PIG-P domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PIG-P, putative

Species:

Leishmania major

UniProt:

Q4Q0T8_LEIMA

TriTrypDb:

LmjF.36.4750 , LMJLV39_360059100 , LMJSD75_360058900

Length:

159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q0T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0T8

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	9
GO:0006505	GPI anchor metabolic process	6	9
GO:0006506	GPI anchor biosynthetic process	6	9
GO:0006629	lipid metabolic process	3	9
GO:0006643	membrane lipid metabolic process	4	9
GO:0006644	phospholipid metabolic process	4	9
GO:0006650	glycerophospholipid metabolic process	5	9
GO:0006661	phosphatidylinositol biosynthetic process	6	9
GO:0006664	glycolipid metabolic process	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0008610	lipid biosynthetic process	4	9
GO:0008654	phospholipid biosynthetic process	5	9
GO:0009058	biosynthetic process	2	9
GO:0009247	glycolipid biosynthetic process	5	9
GO:0009987	cellular process	1	9
GO:0019538	protein metabolic process	3	9
GO:0019637	organophosphate metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	9
GO:0044255	cellular lipid metabolic process	3	9
GO:0045017	glycerolipid biosynthetic process	4	9
GO:0046467	membrane lipid biosynthetic process	4	9
GO:0046474	glycerophospholipid biosynthetic process	5	9
GO:0046486	glycerolipid metabolic process	4	9
GO:0046488	phosphatidylinositol metabolic process	6	9
GO:0071704	organic substance metabolic process	2	9
GO:0090407	organophosphate biosynthetic process	4	9
GO:1901135	carbohydrate derivative metabolic process	3	9
GO:1901137	carbohydrate derivative biosynthetic process	4	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:1901576	organic substance biosynthetic process	3	9
GO:1903509	liposaccharide metabolic process	4	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008194	UDP-glycosyltransferase activity	4	9
GO:0008375	acetylglucosaminyltransferase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016757	glycosyltransferase activity	3	9
GO:0016758	hexosyltransferase activity	4	9
GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	6	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.419
CLV_PCSK_SKI1_1	110	114	PF00082	0.294
CLV_PCSK_SKI1_1	4	8	PF00082	0.281
DEG_MDM2_SWIB_1	92	100	PF02201	0.376
DEG_SPOP_SBC_1	129	133	PF00917	0.423
DOC_PP2B_PxIxI_1	80	86	PF00149	0.286
DOC_USP7_MATH_1	129	133	PF00917	0.427
LIG_14-3-3_CanoR_1	110	119	PF00244	0.483
LIG_14-3-3_CanoR_1	65	71	PF00244	0.254
LIG_FHA_1	101	107	PF00498	0.403
LIG_FHA_1	49	55	PF00498	0.364
LIG_FHA_1	92	98	PF00498	0.259
LIG_FHA_2	111	117	PF00498	0.458
LIG_GBD_Chelix_1	46	54	PF00786	0.382
LIG_LIR_Gen_1	9	17	PF02991	0.465
LIG_LIR_Gen_1	93	101	PF02991	0.306
LIG_LIR_Nem_3	73	78	PF02991	0.228
LIG_LIR_Nem_3	9	13	PF02991	0.467
LIG_LIR_Nem_3	93	99	PF02991	0.348
LIG_NRBOX	12	18	PF00104	0.459
LIG_NRP_CendR_1	157	159	PF00754	0.379
LIG_Pex14_2	92	96	PF04695	0.331
LIG_SH2_STAT5	52	55	PF00017	0.261
LIG_SH2_STAT5	91	94	PF00017	0.258
LIG_SH3_3	136	142	PF00018	0.503
LIG_SH3_3	75	81	PF00018	0.239
LIG_SUMO_SIM_anti_2	42	49	PF11976	0.376
LIG_SUMO_SIM_anti_2	93	103	PF11976	0.289
LIG_SUMO_SIM_par_1	140	147	PF11976	0.439
LIG_SUMO_SIM_par_1	42	49	PF11976	0.315
LIG_SUMO_SIM_par_1	93	103	PF11976	0.376
LIG_WRC_WIRS_1	7	12	PF05994	0.481
MOD_CK1_1	131	137	PF00069	0.459
MOD_CK1_1	144	150	PF00069	0.348
MOD_GSK3_1	100	107	PF00069	0.414
MOD_GSK3_1	110	117	PF00069	0.420
MOD_NEK2_1	100	105	PF00069	0.427
MOD_NEK2_1	128	133	PF00069	0.525
MOD_NEK2_1	26	31	PF00069	0.636
MOD_NEK2_1	39	44	PF00069	0.315
MOD_NEK2_1	66	71	PF00069	0.301
MOD_NEK2_1	92	97	PF00069	0.275
MOD_PIKK_1	26	32	PF00454	0.576
MOD_Plk_4	39	45	PF00069	0.282
MOD_Plk_4	66	72	PF00069	0.239
MOD_Plk_4	92	98	PF00069	0.267
MOD_SUMO_rev_2	114	119	PF00179	0.464
TRG_ENDOCYTIC_2	75	78	PF00928	0.258
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P0	Leptomonas seymouri	85%	100%
A0A0S4JL03	Bodo saltans	45%	100%
A0A1X0P0P7	Trypanosomatidae	51%	100%
A0A3Q8ILG4	Leishmania donovani	97%	100%
A0A3R7KSY5	Trypanosoma rangeli	50%	100%
A4HPZ2	Leishmania braziliensis	86%	76%
A4IDQ3	Leishmania infantum	97%	100%
D0A4E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ATQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O64792	Arabidopsis thaliana	28%	100%
P57054	Homo sapiens	28%	100%
Q5R946	Pongo abelii	28%	100%
Q9JHG1	Mus musculus	29%	100%