Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0T7_LEIMA

TriTrypDb:

LmjF.36.4760 , LMJLV39_360059200 , LMJSD75_360059000

Length:

649

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0T7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.496
CLV_C14_Caspase3-7	149	153	PF00656	0.767
CLV_C14_Caspase3-7	80	84	PF00656	0.550
CLV_NRD_NRD_1	207	209	PF00675	0.764
CLV_NRD_NRD_1	281	283	PF00675	0.412
CLV_NRD_NRD_1	292	294	PF00675	0.386
CLV_NRD_NRD_1	601	603	PF00675	0.416
CLV_NRD_NRD_1	634	636	PF00675	0.624
CLV_PCSK_FUR_1	635	639	PF00082	0.692
CLV_PCSK_KEX2_1	207	209	PF00082	0.694
CLV_PCSK_KEX2_1	281	283	PF00082	0.411
CLV_PCSK_KEX2_1	291	293	PF00082	0.401
CLV_PCSK_KEX2_1	575	577	PF00082	0.515
CLV_PCSK_KEX2_1	601	603	PF00082	0.529
CLV_PCSK_KEX2_1	637	639	PF00082	0.679
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.448
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.454
CLV_PCSK_PC1ET2_1	637	639	PF00082	0.738
CLV_PCSK_SKI1_1	113	117	PF00082	0.576
CLV_PCSK_SKI1_1	208	212	PF00082	0.585
CLV_PCSK_SKI1_1	372	376	PF00082	0.377
CLV_PCSK_SKI1_1	407	411	PF00082	0.400
CLV_PCSK_SKI1_1	601	605	PF00082	0.518
CLV_PCSK_SKI1_1	612	616	PF00082	0.435
CLV_Separin_Metazoa	562	566	PF03568	0.512
CLV_Separin_Metazoa	92	96	PF03568	0.367
DEG_APCC_DBOX_1	291	299	PF00400	0.484
DEG_APCC_DBOX_1	307	315	PF00400	0.549
DEG_APCC_DBOX_1	371	379	PF00400	0.475
DEG_APCC_DBOX_1	385	393	PF00400	0.505
DEG_APCC_DBOX_1	600	608	PF00400	0.419
DEG_APCC_DBOX_1	611	619	PF00400	0.425
DEG_APCC_DBOX_1	64	72	PF00400	0.576
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DOC_CDC14_PxL_1	586	594	PF14671	0.434
DOC_CYCLIN_RxL_1	110	117	PF00134	0.624
DOC_CYCLIN_RxL_1	369	377	PF00134	0.470
DOC_MAPK_gen_1	291	300	PF00069	0.502
DOC_MAPK_gen_1	601	609	PF00069	0.396
DOC_MAPK_MEF2A_6	386	393	PF00069	0.479
DOC_MAPK_MEF2A_6	601	609	PF00069	0.492
DOC_PP1_RVXF_1	481	488	PF00149	0.482
DOC_PP2B_LxvP_1	17	20	PF13499	0.420
DOC_USP7_MATH_1	129	133	PF00917	0.706
DOC_USP7_MATH_1	185	189	PF00917	0.673
DOC_USP7_MATH_1	216	220	PF00917	0.706
DOC_USP7_MATH_1	230	234	PF00917	0.331
DOC_USP7_MATH_1	31	35	PF00917	0.388
DOC_USP7_MATH_1	402	406	PF00917	0.526
DOC_USP7_MATH_1	415	419	PF00917	0.358
DOC_USP7_MATH_1	503	507	PF00917	0.496
DOC_USP7_MATH_1	86	90	PF00917	0.557
DOC_USP7_UBL2_3	263	267	PF12436	0.510
DOC_WW_Pin1_4	106	111	PF00397	0.498
DOC_WW_Pin1_4	144	149	PF00397	0.758
DOC_WW_Pin1_4	202	207	PF00397	0.760
DOC_WW_Pin1_4	251	256	PF00397	0.524
LIG_14-3-3_CanoR_1	122	127	PF00244	0.672
LIG_14-3-3_CanoR_1	186	192	PF00244	0.724
LIG_14-3-3_CanoR_1	207	216	PF00244	0.784
LIG_14-3-3_CanoR_1	349	355	PF00244	0.412
LIG_14-3-3_CanoR_1	386	390	PF00244	0.538
LIG_14-3-3_CanoR_1	399	409	PF00244	0.476
LIG_14-3-3_CanoR_1	41	49	PF00244	0.652
LIG_14-3-3_CanoR_1	434	442	PF00244	0.512
LIG_14-3-3_CanoR_1	514	519	PF00244	0.443
LIG_Actin_WH2_2	64	81	PF00022	0.538
LIG_APCC_ABBA_1	533	538	PF00400	0.462
LIG_CtBP_PxDLS_1	458	462	PF00389	0.545
LIG_deltaCOP1_diTrp_1	395	400	PF00928	0.507
LIG_eIF4E_1	273	279	PF01652	0.428
LIG_eIF4E_1	370	376	PF01652	0.363
LIG_eIF4E_1	72	78	PF01652	0.462
LIG_FHA_1	234	240	PF00498	0.543
LIG_FHA_1	256	262	PF00498	0.501
LIG_FHA_1	386	392	PF00498	0.503
LIG_FHA_1	500	506	PF00498	0.544
LIG_FHA_1	518	524	PF00498	0.356
LIG_FHA_1	89	95	PF00498	0.564
LIG_FHA_2	156	162	PF00498	0.541
LIG_FHA_2	242	248	PF00498	0.595
LIG_FHA_2	269	275	PF00498	0.534
LIG_FHA_2	324	330	PF00498	0.503
LIG_FHA_2	401	407	PF00498	0.517
LIG_FHA_2	43	49	PF00498	0.628
LIG_LIR_Apic_2	7	12	PF02991	0.574
LIG_LIR_Gen_1	556	564	PF02991	0.483
LIG_LIR_Gen_1	99	108	PF02991	0.492
LIG_LIR_Nem_3	161	166	PF02991	0.548
LIG_LIR_Nem_3	176	181	PF02991	0.599
LIG_LIR_Nem_3	537	543	PF02991	0.372
LIG_LIR_Nem_3	556	560	PF02991	0.409
LIG_LIR_Nem_3	99	104	PF02991	0.560
LIG_NRBOX	51	57	PF00104	0.638
LIG_NRBOX	73	79	PF00104	0.566
LIG_OCRL_FandH_1	298	310	PF00620	0.537
LIG_PCNA_yPIPBox_3	348	361	PF02747	0.312
LIG_PCNA_yPIPBox_3	386	397	PF02747	0.505
LIG_PDZ_Class_3	644	649	PF00595	0.654
LIG_PTB_Apo_2	580	587	PF02174	0.290
LIG_RPA_C_Fungi	375	387	PF08784	0.406
LIG_SH2_CRK	101	105	PF00017	0.572
LIG_SH2_CRK	178	182	PF00017	0.643
LIG_SH2_CRK	381	385	PF00017	0.435
LIG_SH2_CRK	9	13	PF00017	0.557
LIG_SH2_GRB2like	270	273	PF00017	0.540
LIG_SH2_PTP2	2	5	PF00017	0.443
LIG_SH2_SRC	273	276	PF00017	0.487
LIG_SH2_STAP1	273	277	PF00017	0.488
LIG_SH2_STAP1	509	513	PF00017	0.512
LIG_SH2_STAP1	536	540	PF00017	0.473
LIG_SH2_STAT5	162	165	PF00017	0.582
LIG_SH2_STAT5	2	5	PF00017	0.585
LIG_SH2_STAT5	270	273	PF00017	0.479
LIG_SH2_STAT5	536	539	PF00017	0.456
LIG_SH3_1	360	366	PF00018	0.558
LIG_SH3_1	9	15	PF00018	0.456
LIG_SH3_3	360	366	PF00018	0.558
LIG_SH3_3	9	15	PF00018	0.456
LIG_SUMO_SIM_anti_2	309	316	PF11976	0.555
LIG_TRAF2_1	559	562	PF00917	0.550
LIG_TRAF2_1	593	596	PF00917	0.344
LIG_UBA3_1	166	171	PF00899	0.577
LIG_UBA3_1	261	267	PF00899	0.503
LIG_UBA3_1	298	304	PF00899	0.478
LIG_WRC_WIRS_1	554	559	PF05994	0.436
MOD_CDC14_SPxK_1	205	208	PF00782	0.726
MOD_CDK_SPK_2	202	207	PF00069	0.570
MOD_CDK_SPxK_1	202	208	PF00069	0.762
MOD_CDK_SPxxK_3	106	113	PF00069	0.511
MOD_CK1_1	125	131	PF00069	0.665
MOD_CK1_1	147	153	PF00069	0.731
MOD_CK1_1	219	225	PF00069	0.736
MOD_CK1_1	233	239	PF00069	0.614
MOD_CK1_1	344	350	PF00069	0.512
MOD_CK1_1	418	424	PF00069	0.513
MOD_CK1_1	517	523	PF00069	0.546
MOD_CK1_1	88	94	PF00069	0.593
MOD_CK1_1	96	102	PF00069	0.459
MOD_CK2_1	155	161	PF00069	0.565
MOD_CK2_1	162	168	PF00069	0.426
MOD_CK2_1	231	237	PF00069	0.619
MOD_CK2_1	241	247	PF00069	0.544
MOD_CK2_1	251	257	PF00069	0.348
MOD_CK2_1	268	274	PF00069	0.448
MOD_CK2_1	400	406	PF00069	0.509
MOD_CK2_1	42	48	PF00069	0.631
MOD_CK2_1	590	596	PF00069	0.334
MOD_CK2_1	86	92	PF00069	0.638
MOD_GlcNHglycan	131	134	PF01048	0.765
MOD_GlcNHglycan	152	155	PF01048	0.646
MOD_GlcNHglycan	220	225	PF01048	0.709
MOD_GlcNHglycan	285	289	PF01048	0.558
MOD_GlcNHglycan	29	32	PF01048	0.350
MOD_GlcNHglycan	344	347	PF01048	0.437
MOD_GlcNHglycan	366	369	PF01048	0.503
MOD_GlcNHglycan	420	423	PF01048	0.535
MOD_GlcNHglycan	9	12	PF01048	0.436
MOD_GSK3_1	125	132	PF00069	0.682
MOD_GSK3_1	142	149	PF00069	0.667
MOD_GSK3_1	216	223	PF00069	0.764
MOD_GSK3_1	251	258	PF00069	0.547
MOD_GSK3_1	27	34	PF00069	0.570
MOD_GSK3_1	319	326	PF00069	0.564
MOD_GSK3_1	340	347	PF00069	0.544
MOD_GSK3_1	499	506	PF00069	0.521
MOD_GSK3_1	509	516	PF00069	0.519
MOD_GSK3_1	522	529	PF00069	0.467
MOD_N-GLC_1	106	111	PF02516	0.564
MOD_N-GLC_1	268	273	PF02516	0.536
MOD_N-GLC_1	341	346	PF02516	0.559
MOD_NEK2_1	111	116	PF00069	0.472
MOD_NEK2_1	231	236	PF00069	0.569
MOD_NEK2_1	26	31	PF00069	0.551
MOD_NEK2_1	261	266	PF00069	0.461
MOD_NEK2_1	268	273	PF00069	0.517
MOD_NEK2_1	35	40	PF00069	0.589
MOD_NEK2_1	350	355	PF00069	0.298
MOD_NEK2_1	374	379	PF00069	0.473
MOD_NEK2_1	42	47	PF00069	0.601
MOD_NEK2_1	459	464	PF00069	0.532
MOD_NEK2_1	491	496	PF00069	0.416
MOD_NEK2_1	571	576	PF00069	0.511
MOD_NEK2_1	85	90	PF00069	0.624
MOD_NEK2_1	93	98	PF00069	0.507
MOD_NEK2_2	255	260	PF00069	0.538
MOD_NEK2_2	31	36	PF00069	0.515
MOD_NEK2_2	478	483	PF00069	0.513
MOD_NEK2_2	509	514	PF00069	0.545
MOD_PIKK_1	120	126	PF00454	0.701
MOD_PIKK_1	344	350	PF00454	0.515
MOD_PK_1	122	128	PF00069	0.640
MOD_PKA_2	185	191	PF00069	0.708
MOD_PKA_2	307	313	PF00069	0.530
MOD_PKA_2	35	41	PF00069	0.574
MOD_PKA_2	385	391	PF00069	0.425
MOD_PKA_2	433	439	PF00069	0.506
MOD_PKA_2	513	519	PF00069	0.326
MOD_Plk_1	194	200	PF00069	0.769
MOD_Plk_1	47	53	PF00069	0.605
MOD_Plk_2-3	519	525	PF00069	0.505
MOD_Plk_4	111	117	PF00069	0.537
MOD_Plk_4	162	168	PF00069	0.353
MOD_Plk_4	307	313	PF00069	0.430
MOD_Plk_4	350	356	PF00069	0.391
MOD_Plk_4	452	458	PF00069	0.464
MOD_Plk_4	465	471	PF00069	0.420
MOD_Plk_4	522	528	PF00069	0.461
MOD_ProDKin_1	106	112	PF00069	0.493
MOD_ProDKin_1	144	150	PF00069	0.757
MOD_ProDKin_1	202	208	PF00069	0.762
MOD_ProDKin_1	251	257	PF00069	0.519
MOD_SUMO_for_1	423	426	PF00179	0.486
TRG_DiLeu_BaEn_1	257	262	PF01217	0.397
TRG_DiLeu_BaEn_1	274	279	PF01217	0.403
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.441
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.510
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.638
TRG_ENDOCYTIC_2	101	104	PF00928	0.457
TRG_ENDOCYTIC_2	178	181	PF00928	0.647
TRG_ENDOCYTIC_2	2	5	PF00928	0.543
TRG_ENDOCYTIC_2	381	384	PF00928	0.429
TRG_ENDOCYTIC_2	642	645	PF00928	0.653
TRG_ER_diArg_1	206	208	PF00400	0.572
TRG_NES_CRM1_1	521	534	PF08389	0.484
TRG_NES_CRM1_1	67	80	PF08389	0.577
TRG_NLS_Bipartite_1	623	640	PF00514	0.634
TRG_NLS_MonoCore_2	634	639	PF00514	0.691
TRG_NLS_MonoExtN_4	635	640	PF00514	0.696
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILX5	Leptomonas seymouri	54%	100%
A0A1X0P0I1	Trypanosomatidae	34%	100%
A0A3Q8IKW8	Leishmania donovani	93%	100%
A0A3R7LEP3	Trypanosoma rangeli	34%	100%
A4HPZ3	Leishmania braziliensis	77%	100%
A4IDQ4	Leishmania infantum	93%	100%
D0A4E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ATR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5B501	Trypanosoma cruzi	33%	100%