PABS domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q0T3_LEIMA

TriTrypDb:

LmjF.36.4800 , LMJLV39_360059700 , LMJSD75_360059400

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0T3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.612
CLV_C14_Caspase3-7	251	255	PF00656	0.584
CLV_NRD_NRD_1	10	12	PF00675	0.576
CLV_NRD_NRD_1	101	103	PF00675	0.602
CLV_NRD_NRD_1	23	25	PF00675	0.527
CLV_PCSK_FUR_1	7	11	PF00082	0.562
CLV_PCSK_KEX2_1	10	12	PF00082	0.576
CLV_PCSK_KEX2_1	162	164	PF00082	0.546
CLV_PCSK_KEX2_1	21	23	PF00082	0.522
CLV_PCSK_KEX2_1	275	277	PF00082	0.527
CLV_PCSK_KEX2_1	7	9	PF00082	0.584
CLV_PCSK_KEX2_1	78	80	PF00082	0.366
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.517
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.585
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.527
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.366
CLV_PCSK_SKI1_1	123	127	PF00082	0.496
CLV_PCSK_SKI1_1	323	327	PF00082	0.360
CLV_PCSK_SKI1_1	403	407	PF00082	0.482
CLV_PCSK_SKI1_1	52	56	PF00082	0.402
CLV_PCSK_SKI1_1	75	79	PF00082	0.420
DEG_ODPH_VHL_1	4	17	PF01847	0.598
DEG_SPOP_SBC_1	268	272	PF00917	0.620
DOC_MAPK_gen_1	7	17	PF00069	0.574
DOC_MAPK_JIP1_4	407	413	PF00069	0.410
DOC_MAPK_MEF2A_6	46	53	PF00069	0.427
DOC_MAPK_NFAT4_5	46	54	PF00069	0.435
DOC_USP7_MATH_1	109	113	PF00917	0.692
DOC_USP7_MATH_1	280	284	PF00917	0.544
DOC_WW_Pin1_4	131	136	PF00397	0.607
LIG_14-3-3_CanoR_1	110	116	PF00244	0.602
LIG_14-3-3_CanoR_1	212	217	PF00244	0.406
LIG_14-3-3_CanoR_1	22	30	PF00244	0.451
LIG_14-3-3_CanoR_1	276	280	PF00244	0.580
LIG_14-3-3_CanoR_1	443	451	PF00244	0.535
LIG_14-3-3_CanoR_1	64	72	PF00244	0.547
LIG_14-3-3_CanoR_1	8	17	PF00244	0.578
LIG_14-3-3_CanoR_1	86	90	PF00244	0.501
LIG_14-3-3_CterR_2	507	511	PF00244	0.365
LIG_Actin_WH2_2	190	206	PF00022	0.332
LIG_Actin_WH2_2	76	94	PF00022	0.366
LIG_FHA_1	10	16	PF00498	0.553
LIG_FHA_1	303	309	PF00498	0.538
LIG_FHA_1	400	406	PF00498	0.439
LIG_FHA_1	53	59	PF00498	0.459
LIG_FHA_1	64	70	PF00498	0.328
LIG_FHA_1	86	92	PF00498	0.542
LIG_FHA_2	137	143	PF00498	0.622
LIG_FHA_2	163	169	PF00498	0.534
LIG_FHA_2	226	232	PF00498	0.553
LIG_FHA_2	235	241	PF00498	0.579
LIG_FHA_2	348	354	PF00498	0.412
LIG_FHA_2	373	379	PF00498	0.349
LIG_FHA_2	468	474	PF00498	0.363
LIG_FHA_2	96	102	PF00498	0.662
LIG_GBD_Chelix_1	474	482	PF00786	0.359
LIG_LIR_Apic_2	112	116	PF02991	0.627
LIG_LIR_Gen_1	194	203	PF02991	0.324
LIG_LIR_Gen_1	375	385	PF02991	0.343
LIG_LIR_Nem_3	194	198	PF02991	0.324
LIG_LIR_Nem_3	375	380	PF02991	0.375
LIG_LIR_Nem_3	383	388	PF02991	0.411
LIG_LIR_Nem_3	473	479	PF02991	0.403
LIG_MYND_1	2	6	PF01753	0.615
LIG_Pex14_1	486	490	PF04695	0.325
LIG_Pex14_2	44	48	PF04695	0.410
LIG_SH2_CRK	113	117	PF00017	0.521
LIG_SH2_CRK	200	204	PF00017	0.394
LIG_SH2_CRK	377	381	PF00017	0.317
LIG_SH2_CRK	428	432	PF00017	0.422
LIG_SH2_NCK_1	113	117	PF00017	0.500
LIG_SH2_NCK_1	428	432	PF00017	0.422
LIG_SH2_STAP1	377	381	PF00017	0.355
LIG_SH2_STAP1	428	432	PF00017	0.422
LIG_SH2_STAP1	463	467	PF00017	0.368
LIG_SH2_STAP1	479	483	PF00017	0.337
LIG_SH2_STAT5	113	116	PF00017	0.503
LIG_SH2_STAT5	148	151	PF00017	0.356
LIG_SH2_STAT5	200	203	PF00017	0.389
LIG_SH3_1	103	109	PF00018	0.586
LIG_SH3_2	3	8	PF14604	0.609
LIG_SH3_3	103	109	PF00018	0.514
LIG_SH3_3	91	97	PF00018	0.444
LIG_SUMO_SIM_par_1	224	240	PF11976	0.427
LIG_SUMO_SIM_par_1	329	336	PF11976	0.353
LIG_TRAF2_1	98	101	PF00917	0.606
LIG_TYR_ITIM	198	203	PF00017	0.388
LIG_TYR_ITSM	373	380	PF00017	0.345
LIG_WRC_WIRS_1	192	197	PF05994	0.324
LIG_WW_3	107	111	PF00397	0.657
MOD_CK1_1	167	173	PF00069	0.451
MOD_CK1_1	191	197	PF00069	0.394
MOD_CK1_1	233	239	PF00069	0.625
MOD_CK2_1	234	240	PF00069	0.556
MOD_CK2_1	284	290	PF00069	0.503
MOD_CK2_1	347	353	PF00069	0.340
MOD_CK2_1	95	101	PF00069	0.652
MOD_GlcNHglycan	128	131	PF01048	0.589
MOD_GlcNHglycan	136	139	PF01048	0.588
MOD_GlcNHglycan	250	253	PF01048	0.753
MOD_GlcNHglycan	420	423	PF01048	0.378
MOD_GSK3_1	230	237	PF00069	0.680
MOD_GSK3_1	280	287	PF00069	0.471
MOD_GSK3_1	347	354	PF00069	0.499
MOD_GSK3_1	368	375	PF00069	0.310
MOD_GSK3_1	457	464	PF00069	0.426
MOD_N-GLC_1	131	136	PF02516	0.577
MOD_N-GLC_1	212	217	PF02516	0.345
MOD_N-GLC_1	247	252	PF02516	0.609
MOD_NEK2_1	17	22	PF00069	0.609
MOD_NEK2_1	38	43	PF00069	0.360
MOD_NEK2_1	465	470	PF00069	0.352
MOD_PIKK_1	123	129	PF00454	0.504
MOD_PIKK_1	269	275	PF00454	0.647
MOD_PIKK_1	63	69	PF00454	0.406
MOD_PKA_1	162	168	PF00069	0.510
MOD_PKA_1	23	29	PF00069	0.489
MOD_PKA_1	275	281	PF00069	0.512
MOD_PKA_1	9	15	PF00069	0.564
MOD_PKA_2	109	115	PF00069	0.652
MOD_PKA_2	162	168	PF00069	0.525
MOD_PKA_2	23	29	PF00069	0.473
MOD_PKA_2	275	281	PF00069	0.590
MOD_PKA_2	63	69	PF00069	0.386
MOD_PKA_2	85	91	PF00069	0.495
MOD_PKA_2	9	15	PF00069	0.560
MOD_PKB_1	7	15	PF00069	0.580
MOD_Plk_1	167	173	PF00069	0.451
MOD_Plk_1	212	218	PF00069	0.340
MOD_Plk_1	38	44	PF00069	0.364
MOD_Plk_2-3	461	467	PF00069	0.353
MOD_Plk_4	172	178	PF00069	0.427
MOD_Plk_4	188	194	PF00069	0.222
MOD_Plk_4	445	451	PF00069	0.361
MOD_Plk_4	478	484	PF00069	0.409
MOD_ProDKin_1	131	137	PF00069	0.607
MOD_SUMO_rev_2	13	17	PF00179	0.632
MOD_SUMO_rev_2	278	288	PF00179	0.539
MOD_SUMO_rev_2	353	358	PF00179	0.500
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.321
TRG_ENDOCYTIC_2	200	203	PF00928	0.389
TRG_ENDOCYTIC_2	377	380	PF00928	0.318
TRG_ENDOCYTIC_2	381	384	PF00928	0.380
TRG_ENDOCYTIC_2	428	431	PF00928	0.363
TRG_ENDOCYTIC_2	479	482	PF00928	0.338
TRG_ER_diArg_1	22	24	PF00400	0.528
TRG_ER_diArg_1	504	507	PF00400	0.357
TRG_ER_diArg_1	6	9	PF00400	0.571
TRG_NES_CRM1_1	217	232	PF08389	0.341
TRG_NLS_Bipartite_1	7	25	PF00514	0.546
TRG_NLS_MonoCore_2	20	25	PF00514	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ0	Leptomonas seymouri	57%	100%
A0A3S7XBN4	Leishmania donovani	92%	100%
A4HPZ7	Leishmania braziliensis	77%	100%
A4IDQ8	Leishmania infantum	92%	100%
E9ATR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%