_CK2_1	688	694	PF00069	0.561
MOD_CK2_1	986	992	PF00069	0.687
MOD_GlcNHglycan	103	106	PF01048	0.720
MOD_GlcNHglycan	118	121	PF01048	0.722
MOD_GlcNHglycan	180	183	PF01048	0.686
MOD_GlcNHglycan	186	189	PF01048	0.715
MOD_GlcNHglycan	190	193	PF01048	0.744
MOD_GlcNHglycan	268	271	PF01048	0.595
MOD_GlcNHglycan	301	304	PF01048	0.602
MOD_GlcNHglycan	362	365	PF01048	0.561
MOD_GlcNHglycan	367	370	PF01048	0.526
MOD_GlcNHglycan	429	432	PF01048	0.657
MOD_GlcNHglycan	489	492	PF01048	0.813
MOD_GlcNHglycan	5	8	PF01048	0.598
MOD_GlcNHglycan	534	537	PF01048	0.763
MOD_GlcNHglycan	572	575	PF01048	0.783
MOD_GlcNHglycan	608	611	PF01048	0.799
MOD_GlcNHglycan	655	658	PF01048	0.751
MOD_GlcNHglycan	660	663	PF01048	0.757
MOD_GlcNHglycan	854	857	PF01048	0.577
MOD_GlcNHglycan	93	96	PF01048	0.681
MOD_GSK3_1	109	116	PF00069	0.528
MOD_GSK3_1	119	126	PF00069	0.459
MOD_GSK3_1	162	169	PF00069	0.395
MOD_GSK3_1	184	191	PF00069	0.555
MOD_GSK3_1	195	202	PF00069	0.586
MOD_GSK3_1	3	10	PF00069	0.401
MOD_GSK3_1	307	314	PF00069	0.718
MOD_GSK3_1	360	367	PF00069	0.809
MOD_GSK3_1	483	490	PF00069	0.579
MOD_GSK3_1	563	570	PF00069	0.633
MOD_GSK3_1	582	589	PF00069	0.424
MOD_GSK3_1	653	660	PF00069	0.542
MOD_GSK3_1	684	691	PF00069	0.555
MOD_GSK3_1	692	699	PF00069	0.557
MOD_GSK3_1	700	707	PF00069	0.539
MOD_GSK3_1	722	729	PF00069	0.559
MOD_GSK3_1	755	762	PF00069	0.519
MOD_GSK3_1	772	779	PF00069	0.458
MOD_GSK3_1	781	788	PF00069	0.545
MOD_GSK3_1	790	797	PF00069	0.512
MOD_GSK3_1	805	812	PF00069	0.452
MOD_GSK3_1	838	845	PF00069	0.768
MOD_GSK3_1	854	861	PF00069	0.655
MOD_GSK3_1	862	869	PF00069	0.747
MOD_GSK3_1	87	94	PF00069	0.549
MOD_N-GLC_1	299	304	PF02516	0.577
MOD_N-GLC_1	450	455	PF02516	0.689
MOD_N-GLC_1	7	12	PF02516	0.601
MOD_N-GLC_1	755	760	PF02516	0.638
MOD_N-GLC_1	793	798	PF02516	0.764
MOD_N-GLC_2	171	173	PF02516	0.675
MOD_NEK2_1	101	106	PF00069	0.546
MOD_NEK2_1	143	148	PF00069	0.553
MOD_NEK2_1	301	306	PF00069	0.797
MOD_NEK2_1	450	455	PF00069	0.489
MOD_NEK2_1	532	537	PF00069	0.547
MOD_NEK2_1	684	689	PF00069	0.553
MOD_NEK2_1	692	697	PF00069	0.559
MOD_NEK2_1	726	731	PF00069	0.569
MOD_NEK2_1	790	795	PF00069	0.541
MOD_NEK2_1	854	859	PF00069	0.721
MOD_NEK2_2	871	876	PF00069	0.707
MOD_PIKK_1	196	202	PF00454	0.459
MOD_PIKK_1	373	379	PF00454	0.774
MOD_PIKK_1	907	913	PF00454	0.746
MOD_PKA_1	568	574	PF00069	0.577
MOD_PKA_2	143	149	PF00069	0.486
MOD_PKA_2	188	194	PF00069	0.601
MOD_PKA_2	236	242	PF00069	0.584
MOD_PKA_2	532	538	PF00069	0.587
MOD_PKA_2	567	573	PF00069	0.555
MOD_PKA_2	696	702	PF00069	0.562
MOD_PKA_2	776	782	PF00069	0.563
MOD_PKA_2	790	796	PF00069	0.531
MOD_PKA_2	861	867	PF00069	0.724
MOD_Plk_1	450	456	PF00069	0.490
MOD_Plk_1	704	710	PF00069	0.555
MOD_Plk_1	755	761	PF00069	0.439
MOD_Plk_1	775	781	PF00069	0.546
MOD_Plk_1	887	893	PF00069	0.808
MOD_Plk_2-3	154	160	PF00069	0.395
MOD_Plk_4	10	16	PF00069	0.459
MOD_Plk_4	154	160	PF00069	0.395
MOD_Plk_4	236	242	PF00069	0.491
MOD_Plk_4	336	342	PF00069	0.761
MOD_Plk_4	688	694	PF00069	0.612
MOD_Plk_4	782	788	PF00069	0.540
MOD_Plk_4	809	815	PF00069	0.481
MOD_Plk_4	819	825	PF00069	0.318
MOD_Plk_4	829	835	PF00069	0.183
MOD_Plk_4	871	877	PF00069	0.708
MOD_Plk_4	88	94	PF00069	0.506
MOD_Plk_4	937	943	PF00069	0.668
MOD_ProDKin_1	123	129	PF00069	0.542
MOD_ProDKin_1	279	285	PF00069	0.748
MOD_ProDKin_1	344	350	PF00069	0.723
MOD_ProDKin_1	441	447	PF00069	0.516
MOD_ProDKin_1	483	489	PF00069	0.617
MOD_ProDKin_1	761	767	PF00069	0.456
MOD_ProDKin_1	794	800	PF00069	0.578
MOD_ProDKin_1	805	811	PF00069	0.463
MOD_ProDKin_1	838	844	PF00069	0.636
MOD_ProDKin_1	879	885	PF00069	0.736
MOD_ProDKin_1	986	992	PF00069	0.654
MOD_SUMO_rev_2	608	618	PF00179	0.574
TRG_ENDOCYTIC_2	231	234	PF00928	0.357
TRG_ENDOCYTIC_2	39	42	PF00928	0.370
TRG_ENDOCYTIC_2	403	406	PF00928	0.411
TRG_ENDOCYTIC_2	667	670	PF00928	0.618
TRG_ENDOCYTIC_2	746	749	PF00928	0.472
TRG_ENDOCYTIC_2	815	818	PF00928	0.513
TRG_ENDOCYTIC_2	876	879	PF00928	0.761
TRG_ER_diArg_1	380	383	PF00400	0.734
TRG_ER_diArg_1	395	398	PF00400	0.632
TRG_ER_diArg_1	59	62	PF00400	0.534
TRG_ER_diArg_1	74	76	PF00400	0.395
TRG_ER_diArg_1	742	744	PF00400	0.585
TRG_ER_diArg_1	876	878	PF00400	0.714
TRG_ER_diArg_1	947	949	PF00400	0.541
TRG_NLS_Bipartite_1	381	399	PF00514	0.654
TRG_Pf-PMV_PEXEL_1	372	377	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.731
TRG_Pf-PMV_PEXEL_1	648	652	PF00026	0.747
TRG_Pf-PMV_PEXEL_1	742	747	PF00026	0.763

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8A1	Leptomonas seymouri	46%	92%
A0A3Q8IPH9	Leishmania donovani	89%	100%
A4HPY7	Leishmania braziliensis	68%	97%
A4IDP8	Leishmania infantum	89%	100%
E9ATQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%