PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pentatricopeptide repeat domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q0T2_LEIMA

TriTrypDb:

LmjF.36.4810 , LMJLV39_360059800 , LMJSD75_360059500

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q0T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0T2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.416
CLV_NRD_NRD_1	166	168	PF00675	0.350
CLV_NRD_NRD_1	47	49	PF00675	0.395
CLV_PCSK_KEX2_1	166	168	PF00082	0.350
CLV_PCSK_KEX2_1	47	49	PF00082	0.395
CLV_PCSK_SKI1_1	121	125	PF00082	0.295
CLV_PCSK_SKI1_1	15	19	PF00082	0.383
CLV_PCSK_SKI1_1	209	213	PF00082	0.281
CLV_PCSK_SKI1_1	230	234	PF00082	0.359
CLV_PCSK_SKI1_1	48	52	PF00082	0.412
CLV_PCSK_SKI1_1	74	78	PF00082	0.396
CLV_Separin_Metazoa	231	235	PF03568	0.388
DEG_APCC_DBOX_1	229	237	PF00400	0.430
DOC_ANK_TNKS_1	216	223	PF00023	0.396
DOC_CKS1_1	170	175	PF01111	0.385
DOC_CYCLIN_RxL_1	227	235	PF00134	0.410
DOC_MAPK_gen_1	206	214	PF00069	0.281
DOC_MAPK_MEF2A_6	100	107	PF00069	0.322
DOC_MAPK_NFAT4_5	100	108	PF00069	0.431
DOC_PP4_FxxP_1	150	153	PF00568	0.396
DOC_WW_Pin1_4	169	174	PF00397	0.390
LIG_14-3-3_CanoR_1	11	17	PF00244	0.421
LIG_14-3-3_CanoR_1	181	185	PF00244	0.470
LIG_14-3-3_CanoR_1	238	243	PF00244	0.540
LIG_14-3-3_CanoR_1	252	261	PF00244	0.553
LIG_APCC_ABBA_1	105	110	PF00400	0.455
LIG_BIR_II_1	1	5	PF00653	0.473
LIG_DLG_GKlike_1	238	245	PF00625	0.463
LIG_eIF4E_1	86	92	PF01652	0.268
LIG_FHA_1	122	128	PF00498	0.268
LIG_FHA_1	16	22	PF00498	0.364
LIG_FHA_1	170	176	PF00498	0.455
LIG_FHA_1	227	233	PF00498	0.360
LIG_FHA_1	52	58	PF00498	0.269
LIG_FHA_1	87	93	PF00498	0.263
LIG_FHA_2	238	244	PF00498	0.479
LIG_GBD_Chelix_1	103	111	PF00786	0.445
LIG_LIR_Apic_2	147	153	PF02991	0.396
LIG_LIR_Gen_1	192	203	PF02991	0.264
LIG_LIR_Gen_1	36	45	PF02991	0.276
LIG_LIR_Gen_1	87	96	PF02991	0.317
LIG_LIR_Nem_3	192	198	PF02991	0.264
LIG_LIR_Nem_3	221	226	PF02991	0.256
LIG_LIR_Nem_3	255	261	PF02991	0.648
LIG_LIR_Nem_3	87	91	PF02991	0.253
LIG_Pex14_1	136	140	PF04695	0.367
LIG_Pex14_2	12	16	PF04695	0.527
LIG_SH2_CRK	195	199	PF00017	0.253
LIG_SH2_CRK	53	57	PF00017	0.253
LIG_SH2_CRK	88	92	PF00017	0.268
LIG_SH2_NCK_1	223	227	PF00017	0.337
LIG_SH2_SRC	223	226	PF00017	0.375
LIG_SH2_STAP1	158	162	PF00017	0.255
LIG_SH2_STAP1	215	219	PF00017	0.251
LIG_SH2_STAP1	228	232	PF00017	0.408
LIG_SH2_STAP1	53	57	PF00017	0.253
LIG_SH2_STAP1	88	92	PF00017	0.276
LIG_SH2_STAT5	158	161	PF00017	0.255
LIG_SH2_STAT5	228	231	PF00017	0.394
LIG_SH2_STAT5	261	264	PF00017	0.645
LIG_SH2_STAT5	53	56	PF00017	0.279
LIG_SH2_STAT5	86	89	PF00017	0.253
LIG_SH3_3	111	117	PF00018	0.359
LIG_SH3_3	167	173	PF00018	0.390
LIG_SUMO_SIM_par_1	124	131	PF11976	0.329
LIG_TRAF2_1	273	276	PF00917	0.562
LIG_TYR_ITIM	193	198	PF00017	0.253
LIG_WRC_WIRS_1	21	26	PF05994	0.396
LIG_WRC_WIRS_1	34	39	PF05994	0.275
MOD_CK1_1	128	134	PF00069	0.432
MOD_CK2_1	253	259	PF00069	0.554
MOD_GlcNHglycan	26	29	PF01048	0.305
MOD_GSK3_1	11	18	PF00069	0.401
MOD_GSK3_1	121	128	PF00069	0.347
MOD_GSK3_1	20	27	PF00069	0.401
MOD_GSK3_1	262	269	PF00069	0.558
MOD_GSK3_1	51	58	PF00069	0.321
MOD_N-GLC_2	93	95	PF02516	0.313
MOD_NEK2_1	156	161	PF00069	0.268
MOD_NEK2_1	237	242	PF00069	0.419
MOD_NEK2_1	24	29	PF00069	0.386
MOD_NEK2_1	40	45	PF00069	0.311
MOD_NEK2_1	51	56	PF00069	0.242
MOD_PIKK_1	183	189	PF00454	0.565
MOD_PKA_2	10	16	PF00069	0.473
MOD_PKA_2	180	186	PF00069	0.550
MOD_PKA_2	237	243	PF00069	0.487
MOD_PKA_2	253	259	PF00069	0.436
MOD_Plk_1	191	197	PF00069	0.268
MOD_Plk_4	194	200	PF00069	0.268
MOD_Plk_4	41	47	PF00069	0.484
MOD_Plk_4	52	58	PF00069	0.231
MOD_Plk_4	87	93	PF00069	0.364
MOD_ProDKin_1	169	175	PF00069	0.387
TRG_ENDOCYTIC_2	195	198	PF00928	0.253
TRG_ENDOCYTIC_2	215	218	PF00928	0.124
TRG_ENDOCYTIC_2	223	226	PF00928	0.231
TRG_ENDOCYTIC_2	53	56	PF00928	0.288
TRG_ENDOCYTIC_2	88	91	PF00928	0.268
TRG_ER_diArg_1	251	254	PF00400	0.441
TRG_ER_diArg_1	46	48	PF00400	0.472
TRG_NES_CRM1_1	102	115	PF08389	0.465
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J7	Leptomonas seymouri	80%	100%
A0A0S4IYI9	Bodo saltans	48%	100%
A0A1X0NXK5	Trypanosomatidae	24%	100%
A0A1X0P0D8	Trypanosomatidae	60%	88%
A0A3Q8IJ22	Leishmania donovani	95%	100%
A0A3R7KPI7	Trypanosoma rangeli	57%	99%
A4HPZ8	Leishmania braziliensis	90%	100%
A4IDQ9	Leishmania infantum	95%	100%
D0A4F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	71%
E9ATR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QAB0	Leishmania major	23%	100%
Q5BIV3	Arabidopsis thaliana	24%	76%
Q940Z1	Arabidopsis thaliana	26%	88%
Q9FFZ2	Arabidopsis thaliana	22%	84%
Q9LG23	Arabidopsis thaliana	21%	70%
Q9SAB4	Arabidopsis thaliana	22%	69%
V5DLI8	Trypanosoma cruzi	58%	91%