Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4Q0T1_LEIMA

TriTrypDb:

LmjF.36.4820 , LMJLV39_360059900 , LMJSD75_360059600

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	2
GO:0005654	nucleoplasm	2	2
GO:0005681	spliceosomal complex	3	2
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4Q0T1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0T1

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.679
CLV_NRD_NRD_1	453	455	PF00675	0.618
CLV_NRD_NRD_1	457	459	PF00675	0.590
CLV_NRD_NRD_1	57	59	PF00675	0.561
CLV_PCSK_KEX2_1	453	455	PF00082	0.583
CLV_PCSK_KEX2_1	457	459	PF00082	0.556
CLV_PCSK_KEX2_1	56	58	PF00082	0.672
CLV_PCSK_PC7_1	453	459	PF00082	0.609
CLV_PCSK_SKI1_1	152	156	PF00082	0.560
CLV_PCSK_SKI1_1	177	181	PF00082	0.429
CLV_PCSK_SKI1_1	264	268	PF00082	0.330
CLV_PCSK_SKI1_1	402	406	PF00082	0.689
CLV_PCSK_SKI1_1	430	434	PF00082	0.415
CLV_PCSK_SKI1_1	492	496	PF00082	0.263
CLV_PCSK_SKI1_1	500	504	PF00082	0.256
CLV_Separin_Metazoa	261	265	PF03568	0.429
DEG_Nend_UBRbox_3	1	3	PF02207	0.617
DEG_SPOP_SBC_1	123	127	PF00917	0.635
DOC_CYCLIN_RxL_1	352	363	PF00134	0.542
DOC_MAPK_gen_1	150	157	PF00069	0.637
DOC_MAPK_gen_1	175	183	PF00069	0.429
DOC_MAPK_gen_1	352	362	PF00069	0.456
DOC_PP1_RVXF_1	356	363	PF00149	0.540
DOC_PP2B_LxvP_1	26	29	PF13499	0.633
DOC_USP7_MATH_1	123	127	PF00917	0.719
DOC_USP7_MATH_1	202	206	PF00917	0.481
DOC_USP7_MATH_1	230	234	PF00917	0.525
DOC_USP7_MATH_1	278	282	PF00917	0.497
DOC_USP7_MATH_1	368	372	PF00917	0.548
DOC_USP7_MATH_1	403	407	PF00917	0.705
DOC_USP7_MATH_1	434	438	PF00917	0.380
DOC_USP7_MATH_1	49	53	PF00917	0.711
DOC_USP7_MATH_1	79	83	PF00917	0.719
DOC_WW_Pin1_4	168	173	PF00397	0.658
DOC_WW_Pin1_4	237	242	PF00397	0.453
DOC_WW_Pin1_4	425	430	PF00397	0.378
LIG_14-3-3_CanoR_1	232	237	PF00244	0.481
LIG_14-3-3_CanoR_1	402	408	PF00244	0.762
LIG_14-3-3_CanoR_1	421	429	PF00244	0.320
LIG_BRCT_BRCA1_1	331	335	PF00533	0.542
LIG_BRCT_BRCA1_1	383	387	PF00533	0.540
LIG_FHA_1	215	221	PF00498	0.403
LIG_FHA_1	291	297	PF00498	0.474
LIG_FHA_1	310	316	PF00498	0.364
LIG_FHA_1	391	397	PF00498	0.657
LIG_FHA_1	410	416	PF00498	0.413
LIG_FHA_1	466	472	PF00498	0.436
LIG_FHA_1	483	489	PF00498	0.456
LIG_FHA_1	73	79	PF00498	0.748
LIG_FHA_2	111	117	PF00498	0.684
LIG_FHA_2	190	196	PF00498	0.533
LIG_FHA_2	2	8	PF00498	0.691
LIG_FHA_2	82	88	PF00498	0.653
LIG_FHA_2	90	96	PF00498	0.747
LIG_LIR_Apic_2	446	450	PF02991	0.494
LIG_LIR_Gen_1	203	212	PF02991	0.542
LIG_LIR_Gen_1	332	342	PF02991	0.542
LIG_LIR_LC3C_4	153	157	PF02991	0.634
LIG_LIR_LC3C_4	317	320	PF02991	0.517
LIG_LIR_Nem_3	203	209	PF02991	0.542
LIG_LIR_Nem_3	332	338	PF02991	0.542
LIG_PCNA_yPIPBox_3	253	267	PF02747	0.542
LIG_Pex14_1	63	67	PF04695	0.682
LIG_Pex14_2	335	339	PF04695	0.542
LIG_REV1ctd_RIR_1	264	274	PF16727	0.542
LIG_RPA_C_Fungi	53	65	PF08784	0.628
LIG_SH2_CRK	170	174	PF00017	0.560
LIG_SH2_NCK_1	170	174	PF00017	0.595
LIG_SH2_STAP1	418	422	PF00017	0.589
LIG_SH2_STAP1	445	449	PF00017	0.501
LIG_SH2_STAT5	337	340	PF00017	0.308
LIG_SH3_2	33	38	PF14604	0.758
LIG_SH3_3	30	36	PF00018	0.735
LIG_SUMO_SIM_anti_2	281	287	PF11976	0.308
LIG_SUMO_SIM_par_1	105	111	PF11976	0.752
LIG_SUMO_SIM_par_1	431	437	PF11976	0.377
LIG_TRAF2_1	161	164	PF00917	0.620
LIG_TRAF2_1	5	8	PF00917	0.643
MOD_CDK_SPK_2	425	430	PF00069	0.413
MOD_CDK_SPxxK_3	168	175	PF00069	0.639
MOD_CK1_1	111	117	PF00069	0.701
MOD_CK1_1	122	128	PF00069	0.667
MOD_CK1_1	237	243	PF00069	0.375
MOD_CK1_1	314	320	PF00069	0.310
MOD_CK1_1	329	335	PF00069	0.324
MOD_CK1_1	37	43	PF00069	0.704
MOD_CK1_1	498	504	PF00069	0.324
MOD_CK1_1	81	87	PF00069	0.737
MOD_CK2_1	1	7	PF00069	0.604
MOD_CK2_1	110	116	PF00069	0.679
MOD_CK2_1	189	195	PF00069	0.417
MOD_CK2_1	81	87	PF00069	0.617
MOD_GlcNHglycan	113	116	PF01048	0.733
MOD_GlcNHglycan	121	124	PF01048	0.722
MOD_GlcNHglycan	126	129	PF01048	0.705
MOD_GlcNHglycan	152	155	PF01048	0.637
MOD_GlcNHglycan	244	247	PF01048	0.326
MOD_GlcNHglycan	270	273	PF01048	0.364
MOD_GlcNHglycan	286	289	PF01048	0.249
MOD_GlcNHglycan	328	331	PF01048	0.308
MOD_GlcNHglycan	342	345	PF01048	0.399
MOD_GlcNHglycan	383	386	PF01048	0.506
MOD_GlcNHglycan	407	410	PF01048	0.741
MOD_GlcNHglycan	46	50	PF01048	0.746
MOD_GlcNHglycan	487	491	PF01048	0.308
MOD_GSK3_1	111	118	PF00069	0.691
MOD_GSK3_1	119	126	PF00069	0.663
MOD_GSK3_1	230	237	PF00069	0.429
MOD_GSK3_1	244	251	PF00069	0.318
MOD_GSK3_1	286	293	PF00069	0.340
MOD_GSK3_1	386	393	PF00069	0.522
MOD_GSK3_1	398	405	PF00069	0.669
MOD_GSK3_1	416	423	PF00069	0.416
MOD_GSK3_1	45	52	PF00069	0.755
MOD_GSK3_1	463	470	PF00069	0.439
MOD_GSK3_1	482	489	PF00069	0.268
MOD_GSK3_1	67	74	PF00069	0.721
MOD_GSK3_1	91	98	PF00069	0.731
MOD_N-GLC_1	111	116	PF02516	0.768
MOD_N-GLC_1	119	124	PF02516	0.674
MOD_N-GLC_1	222	227	PF02516	0.324
MOD_N-GLC_1	389	394	PF02516	0.466
MOD_N-GLC_1	44	49	PF02516	0.754
MOD_NEK2_1	155	160	PF00069	0.588
MOD_NEK2_1	222	227	PF00069	0.314
MOD_NEK2_1	360	365	PF00069	0.363
MOD_PIKK_1	434	440	PF00454	0.385
MOD_PIKK_1	89	95	PF00454	0.783
MOD_PKA_2	348	354	PF00069	0.308
MOD_PKA_2	37	43	PF00069	0.616
MOD_PKA_2	420	426	PF00069	0.362
MOD_Plk_1	248	254	PF00069	0.308
MOD_Plk_1	290	296	PF00069	0.315
MOD_Plk_1	416	422	PF00069	0.617
MOD_Plk_1	45	51	PF00069	0.562
MOD_Plk_1	498	504	PF00069	0.343
MOD_Plk_4	105	111	PF00069	0.720
MOD_Plk_4	304	310	PF00069	0.359
MOD_Plk_4	311	317	PF00069	0.287
MOD_ProDKin_1	168	174	PF00069	0.644
MOD_ProDKin_1	237	243	PF00069	0.305
MOD_ProDKin_1	425	431	PF00069	0.380
MOD_SUMO_rev_2	392	401	PF00179	0.506
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.343
TRG_ER_diArg_1	299	302	PF00400	0.408
TRG_ER_diArg_1	452	454	PF00400	0.617
TRG_ER_diArg_1	505	508	PF00400	0.524
TRG_ER_diArg_1	55	58	PF00400	0.643
TRG_NES_CRM1_1	19	32	PF08389	0.642
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N2	Leptomonas seymouri	70%	99%
A0A0N1PBF5	Leptomonas seymouri	26%	74%
A0A0S4IWG1	Bodo saltans	43%	100%
A0A0S4JE21	Bodo saltans	27%	100%
A0A0S4JL38	Bodo saltans	28%	95%
A0A0S4KJ87	Bodo saltans	25%	85%
A0A1X0NQ96	Trypanosomatidae	26%	100%
A0A1X0P0F0	Trypanosomatidae	52%	100%
A0A3Q8IBR2	Leishmania donovani	22%	100%
A0A3Q8IGD2	Leishmania donovani	26%	100%
A0A3R7KUH0	Trypanosoma rangeli	27%	100%
A0A3R7MCP0	Trypanosoma rangeli	53%	100%
A0A3R7N6M9	Trypanosoma rangeli	22%	98%
A0A3S5H5M7	Leishmania donovani	26%	75%
A0A3S7WR72	Leishmania donovani	25%	100%
A0A3S7X9Q7	Leishmania donovani	25%	100%
A0A3S7XBP3	Leishmania donovani	93%	100%
A0DB19	Paramecium tetraurelia	22%	100%
A4H4H1	Leishmania braziliensis	27%	77%
A4H666	Leishmania braziliensis	25%	100%
A4HBK3	Leishmania braziliensis	21%	100%
A4HPZ9	Leishmania braziliensis	85%	100%
A4HSP6	Leishmania infantum	26%	75%
A4HUJ0	Leishmania infantum	25%	100%
A4HZL2	Leishmania infantum	22%	100%
A4I8M2	Leishmania infantum	26%	100%
A4IBS6	Leishmania infantum	25%	100%
A4IDR0	Leishmania infantum	93%	100%
C9ZVL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZW72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	83%
D0A4F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
D3Z902	Rattus norvegicus	27%	71%
E9AFL2	Leishmania major	25%	100%
E9AKN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	76%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ATR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AUX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B4L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	71%
E9B6R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
F1MNN4	Bos taurus	27%	72%
O13615	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
O60907	Homo sapiens	20%	88%
O74855	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
P0CS48	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	40%	100%
P0CS49	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	40%	100%
P25382	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	99%
P36408	Dictyostelium discoideum	24%	100%
P49846	Drosophila melanogaster	23%	72%
Q1LV15	Danio rerio	23%	100%
Q4Q4L7	Leishmania major	26%	100%
Q4QCL0	Leishmania major	21%	100%
Q4QHD6	Leishmania major	25%	100%
Q4QJ76	Leishmania major	25%	75%
Q4R8H1	Macaca fascicularis	20%	89%
Q58D20	Bos taurus	21%	100%
Q5A7Q3	Candida albicans (strain SC5314 / ATCC MYA-2876)	37%	100%
Q5BE22	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	38%	100%
Q5RFF8	Pongo abelii	20%	100%
Q6BU94	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	32%	100%
Q6CKE8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	37%	100%
Q6FJZ9	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	100%
Q7QJ33	Anopheles gambiae	25%	100%
Q7ZXK9	Xenopus laevis	24%	100%
Q86TI4	Homo sapiens	24%	100%
Q8VBV4	Mus musculus	27%	72%
Q8VEJ4	Mus musculus	21%	100%
Q93847	Caenorhabditis elegans	24%	100%
Q969H0	Homo sapiens	27%	72%
Q9FN19	Arabidopsis thaliana	21%	83%
Q9NVX2	Homo sapiens	20%	100%
V5B4Z8	Trypanosoma cruzi	52%	100%
V5BEB2	Trypanosoma cruzi	24%	94%
V5BP59	Trypanosoma cruzi	26%	100%
V5BRT6	Trypanosoma cruzi	28%	69%