Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0T4_LEIMA

TriTrypDb:

LmjF.36.4790 , LMJLV39_360059600 , LMJSD75_360059300

Length:

927

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q0T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0T4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	565	569	PF00656	0.739
CLV_C14_Caspase3-7	897	901	PF00656	0.671
CLV_C14_Caspase3-7	93	97	PF00656	0.665
CLV_NRD_NRD_1	141	143	PF00675	0.586
CLV_NRD_NRD_1	149	151	PF00675	0.555
CLV_NRD_NRD_1	199	201	PF00675	0.517
CLV_NRD_NRD_1	320	322	PF00675	0.578
CLV_NRD_NRD_1	394	396	PF00675	0.612
CLV_NRD_NRD_1	452	454	PF00675	0.614
CLV_NRD_NRD_1	526	528	PF00675	0.736
CLV_NRD_NRD_1	531	533	PF00675	0.742
CLV_NRD_NRD_1	549	551	PF00675	0.555
CLV_NRD_NRD_1	581	583	PF00675	0.674
CLV_NRD_NRD_1	615	617	PF00675	0.668
CLV_NRD_NRD_1	673	675	PF00675	0.560
CLV_NRD_NRD_1	715	717	PF00675	0.756
CLV_NRD_NRD_1	755	757	PF00675	0.737
CLV_NRD_NRD_1	887	889	PF00675	0.739
CLV_NRD_NRD_1	908	910	PF00675	0.697
CLV_PCSK_FUR_1	547	551	PF00082	0.742
CLV_PCSK_FUR_1	885	889	PF00082	0.716
CLV_PCSK_KEX2_1	140	142	PF00082	0.586
CLV_PCSK_KEX2_1	148	150	PF00082	0.534
CLV_PCSK_KEX2_1	201	203	PF00082	0.422
CLV_PCSK_KEX2_1	320	322	PF00082	0.576
CLV_PCSK_KEX2_1	394	396	PF00082	0.565
CLV_PCSK_KEX2_1	403	405	PF00082	0.567
CLV_PCSK_KEX2_1	451	453	PF00082	0.603
CLV_PCSK_KEX2_1	488	490	PF00082	0.581
CLV_PCSK_KEX2_1	526	528	PF00082	0.828
CLV_PCSK_KEX2_1	547	549	PF00082	0.739
CLV_PCSK_KEX2_1	615	617	PF00082	0.705
CLV_PCSK_KEX2_1	715	717	PF00082	0.756
CLV_PCSK_KEX2_1	755	757	PF00082	0.708
CLV_PCSK_KEX2_1	884	886	PF00082	0.747
CLV_PCSK_KEX2_1	887	889	PF00082	0.731
CLV_PCSK_KEX2_1	908	910	PF00082	0.592
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.416
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.644
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.581
CLV_PCSK_PC1ET2_1	884	886	PF00082	0.759
CLV_PCSK_PC7_1	144	150	PF00082	0.602
CLV_PCSK_SKI1_1	124	128	PF00082	0.634
CLV_PCSK_SKI1_1	157	161	PF00082	0.601
CLV_PCSK_SKI1_1	202	206	PF00082	0.447
CLV_PCSK_SKI1_1	395	399	PF00082	0.581
CLV_PCSK_SKI1_1	423	427	PF00082	0.592
CLV_PCSK_SKI1_1	453	457	PF00082	0.622
CLV_PCSK_SKI1_1	473	477	PF00082	0.644
CLV_PCSK_SKI1_1	488	492	PF00082	0.521
CLV_PCSK_SKI1_1	50	54	PF00082	0.506
CLV_PCSK_SKI1_1	587	591	PF00082	0.624
CLV_Separin_Metazoa	680	684	PF03568	0.675
DEG_APCC_DBOX_1	825	833	PF00400	0.753
DEG_Nend_Nbox_1	1	3	PF02207	0.711
DEG_SPOP_SBC_1	33	37	PF00917	0.625
DOC_CYCLIN_RxL_1	582	595	PF00134	0.635
DOC_CYCLIN_yCln2_LP_2	510	516	PF00134	0.723
DOC_MAPK_gen_1	884	894	PF00069	0.738
DOC_MAPK_HePTP_8	299	311	PF00069	0.652
DOC_MAPK_MEF2A_6	302	311	PF00069	0.660
DOC_PP1_RVXF_1	888	895	PF00149	0.746
DOC_PP2B_LxvP_1	510	513	PF13499	0.725
DOC_PP4_FxxP_1	767	770	PF00568	0.734
DOC_PP4_FxxP_1	914	917	PF00568	0.687
DOC_USP7_MATH_1	109	113	PF00917	0.796
DOC_USP7_MATH_1	212	216	PF00917	0.613
DOC_USP7_MATH_1	223	227	PF00917	0.680
DOC_USP7_MATH_1	250	254	PF00917	0.566
DOC_USP7_MATH_1	33	37	PF00917	0.696
DOC_USP7_MATH_1	455	459	PF00917	0.699
DOC_USP7_MATH_1	723	727	PF00917	0.682
DOC_USP7_MATH_1	758	762	PF00917	0.684
DOC_USP7_MATH_1	789	793	PF00917	0.671
DOC_USP7_MATH_1	847	851	PF00917	0.747
DOC_USP7_MATH_1	867	871	PF00917	0.781
DOC_USP7_UBL2_3	201	205	PF12436	0.573
DOC_USP7_UBL2_3	352	356	PF12436	0.568
DOC_USP7_UBL2_3	428	432	PF12436	0.655
DOC_USP7_UBL2_3	533	537	PF12436	0.765
DOC_WW_Pin1_4	105	110	PF00397	0.788
DOC_WW_Pin1_4	116	121	PF00397	0.621
DOC_WW_Pin1_4	34	39	PF00397	0.623
DOC_WW_Pin1_4	466	471	PF00397	0.640
DOC_WW_Pin1_4	554	559	PF00397	0.765
DOC_WW_Pin1_4	703	708	PF00397	0.713
DOC_WW_Pin1_4	719	724	PF00397	0.686
DOC_WW_Pin1_4	831	836	PF00397	0.753
DOC_WW_Pin1_4	853	858	PF00397	0.717
DOC_WW_Pin1_4	865	870	PF00397	0.548
DOC_WW_Pin1_4	99	104	PF00397	0.573
LIG_14-3-3_CanoR_1	320	328	PF00244	0.593
LIG_14-3-3_CanoR_1	494	504	PF00244	0.608
LIG_14-3-3_CanoR_1	548	554	PF00244	0.756
LIG_14-3-3_CanoR_1	587	592	PF00244	0.690
LIG_14-3-3_CanoR_1	632	641	PF00244	0.679
LIG_14-3-3_CanoR_1	683	688	PF00244	0.646
LIG_14-3-3_CanoR_1	701	708	PF00244	0.694
LIG_14-3-3_CanoR_1	74	78	PF00244	0.664
LIG_14-3-3_CanoR_1	878	884	PF00244	0.778
LIG_14-3-3_CanoR_1	887	893	PF00244	0.731
LIG_14-3-3_CanoR_1	909	915	PF00244	0.699
LIG_APCC_ABBAyCdc20_2	395	401	PF00400	0.660
LIG_APCC_Cbox_1	246	252	PF00515	0.441
LIG_APCC_Cbox_2	246	252	PF00515	0.441
LIG_BRCT_BRCA1_1	75	79	PF00533	0.696
LIG_BRCT_BRCA1_1	753	757	PF00533	0.497
LIG_BRCT_BRCA1_1	890	894	PF00533	0.749
LIG_CaM_IQ_9	540	556	PF13499	0.583
LIG_Clathr_ClatBox_1	180	184	PF01394	0.520
LIG_eIF4E_1	824	830	PF01652	0.755
LIG_FHA_1	165	171	PF00498	0.678
LIG_FHA_1	223	229	PF00498	0.562
LIG_FHA_1	349	355	PF00498	0.677
LIG_FHA_1	424	430	PF00498	0.693
LIG_FHA_1	470	476	PF00498	0.551
LIG_FHA_1	586	592	PF00498	0.509
LIG_FHA_1	682	688	PF00498	0.662
LIG_FHA_1	7	13	PF00498	0.811
LIG_FHA_1	700	706	PF00498	0.645
LIG_FHA_1	735	741	PF00498	0.607
LIG_FHA_1	797	803	PF00498	0.806
LIG_FHA_1	807	813	PF00498	0.761
LIG_FHA_1	878	884	PF00498	0.730
LIG_FHA_2	29	35	PF00498	0.757
LIG_FHA_2	442	448	PF00498	0.601
LIG_FHA_2	588	594	PF00498	0.436
LIG_FHA_2	618	624	PF00498	0.578
LIG_FHA_2	631	637	PF00498	0.576
LIG_FHA_2	739	745	PF00498	0.653
LIG_FHA_2	87	93	PF00498	0.753
LIG_IRF3_LxIS_1	307	312	PF10401	0.676
LIG_LIR_Apic_2	913	917	PF02991	0.762
LIG_LIR_Gen_1	828	838	PF02991	0.658
LIG_LIR_Nem_3	828	833	PF02991	0.657
LIG_MYND_1	466	470	PF01753	0.559
LIG_NRBOX	295	301	PF00104	0.637
LIG_Pex14_2	388	392	PF04695	0.529
LIG_PTB_Apo_2	505	512	PF02174	0.681
LIG_PTB_Phospho_1	505	511	PF10480	0.680
LIG_RPA_C_Fungi	441	453	PF08784	0.610
LIG_SH2_CRK	824	828	PF00017	0.756
LIG_SH2_NCK_1	342	346	PF00017	0.527
LIG_SH2_NCK_1	511	515	PF00017	0.726
LIG_SH2_NCK_1	824	828	PF00017	0.681
LIG_SH2_SRC	399	402	PF00017	0.663
LIG_SH2_SRC	511	514	PF00017	0.726
LIG_SH2_STAP1	171	175	PF00017	0.681
LIG_SH2_STAP1	326	330	PF00017	0.630
LIG_SH2_STAT3	598	601	PF00017	0.532
LIG_SH2_STAT5	474	477	PF00017	0.507
LIG_SH2_STAT5	638	641	PF00017	0.653
LIG_SH3_1	460	466	PF00018	0.608
LIG_SH3_3	301	307	PF00018	0.644
LIG_SH3_3	357	363	PF00018	0.758
LIG_SH3_3	460	466	PF00018	0.630
LIG_SH3_3	717	723	PF00018	0.787
LIG_SH3_3	72	78	PF00018	0.644
LIG_SH3_3	762	768	PF00018	0.714
LIG_SUMO_SIM_anti_2	684	689	PF11976	0.503
LIG_SUMO_SIM_par_1	307	312	PF11976	0.638
LIG_SUMO_SIM_par_1	587	593	PF11976	0.607
LIG_TRAF2_1	182	185	PF00917	0.474
LIG_TRAF2_1	413	416	PF00917	0.663
LIG_TRAF2_1	620	623	PF00917	0.545
LIG_UBA3_1	308	313	PF00899	0.525
MOD_CDC14_SPxK_1	706	709	PF00782	0.659
MOD_CDK_SPK_2	554	559	PF00069	0.748
MOD_CDK_SPxK_1	703	709	PF00069	0.702
MOD_CDK_SPxxK_3	34	41	PF00069	0.619
MOD_CDK_SPxxK_3	466	473	PF00069	0.690
MOD_CDK_SPxxK_3	853	860	PF00069	0.720
MOD_CK1_1	114	120	PF00069	0.776
MOD_CK1_1	274	280	PF00069	0.607
MOD_CK1_1	312	318	PF00069	0.688
MOD_CK1_1	344	350	PF00069	0.690
MOD_CK1_1	417	423	PF00069	0.568
MOD_CK1_1	441	447	PF00069	0.601
MOD_CK1_1	469	475	PF00069	0.634
MOD_CK1_1	492	498	PF00069	0.700
MOD_CK1_1	5	11	PF00069	0.705
MOD_CK1_1	552	558	PF00069	0.713
MOD_CK1_1	692	698	PF00069	0.698
MOD_CK1_1	700	706	PF00069	0.723
MOD_CK1_1	805	811	PF00069	0.796
MOD_CK1_1	828	834	PF00069	0.694
MOD_CK1_1	86	92	PF00069	0.755
MOD_CK2_1	28	34	PF00069	0.767
MOD_CK2_1	289	295	PF00069	0.592
MOD_CK2_1	441	447	PF00069	0.612
MOD_CK2_1	455	461	PF00069	0.686
MOD_CK2_1	587	593	PF00069	0.451
MOD_CK2_1	617	623	PF00069	0.528
MOD_CK2_1	719	725	PF00069	0.745
MOD_CK2_1	738	744	PF00069	0.663
MOD_CK2_1	8	14	PF00069	0.754
MOD_CK2_1	890	896	PF00069	0.801
MOD_Cter_Amidation	318	321	PF01082	0.626
MOD_Cter_Amidation	909	912	PF01082	0.665
MOD_GlcNHglycan	111	114	PF01048	0.781
MOD_GlcNHglycan	120	123	PF01048	0.590
MOD_GlcNHglycan	273	276	PF01048	0.614
MOD_GlcNHglycan	290	294	PF01048	0.613
MOD_GlcNHglycan	314	317	PF01048	0.746
MOD_GlcNHglycan	343	346	PF01048	0.723
MOD_GlcNHglycan	420	423	PF01048	0.726
MOD_GlcNHglycan	440	443	PF01048	0.375
MOD_GlcNHglycan	457	460	PF01048	0.684
MOD_GlcNHglycan	498	501	PF01048	0.746
MOD_GlcNHglycan	538	541	PF01048	0.792
MOD_GlcNHglycan	565	568	PF01048	0.683
MOD_GlcNHglycan	642	645	PF01048	0.719
MOD_GlcNHglycan	661	664	PF01048	0.508
MOD_GlcNHglycan	691	694	PF01048	0.714
MOD_GlcNHglycan	838	841	PF01048	0.721
MOD_GlcNHglycan	844	847	PF01048	0.702
MOD_GlcNHglycan	849	852	PF01048	0.676
MOD_GlcNHglycan	863	866	PF01048	0.724
MOD_GlcNHglycan	869	872	PF01048	0.739
MOD_GlcNHglycan	923	926	PF01048	0.684
MOD_GSK3_1	105	112	PF00069	0.787
MOD_GSK3_1	114	121	PF00069	0.716
MOD_GSK3_1	2	9	PF00069	0.782
MOD_GSK3_1	212	219	PF00069	0.666
MOD_GSK3_1	28	35	PF00069	0.759
MOD_GSK3_1	307	314	PF00069	0.704
MOD_GSK3_1	344	351	PF00069	0.731
MOD_GSK3_1	368	375	PF00069	0.621
MOD_GSK3_1	414	421	PF00069	0.615
MOD_GSK3_1	488	495	PF00069	0.603
MOD_GSK3_1	548	555	PF00069	0.740
MOD_GSK3_1	699	706	PF00069	0.652
MOD_GSK3_1	719	726	PF00069	0.678
MOD_GSK3_1	734	741	PF00069	0.665
MOD_GSK3_1	802	809	PF00069	0.790
MOD_GSK3_1	82	89	PF00069	0.663
MOD_GSK3_1	861	868	PF00069	0.782
MOD_LATS_1	524	530	PF00433	0.742
MOD_LATS_1	585	591	PF00433	0.646
MOD_LATS_1	886	892	PF00433	0.602
MOD_N-GLC_1	164	169	PF02516	0.723
MOD_N-GLC_1	28	33	PF02516	0.565
MOD_N-GLC_1	300	305	PF02516	0.680
MOD_N-GLC_1	363	368	PF02516	0.710
MOD_N-GLC_1	888	893	PF02516	0.746
MOD_NEK2_1	207	212	PF00069	0.493
MOD_NEK2_1	300	305	PF00069	0.673
MOD_NEK2_1	309	314	PF00069	0.697
MOD_NEK2_1	328	333	PF00069	0.485
MOD_NEK2_1	409	414	PF00069	0.703
MOD_NEK2_1	438	443	PF00069	0.623
MOD_NEK2_1	681	686	PF00069	0.687
MOD_NEK2_1	73	78	PF00069	0.634
MOD_NEK2_1	872	877	PF00069	0.764
MOD_NEK2_1	879	884	PF00069	0.714
MOD_PIKK_1	213	219	PF00454	0.671
MOD_PIKK_1	223	229	PF00454	0.591
MOD_PIKK_1	489	495	PF00454	0.652
MOD_PIKK_1	526	532	PF00454	0.762
MOD_PIKK_1	759	765	PF00454	0.769
MOD_PK_1	888	894	PF00069	0.723
MOD_PKA_1	488	494	PF00069	0.661
MOD_PKA_1	526	532	PF00069	0.692
MOD_PKA_1	548	554	PF00069	0.818
MOD_PKA_2	319	325	PF00069	0.603
MOD_PKA_2	409	415	PF00069	0.652
MOD_PKA_2	488	494	PF00069	0.622
MOD_PKA_2	495	501	PF00069	0.649
MOD_PKA_2	526	532	PF00069	0.758
MOD_PKA_2	548	554	PF00069	0.653
MOD_PKA_2	700	706	PF00069	0.753
MOD_PKA_2	73	79	PF00069	0.665
MOD_PKA_2	825	831	PF00069	0.751
MOD_PKA_2	877	883	PF00069	0.721
MOD_PKA_2	910	916	PF00069	0.657
MOD_PKB_1	494	502	PF00069	0.646
MOD_PKB_1	547	555	PF00069	0.744
MOD_PKB_1	630	638	PF00069	0.647
MOD_PKB_1	888	896	PF00069	0.722
MOD_Plk_1	207	213	PF00069	0.612
MOD_Plk_1	300	306	PF00069	0.671
MOD_Plk_1	5	11	PF00069	0.774
MOD_Plk_1	625	631	PF00069	0.632
MOD_Plk_1	888	894	PF00069	0.723
MOD_Plk_1	90	96	PF00069	0.681
MOD_Plk_2-3	617	623	PF00069	0.532
MOD_Plk_4	216	222	PF00069	0.698
MOD_Plk_4	683	689	PF00069	0.617
MOD_Plk_4	825	831	PF00069	0.697
MOD_ProDKin_1	116	122	PF00069	0.617
MOD_ProDKin_1	34	40	PF00069	0.614
MOD_ProDKin_1	466	472	PF00069	0.638
MOD_ProDKin_1	554	560	PF00069	0.765
MOD_ProDKin_1	703	709	PF00069	0.715
MOD_ProDKin_1	719	725	PF00069	0.686
MOD_ProDKin_1	831	837	PF00069	0.753
MOD_ProDKin_1	853	859	PF00069	0.720
MOD_ProDKin_1	865	871	PF00069	0.548
MOD_ProDKin_1	99	105	PF00069	0.575
MOD_SUMO_for_1	402	405	PF00179	0.566
MOD_SUMO_rev_2	197	207	PF00179	0.535
MOD_SUMO_rev_2	529	539	PF00179	0.768
MOD_SUMO_rev_2	614	621	PF00179	0.628
TRG_DiLeu_BaEn_1	295	300	PF01217	0.634
TRG_DiLeu_BaEn_1	677	682	PF01217	0.663
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.497
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.506
TRG_ENDOCYTIC_2	190	193	PF00928	0.627
TRG_ENDOCYTIC_2	399	402	PF00928	0.528
TRG_ENDOCYTIC_2	42	45	PF00928	0.629
TRG_ENDOCYTIC_2	638	641	PF00928	0.566
TRG_ER_diArg_1	139	142	PF00400	0.621
TRG_ER_diArg_1	148	150	PF00400	0.588
TRG_ER_diArg_1	334	337	PF00400	0.529
TRG_ER_diArg_1	393	395	PF00400	0.616
TRG_ER_diArg_1	451	453	PF00400	0.654
TRG_ER_diArg_1	526	528	PF00400	0.590
TRG_ER_diArg_1	547	550	PF00400	0.742
TRG_ER_diArg_1	629	632	PF00400	0.594
TRG_ER_diArg_1	714	716	PF00400	0.748
TRG_ER_diArg_1	755	757	PF00400	0.542
TRG_ER_diArg_1	885	888	PF00400	0.778
TRG_ER_diArg_1	908	911	PF00400	0.761
TRG_NES_CRM1_1	173	185	PF08389	0.613
TRG_NLS_MonoExtC_3	883	888	PF00514	0.730
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	587	592	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	745	749	PF00026	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6T1	Leptomonas seymouri	42%	97%
A0A3S7XBQ9	Leishmania donovani	88%	100%
A4HPZ6	Leishmania braziliensis	68%	99%
A4IDQ7	Leishmania infantum	89%	100%
D0A4F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ATR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BQ47	Trypanosoma cruzi	28%	100%